Apoptosis – Fueling the oncogenic fire

Apoptotic cell-derived exosomes: messages from dying cells

(2020) Ramesh Kakarla et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Blood contains circulating cell‐free respiratory competent mitochondria

(2020) Zahra Al Amir Dache et al.   FASEB JOURNAL

The cell biology of mitochondrial membrane dynamics

(2020) Marta Giacomello et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial DNA in inflammation and immunity

(2020) Joel S Riley et al.   EMBO REPORTS

Prostaglandin E2 confers protection against diabetic coronary atherosclerosis by stimulating M2 macrophage polarization via the activation of the CREB/BDNF/TrkB signaling pathway

(2020) Changlong Bi et al.   FASEB JOURNAL

Fractalkine/CX3CL1 in Neoplastic Processes

(2020) Jan Korbecki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pivotal Involvement of the CX3CL1-CX3CR1 Axis for the Recruitment of M2 Tumor-Associated Macrophages in Skin Carcinogenesis

(2020) Yuko Ishida et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Metabolites released from apoptotic cells act as tissue messengers

(2020) Christopher B. Medina et al.   NATURE

Extracellular ATP promotes breast cancer invasion and chemoresistance via SOX9 signaling

(2020) Hui Yang et al.   ONCOGENE

BIK drives an aggressive breast cancer phenotype through sublethal apoptosis and predicts poor prognosis of ER-positive breast cancer

(2020) Vrajesh Pandya et al.   Cell Death & Disease

Failed Apoptosis Enhances Melanoma Cancer Cell Aggressiveness

(2020) Kevin Berthenet et al.   Cell Reports

Non-apoptotic function of Drosophila caspase activation in epithelial thorax closure and wound healing

(2019) Yuya Fujisawa et al.   DEVELOPMENT

Non-canonical processes that shape the cell migration landscape

(2019) Ritankar Majumdar et al.   CURRENT OPINION IN CELL BIOLOGY

MYC REGULATION OF A MITOCHONDRIAL TRAFFICKING NETWORK MEDIATES TUMOR CELL INVASION AND METASTASIS

(2019) Ekta Agarwal et al.   MOLECULAR AND CELLULAR BIOLOGY

On the Complexity of Mechanisms and Consequences of Chromothripsis: An Update

(2019) Alla S. Koltsova et al.   Frontiers in Genetics

Procaspase-3 Overexpression in Cancer: A Paradoxical Observation with Therapeutic Potential

(2019) Matthew W. Boudreau et al.   ACS Chemical Biology

Mesenchymal stem cell repression of Th17 cells is triggered by mitochondrial transfer

(2019) Patricia Luz-Crawford et al.   Stem Cell Research & Therapy

Bile acid-induced “Minority MOMP” promotes esophageal carcinogenesis while maintaining apoptotic resistance via Mcl-1

(2019) Yuan Xu et al.   ONCOGENE

RIPK3 Activation Leads to Cytokine Synthesis that Continues after Loss of Cell Membrane Integrity

(2019) Susana L. Orozco et al.   Cell Reports

Cleaved Caspase-3 Transcriptionally Regulates Angiogenesis-Promoting Chemotherapy Resistance

(2019) Antoine Bernard et al.   CANCER RESEARCH

The Cytosolic DNA-Sensing cGAS–STING Pathway in Cancer

(2019) John Kwon et al.   Cancer Discovery

Caspase-independent cell death does not elicit a proliferative response in melanoma cancer cells

(2018) Ahlima Roumane et al.   BMC CELL BIOLOGY

Apoptotic Cell-Derived Extracellular Vesicles Promote Malignancy of Glioblastoma Via Intercellular Transfer of Splicing Factors

(2018) Marat S. Pavlyukov et al.   CANCER CELL

Caspase-independent cell death: An anti-cancer double whammy

(2018) Evangelos Giampazolias et al.   CELL CYCLE

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Plasma Membrane Localization of Apoptotic Caspases for Non-apoptotic Functions

(2018) Alla Amcheslavsky et al.   DEVELOPMENTAL CELL

Caspase-3 regulates the migration, invasion and metastasis of colon cancer cells

(2018) Min Zhou et al.   INTERNATIONAL JOURNAL OF CANCER

Apoptosis: A Target for Anticancer Therapy

(2018) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Caspase-3 Regulates YAP-Dependent Cell Proliferation and Organ Size

(2018) Yahav Yosefzon et al.   MOLECULAR CELL

A New Role for the Mitochondrial Pro-apoptotic Protein SMAC/Diablo in Phospholipid Synthesis Associated with Tumorigenesis

(2018) Avijit Paul et al.   MOLECULAR THERAPY

Diablo: A Double-Edged Sword in Cancer?

(2018) Jack L. Arbiser   MOLECULAR THERAPY

Chromosomal instability drives metastasis through a cytosolic DNA response

(2018) Samuel F. Bakhoum et al.   NATURE

Explaining the dynamics of tumor aggressiveness: At the crossroads between biology, artificial intelligence and complex systems

(2018) Caterina A.M. La Porta et al.   SEMINARS IN CANCER BIOLOGY

Apoptotic Caspases: Multiple or Mistaken Identities?

(2018) Kate McArthur et al.   TRENDS IN CELL BIOLOGY

Mitochondria are transported along microtubules in membrane nanotubes to rescue distressed cardiomyocytes from apoptosis

(2018) Jing Shen et al.   Cell Death & Disease

Caspases maintain tissue integrity by an apoptosis-independent inhibition of cell migration and invasion

(2018) Anna Gorelick-Ashkenazi et al.   Nature Communications

Apoptotic Cell-Derived Extracellular Vesicles: More Than Just Debris

(2018) Sarah Caruso et al.   Frontiers in Immunology

Apoptosis Reversal Promotes Cancer Stem Cell-Like Cell Formation

(2018) Yiyue Xu et al.   NEOPLASIA

Bax, Bcl-2, and Bax/Bcl-2 as prognostic markers in acute myeloid leukemia: are we ready for Bcl-2-directed therapy?

(2018) Bibi Kulsoom et al.   Cancer Management and Research

Efferocytosis in the tumor microenvironment

(2018) Thomas A. Werfel et al.   Seminars in Immunopathology

Comparing the effects of different cell death programs in tumor progression and immunotherapy

(2018) Michelle N. Messmer et al.   CELL DEATH AND DIFFERENTIATION

Mitochondrial dynamics and metastasis

(2018) Dario C. Altieri   CELLULAR AND MOLECULAR LIFE SCIENCES

To the edge of cell death and back

(2018) Yi-Nan Gong et al.   FEBS Journal

Cancer stem cell pipeline flounders

(2018) Ken Garber   NATURE REVIEWS DRUG DISCOVERY

A molecular signature for anastasis, recovery from the brink of apoptotic cell death

(2017) Gongping Sun et al.   JOURNAL OF CELL BIOLOGY

Apoptotic forces in tissue morphogenesis

(2017) Arnaud Ambrosini et al.   MECHANISMS OF DEVELOPMENT

Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency

(2017) Evangelos Giampazolias et al.   NATURE CELL BIOLOGY

Bladder cancer: Benefit of adjuvant chemotherapy in UTUC unclear

(2017) Clemens Thoma   Nature Reviews Urology

An apoptosis-driven ‘onco-regenerative niche’: roles of tumour-associated macrophages and extracellular vesicles

(2017) Christopher D. Gregory et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Expression levels of cleaved caspase-3 and caspase-3 in tumorigenesis and prognosis of oral tongue squamous cell carcinoma

(2017) Pei-Feng Liu et al.   PLoS One

High expression of anti-apoptotic protein Bcl-2 is a good prognostic factor in colorectal cancer: Result of a meta-analysis

(2017) Qi Huang et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Executioner caspases and CAD are essential for mutagenesis induced by TRAIL or vincristine

(2017) Mark A Miles et al.   Cell Death & Disease

Ubiquitin-dependent regulation of Cdc42 by XIAP

(2017) Arun Murali et al.   Cell Death & Disease

Tumor-promoting function of apoptotic caspases by an amplification loop involving ROS, macrophages and JNK in Drosophila

(2017) Ernesto Pérez et al.   eLife

Essential roles of Caspase-3 in facilitating Myc-induced genetic instability and carcinogenesis

(2017) Ian M Cartwright et al.   eLife

Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cells

(2017) Lan-Feng Dong et al.   eLife

Extracellular Vesicles Arising from Apoptotic Cells in Tumors: Roles in Cancer Pathogenesis and Potential Clinical Applications

(2017) Catherine Lynch et al.   Frontiers in Immunology

Protective mitochondrial transfer from bone marrow stromal cells to acute myeloid leukemic cells during chemotherapy

(2016) R. Moschoi et al.   BLOOD

Extracellular Reactive Oxygen Species Drive Apoptosis-Induced Proliferation via Drosophila Macrophages

(2016) Caitlin E. Fogarty et al.   CURRENT BIOLOGY

Extracellular ATP a New Player in Cancer Metabolism: NSCLC Cells Internalize ATP In Vitro and In Vivo Using Multiple Endocytic Mechanisms

(2016) Y. Qian et al.   MOLECULAR CANCER RESEARCH

Low levels of Caspase-3 predict favourable response to 5FU-based chemotherapy in advanced colorectal cancer: Caspase-3 inhibition as a therapeutic approach

(2016) L Flanagan et al.   Cell Death & Disease

A neuronal network of mitochondrial dynamics regulates metastasis

(2016) M. Cecilia Caino et al.   Nature Communications

Tead and AP1 Coordinate Transcription and Motility

(2016) Xiangfan Liu et al.   Cell Reports

Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity

(2015) Santiago Zelenay et al.   CELL

Cancer cells exploit adaptive mitochondrial dynamics to increase tumor cell invasion

(2015) M Cecilia Caino et al.   CELL CYCLE

Transfer of mitochondria via tunneling nanotubes rescues apoptotic PC12 cells

(2015) X Wang et al.   CELL DEATH AND DIFFERENTIATION

Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA

(2015) An S. Tan et al.   Cell Metabolism

Oncogenic Properties of Apoptotic Tumor Cells in Aggressive B Cell Lymphoma

(2015) Catriona A. Ford et al.   CURRENT BIOLOGY

Mitochondria and the hallmarks of cancer

(2015) Evangelos Giampazolias et al.   FEBS Journal

Chromothripsis in cancer cells: An update

(2015) Agata Rode et al.   INTERNATIONAL JOURNAL OF CANCER

Limited Mitochondrial Permeabilization Causes DNA Damage and Genomic Instability in the Absence of Cell Death

(2015) Gabriel Ichim et al.   MOLECULAR CELL

Caspase-3 Promotes Genetic Instability and Carcinogenesis

(2015) Xinjian Liu et al.   MOLECULAR CELL

Mitochondrial Division Is Requisite to RAS-Induced Transformation and Targeted by Oncogenic MAPK Pathway Inhibitors

(2015) Madhavika N. Serasinghe et al.   MOLECULAR CELL

Erk2 Phosphorylation of Drp1 Promotes Mitochondrial Fission and MAPK-Driven Tumor Growth

(2015) Jennifer A. Kashatus et al.   MOLECULAR CELL

Upregulation of fractalkine contributes to the proliferative response of prostate cancer cells to hypoxia via promoting the G1/S phase transition

(2015) JIEBING TANG et al.   Molecular Medicine Reports

Apico-basal forces exerted by apoptotic cells drive epithelium folding

(2015) Bruno Monier et al.   NATURE

Mechanical induction of the tumorigenic β-catenin pathway by tumour growth pressure

(2015) María Elena Fernández-Sánchez et al.   NATURE

Live to die another way: modes of programmed cell death and the signals emanating from dying cells

(2015) Yaron Fuchs et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Caspase 3 cleavage of Pax7 inhibits self-renewal of satellite cells

(2015) Sarah A. Dick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CREB pathway links PGE2 signaling with macrophage polarization

(2015) Bing Luan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion

(2015) M. Cecilia Caino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IAPs and cell migration

(2015) Laurence Dubrez et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

How cell death shapes cancer

(2015) V Labi et al.   Cell Death & Disease

Decoding the regulatory landscape of melanoma reveals TEADS as regulators of the invasive cell state

(2015) Annelien Verfaillie et al.   Nature Communications

MitoCeption as a new tool to assess the effects of mesenchymal stem/stromal cell mitochondria on cancer cell metabolism and function

(2015) Andrés Caicedo et al.   Scientific Reports

ROS-Induced JNK and p38 Signaling Is Required for Unpaired Cytokine Activation during Drosophila Regeneration

(2015) Paula Santabárbara-Ruiz et al.   PLoS Genetics

Sublethal Caspase Activation Promotes Generation of Cardiomyocytes from Embryonic Stem Cells

(2015) Ivana Bulatovic et al.   PLoS One

The p53 control of apoptosis and proliferation: lessons from Drosophila

(2014) Bertrand Mollereau et al.   APOPTOSIS

Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production

(2014) Michael J. White et al.   CELL

Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA

(2014) Anthony Rongvaux et al.   CELL

Getting more for your marrow: Boosting hematopoietic stem cell numbers with PGE2

(2014) Elliott J. Hagedorn et al.   EXPERIMENTAL CELL RESEARCH

Tug of War between Survival and Death: Exploring ATM Function in Cancer

(2014) Venturina Stagni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Caspase 3 Promotes Surviving Melanoma Tumor Cell Growth after Cytotoxic Therapy

(2014) Anne L. Donato et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Mesenchymal stem cells rescue injured endothelial cells in an in vitro ischemia–reperfusion model via tunneling nanotube like structure-mediated mitochondrial transfer

(2014) Kaiming Liu et al.   MICROVASCULAR RESEARCH

Caspase-8 mutations in head and neck cancer confer resistance to death receptor-mediated apoptosis and enhance migration, invasion, and tumor growth

(2014) Changyou Li et al.   Molecular Oncology

Dying tumor cells stimulate proliferation of living tumor cells via caspase-dependent protein kinase Cδ activation in pancreatic ductal adenocarcinoma

(2014) Jin Cheng et al.   Molecular Oncology

Blocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance

(2014) Antonina V. Kurtova et al.   NATURE

Endonuclease G initiates DNA rearrangements at the MLL breakpoint cluster upon replication stress

(2014) B Gole et al.   ONCOGENE

Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure

(2014) K. Segawa et al.   SCIENCE

Inflammation-driven carcinogenesis is mediated through STING

(2014) Jeonghyun Ahn et al.   Nature Communications

Genetic Models of Apoptosis-Induced Proliferation Decipher Activation of JNK and Identify a Requirement of EGFR Signaling for Tissue Regenerative Responses in Drosophila

(2014) Yun Fan et al.   PLoS Genetics

New roles for old enzymes: killer caspases as the engine of cell behavior changes

(2014) Patrick F. Connolly et al.   Frontiers in Physiology

Mitochondrial Localization and the Persistent Migration of Epithelial Cancer cells

(2013) Salil P. Desai et al.   BIOPHYSICAL JOURNAL

CX3CL1 Promotes Breast Cancer via Transactivation of the EGF Pathway

(2013) M. Tardaguila et al.   CANCER RESEARCH

Caspase signalling in the absence of apoptosis drives Jnk-dependent invasion

(2013) Vivek A Rudrapatna et al.   EMBO REPORTS

Death takes a holiday—non-apoptotic role for caspases in cell migration and invasion

(2013) Marta Portela et al.   EMBO REPORTS

Preferential transfer of mitochondria from endothelial to cancer cells through tunneling nanotubes modulates chemoresistance

(2013) Jennifer Pasquier et al.   Journal of Translational Medicine

Xk-Related Protein 8 and CED-8 Promote Phosphatidylserine Exposure in Apoptotic Cells

(2013) J. Suzuki et al.   SCIENCE

IAPs on the move: role of inhibitors of apoptosis proteins in cell migration

(2013) T K Oberoi-Khanuja et al.   Cell Death & Disease

Dying endothelial cells stimulate proliferation of malignant glioma cells via a caspase 3-mediated pathway

(2013) PING MAO et al.   Oncology Letters

CX3CL1 at the crossroad of EGF signals

(2013) Manuel Tardáguila et al.   OncoImmunology

Endothelial Microparticle Uptake in Target Cells Is Annexin I/Phosphatidylserine Receptor Dependent and Prevents Apoptosis

(2012) Felix Jansen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Compensatory proliferation and apoptosis-induced proliferation: a need for clarification

(2012) B Mollereau et al.   CELL DEATH AND DIFFERENTIATION

Role of Melanoma Inhibitor of Apoptosis (ML-IAP) Protein, a Member of the Baculoviral IAP Repeat (BIR) Domain Family, in the Regulation of C-RAF Kinase and Cell Migration

(2012) Tripat Kaur Oberoi-Khanuja et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell survival, DNA damage, and oncogenic transformation after a transient and reversible apoptotic response

(2012) Ho Lam Tang et al.   MOLECULAR BIOLOGY OF THE CELL

Mitochondrial dynamics regulates migration and invasion of breast cancer cells

(2012) J Zhao et al.   ONCOGENE

A dp53/JNK-dependant feedback amplification loop is essential for the apoptotic response to stress in Drosophila

(2011) E Shlevkov et al.   CELL DEATH AND DIFFERENTIATION

IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation

(2011) Tripat Kaur Oberoi et al.   EMBO JOURNAL

Live imaging of apoptosis in a novel transgenic mouse highlights its role in neural tube closure

(2011) Yoshifumi Yamaguchi et al.   JOURNAL OF CELL BIOLOGY

When catastrophe strikes a cell

(2011) Jose M. C. Tubio et al.   NATURE

Caspase 3–mediated stimulation of tumor cell repopulation during cancer radiotherapy

(2011) Qian Huang et al.   NATURE MEDICINE

The Phenotypic Radiation Resistance of CD44+/CD24−or low Breast Cancer Cells Is Mediated through the Enhanced Activation of ATM Signaling

(2011) Hong Yin et al.   PLoS One

The BH3 Mimetic ABT-737 Induces Cancer Cell Senescence

(2010) Jin H. Song et al.   CANCER RESEARCH

Apoptotic Caspases Regulate Induction of iPSCs from Human Fibroblasts

(2010) Fang Li et al.   Cell Stem Cell

Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials

(2010) Peter M Rothwell et al.   LANCET

TRAIL treatment provokes mutations in surviving cells

(2010) M M Lovric et al.   ONCOGENE

Apoptotic Cells Activate the "Phoenix Rising" Pathway to Promote Wound Healing and Tissue Regeneration

(2010) F. Li et al.   Science Signaling

Caspase-8 Association with the Focal Adhesion Complex Promotes Tumor Cell Migration and Metastasis

(2009) S. Barbero et al.   CANCER RESEARCH

Apoptosis in Drosophila: compensatory proliferation and undead cells

(2009) Francisco A. Martin et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Prognostic value of the apoptotic index analysed jointly with selected cell cycle regulators and proliferation markers in non-small cell lung cancer

(2009) Dorota Dworakowska et al.   LUNG CANCER

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

(2009) David A. Barbie et al.   NATURE

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

(2009) Michael R. Elliott et al.   NATURE

Hematopoietic Stem Cell Responsiveness to Exogenous Signals Is Limited by Caspase-3

(2008) Viktor Janzen et al.   Cell Stem Cell

Caspase Activity Mediates the Differentiation of Embryonic Stem Cells

(2008) Jun Fujita et al.   Cell Stem Cell

Prognostic value of Bcl-2 in breast cancer patients treated with neoadjuvant anthracycline based chemotherapy

(2008) Laura M. Vargas-Roig et al.   Molecular Oncology