IAPs on the move: role of inhibitors of apoptosis proteins in cell migration

HtrA Protease Family as Therapeutic Targets

(2013) Joanna Skorko-Glonek et al.   CURRENT PHARMACEUTICAL DESIGN

Identification of non-canonical NF-κB signaling as a critical mediator of Smac mimetic-stimulated migration and invasion of glioblastoma cells

(2013) A Tchoghandjian et al.   Cell Death & Disease

Ubiquitin-Binding Proteins: Decoders of Ubiquitin-Mediated Cellular Functions

(2012) Koraljka Husnjak et al.   Annual Review of Biochemistry

XIAP reverses various functional activities of FRNK in endothelial cells

(2012) Sunyoung Ahn et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

IAP proteins: regulators of cell migration and development

(2012) Niall S Kenneth et al.   CURRENT OPINION IN CELL BIOLOGY

Predictive in vivo animal models and translation to clinical trials

(2012) Natalie Cook et al.   DRUG DISCOVERY TODAY

Rnd3/RhoE Is down-regulated in hepatocellular carcinoma and controls cellular invasion

(2012) Florence Grise et al.   HEPATOLOGY

Role of Melanoma Inhibitor of Apoptosis (ML-IAP) Protein, a Member of the Baculoviral IAP Repeat (BIR) Domain Family, in the Regulation of C-RAF Kinase and Cell Migration

(2012) Tripat Kaur Oberoi-Khanuja et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RhoGDI SUMOylation at Lys-138 Increases Its Binding Activity to Rho GTPase and Its Inhibiting Cancer Cell Motility

(2012) Jianxiu Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tiam1 interaction with the PAR complex promotes talin-mediated Rac1 activation during polarized cell migration

(2012) Shujie Wang et al.   JOURNAL OF CELL BIOLOGY

Targeting IAP proteins for therapeutic intervention in cancer

(2012) Simone Fulda et al.   NATURE REVIEWS DRUG DISCOVERY

New dimensions in cell migration

(2012) Peter Friedl et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Combination Anastrozole and Fulvestrant in Metastatic Breast Cancer

(2012) Rita S. Mehta et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Clinical Effect of the Inhibitor of Apopotosis Protein Livin in Melanoma

(2012) Itay Lazar et al.   ONCOLOGY

E3 Ligase Activity of XIAP RING Domain Is Required for XIAP-Mediated Cancer Cell Migration, but Not for Its RhoGDI Binding Activity

(2012) Jinyi Liu et al.   PLoS One

Prokaryotic Caspase Homologs: Phylogenetic Patterns and Functional Characteristics Reveal Considerable Diversity

(2012) Johannes Asplund-Samuelsson et al.   PLoS One

Association of expression of XIAP-associated factor 1 (XAF1) with clinicopathologic factors, overall survival, microvessel density and cisplatin-resistance in ovarian cancer

(2012) YunXia Wang et al.   REGULATORY PEPTIDES

Boolean Model of Yeast Apoptosis as a Tool to Study Yeast and Human Apoptotic Regulations

(2012) Laleh Kazemzadeh et al.   Frontiers in Physiology

Metacaspases

(2011) L Tsiatsiani et al.   CELL DEATH AND DIFFERENTIATION

X-linked inhibitor of apoptosis positive nuclear labeling: a new independent prognostic biomarker of breast invasive ductal carcinoma

(2011) Yutao Zhang et al.   Diagnostic Pathology

IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation

(2011) Tripat Kaur Oberoi et al.   EMBO JOURNAL

ARTS-based anticancer therapy: taking aim at cancer stem cells

(2011) Ronit Elhasid et al.   Future Oncology

X-linked Inhibitor of Apoptosis Protein (XIAP) Mediates Cancer Cell Motility via Rho GDP Dissociation Inhibitor (RhoGDI)-dependent Regulation of the Cytoskeleton

(2011) Jinyi Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Down-regulation of RhoE is associated with progression and poor prognosis in hepatocellular carcinoma

(2011) Hesan Luo et al.   JOURNAL OF SURGICAL ONCOLOGY

CARD-Mediated Autoinhibition of cIAP1's E3 Ligase Activity Suppresses Cell Proliferation and Migration

(2011) Juanita Lopez et al.   MOLECULAR CELL

ERK-MAPK Drives Lamellipodia Protrusion by Activating the WAVE2 Regulatory Complex

(2011) Michelle C. Mendoza et al.   MOLECULAR CELL

Correlation of Smac/DIABLO protein expression with the clinico-pathological features of breast cancer patients

(2011) P. PLUTA et al.   NEOPLASMA

Development of Novel Combination Therapies

(2011) Janet Woodcock et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells

(2011) C. C. Ong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cleavage of NIK by the API2-MALT1 Fusion Oncoprotein Leads to Noncanonical NF- B Activation

(2011) S. Rosebeck et al.   SCIENCE

Antagonists Induce a Conformational Change in cIAP1 That Promotes Autoubiquitination

(2011) E. C. Dueber et al.   SCIENCE

Nuclear cIAP1 overexpression is a tumor stage- and grade-independent predictor of poor prognosis in human bladder cancer patients

(2011) Xiangyu Che et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

X-linked inhibitor of apoptosis protein controls α5-integrin-mediated cell adhesion and migration

(2010) Jongmin Kim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

XIAP is essential for shear stress-enhanced Tyr-576 phosphorylation of FAK

(2010) Sunyoung Ahn et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

IAP Regulation of Metastasis

(2010) Swarna Mehrotra et al.   CANCER CELL

The Rac activator STEF (Tiam2) regulates cell migration by microtubule-mediated focal adhesion disassembly

(2010) Claire Rooney et al.   EMBO REPORTS

Expression and prognostic significance of the inhibitor of apoptosis protein (IAP) family and its antagonists in chronic lymphocytic leukaemia

(2010) Olga Grzybowska-Izydorczyk et al.   EUROPEAN JOURNAL OF CANCER

Prognostic significance of second mitochondria-derived activator of caspase (Smac/DIABLO) expression in bladder cancer and target for therapy

(2010) Mizutani   INTERNATIONAL JOURNAL OF ONCOLOGY

Influence of high expression of Smac/DIABLO protein on the clinical outcome in acute myeloid leukemia patients

(2010) Agnieszka Pluta et al.   LEUKEMIA RESEARCH

The role of fibroblast Tiam1 in tumor cell invasion and metastasis

(2010) K Xu et al.   ONCOGENE

Rac1 is crucial for Ras-dependent skin tumor formation by controlling Pak1-Mek-Erk hyperactivation and hyperproliferation in vivo

(2010) Z Wang et al.   ONCOGENE

A Smac-mimetic sensitizes prostate cancer cells to TRAIL-induced apoptosis via modulating both IAPs and NF-kappaB

(2009) Yao Dai et al.   BMC CANCER

Stabilization of Snail by NF-κB Is Required for Inflammation-Induced Cell Migration and Invasion

(2009) Yadi Wu et al.   CANCER CELL

MMP13, Birc2 (cIAP1), and Birc3 (cIAP2), Amplified on Chromosome 9, Collaborate with p53 Deficiency in Mouse Osteosarcoma Progression

(2009) O. Ma et al.   CANCER RESEARCH

XAF1 as a prognostic biomarker and therapeutic target in pancreatic cancer

(2009) Jia Huang et al.   CANCER SCIENCE

TNF induction of jagged-1 in endothelial cells is NFκB-dependent

(2009) Douglas A. Johnston et al.   GENE

Expression of X-linked inhibitor of apoptosis protein in human colorectal cancer and its correlation with prognosis

(2009) Xiang Guoan et al.   JOURNAL OF SURGICAL ONCOLOGY

To adhere or not to adhere?

(2009) Peter Friedl   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP21

(2008) John W. Blankenship et al.   BIOCHEMICAL JOURNAL

High nuclear Livin expression is a favourable prognostic indicator in renal cell carcinoma

(2008) Axel Haferkamp et al.   BJU INTERNATIONAL

Rac Activation and Inactivation Control Plasticity of Tumor Cell Movement

(2008) Victoria Sanz-Moreno et al.   CELL

X-linked inhibitor of apoptosis deficiency in the TRAMP mouse prostate cancer model

(2008) C Hwang et al.   CELL DEATH AND DIFFERENTIATION

Tumour cell survival signalling by the ERK1/2 pathway

(2008) K Balmanno et al.   CELL DEATH AND DIFFERENTIATION

X-Linked Inhibitor of Apoptosis Protein Is an Important Regulator of Vascular Endothelial Growth Factor–Dependent Bovine Aortic Endothelial Cell Survival

(2008) Jongmin Kim et al.   CIRCULATION RESEARCH

DOCK10-Mediated Cdc42 Activation Is Necessary for Amoeboid Invasion of Melanoma Cells

(2008) Gilles Gadea et al.   CURRENT BIOLOGY

Activated macrophages promote Wnt signalling through tumour necrosis factor-α in gastric tumour cells

(2008) Keisuke Oguma et al.   EMBO JOURNAL

Role of Smac/DIABLO in cancer progression

(2008) Gustavo Martinez-Ruiz et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The RING Domain of cIAP1 Mediates the Degradation of RING-bearing Inhibitor of Apoptosis Proteins by Distinct Pathways

(2008) Herman H. Cheung et al.   MOLECULAR BIOLOGY OF THE CELL

X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility

(2008) Taner Dogan et al.   NATURE CELL BIOLOGY

IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-κB as well as cell survival and oncogenesis

(2008) Mads Gyrd-Hansen et al.   NATURE CELL BIOLOGY

IAP-targeted therapies for cancer

(2008) E C LaCasse et al.   ONCOGENE

Snail promotes Wnt target gene expression and interacts with β-catenin

(2008) V Stemmer et al.   ONCOGENE