Targeting translesion synthesis (TLS) to expose replication gaps, a unique cancer vulnerability

Regulation of translesion DNA synthesis in mammalian cells

(2020) Xiaolu Ma et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Involvement of Rev1 in alkylating agent‐induced loss of heterozygosity in Oryzias latipes

(2020) Yoshihiro Fujikawa et al.   GENES TO CELLS

The repertoire of mutational signatures in human cancer

(2020) Ludmil B. Alexandrov et al.   NATURE

Physiological Tolerance to ssDNA Enables Strand Uncoupling during DNA Replication

(2020) Amaia Ercilla et al.   Cell Reports

Genetic evidence for reconfiguration of DNA polymerase θ active site for error-free translesion synthesis in human cells

(2020) Jung-Hoon Yoon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of the translesion synthesis polymerase REV1 exploits replication gaps as a cancer vulnerability

(2020) Sumeet Nayak et al.   Science Advances

Inactivation of REV7 enhances chemosensitivity and overcomes acquired chemoresistance in testicular germ cell tumors

(2020) Yasutaka Sakurai et al.   CANCER LETTERS

DNA polymerase kappa counteracts inflammation-induced mutagenesis in multiple organs of mice

(2019) Atsushi Hakura et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Overexpression of Claspin and Timeless protects cancer cells from replication stress in a checkpoint-independent manner

(2019) Julien N. Bianco et al.   Nature Communications

AKT inhibition impairs PCNA ubiquitylation and triggers synthetic lethality in homologous recombination-deficient cells submitted to replication stress

(2019) Florencia Villafañez et al.   ONCOGENE

Error-Prone Replication through UV Lesions by DNA Polymerase θ Protects against Skin Cancers

(2019) Jung-Hoon Yoon et al.   CELL

Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis

(2019) Meng Li et al.   CANCER CELL

A Small Molecule Targeting Mutagenic Translesion Synthesis Improves Chemotherapy

(2019) Jessica L. Wojtaszek et al.   CELL

Processing of DNA Polymerase-Blocking Lesions during Genome Replication Is Spatially and Temporally Segregated from Replication Forks

(2019) Ronald P. Wong et al.   MOLECULAR CELL

RAD6B is a major mediator of triple negative breast cancer cisplatin resistance: Regulation of translesion synthesis/Fanconi anemia crosstalk and BRCA1 independence

(2019) Brittany Haynes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Polymerase iota - an odd sibling among Y family polymerases

(2019) Justyna McIntyre   DNA REPAIR

Diverse roles of RAD18 and Y-family DNA polymerases in tumorigenesis

(2018) Yang Yang et al.   CELL CYCLE

Polη, a Y-family translesion synthesis polymerase, promotes cellular tolerance of Myc-induced replication stress

(2018) Kiminori Kurashima et al.   JOURNAL OF CELL SCIENCE

Mechanisms of Oncogene-Induced Replication Stress: Jigsaw Falling into Place

(2018) Panagiotis Kotsantis et al.   Cancer Discovery

Precision cancer therapy: profiting from tumor specific defects in the DNA damage tolerance system

(2018) Olimpia Alessandra Buoninfante et al.   Oncotarget

p53 orchestrates DNA replication restart homeostasis by suppressing mutagenic RAD52 and POLθ pathways

(2018) Sunetra Roy et al.   eLife

Eukaryotic translesion synthesis: Choosing the right tool for the job

(2018) Kyle T. Powers et al.   DNA REPAIR

In vitro lesion bypass by human PrimPol

(2018) Alena V. Makarova et al.   DNA REPAIR

Intragenic origins due to short G1 phases underlie oncogene-induced DNA replication stress

(2018) Morgane Macheret et al.   NATURE

Translesion polymerase kappa-dependent DNA synthesis underlies replication fork recovery

(2018) Peter Tonzi et al.   eLife

Homologous Recombination: To Fork and Beyond

(2018) Félix Prado   Genes

Moonlighting at replication forks - a new life for homologous recombination proteins BRCA1, BRCA2 and RAD51

(2017) Arun Mouli Kolinjivadi et al.   FEBS LETTERS

Pharmacological targeting of RAD6 enzyme-mediated translesion synthesis overcomes resistance to platinum-based drugs

(2017) Matthew A. Sanders et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA repair factor RAD18 and DNA polymerase Polκ confer tolerance of oncogenic DNA replication stress

(2017) Yang Yang et al.   JOURNAL OF CELL BIOLOGY

Forging Ahead through Darkness: PCNA, Still the Principal Conductor at the Replication Fork

(2017) Katherine N. Choe et al.   MOLECULAR CELL

Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments

(2017) Arun Mouli Kolinjivadi et al.   MOLECULAR CELL

PrimPol is required for replication reinitiation after mtDNA damage

(2017) Rubén Torregrosa-Muñumer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Replication fork reversal triggers fork degradation in BRCA2-defective cells

(2017) Sofija Mijic et al.   Nature Communications

Inhibition of mutagenic translesion synthesis: A possible strategy for improving chemotherapy?

(2017) Kinrin Yamanaka et al.   PLoS Genetics

The Error-Prone DNA Polymerase κ Promotes Temozolomide Resistance in Glioblastoma through Rad17-Dependent Activation of ATR-Chk1 Signaling

(2016) Chenghao Peng et al.   CANCER RESEARCH

Pathological trans-lesion synthesis in cancer

(2016) Yanzhe Gao et al.   CELL CYCLE

Drugging the addict: non‐oncogene addiction as a target for cancer therapy

(2016) Remco Nagel et al.   EMBO REPORTS

APOBEC-induced mutations in human cancers are strongly enriched on the lagging DNA strand during replication

(2016) Vladimir B. Seplyarskiy et al.   GENOME RESEARCH

Targeting the Translesion Synthesis Pathway for the Development of Anti-Cancer Chemotherapeutics

(2016) Dmitry M. Korzhnev et al.   JOURNAL OF MEDICINAL CHEMISTRY

Replication fork stability confers chemoresistance in BRCA-deficient cells

(2016) Arnab Ray Chaudhuri et al.   NATURE

Replication stress: getting back on track

(2016) Matteo Berti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Predominant role of DNA polymerase eta and p53-dependent translesion synthesis in the survival of ultraviolet-irradiated human cells

(2016) Leticia K. Lerner et al.   NUCLEIC ACIDS RESEARCH

Translesion synthesis mechanisms depend on the nature of DNA damage in UV-irradiated human cells

(2016) Annabel Quinet et al.   NUCLEIC ACIDS RESEARCH

PCNA tool belts and polymerase bridges form during translesion synthesis

(2016) Elizabeth M. Boehm et al.   NUCLEIC ACIDS RESEARCH

Replication stress: getting back on track

(2016) Matteo Berti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Cell-Cycle Arrest and Apoptotic Functions of p53 in Tumor Initiation and Progression

(2016) Jiandong Chen   Cold Spring Harbor Perspectives in Medicine

Kynurenine Signaling Increases DNA Polymerase Kappa Expression and Promotes Genomic Instability in Glioblastoma Cells

(2015) April C.L. Bostian et al.   CHEMICAL RESEARCH IN TOXICOLOGY

RAD18 Is a Maternal Limiting Factor Silencing the UV-Dependent DNA Damage Checkpoint in Xenopus Embryos

(2015) Chames Kermi et al.   DEVELOPMENTAL CELL

Regulation of translesion DNA synthesis: Posttranslational modification of lysine residues in key proteins

(2015) Justyna McIntyre et al.   DNA REPAIR

Alternative solutions and new scenarios for translesion DNA synthesis by human PrimPol

(2015) María I. Martínez-Jiménez et al.   DNA REPAIR

Resistance to therapy inBRCA2mutant cells due to loss of the nucleosome remodeling factor CHD4

(2015) Shawna Guillemette et al.   GENES & DEVELOPMENT

Non-coding recurrent mutations in chronic lymphocytic leukaemia

(2015) Xose S. Puente et al.   NATURE

Replication fork reversal in eukaryotes: from dead end to dynamic response

(2015) Kai J. Neelsen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

FANCD2 and REV1 cooperate in the protection of nascent DNA strands in response to replication stress

(2015) Yeran Yang et al.   NUCLEIC ACIDS RESEARCH

DNA replication stress as an Achilles’ heel of cancer

(2015) Caterina Da-Rè et al.   Oncotarget

Translesion Polymerase   Is Upregulated by Cancer Therapeutics and Confers Anticancer Drug Resistance

(2014) M. T. Tomicic et al.   CANCER RESEARCH

Gap-filling and bypass at the replication fork are both active mechanisms for tolerance of low-dose ultraviolet-induced DNA damage in the human genome

(2014) Annabel Quinet et al.   DNA REPAIR

DNA replication stress: Causes, resolution and disease

(2014) Abdelghani Mazouzi et al.   EXPERIMENTAL CELL RESEARCH

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

(2014) Helge Gad et al.   NATURE

Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features

(2014) Davor Lessel et al.   NATURE GENETICS

Repair of naturally occurring mismatches can induce mutations in flanking DNA

(2014) Jia Chen et al.   eLife

The balancing act of DNA repeat expansions

(2013) Jane C Kim et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

DNA synthesis by Pol η promotes fragile site stability by preventing under-replicated DNA in mitosis

(2013) Valérie Bergoglio et al.   JOURNAL OF CELL BIOLOGY

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Causes and consequences of replication stress

(2013) Michelle K. Zeman et al.   NATURE CELL BIOLOGY

Transcription-replication encounters, consequences and genomic instability

(2013) Anne Helmrich et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Expression of DNA Translesion Synthesis Polymerase η in Head and Neck Squamous Cell Cancer Predicts Resistance to Gemcitabine and Cisplatin-Based Chemotherapy

(2013) Wendi Zhou et al.   PLoS One

Dual role for mammalian DNA polymerase   in maintaining genome stability and proliferative responses

(2013) S. S. Lange et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhancing tumor cell response to chemotherapy through nanoparticle-mediated codelivery of siRNA and cisplatin prodrug

(2013) X. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA polymerase η modulates replication fork progression and DNA damage responses in platinum-treated human cells

(2013) Anna M. Sokol et al.   Scientific Reports

DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis

(2013) Benjamin JM Taylor et al.   eLife

Temporally distinct translesion synthesis pathways for ultraviolet light-induced photoproducts in the mammalian genome

(2012) Piya Temviriyanukul et al.   DNA REPAIR

dNTP pools determine fork progression and origin usage under replication stress

(2012) Jérôme Poli et al.   EMBO JOURNAL

Clustered Mutations in Yeast and in Human Cancers Can Arise from Damaged Long Single-Strand DNA Regions

(2012) Steven A. Roberts et al.   MOLECULAR CELL

DNA secondary structures: stability and function of G-quadruplex structures

(2012) Matthew L. Bochman et al.   NATURE REVIEWS GENETICS

Y-family DNA polymerases and their role in tolerance of cellular DNA damage

(2012) Julian E. Sale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural basis of human DNA polymerase  -mediated chemoresistance to cisplatin

(2012) Y. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

(2011) Katharina Schlacher et al.   CELL

Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development

(2011) Assaf C. Bester et al.   CELL

Dual functions of DNA replication forks in checkpoint signaling and PCNA ubiquitination

(2011) Xiaohong H. Yang et al.   CELL CYCLE

Multiple two-polymerase mechanisms in mammalian translesion DNA synthesis

(2011) Zvi Livneh et al.   CELL CYCLE

Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

(2011) Xose S. Puente et al.   NATURE

Loss of DNA Polymerase ζ Enhances Spontaneous Tumorigenesis

(2010) John P. Wittschieben et al.   CANCER RESEARCH

What happens when replication and transcription complexes collide?

(2010) Richard T. Pomerantz et al.   CELL CYCLE

A new model for SOS-induced mutagenesis: how RecA protein activates DNA polymerase V

(2010) Meghna Patel et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Maintaining genome stability at the replication fork

(2010) Dana Branzei et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA polymerase   up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability

(2010) F. Lemee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Error-prone translesion synthesis mediates acquired chemoresistance

(2010) K. Xie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suppression of Rev3, the catalytic subunit of Pol , sensitizes drug-resistant lung tumors to chemotherapy

(2010) J. Doles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction

(2009) Ji Luo et al.   CELL

A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene

(2009) Ji Luo et al.   CELL

The checkpoint response to replication stress

(2009) Dana Branzei et al.   DNA REPAIR

Separate Domains of Rev1 Mediate Two Modes of DNA Damage Bypass in Mammalian Cells

(2009) J. G. Jansen et al.   MOLECULAR AND CELLULAR BIOLOGY

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

DNA damage tolerance: when it's OK to make mistakes

(2009) Debbie J Chang et al.   Nature Chemical Biology

DNA Damage, Aging, and Cancer

(2009) Jan H.J. Hoeijmakers   NEW ENGLAND JOURNAL OF MEDICINE

Replication fork reversal and the maintenance of genome stability

(2009) J. Atkinson et al.   NUCLEIC ACIDS RESEARCH

Error-prone translesion replication of damaged DNA suppresses skin carcinogenesis by controlling inflammatory hyperplasia

(2009) A. Tsaalbi-Shtylik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chk1 and Claspin potentiate PCNA ubiquitination

(2008) X. H. Yang et al.   GENES & DEVELOPMENT

Miscoding Properties of 2′-Deoxyinosine, a Nitric Oxide-Derived DNA Adduct, during Translesion Synthesis Catalyzed by Human DNA Polymerases

(2008) Manabu Yasui et al.   JOURNAL OF MOLECULAR BIOLOGY

PCNA Ubiquitination and REV1 Define Temporally Distinct Mechanisms for Controlling Translesion Synthesis in the Avian Cell Line DT40

(2008) Charlotte E. Edmunds et al.   MOLECULAR CELL

DNA polymerases and human disease

(2008) Lawrence A. Loeb et al.   NATURE REVIEWS GENETICS

Low-fidelity DNA synthesis by human DNA polymerase theta

(2008) M. E. Arana et al.   NUCLEIC ACIDS RESEARCH

An Oncogene-Induced DNA Damage Model for Cancer Development

(2008) T. D. Halazonetis et al.   SCIENCE