Current status and future prospects of p38α/MAPK14 kinase and its inhibitors
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Title
Current status and future prospects of p38α/MAPK14 kinase and its inhibitors
Authors
Keywords
Cancer, Inflammation, Kinase inhibitors, MAPK14, Neurodegenerative disorders, p38α
Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume -, Issue -, Pages 113216
Publisher
Elsevier BV
Online
2021-01-22
DOI
10.1016/j.ejmech.2021.113216
References
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Note: Only part of the references are listed.- Pyrazolyl-Ureas as Interesting Scaffold in Medicinal Chemistry
- (2020) Chiara Brullo et al. MOLECULES
- MAPK14 (p38α) inhibition effects against metastatic gastric cancer cells: A potential biomarker and pharmacological target
- (2020) Felipe Pantoja Mesquita et al. TOXICOLOGY IN VITRO
- In silico molecular target prediction unveils mebendazole as a potent MAPK14 inhibitor
- (2020) Jeremy Ariey‐Bonnet et al. Molecular Oncology
- Selective targeting of the αC and DFG-out pocket in p38 MAPK
- (2020) Sandra Röhm et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- A Selective and Brain Penetrant p38αMAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction
- (2019) Saktimayee M. Roy et al. JOURNAL OF MEDICINAL CHEMISTRY
- Vascular smooth muscle-MAPK14 is required for neointimal hyperplasia by suppressing VSMC differentiation and inducing proliferation and inflammation
- (2019) Wen Wu et al. Redox Biology
- The depletion of p38alpha kinase upregulates NADPH oxidase 2/NOX2/gp91 expression and the production of superoxide in mouse embryonic stem cells
- (2019) Lucia Binó et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Pyridinylimidazoles as dual glycogen synthase kinase 3β/p38α mitogen-activated protein kinase inhibitors
- (2019) Fabian Heider et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Pyridinylimidazoles as GSK3β Inhibitors: The Impact of Tautomerism on Compound Activity via Water Networks
- (2019) Fabian Heider et al. ACS Medicinal Chemistry Letters
- Discovery of potent p38α MAPK inhibitors through a funnel like workflow combining in silico screening and in vitro validation
- (2019) Andrea Astolfi et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Apigenin, a flavonoid constituent derived from P. villosa, inhibits hepatocellular carcinoma cell growth by CyclinD1/CDK4 regulation via p38 MAPK-p21 signaling
- (2019) Yue Li et al. PATHOLOGY RESEARCH AND PRACTICE
- p38α Mitogen-Activated Protein Kinase Is a Druggable Target in Pancreatic Adenocarcinoma
- (2019) Ling Yang et al. Frontiers in Oncology
- Discovery of a potent p38α/MAPK14 kinase inhibitor: Synthesis, in vitro/in vivo biological evaluation, and docking studies
- (2019) Mohammed I. El-Gamal et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Discovering novel P38α inhibitors for the treatment of prostate cancer through virtual screening methods
- (2019) Kaiwen Li et al. Future Medicinal Chemistry
- Macrophages-derived p38α promotes the experimental severe acute pancreatitis by regulating inflammation and autophagy
- (2019) Hui-Ning Fan et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Knockdown of MAPK14 inhibits the proliferation and migration of clear cell renal cell carcinoma by downregulating the expression of CDC25B
- (2019) Junlong Liu et al. Cancer Medicine
- Synthesis, p38α MAP kinase inhibition, anti-inflammatory activity, and molecular docking studies of 1,2,4-triazole-based benzothiazole-2-amines
- (2018) Sana Tariq et al. ARCHIV DER PHARMAZIE
- Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells
- (2018) Begoña Cánovas et al. CANCER CELL
- Selective inhibition of the p38α MAPK–MK2 axis inhibits inflammatory cues including inflammasome priming signals
- (2018) Chun Wang et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Selective p38α MAPK inhibitor shows promise
- (2018) Jessica McHugh Nature Reviews Rheumatology
- An isoform-selective p38α mitogen-activated protein kinase inhibitor rescues early entorhinal cortex dysfunctions in a mouse model of Alzheimer's disease
- (2018) Grazia Rutigliano et al. NEUROBIOLOGY OF AGING
- The p38α MAPK Deletion in Oligodendroglia does not Attenuate Myelination Defects in a Mouse Model of Periventricular Leukomalacia
- (2018) Seung H. Chung et al. NEUROSCIENCE
- Inhibition of pMAPK14 Overcomes Resistance to Sorafenib in Hepatoma Cells with Hepatitis B Virus
- (2018) Dvora Witt-Kehati et al. Translational Oncology
- Protein kinase p38α signaling in dendritic cells regulates colon inflammation and tumorigenesis
- (2018) Tingting Zheng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- p38α MAPK signaling drives pharmacologically reversible brain and gastrointestinal phenotypes in the SERT Ala56 mouse
- (2018) Matthew J. Robson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Selective p38α MAP kinase/MAPK14 inhibition in enzymatically modified LDL-stimulated human monocytes: implications for atherosclerosis
- (2017) Fei Cheng et al. FASEB JOURNAL
- Novel Noncatalytic Substrate-Selective p38α-Specific MAPK Inhibitors with Endothelial-Stabilizing and Anti-Inflammatory Activity
- (2017) Nirav G. Shah et al. JOURNAL OF IMMUNOLOGY
- Design, Synthesis, and Biological Evaluation of Novel Type I1/2 p38α MAP Kinase Inhibitors with Excellent Selectivity, High Potency, and Prolonged Target Residence Time by Interfering with the R-Spine
- (2017) Niklas M. Walter et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of N-{4-[5-(4-Fluorophenyl)-3-methyl-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-acetamide (CBS-3595), a Dual p38α MAPK/PDE-4 Inhibitor with Activity against TNFα-Related Diseases
- (2017) Wolfgang Albrecht et al. JOURNAL OF MEDICINAL CHEMISTRY
- Recent Advances in the Inhibition of p38 MAPK as a Potential Strategy for the Treatment of Alzheimer’s Disease
- (2017) Jong Kil Lee et al. MOLECULES
- Phenylindenone isomers as divergent modulators of p38α MAP kinase
- (2016) Andrea Cappelli et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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- (2016) Sarah Taves et al. BRAIN BEHAVIOR AND IMMUNITY
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- (2016) Najoua Lalaoui et al. CANCER CELL
- Pexmetinib: A Novel Dual Inhibitor of Tie2 and p38 MAPK with Efficacy in Preclinical Models of Myelodysplastic Syndromes and Acute Myeloid Leukemia
- (2016) L. Bachegowda et al. CANCER RESEARCH
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- (2016) Ming Jia et al. Translational Oncology
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- (2016) L. K. Petersen et al. MedChemComm
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- The Pyrazolobenzothiazine Core as a New Chemotype of p38 Alpha Mitogen-Activated Protein Kinase Inhibitors
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- Roles of p38α mitogen-activated protein kinase in mouse models of inflammatory diseases and cancer
- (2015) Jalaj Gupta et al. FEBS Journal
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- p38α MAPK and Type I Inhibitors: Binding Site Analysis and Use of Target Ensembles in Virtual Screening
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- (2015) Xue-mei Zhang et al. NEUROCHEMISTRY INTERNATIONAL
- Synthesis and structure–activity relationships of 4-fluorophenyl-imidazole p38α MAPK, CK1δ and JAK2 kinase inhibitors
- (2014) Jean-Paul G. Seerden et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- A Phase I Study of Oral ARRY-614, a p38 MAPK/Tie2 Dual Inhibitor, in Patients with Low or Intermediate-1 Risk Myelodysplastic Syndromes
- (2014) G. Garcia-Manero et al. CLINICAL CANCER RESEARCH
- Loss of Epidermal p38α Signaling Prevents UVR-Induced Inflammation via Acute and Chronic Mechanisms
- (2014) Yasuyo Sano et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Tetra-Substituted Pyridinylimidazoles As Dual Inhibitors of p38α Mitogen-Activated Protein Kinase and c-Jun N-Terminal Kinase 3 for Potential Treatment of Neurodegenerative Diseases
- (2014) Felix Muth et al. JOURNAL OF MEDICINAL CHEMISTRY
- The p38alpha mitogen-activated protein kinase limits the CNS proinflammatory cytokine response to systemic lipopolysaccharide, potentially through an IL-10 dependent mechanism
- (2014) Adam D Bachstetter et al. Journal of Neuroinflammation
- Synthesis and Biological Evaluation of Chromenylurea and Chromanylurea Derivatives as Anti-TNF-α agents that Target the p38 MAPK Pathway
- (2014) Xingzhou Li et al. MOLECULES
- In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer
- (2014) Ramona Rudalska et al. NATURE MEDICINE
- Design, Synthesis, and Biological Evaluation of Tetra-Substituted Thiophenes as Inhibitors of p38α MAPK
- (2014) Natalie B. Vinh et al. ChemistryOpen
- The identification of novel p38α isoform selective kinase inhibitors having an unprecedented p38α binding mode
- (2013) Stephen T. Wrobleski et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents
- (2013) Xinbing Sui et al. CANCER LETTERS
- Sunlight UV-Induced Skin Cancer Relies upon Activation of the p38 Signaling Pathway
- (2013) K. Liu et al. CANCER RESEARCH
- OA10 Is a Novel p38alpha Mitogen-Activated Protein Kinase Inhibitor That Suppresses Osteoclast Differentiation and Bone Resorption
- (2013) T. Jiang et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- The synthetic flavonoid WYC02-9 inhibits colorectal cancer cell growth through ROS-mediated activation of MAPK14 pathway
- (2013) Yun-Ju Chen et al. LIFE SCIENCES
- Inhibition of p38 MAPK-dependent MutS homologue-2 (MSH2) expression by metformin enhances gefitinib-induced cytotoxicity in human squamous lung cancer cells
- (2013) Jen-Chung Ko et al. LUNG CANCER
- A role for p38 MAPK in head and neck cancer cell growth and tumor-induced angiogenesis and lymphangiogenesis
- (2013) Kantima Leelahavanichkul et al. Molecular Oncology
- Dual p38/JNK Mitogen Activated Protein Kinase Inhibitors Prevent Ozone-Induced Airway Hyperreactivity in Guinea Pigs
- (2013) Kirsten C. Verhein et al. PLoS One
- Design and synthesis of novel p38α MAP kinase inhibitors: Discovery of pyrazole-benzyl ureas bearing 2-molpholinopyrimidine moiety
- (2012) Tadamasa Arai et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- The discovery of N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]benzamide (AZD6703), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseases
- (2012) Dearg S. Brown et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Novel triazolopyridylbenzamides as potent and selective p38α inhibitors
- (2012) Josep Aiguadé et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- New Therapeutic Targets in Cardiology
- (2012) Eva Denise Martin et al. CIRCULATION
- Anti-inflammatory effect and selectivity profile of AS1940477, a novel and potent p38 mitogen-activated protein kinase inhibitor
- (2012) Masaomi Terajima et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Blockade of VEGF-induced GSK/β-catenin signaling, uPAR expression and increased permeability by dominant negative p38α
- (2012) Jinling Yang et al. EXPERIMENTAL EYE RESEARCH
- Up-regulation of p38 Mitogen-activated Protein Kinase during Pulp Injury–induced Glial Cell/Neuronal Interaction in the Rat Thalamus
- (2012) Tomoatsu Kaneko et al. JOURNAL OF ENDODONTICS
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- (2012) Toru Asano et al. JOURNAL OF MEDICINAL CHEMISTRY
- Design, Synthesis, and Biological Evaluation of Novel Disubstituted Dibenzosuberones as Highly Potent and Selective Inhibitors of p38 Mitogen Activated Protein Kinase
- (2012) Solveigh C. Koeberle et al. JOURNAL OF MEDICINAL CHEMISTRY
- Virtual screening filters for the design of type II p38 MAP kinase inhibitors: A fragment based library generation approach
- (2012) Preethi Badrinarayan et al. JOURNAL OF MOLECULAR GRAPHICS & MODELLING
- Discovery of PH-797804, a highly selective and potent inhibitor of p38 MAP kinase
- (2011) Shaun R. Selness et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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- (2011) Balekudru Devadas et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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- (2011) Alaric J. Dyckman et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Indolin-2-one p38α inhibitors I: Design, profiling and crystallographic binding mode
- (2011) Paul Eastwood et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- 3-Amino-pyrazolo[3,4-d]pyrimidines as p38α kinase inhibitors: Design and development to a highly selective lead
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- Discovery and Characterization of Atropisomer PH-797804, a p38 MAP Kinase Inhibitor, as a Clinical Drug Candidate
- (2011) Li Xing et al. ChemMedChem
- Structure-based design, synthesis and biological evaluation of N-pyrazole, N′-thiazole urea inhibitors of MAP kinase p38α
- (2011) Matthäus Getlik et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- A possible mechanism for hepatotoxicity induced by BIRB-796, an orally active p38 mitogen-activated protein kinase inhibitor
- (2011) Shunsuke Iwano et al. JOURNAL OF APPLIED TOXICOLOGY
- 1,7-Naphthyridine 1-Oxides as Novel Potent and Selective Inhibitors of p38 Mitogen Activated Protein Kinase
- (2011) Wenceslao Lumeras et al. JOURNAL OF MEDICINAL CHEMISTRY
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- (2011) David M. Goldstein et al. JOURNAL OF MEDICINAL CHEMISTRY
- Design and Synthesis of Inhaled p38 Inhibitors for the Treatment of Chronic Obstructive Pulmonary Disease
- (2011) David S. Millan et al. JOURNAL OF MEDICINAL CHEMISTRY
- Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases
- (2011) M. Cargnello et al. MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
- Selective p38α MAPK Deletion in Serotonergic Neurons Produces Stress Resilience in Models of Depression and Addiction
- (2011) Michael R. Bruchas et al. NEURON
- The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor
- (2011) John P. Duffy et al. ACS Medicinal Chemistry Letters
- Mitogen activated protein kinases: a role in inflammatory bowel disease?
- (2009) O. J. Broom et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- Targeting protein kinases for the development of anti-inflammatory drugs
- (2009) Philip Cohen CURRENT OPINION IN CELL BIOLOGY
- The p38α Kinase Plays a Central Role In Inflammation
- (2009) Gary Schieven CURRENT TOPICS IN MEDICINAL CHEMISTRY
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- (2009) T. Yoshizawa et al. JOURNAL OF IMMUNOLOGY
- p38α Mitogen-Activated Protein Kinase Inhibitors: Optimization of a Series of Biphenylamides to Give a Molecule Suitable for Clinical Progression
- (2009) Nicola M. Aston et al. JOURNAL OF MEDICINAL CHEMISTRY
- Targeting p38 MAPK pathway for the treatment of Alzheimer's disease
- (2009) Lenka Munoz et al. NEUROPHARMACOLOGY
- Signal-dependent regulation of gene expression as a target for cancer treatment: Inhibiting p38α in colorectal tumors
- (2008) Fulvio Chiacchiera et al. CANCER LETTERS
- Increased activation of p38 MAPK in COPD
- (2007) T. Renda et al. EUROPEAN RESPIRATORY JOURNAL
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