The p38alpha mitogen-activated protein kinase limits the CNS proinflammatory cytokine response to systemic lipopolysaccharide, potentially through an IL-10 dependent mechanism

Therapeutic Potential of p38 MAP Kinase Inhibition in the Management of Cardiovascular Disease

(2014) Marie Fisk et al.   American Journal of Cardiovascular Drugs

TGFβ produced by IL-10 redirected astrocytes attenuates microglial activation

(2014) Diana M. Norden et al.   GLIA

Macrophage Deletion of p38  Partially Impairs Lipopolysaccharide-Induced Cellular Activation

(2014) Y. J. Kang et al.   JOURNAL OF IMMUNOLOGY

Target Engagement Analysis and Link to Pharmacodynamic Endpoint for a Novel Class of CNS-penetrant and Efficacious p38α MAPK Inhibitors

(2014) Adam D. Bachstetter et al.   Journal of Neuroimmune Pharmacology

The p38  MAPK Regulates Microglial Responsiveness to Diffuse Traumatic Brain Injury

(2013) A. D. Bachstetter et al.   JOURNAL OF NEUROSCIENCE

A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation

(2013) Tobias Goldmann et al.   NATURE NEUROSCIENCE

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

Deficiency in p38β MAPK Fails to Inhibit Cytokine Production or Protect Neurons against Inflammatory Insult in In Vitro and In Vivo Mouse Models

(2013) Bin Xing et al.   PLoS One

Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction

(2013) D. Martin Watterson et al.   PLoS One

Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature

(2013) T. Wyss-Coray et al.   Cold Spring Harbor Perspectives in Medicine

Antiinflammatory functions of p38 in mouse models of rheumatoid arthritis: Advantages of targeting upstream kinases MKK-3 or MKK-6

(2012) Monica Guma et al.   ARTHRITIS AND RHEUMATISM

Lipopolysaccharide-Induced Fever Depends on Prostaglandin E2 Production Specifically in Brain Endothelial Cells

(2012) Linda Engström et al.   ENDOCRINOLOGY

New perspectives on central and peripheral immune responses to acute traumatic brain injury

(2012) Mahasweta Das et al.   Journal of Neuroinflammation

Early Stage Drug Treatment That Normalizes Proinflammatory Cytokine Production Attenuates Synaptic Dysfunction in a Mouse Model That Exhibits Age-Dependent Progression of Alzheimer's Disease-Related Pathology

(2012) A. D. Bachstetter et al.   JOURNAL OF NEUROSCIENCE

Lipopolysaccharide-Induced Microglial Activation and Neuroprotection against Experimental Brain Injury Is Independent of Hematogenous TLR4

(2012) Z. Chen et al.   JOURNAL OF NEUROSCIENCE

Signaling via the kinase p38α programs dendritic cells to drive TH17 differentiation and autoimmune inflammation

(2012) Gonghua Huang et al.   NATURE IMMUNOLOGY

Distinct Functions of the Mitogen-activated Protein Kinase-activated Protein (MAPKAP) Kinases MK2 and MK3

(2011) Christian Ehlting et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Fractalkine Receptor but Not CCR2 Is Present on Microglia from Embryonic Development throughout Adulthood

(2011) M. Mizutani et al.   JOURNAL OF IMMUNOLOGY

Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)

(2011) Adam D Bachstetter et al.   Journal of Neuroinflammation

Microglial p38α MAPK is critical for LPS-induced neuron degeneration, through a mechanism involving TNFα

(2011) Bin Xing et al.   Molecular Neurodegeneration

The immunology of stroke: from mechanisms to translation

(2011) Costantino Iadecola et al.   NATURE MEDICINE

Repertoire of microglial and macrophage responses after spinal cord injury

(2011) Samuel David et al.   NATURE REVIEWS NEUROSCIENCE

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

"Go upstream, young man": lessons learned from the p38 saga

(2009) D Hammaker et al.   ANNALS OF THE RHEUMATIC DISEASES

MSK1 regulates the transcription of IL-1ra in response to TLR activation in macrophages

(2009) Joanne Darragh et al.   BIOCHEMICAL JOURNAL

Monocytes/macrophages and/or neutrophils are the target of IL-10 in the LPS endotoxemia model

(2009) Marina C. Pils et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention

(2009) Malú G. Tansey et al.   NEUROBIOLOGY OF DISEASE

Targeting p38 MAPK pathway for the treatment of Alzheimer's disease

(2009) Lenka Munoz et al.   NEUROPHARMACOLOGY

Exacerbated fatigue and motor deficits in interleukin-10-deficient mice after peripheral immune stimulation

(2008) C. P. Krzyszton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

MSK activation and physiological roles

(2008) J. Simon et al.   Frontiers in Bioscience-Landmark

TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease

(2008) Melissa K McCoy et al.   Journal of Neuroinflammation

Immune-To-Brain Signaling: How Important are the Blood–Brain Barrier-independent Pathways?

(2008) Ning Quan   MOLECULAR NEUROBIOLOGY

The kinase p38α serves cell type–specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression

(2008) Chun Kim et al.   NATURE IMMUNOLOGY

The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling

(2008) Olga Ananieva et al.   NATURE IMMUNOLOGY