Journal
NEUROBIOLOGY OF AGING
Volume 70, Issue -, Pages 86-91Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2018.06.006
Keywords
beta-amyloid; Entorhinal cortex; Neuroinflammation; p38 alpha MAPK inhibitor; Long-term potentiation; Novel object recognition
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Funding
- CNR Research Project on Aging
- [U01 AG043415]
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Neuroinflammation is a fundamental mechanism in Alzheimer's disease (AD) progression. The stress-induced activation of the p38 alpha mitogen-activated protein kinase (MAPK) leads to increased production of proinflammatory cytokines and neurodegeneration. We investigated the effects of an isoform selective p38 alpha MAPK inhibitor, MW01-18-150SRM (MW150), administered at 2.5 mg/kg/d (i.p.; 14 days) on early entorhinal cortex (EC) alterations in an AD mouse model carrying human mutations of the amyloid precursor protein (mhAPP). We used electrophysiological analyses with long-term potentiation induction in EC-containing brain slices and EC-relevant associative memory tasks. We found that MW150 was capable of rescuing long-term potentiation in 2-month old mhAPP mice. Acute delivery of MW150 to brain slices was similarly effective in rescuing long-term potentiation, with a comparable efficacy to that of the widely used multikinase inhibitor SB203580. MW150-treated mhAPP mice demonstrated improved ability to discriminate novel associations between objects and their position/context. Our findings suggest that the selective inhibition of the stress-activated p38 alpha MAPK with MW150 can attenuate the EC dysfunctions associated with neuroinflammation in an early stage of AD progression. (C) 2018 Elsevier Inc. All rights reserved.
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