The Gut Microbial Endocrine Organ in Type 2 Diabetes

Postbiotics for NOD2 require non-hematopoietic RIPK2 to improve blood glucose and metabolic inflammation in mice

(2020) Joseph F. Cavallari et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Differential activation of human pregnane X receptor PXR by isomeric mono-methylated indoles in intestinal and hepatic in vitro models

(2020) Barbora Vyhlídalová et al.   TOXICOLOGY LETTERS

Small molecule inhibition of gut microbial choline trimethylamine lyase activity alters host cholesterol and bile acid metabolism

(2020) Preeti Pathak et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors

(2020) Ina Nemet et al.   CELL

Tryptophan Metabolic Pathways Are Altered in Obesity and Are Associated With Systemic Inflammation

(2020) Sofia Cussotto et al.   Frontiers in Immunology

NOD2 in hepatocytes engages a liver-gut axis to protect against steatosis, fibrosis, and gut dysbiosis during fatty liver disease in mice

(2020) Joseph F. Cavallari et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Gut microbial metabolites in obesity, NAFLD and T2DM

(2019) Emanuel E. Canfora et al.   Nature Reviews Endocrinology

Type 2 Diabetes Is Associated with a Different Pattern of Serum Polyamines: A Case–Control Study from the PREDIMED-Plus Trial

(2019) Jose Fernandez-Garcia et al.   Journal of Clinical Medicine

Trimethylamine N ‐Oxide Aggravates Liver Steatosis through Modulation of Bile Acid Metabolism and Inhibition of Farnesoid X Receptor Signaling in Nonalcoholic Fatty Liver Disease

(2019) Xuying Tan et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Assessment of Causal Direction Between Gut Microbiota-Dependent Metabolites and Cardiometabolic Health: Abi-Directional Mendelian Randomisation Analysis

(2019) Jinzhu Jia et al.   DIABETES

Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy

(2019) Rosina Pryor et al.   CELL

Mapping Interactions of Microbial Metabolites with Human G-Protein-Coupled Receptors

(2019) Dominic A. Colosimo et al.   Cell Host & Microbe

Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction

(2019) Sifan Chen et al.   Cell Metabolism

Genetic Basis of Obesity and Type 2 Diabetes in Africans: Impact on Precision Medicine

(2019) Ayo P. Doumatey et al.   Current Diabetes Reports

Bile acids in glucose metabolism and insulin signalling — mechanisms and research needs

(2019) Tiara R. Ahmad et al.   Nature Reviews Endocrinology

Gut-associated IgA+ immune cells regulate obesity-related insulin resistance

(2019) Helen Luck et al.   Nature Communications

Quantification of bile acids: a mass spectrometry platform for studying gut microbe connection to metabolic diseases

(2019) Ibrahim Choucair et al.   JOURNAL OF LIPID RESEARCH

Depletion of microbiome-derived molecules in the host using Clostridium genetics

(2019) Chun-Jun Guo et al.   SCIENCE

Flagellin-elicited adaptive immunity suppresses flagellated microbiota and vaccinates against chronic inflammatory diseases

(2019) Hao Q. Tran et al.   Nature Communications

Flavonoid metabolism: the interaction of metabolites and gut microbiota

(2018) Kaeko Murota et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism

(2018) Graeme I. Lancaster et al.   Cell Metabolism

GPR119 Agonism Increases Glucagon Secretion During Insulin-Induced Hypoglycemia

(2018) Nina Xiaoyan Li et al.   DIABETES

A prospective evaluation of plasma polyphenol levels and colon cancer risk

(2018) Neil Murphy et al.   INTERNATIONAL JOURNAL OF CANCER

Flavin monooxygenase 3, the host hepatic enzyme in the metaorganismal trimethylamine N-oxide-generating pathway, modulates platelet responsiveness and thrombosis risk

(2018) W. Zhu et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Structure-Dependent Modulation of Aryl Hydrocarbon Receptor-Mediated Activities by Flavonoids

(2018) Un-Ho Jin et al.   TOXICOLOGICAL SCIENCES

Associations of serum indolepropionic acid, a gut microbiota metabolite, with type 2 diabetes and low-grade inflammation in high-risk individuals

(2018) Marjo Tuomainen et al.   Nutrition & Diabetes

Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas

(2018) Rune E. Kuhre et al.   Molecular Metabolism

Impaired Aryl Hydrocarbon Receptor Ligand Production by the Gut Microbiota Is a Key Factor in Metabolic Syndrome

(2018) Jane M. Natividad et al.   Cell Metabolism

Targeting FXR and FGF19 to Treat Metabolic Diseases—Lessons Learned From Bariatric Surgery

(2018) Nadejda Bozadjieva et al.   DIABETES

Development of a gut microbe–targeted nonlethal therapeutic to inhibit thrombosis potential

(2018) Adam B. Roberts et al.   NATURE MEDICINE

G Protein-Coupled Receptor 109A and Host Microbiota Modulate Intestinal Epithelial Integrity During Sepsis

(2018) Guangxin Chen et al.   Frontiers in Immunology

Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1

(2018) Ara Koh et al.   CELL

Indole-3-Pyruvic Acid, an Aryl Hydrocarbon Receptor Activator, Suppresses Experimental Colitis in Mice

(2018) Reiji Aoki et al.   JOURNAL OF IMMUNOLOGY

Plasma microbiome-modulated indole- and phenyl-derived metabolites associate with advanced atherosclerosis and postoperative outcomes

(2017) Cori A. Cason et al.   JOURNAL OF VASCULAR SURGERY

Commensal bacteria make GPCR ligands that mimic human signalling molecules

(2017) Louis J. Cohen et al.   NATURE

Microbiota-derived tryptophan indoles increase after gastric bypass surgery and reduce intestinal permeability in vitro and in vivo

(2017) M. Jennis et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Lithocholic acid controls adaptive immune responses by inhibition of Th1 activation through the Vitamin D receptor

(2017) Thijs W. H. Pols et al.   PLoS One

Sodium butyrate attenuates high-fat diet-induced steatohepatitis in mice by improving gut microbiota and gastrointestinal barrier

(2017) Da Zhou et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Analysis of inflammatory cytokine and TLR expression levels in Type 2 Diabetes with complications

(2017) Saket Gupta et al.   Scientific Reports

Circulating NOD1 Activators and Hematopoietic NOD1 Contribute to Metabolic Inflammation and Insulin Resistance

(2017) Kenny L. Chan et al.   Cell Reports

The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue

(2017) Rebecca C. Schugar et al.   Cell Reports

Uncovering the trimethylamine-producing bacteria of the human gut microbiota

(2017) Silke Rath et al.   Microbiome

Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study

(2017) Vanessa D. de Mello et al.   Scientific Reports

Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk

(2016) Weifei Zhu et al.   CELL

Toll-like receptor 2 and type 2 diabetes

(2016) Zahra Sepehri et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Natural polyphenols: An overview

(2016) Munawar Abbas et al.   INTERNATIONAL JOURNAL OF FOOD PROPERTIES

Reprogramming of hepatic fat accumulation and 'browning' of adipose tissue by the short-chain fatty acid acetate

(2016) M Sahuri-Arisoylu et al.   INTERNATIONAL JOURNAL OF OBESITY

Increased expression of TLR9 associated with pro-inflammatory S100A8 and IL-8 in diabetic wounds could lead to unresolved inflammation in type 2 diabetes mellitus (T2DM) cases with impaired wound healing

(2016) Kanhaiya Singh et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Increased adipose tissue expression of TLR8 in obese individuals with or without type-2 diabetes: significance in metabolic inflammation

(2016) Rasheed Ahmad et al.   Journal of Inflammation-London

Microbiota-Derived Phenylacetylglutamine Associates with Overall Mortality and Cardiovascular Disease in Patients with CKD

(2016) R. Poesen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

GPR41 and GPR43 in Obesity and Inflammation – Protective or Causative?

(2016) Zhiwei Ang et al.   Frontiers in Immunology

Branched short-chain fatty acids modulate glucose and lipid metabolism in primary adipocytes

(2016) Emilia Heimann et al.   Adipocyte

Age-Related Changes of Plasma Bile Acid Concentrations in Healthy Adults—Results from the Cross-Sectional KarMeN Study

(2016) Lara Frommherz et al.   PLoS One

Associations of gut-flora-dependent metabolite trimethylamine-N-oxide, betaine and choline with non-alcoholic fatty liver disease in adults

(2016) Yu-ming Chen et al.   Scientific Reports

Supplementation of sodium butyrate protects mice from the development of non-alcoholic steatohepatitis (NASH)

(2015) Cheng Jun Jin et al.   BRITISH JOURNAL OF NUTRITION

Expression of odorant receptor Olfr78 in enteroendocrine cells of the colon

(2015) Joerg Fleischer et al.   CELL AND TISSUE RESEARCH

Defective NOD2 peptidoglycan sensing promotes diet-induced inflammation, dysbiosis, and insulin resistance

(2015) E. Denou et al.   EMBO Molecular Medicine

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

(2015) Sungsoon Fang et al.   NATURE MEDICINE

Functional metagenomic discovery of bacterial effectors in the human microbiome and isolation of commendamide, a GPCR G2A/132 agonist

(2015) Louis J. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis

(2015) Ji Miao et al.   Nature Communications

Polyamine biosynthesis is critical for growth and differentiation of the pancreas

(2015) Teresa L. Mastracci et al.   Scientific Reports

The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance

(2015) Manya Warrier et al.   Cell Reports

Intestinal Epithelial Cell Toll-like Receptor 5 Regulates the Intestinal Microbiota to Prevent Low-Grade Inflammation and Metabolic Syndrome in Mice

(2014) Benoit Chassaing et al.   GASTROENTEROLOGY

Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults

(2014) Edward S Chambers et al.   GUT

Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis

(2014) Nagendra Singh et al.   IMMUNITY

Dietary trimethylamine N-oxide exacerbates impaired glucose tolerance in mice fed a high fat diet

(2014) Xiang Gao et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Enzymatic routes for the synthesis of ursodeoxycholic acid

(2014) Thorsten Eggert et al.   JOURNAL OF BIOTECHNOLOGY

TGR5 reduces macrophage migration through mTOR-induced C/EBPβ differential translation

(2014) Alessia Perino et al.   JOURNAL OF CLINICAL INVESTIGATION

Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis

(2014) Diana M. Shih et al.   JOURNAL OF LIPID RESEARCH

Regulation of Energy Homeostasis by GPR41

(2014) Daisuke Inoue et al.   Frontiers in Endocrinology

The SCFA Receptor GPR43 and Energy Metabolism

(2014) Ikuo Kimura et al.   Frontiers in Endocrinology

A Nonsense Polymorphism (R392X) in TLR5 Protects from Obesity but Predisposes to Diabetes

(2013) N. M. Al-Daghri et al.   JOURNAL OF IMMUNOLOGY

Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

(2013) Robert A Koeth et al.   NATURE MEDICINE

Human Trace Amine-Associated Receptor TAAR5 Can Be Activated by Trimethylamine

(2013) Ivonne Wallrabenstein et al.   PLoS One

Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation

(2013) Jennifer L. Pluznick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43

(2013) Ikuo Kimura et al.   Nature Communications

Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice

(2012) Tiphaine Le Roy et al.   GUT

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

(2012) Jorge Henao-Mejia et al.   NATURE

Diet-induced Obesity Up-regulates the Abundance of GPR43 and GPR120 in a Tissue Specific Manner

(2011) Lauren M. Cornall et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

NOD1 Activators Link Innate Immunity to Insulin Resistance

(2011) J. D. Schertzer et al.   DIABETES

Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein-Coupled Receptor FFAR2

(2011) G. Tolhurst et al.   DIABETES

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)

(2011) I. Kimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improved glucose control and reduced body fat mass in free fatty acid receptor 2-deficient mice fed a high-fat diet

(2010) Mikael Bjursell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Flavonoids activate pregnane × receptor-mediated CYP3A4 gene expression by inhibiting cyclin-dependent kinases in HepG2 liver carcinoma cells

(2010) Hanqing Dong et al.   BMC BIOCHEMISTRY

Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies

(2010) The Emerging Risk Factors Collaboration   LANCET

TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

(2009) Charles Thomas et al.   Cell Metabolism

Defining and Characterizing the Progression of Type 2 Diabetes

(2009) V. A. Fonseca   DIABETES CARE

Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41

(2008) B. S. Samuel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GPR119, a novel G protein-coupled receptor target for the treatment of type 2 diabetes and obesity

(2007) H A Overton et al.   BRITISH JOURNAL OF PHARMACOLOGY