Indole-3-Pyruvic Acid, an Aryl Hydrocarbon Receptor Activator, Suppresses Experimental Colitis in Mice

The aryl hydrocarbon receptor: a multifunctional chemical sensor for host defense and homeostatic maintenance

(2017) Kaname KAWAJIRI et al.   EXPERIMENTAL ANIMALS

Mesenteric lymph node CD11b− CD103+ PD-L1High dendritic cells highly induce regulatory T cells

(2017) Aya Shiokawa et al.   IMMUNOLOGY

Cellular and Molecular Dynamics of Th17 Differentiation and its Developmental Plasticity in the Intestinal Immune Response

(2017) Suniti Bhaumik et al.   Frontiers in Immunology

IRF8 Transcription-Factor-Dependent Classical Dendritic Cells Are Essential for Intestinal T Cell Homeostasis

(2016) Katarzyna M. Luda et al.   IMMUNITY

A dendritic cell subset designed for oral tolerance

(2016) Reinhard Hinterleitner et al.   NATURE IMMUNOLOGY

CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands

(2016) Bruno Lamas et al.   NATURE MEDICINE

Trypanosoma bruceimetabolite indolepyruvate decreases HIF-1α and glycolysis in macrophages as a mechanism of innate immune evasion

(2016) Anne F. McGettrick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammatory Th1 and Th17 in the Intestine Are Each Driven by Functionally Specialized Dendritic Cells with Distinct Requirements for MyD88

(2016) Jie Liang et al.   Cell Reports

AHR Activation Is Protective against Colitis Driven by T Cells in Humanized Mice

(2016) Jeremy A. Goettel et al.   Cell Reports

Corticosteroid Use and Complications in a US Inflammatory Bowel Disease Cohort

(2016) Akbar K. Waljee et al.   PLoS One

Ablating the aryl hydrocarbon receptor (AhR) in CD11c+ cells perturbs intestinal epithelium development and intestinal immunity

(2016) Song Hui Chng et al.   Scientific Reports

Evidence for New Light-Independent Pathways for Generation of the Endogenous Aryl Hydrocarbon Receptor Agonist FICZ

(2015) Anna Smirnova et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Intestinal CD103+CD11b− dendritic cells restrain colitis via IFN-γ-induced anti-inflammatory response in epithelial cells

(2015) A R B M Muzaki et al.   Mucosal Immunology

CD103+CD11b+ Dendritic Cells Induce Th17 T Cells in Muc2-Deficient Mice with Extensively Spread Colitis

(2015) Ulf A. Wenzel et al.   PLoS One

Activation of the aryl hydrocarbon receptor affects activation and function of human monocyte-derived dendritic cells

(2014) C. Wang et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Lymph-borne CD8α+ dendritic cells are uniquely able to cross-prime CD8+ T cells with antigen acquired from intestinal epithelial cells

(2014) V Cerovic et al.   Mucosal Immunology

Protective Effect of Indole-3-Pyruvate against Ultraviolet B-Induced Damage to Cultured HaCaT Keratinocytes and the Skin of Hairless Mice

(2014) Reiji Aoki et al.   PLoS One

Osteopontin expression by CD103−dendritic cells drives intestinal inflammation

(2014) Evangelia Kourepini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammatory Bowel Disease: The Classic Gastrointestinal Autoimmune Disease

(2014) Abha Kaistha et al.   Current Problems in Pediatric and Adolescent Health Care

Optimizing anti-TNF treatments in inflammatory bowel disease

(2013) Shomron Ben-Horin et al.   AUTOIMMUNITY REVIEWS

5-Aminosalicylic Acid and Chemoprevention: Does It Work?

(2013) Anthony Lopez et al.   DIGESTIVE DISEASES

Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22

(2013) Teresa Zelante et al.   IMMUNITY

IRF4 Transcription-Factor-Dependent CD103+CD11b+ Dendritic Cells Drive Mucosal T Helper 17 Cell Differentiation

(2013) Emma K. Persson et al.   IMMUNITY

IRF4 Transcription Factor-Dependent CD11b+ Dendritic Cells in Human and Mouse Control Mucosal IL-17 Cytokine Responses

(2013) Andreas Schlitzer et al.   IMMUNITY

Safety and Efficacy of Antigen-Specific Regulatory T-Cell Therapy for Patients With Refractory Crohn's Disease

(2012) Pierre Desreumaux et al.   GASTROENTEROLOGY

IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4+Th17 cells

(2012) Margherita Coccia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intestinal CD103− dendritic cells migrate in lymph and prime effector T cells

(2012) V Cerovic et al.   Mucosal Immunology

Probiotic Bifidobacterium breve Induces IL-10-Producing Tr1 Cells in the Colon

(2012) Seong Gyu Jeon et al.   PLoS Pathogens

Aryl Hydrocarbon Receptor-Induced Signals Up-regulate IL-22 Production and Inhibit Inflammation in the Gastrointestinal Tract

(2011) Ivan Monteleone et al.   GASTROENTEROLOGY

Identification of a High-Affinity Ligand That Exhibits Complete Aryl Hydrocarbon Receptor Antagonism

(2011) K. J. Smith et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Dietary Ligands of the Aryl Hydrocarbon Receptor Induce Anti-Inflammatory and Immunoregulatory Effects on Murine Dendritic Cells

(2011) Jenna M. Benson et al.   TOXICOLOGICAL SCIENCES

Inflammatory Bowel Disease

(2010) Arthur Kaser et al.   Annual Review of Immunology

E-Cadherin Marks a Subset of Inflammatory Dendritic Cells that Promote T Cell-Mediated Colitis

(2010) Karima R.R. Siddiqui et al.   IMMUNITY

The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27

(2010) Lionel Apetoh et al.   NATURE IMMUNOLOGY

Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell–like and Foxp3+ regulatory T cells

(2010) Roopali Gandhi et al.   NATURE IMMUNOLOGY

Consequences of AhR Activation in Steady-State Dendritic Cells

(2010) T. Simones et al.   TOXICOLOGICAL SCIENCES

Aryl Hydrocarbon Receptor Activation by TCDD Reduces Inflammation Associated with Crohn's Disease

(2010) Jenna M. Benson et al.   TOXICOLOGICAL SCIENCES

Functional and phenotypic effects of AhR activation in inflammatory dendritic cells

(2010) Jaishree Bankoti et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Regulatory T Cells Reinforce Intestinal Homeostasis

(2009) Michael J. Barnes et al.   IMMUNITY

Mesenteric Lymph Nodes Confine Dendritic Cell-Mediated Dissemination of Salmonella enterica Serovar Typhimurium and Limit Systemic Disease in Mice

(2009) S. Voedisch et al.   INFECTION AND IMMUNITY

A role for CD47 in the development of experimental colitis mediated by SIRPα+CD103−dendritic cells

(2009) Genevieve Fortin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor

(2008) Francisco J. Quintana et al.   NATURE

Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells

(2008) A. Kimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA