TGR5 reduces macrophage migration through mTOR-induced C/EBPβ differential translation

Local Proliferation of Macrophages Contributes to Obesity-Associated Adipose Tissue Inflammation

(2014) Shinya U. Amano et al.   Cell Metabolism

Inflammatory Cytokine Production by Human Neutrophils Involves C/EBP Transcription Factors

(2014) A. Cloutier et al.   JOURNAL OF IMMUNOLOGY

Loss of CCR5 results in glucose intolerance in diet-induced obese mice

(2013) Arion Kennedy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Ciliary subcellular localization of TGR5 determines the cholangiocyte functional response to bile acid signaling

(2013) Anatoliy I. Masyuk et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The Origins and Drivers of Insulin Resistance

(2013) Andrew M.F. Johnson et al.   CELL

The receptor TGR5 protects the liver from bile acid overload during liver regeneration in mice

(2013) Noémie Péan et al.   HEPATOLOGY

TGR5 signalling inhibits the production of pro-inflammatory cytokines byin vitrodifferentiated inflammatory and intestinal macrophages in Crohn's disease

(2013) Kazuaki Yoneno et al.   IMMUNOLOGY

The TGR5 receptor mediates bile acid–induced itch and analgesia

(2013) Farzad Alemi et al.   JOURNAL OF CLINICAL INVESTIGATION

The Complement Anaphylatoxin C5a Receptor Contributes to Obese Adipose Tissue Inflammation and Insulin Resistance

(2013) J. Phieler et al.   JOURNAL OF IMMUNOLOGY

Bile acids PKA-dependently induce a switch of the IL-10/IL-12 ratio and reduce proinflammatory capability of human macrophages

(2013) Katrin Haselow et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

The bile acid receptor, TGR5, regulates basal and cholinergic-induced secretory responses in rat colon

(2013) J. B. J. Ward et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Gene silencing in adipose tissue macrophages regulates whole-body metabolism in obese mice

(2013) M. Aouadi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pleiotropic Actions of Insulin Resistance and Inflammation in Metabolic Homeostasis

(2013) J. I. Odegaard et al.   SCIENCE

The role of innate immune cells in obese adipose tissue inflammation and development of insulin resistance

(2013) Triantafyllos Chavakis et al.   THROMBOSIS AND HAEMOSTASIS

Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice

(2012) Matthew J. Potthoff et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Activation of transmembrane bile acid receptor TGR5 stimulates insulin secretion in pancreatic β cells

(2012) Divya P. Kumar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inflammation and Lipid Signaling in the Etiology of Insulin Resistance

(2012) Christopher K. Glass et al.   Cell Metabolism

C5L2 and C5aR interaction in adipocytes and macrophages: Insights into adipoimmunology

(2012) Pegah Poursharifi et al.   CELLULAR SIGNALLING

Neuropeptide Y1 Receptor in Immune Cells Regulates Inflammation and Insulin Resistance Associated With Diet-Induced Obesity

(2012) L. Macia et al.   DIABETES

Monocyte chemoattractant protein-1 (MCP-1) deficiency enhances alternatively activated M2 macrophages and ameliorates insulin resistance and fatty liver in lipoatrophic diabetic A-ZIP transgenic mice

(2012) Y. Nio et al.   DIABETOLOGIA

C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling

(2012) Junxian Lim et al.   FASEB JOURNAL

The Receptor TGR5 Mediates the Prokinetic Actions of Intestinal Bile Acids and Is Required for Normal Defecation in Mice

(2012) Farzad Alemi et al.   GASTROENTEROLOGY

Transcriptional Repression ofATF4Gene by CCAAT/Enhancer-binding Protein β (C/EBPβ) Differentially Regulates Integrated Stress Response

(2012) Souvik Dey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CCAAT/Enhancer-binding Protein β (C/EBPβ) Expression Regulates Dietary-induced Inflammation in Macrophages and Adipose Tissue in Mice

(2012) Shaikh M. Rahman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G protein–coupled receptor 21 deletion improves insulin sensitivity in diet-induced obese mice

(2012) Olivia Osborn et al.   JOURNAL OF CLINICAL INVESTIGATION

The cellular and signaling networks linking the immune system and metabolism in disease

(2012) Olivia Osborn et al.   NATURE MEDICINE

JNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation

(2012) M. S. Han et al.   SCIENCE

TGR5 potentiates GLP-1 secretion in response to anionic exchange resins

(2012) Taoufiq Harach et al.   Scientific Reports

Inflammatory Mechanisms in Obesity

(2011) Margaret F. Gregor et al.   Annual Review of Immunology

TGR5 Activation Inhibits Atherosclerosis by Reducing Macrophage Inflammation and Lipid Loading

(2011) Thijs W.H. Pols et al.   Cell Metabolism

The Bile Acid Membrane Receptor TGR5: A Valuable Metabolic Target

(2011) Thijs W.H. Pols et al.   DIGESTIVE DISEASES

The G-Protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor kappa light-chain enhancer of activated B cells (NF-κB) in mice

(2011) Yan-Dong Wang et al.   HEPATOLOGY

Inflammatory links between obesity and metabolic disease

(2011) Carey N. Lumeng et al.   JOURNAL OF CLINICAL INVESTIGATION

Rapamycin inhibits osteoclast formation in giant cell tumor of bone through the C/EBPβ - MafB axis

(2011) Jeske J. Smink et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Type 2 diabetes across generations: from pathophysiology to prevention and management

(2011) Christopher J Nolan et al.   LANCET

C/EBP , C/EBP  Oncoproteins, or C/EBP  Preferentially Bind NF- B p50 Compared with p65, Focusing Therapeutic Targeting on the C/EBP:p50 Interaction

(2011) J. E. Dooher et al.   MOLECULAR CANCER RESEARCH

The G Protein-Coupled Bile Acid Receptor, TGR5, Stimulates Gallbladder Filling

(2011) Tingting Li et al.   MOLECULAR ENDOCRINOLOGY

The Bile Acid Receptor GPBAR-1 (TGR5) Modulates Integrity of Intestinal Barrier and Immune Response to Experimental Colitis

(2011) Sabrina Cipriani et al.   PLoS One

Macrophages, Inflammation, and Insulin Resistance

(2010) Jerrold M. Olefsky et al.   Annual Review of Physiology

HER2 Silences Tumor Suppression in Breast Cancer Cells by Switching Expression of C/EBP  Isoforms

(2010) A. Arnal-Estape et al.   CANCER RESEARCH

GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects

(2010) Da Young Oh et al.   CELL

C/EBP  uORF mice--a genetic model for uORF-mediated translational control in mammals

(2010) K. Wethmar et al.   GENES & DEVELOPMENT

CCAAT/Enhancer-binding Protein β and NF-κB Mediate High Level Expression of Chemokine GenesCCL3andCCL4by Human Chondrocytes in Response to IL-1β

(2010) Zhiqi Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation

(2010) Thijs W.H. Pols et al.   JOURNAL OF HEPATOLOGY

Hydrophobic bile salts inhibit gallbladder smooth muscle function via stimulation of GPBAR1 receptors and activation of KATPchannels

(2010) Brigitte Lavoie et al.   JOURNAL OF PHYSIOLOGY-LONDON

Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system

(2010) D. P. Poole et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Mutational Characterization of the Bile Acid Receptor TGR5 in Primary Sclerosing Cholangitis

(2010) Johannes R. Hov et al.   PLoS One

TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

(2009) Charles Thomas et al.   Cell Metabolism

Transcription factor C/EBPβ isoform ratio regulates osteoclastogenesis through MafB

(2009) Jeske J Smink et al.   EMBO JOURNAL

The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders

(2009) Verena Keitel et al.   HEPATOLOGY

Discovery of 6α-Ethyl-23(S)-methylcholic Acid (S-EMCA, INT-777) as a Potent and Selective Agonist for the TGR5 Receptor, a Novel Target for Diabesity

(2009) Roberto Pellicciari et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of CCR2 Ameliorates Insulin Resistance and Hepatic Steatosis in db/db Mice

(2008) Yukinori Tamura et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Novel Potent and Selective Bile Acid Derivatives as TGR5 Agonists: Biological Screening, Structure−Activity Relationships, and Molecular Modeling Studies

(2008) Hiroyuki Sato et al.   JOURNAL OF MEDICINAL CHEMISTRY

Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity

(2008) Oded Shaham et al.   Molecular Systems Biology