Quantification of bile acids: a mass spectrometry platform for studying gut microbe connection to metabolic diseases

Deficiency of both farnesoid X receptor and Takeda G protein-coupled receptor 5 exacerbated liver fibrosis in mice

(2019) Jessica M. Ferrell et al.   HEPATOLOGY

Alteration of Bile Acid Metabolism by a High-Fat Diet Is Associated with Plasma Transaminase Activities and Glucose Intolerance in Rats

(2019) Reika YOSHITSUGU et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

Intestinal Microbiota in Cardiovascular Health and Disease

(2019) W.H. Wilson Tang et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Analysis of human C24 bile acids metabolome in serum and urine based on enzyme digestion of conjugated bile acids and LC-MS determination of unconjugated bile acids

(2018) Pingping Zhu et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Impacts of the Human Gut Microbiome on Therapeutics

(2018) Yoshiki Vázquez-Baeza et al.   Annual Review of Pharmacology and Toxicology

Farnesoid X receptor modulators 2014-present: a patent review

(2018) Valentina Sepe et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism

(2018) Preeti Pathak et al.   HEPATOLOGY

Microbial modulation of cardiovascular disease

(2018) J. Mark Brown et al.   NATURE REVIEWS MICROBIOLOGY

Role of Bile Acids in Metabolic Control

(2018) Antonio Molinaro et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Liver–Microbiome Axis in Health and Disease

(2018) Timon E. Adolph et al.   TRENDS IN IMMUNOLOGY

TGR5 signalling promotes mitochondrial fission and beige remodelling of white adipose tissue

(2018) Laura A. Velazquez-Villegas et al.   Nature Communications

Deoxycholic acid supplementation impairs glucose homeostasis in mice

(2018) Karolina E. Zaborska et al.   PLoS One

Bile Acid Control of Metabolism and Inflammation in Obesity, Type 2 Diabetes, Dyslipidemia, and Nonalcoholic Fatty Liver Disease

(2017) Oscar Chávez-Talavera et al.   GASTROENTEROLOGY

Bile acid–microbiota crosstalk in gastrointestinal inflammation and carcinogenesis

(2017) Wei Jia et al.   Nature Reviews Gastroenterology & Hepatology

Analyses of gut microbiota and plasma bile acids enable stratification of patients for antidiabetic treatment

(2017) Yanyun Gu et al.   Nature Communications

Clinical relevance of the bile acid receptor TGR5 in metabolism

(2017) F Samuel van Nierop et al.   Lancet Diabetes & Endocrinology

Rapid analysis of bile acids in different biological matrices using LC-ESI-MS/MS for the investigation of bile acid transformation by mammalian gut bacteria

(2016) Katrin Wegner et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Bile Acid Analog Intercepts Liver Fibrosis

(2016) C. Daniel De Magalhaes Filho et al.   CELL

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism

(2016) Annika Wahlström et al.   Cell Metabolism

Bile Acid Metabolome after an Oral Lipid Tolerance Test by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

(2016) Andreas Schmid et al.   PLoS One

Bile Acid Profiling and Quantification in Biofluids Using Ultra-Performance Liquid Chromatography Tandem Mass Spectrometry

(2015) Magali H. Sarafian et al.   ANALYTICAL CHEMISTRY

A biosynthetic pathway for a prominent class of microbiota-derived bile acids

(2015) A Sloan Devlin et al.   Nature Chemical Biology

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

(2015) Sungsoon Fang et al.   NATURE MEDICINE

Metabolic Profiling of Bile Acids in Human and Mouse Blood by LC–MS/MS in Combination with Phospholipid-Depletion Solid-Phase Extraction

(2014) Jun Han et al.   ANALYTICAL CHEMISTRY

A liquid chromatography-tandem mass spectrometry-based method for the simultaneous determination of hydroxy sterols and bile acids

(2014) Clara John et al.   JOURNAL OF CHROMATOGRAPHY A

Fasting Serum Taurine-Conjugated Bile Acids Are Elevated in Type 2 Diabetes and Do Not Change With Intensification of Insulin

(2014) Marlene Wewalka et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

TGR5 reduces macrophage migration through mTOR-induced C/EBPβ differential translation

(2014) Alessia Perino et al.   JOURNAL OF CLINICAL INVESTIGATION

Beyond intestinal soap—bile acids in metabolic control

(2014) Folkert Kuipers et al.   Nature Reviews Endocrinology

Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist

(2013) Sama I. Sayin et al.   Cell Metabolism

Human Insulin Resistance Is Associated With Increased Plasma Levels of 12 -Hydroxylated Bile Acids

(2013) R. A. Haeusler et al.   DIABETES

Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk

(2013) W.H. Wilson Tang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeted profiling of circulating and hepatic bile acids in human, mouse, and rat using a UPLC-MRM-MS-validated method

(2012) Juan C. García-Cañaveras et al.   JOURNAL OF LIPID RESEARCH

TGR5 Activation Inhibits Atherosclerosis by Reducing Macrophage Inflammation and Lipid Loading

(2011) Thijs W.H. Pols et al.   Cell Metabolism

Impaired Generation of 12-Hydroxylated Bile Acids Links Hepatic Insulin Signaling with Dyslipidemia

(2011) Rebecca A. Haeusler et al.   Cell Metabolism

Glucose and Insulin Induction of Bile Acid Synthesis

(2011) Tiangang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

(2009) Charles Thomas et al.   Cell Metabolism

Rapid quantification of bile acids and their conjugates in serum by liquid chromatography–tandem mass spectrometry

(2009) Max Scherer et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Antiatherosclerotic effect of farnesoid X receptor

(2008) Andrea Mencarelli et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Bile Acids: Chemistry, Pathochemistry, Biology, Pathobiology, and Therapeutics

(2008) A. F. Hofmann et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Quantitative-profiling of bile acids and their conjugates in mouse liver, bile, plasma, and urine using LC–MS/MS

(2008) Yazen Alnouti et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Improved analysis of bile acids in tissues and intestinal contents of rats using LC/ESI-MS

(2008) Masahito Hagio et al.   JOURNAL OF LIPID RESEARCH

Hepatic insulin resistance directly promotes formation of cholesterol gallstones

(2008) Sudha B Biddinger et al.   NATURE MEDICINE

Targeting bile-acid signalling for metabolic diseases

(2008) Charles Thomas et al.   NATURE REVIEWS DRUG DISCOVERY