G Protein-Coupled Receptor 109A and Host Microbiota Modulate Intestinal Epithelial Integrity During Sepsis

Sodium Butyrate Inhibits Inflammation and Maintains Epithelium Barrier Integrity in a TNBS-induced Inflammatory Bowel Disease Mice Model

(2018) Guangxin Chen et al.   EBioMedicine

Distinct Microbial Communities Trigger Colitis Development upon Intestinal Barrier Damage via Innate or Adaptive Immune Cells

(2017) Urmi Roy et al.   Cell Reports

How to Feed the Mammalian Gut Microbiota: Bacterial and Metabolic Modulation by Dietary Fibers

(2017) Chiara Ferrario et al.   Frontiers in Microbiology

Effect of Functional Oligosaccharides and Ordinary Dietary Fiber on Intestinal Microbiota Diversity

(2017) Weiwei Cheng et al.   Frontiers in Microbiology

The Spectrum and Regulatory Landscape of Intestinal Innate Lymphoid Cells Are Shaped by the Microbiome

(2016) Meital Gury-BenAri et al.   CELL

A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility

(2016) Mahesh S. Desai et al.   CELL

Critically ill patients demonstrate large interpersonal variation in intestinal microbiota dysregulation: a pilot study

(2016) Jacqueline M. Lankelma et al.   INTENSIVE CARE MEDICINE

Intestinal microbiota sustains inflammation and autoimmunity induced by hypomorphicRAGdefects

(2016) Rosita Rigoni et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Metagenomic Analysis Reveals Dynamic Changes of Whole Gut Microbiota in the Acute Phase of Intensive Care Unit Patients

(2015) Masahiro Ojima et al.   DIGESTIVE DISEASES AND SCIENCES

Dysbiotic gut microbiota causes transmissible Crohn's disease-like ileitis independent of failure in antimicrobial defence

(2015) Monika Schaubeck et al.   GUT

The gut microbiota and inflammatory noncommunicable diseases: Associations and potentials for gut microbiota therapies

(2015) Christina E. West et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome

(2015) Laurence Macia et al.   Nature Communications

Transkingdom Control of Microbiota Diurnal Oscillations Promotes Metabolic Homeostasis

(2014) Christoph A. Thaiss et al.   CELL

Sepsis: Current Dogma and New Perspectives

(2014) Clifford S. Deutschman et al.   IMMUNITY

GPR109a: The Missing Link between Microbiome and Good Health?

(2014) Christian Jobin   IMMUNITY

Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis

(2014) Nagendra Singh et al.   IMMUNITY

Immunotherapy for the Adjunctive Treatment of Sepsis: From Immunosuppression to Immunostimulation. Time for a Paradigm Change?

(2013) Jenneke Leentjens et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF

(2013) Roosmarijn E. Vandenbroucke et al.   EMBO Molecular Medicine

Sepsis definitions: time for change

(2013) Jean-Louis Vincent et al.   LANCET

Niacin Increases Adiponectin and Decreases Adipose Tissue Inflammation in High Fat Diet-Fed Mice

(2013) Desiree Wanders et al.   PLoS One

The Commensal Microbiota and Enteropathogens in the Pathogenesis of Inflammatory Bowel Diseases

(2011) Benoit Chassaing et al.   GASTROENTEROLOGY

Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells

(2011) Martina Lukasova et al.   JOURNAL OF CLINICAL INVESTIGATION

Cecal ligation and puncture: the gold standard model for polymicrobial sepsis?

(2011) Lien Dejager et al.   TRENDS IN MICROBIOLOGY

Niacin attenuates lung inflammation and improves survival during sepsis by downregulating the nuclear factor-κB pathway*

(2010) Woon Yong Kwon et al.   CRITICAL CARE MEDICINE

Enterocyte-specific epidermal growth factor prevents barrier dysfunction and improves mortality in murine peritonitis

(2009) Jessica A. Clark et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

EPIDERMAL GROWTH FACTOR TREATMENT DECREASES MORTALITY AND IS ASSOCIATED WITH IMPROVED GUT INTEGRITY IN SEPSIS

(2009) Jessica A. Clark et al.   SHOCK

Diet-Induced Obesity Is Linked to Marked but Reversible Alterations in the Mouse Distal Gut Microbiome

(2008) Peter J. Turnbaugh et al.   Cell Host & Microbe

Reducing small intestinal permeability attenuates colitis in the IL10 gene-deficient mouse

(2008) M C Arrieta et al.   GUT