Commensal bacteria make GPCR ligands that mimic human signalling molecules

Dysbiosis of small intestinal microbiota in liver cirrhosis and its association with etiology

(2016) Yanfei Chen et al.   Scientific Reports

Mucosally transplanted mesenchymal stem cells stimulate intestinal healing by promoting angiogenesis

(2015) Nicholas A. Manieri et al.   JOURNAL OF CLINICAL INVESTIGATION

G Protein-Coupled Receptor 119 (GPR119) Agonists for the Treatment of Diabetes: Recent Progress and Prevailing Challenges

(2015) Kurt Ritter et al.   JOURNAL OF MEDICINAL CHEMISTRY

Endocannabinoids — at the crossroads between the gut microbiota and host metabolism

(2015) Patrice D. Cani et al.   Nature Reviews Endocrinology

Functional metagenomic discovery of bacterial effectors in the human microbiome and isolation of commendamide, a GPCR G2A/132 agonist

(2015) Louis J. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysine and novel hydroxylysine lipids in soil bacteria: amino acid membrane lipid response to temperature and pH in Pseudopedobacter saltans

(2015) Eli K. Moore et al.   Frontiers in Microbiology

Programming a Human Commensal Bacterium, Bacteroides thetaiotaomicron, to Sense and Respond to Stimuli in the Murine Gut Microbiota

(2015) Mark Mimee et al.   Cell Systems

Incorporation of therapeutically modified bacteria into gut microbiota inhibits obesity

(2014) Zhongyi Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

MOLECULAR EVOLUTION OF GPCRS: CRH/CRH receptors

(2014) David A Lovejoy et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

MOLECULAR EVOLUTION OF GPCRS: What we know and what the future holds

(2014) Hubert Vaudry   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Gut Hormone Pharmacology of a Novel GPR119 Agonist (GSK1292263), Metformin, and Sitagliptin in Type 2 Diabetes Mellitus: Results from Two Randomized Studies

(2014) Derek J. Nunez et al.   PLoS One

Relating the metatranscriptome and metagenome of the human gut

(2014) E. A. Franzosa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional expression of dental plaque microbiota

(2014) Scott N. Peterson et al.   Frontiers in Cellular and Infection Microbiology

Novel GPR119 agonist HD0471042 attenuated type 2 diabetes mellitus

(2013) Tae-Young Ha et al.   ARCHIVES OF PHARMACAL RESEARCH

Duodenal microbiota composition and mucosal homeostasis in pediatric celiac disease

(2013) Jing Cheng et al.   BMC GASTROENTEROLOGY

Modulating the endocannabinoid system in human health and disease - successes and failures

(2013) Pál Pacher et al.   FEBS Journal

E-type prostanoid receptor 4 (EP4) in disease and therapy

(2013) Viktoria Konya et al.   PHARMACOLOGY & THERAPEUTICS

Production of α-Galactosylceramide by a Prominent Member of the Human Gut Microbiota

(2013) Laura C. Wieland Brown et al.   PLOS BIOLOGY

Effects of JNJ-38431055, a novel GPR119 receptor agonist, in randomized, double-blind, placebo-controlled studies in subjects with type 2 diabetes

(2012) L. B. Katz et al.   DIABETES OBESITY & METABOLISM

Structure, function and diversity of the healthy human microbiome

(2012)   NATURE

Sphingosine-1-phospate receptor 4 (S1P4) deficiency profoundly affects dendritic cell function and TH17-cell differentiation in a murine model

(2011) Tobias Schulze et al.   FASEB JOURNAL

2-Oleoyl Glycerol Is a GPR119 Agonist and Signals GLP-1 Release in Humans

(2011) Katrine B. Hansen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Lysophosphatidylcholines activate G2A inducing Gαi-1-/Gαq/11- Ca2+flux, Gβγ-Hck activation and clathrin/β-arrestin-1/GRK6 recruitment in PMNs

(2010) Samina Y. Khan et al.   BIOCHEMICAL JOURNAL

GPR119 Regulates Murine Glucose Homeostasis Through Incretin Receptor-Dependent and Independent Mechanisms

(2010) Grace Flock et al.   ENDOCRINOLOGY

Oleoylethanolamide: Effects on hypothalamic transmitters and gut peptides regulating food intake

(2010) Antonia Serrano et al.   NEUROPHARMACOLOGY

Proximal Small Intestinal Microbiota and Identification of Rod-Shaped Bacteria Associated With Childhood Celiac Disease

(2009) Gangwei Ou et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

GPR119 Is Essential for Oleoylethanolamide-Induced Glucagon-Like Peptide-1 Secretion From the Intestinal Enteroendocrine L-Cell

(2009) L. M. Lauffer et al.   DIABETES

GPR119 is required for physiological regulation of glucagon-like peptide-1 secretion but not for metabolic homeostasis

(2009) Hong Lan et al.   JOURNAL OF ENDOCRINOLOGY

Amino acid-containing membrane lipids in bacteria

(2009) Otto Geiger et al.   PROGRESS IN LIPID RESEARCH

G2A and LPC: Regulatory functions in immunity

(2009) Janusz H. Kabarowski   PROSTAGLANDINS & OTHER LIPID MEDIATORS

GPR119: “Double-Dipping” for Better Glycemic Control

(2008) L. Lauffer et al.   ENDOCRINOLOGY

A Role for Intestinal Endocrine Cell-Expressed G Protein-Coupled Receptor 119 in Glycemic Control by Enhancing Glucagon-Like Peptide-1 and Glucose-Dependent Insulinotropic Peptide Release

(2008) Zhi-Liang Chu et al.   ENDOCRINOLOGY

Characterization of ornithine and glutamine lipids extracted from cell membranes of Rhodobacter sphaeroides

(2008) Xi Zhang et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

N-Palmitoyl Glycine, a Novel Endogenous Lipid That Acts As a Modulator of Calcium Influx and Nitric Oxide Production in Sensory Neurons

(2008) N. Rimmerman et al.   MOLECULAR PHARMACOLOGY

Chemical ecology in retrospect and prospect

(2008) J. Meinwald et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA