The formation and function of the cardiac conduction system

GATA-dependent transcriptional and epigenetic control of cardiac lineage specification and differentiation

(2015) Sonia Stefanovic et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

RNA Sequencing of Mouse Sinoatrial Node Reveals an Upstream Regulatory Role for Islet-1 in Cardiac Pacemaker Cells

(2015) V. Vedantham et al.   CIRCULATION RESEARCH

GATA-Binding Factor 6 Contributes to Atrioventricular Node Development and FunctionCLINICAL PERSPECTIVE

(2015) Fang Liu et al.   Circulation-Cardiovascular Genetics

A common Shox2-Nkx2-5 antagonistic mechanism primes the pacemaker cell fate in the pulmonary vein myocardium and sinoatrial node

(2015) W. Ye et al.   DEVELOPMENT

Genetic defects in a His-Purkinje system transcription factor,IRX3, cause lethal cardiac arrhythmias

(2015) Akiko Koizumi et al.   EUROPEAN HEART JOURNAL

Transcription factor ISL1 is essential for pacemaker development and function

(2015) Xingqun Liang et al.   JOURNAL OF CLINICAL INVESTIGATION

Expansion and patterning of cardiovascular progenitors derived from human pluripotent stem cells

(2015) Matthew J Birket et al.   NATURE BIOTECHNOLOGY

Direct Nkx2-5 Transcriptional Repression of Isl1 Controls Cardiomyocyte Subtype Identity

(2015) Tatjana Dorn et al.   STEM CELLS

GATA-Binding Factor 6 Contributes to Atrioventricular Node Development and FunctionCLINICAL PERSPECTIVE

(2015) Fang Liu et al.   Circulation-Cardiovascular Genetics

SHOX2 Overexpression Favors Differentiation of Embryonic Stem Cells into Cardiac Pacemaker Cells, Improving Biological Pacing Ability

(2015) Vittoria Ionta et al.   Stem Cell Reports

Baf250a orchestrates an epigenetic pathway to repress the Nkx2.5-directed contractile cardiomyocyte program in the sinoatrial node

(2014) Meng Wu et al.   CELL RESEARCH

A Large Permissive Regulatory Domain Exclusively Controls Tbx3 Expression in the Cardiac Conduction System

(2014) Jan Hendrik van Weerd et al.   CIRCULATION RESEARCH

Genetic Determinants of P Wave Duration and PR Segment

(2014) N. Verweij et al.   Circulation-Cardiovascular Genetics

Reciprocal myocardial-endocardial interactions pattern the delay in atrioventricular junction conduction

(2014) M. Bressan et al.   DEVELOPMENT

Alk3 mediated Bmp signaling controls the contribution of epicardially derived cells to the tissues of the atrioventricular junction

(2014) Marie M. Lockhart et al.   DEVELOPMENTAL BIOLOGY

Specification of the mouse cardiac conduction system in the absence of Endothelin signaling

(2014) Lisa L. Hua et al.   DEVELOPMENTAL BIOLOGY

Histone deacetylase 3 modulates Tbx5 activity to regulate early cardiogenesis

(2014) Sara L. Lewandowski et al.   HUMAN MOLECULAR GENETICS

A common genetic variant within SCN10A modulates cardiac SCN5A expression

(2014) Malou van den Boogaard et al.   JOURNAL OF CLINICAL INVESTIGATION

MyoR Modulates Cardiac Conduction by Repressing Gata4

(2014) John P. Harris et al.   MOLECULAR AND CELLULAR BIOLOGY

Pitx2-microRNA pathway that delimits sinoatrial node development and inhibits predisposition to atrial fibrillation

(2014) J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biological pacemaker created by minimally invasive somatic reprogramming in pigs with complete heart block

(2014) Y.-F. Hu et al.   Science Translational Medicine

GATA-dependent regulatory switches establish atrioventricular canal specificity during heart development

(2014) Sonia Stefanovic et al.   Nature Communications

Cardiac Cell Lineages that Form the Heart

(2014) S. M. Meilhac et al.   Cold Spring Harbor Perspectives in Medicine

Heart Fields and Cardiac Morphogenesis

(2014) R. G. Kelly et al.   Cold Spring Harbor Perspectives in Medicine

Islet1 is a direct transcriptional target of the homeodomain transcription factor Shox2 and rescues the Shox2-mediated bradycardia

(2013) Sandra Hoffmann et al.   BASIC RESEARCH IN CARDIOLOGY

HCN4 Dynamically Marks the First Heart Field and Conduction System Precursors

(2013) Xingqun Liang et al.   CIRCULATION RESEARCH

Resolving cell lineage contributions to the ventricular conduction system with a Cx40-GFP allele: A dual contribution of the first and second heart fields

(2013) Lucile Miquerol et al.   DEVELOPMENTAL DYNAMICS

Topology of mammalian developmental enhancers and their regulatory landscapes

(2013) Wouter de Laat et al.   NATURE

A high-resolution map of the three-dimensional chromatin interactome in human cells

(2013) Fulai Jin et al.   NATURE

A HCN4+ cardiomyogenic progenitor derived from the first heart field and human pluripotent stem cells

(2013) Daniela Später et al.   NATURE CELL BIOLOGY

Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death

(2013) Connie R Bezzina et al.   NATURE GENETICS

Identification of heart rate–associated loci and their effects on cardiac conduction and rhythm disorders

(2013) Marcel den Hoed et al.   NATURE GENETICS

Early Mesodermal Cues Assign Avian Cardiac Pacemaker Fate Potential in a Tertiary Heart Field

(2013) M. Bressan et al.   SCIENCE

Shox2 Regulates the Pacemaker Gene Program in Embryoid Bodies

(2013) Sherin I. Hashem et al.   STEM CELLS AND DEVELOPMENT

Homeobox transcription factor Pitx2: The rise of an asymmetry gene in cardiogenesis and arrhythmogenesis

(2013) Diego Franco et al.   TRENDS IN CARDIOVASCULAR MEDICINE

T-box transcription factor TBX3 reprogrammes mature cardiac myocytes into pacemaker-like cells

(2012) Martijn L. Bakker et al.   CARDIOVASCULAR RESEARCH

Myocardial Notch Signaling Reprograms Cardiomyocytes to a Conduction-Like Phenotype

(2012) Stacey Rentschler et al.   CIRCULATION

Asymmetric Fate of the Posterior Part of the Second Heart Field Results in Unexpected Left/Right Contributions to Both Poles of the Heart

(2012) Jorge N. Domínguez et al.   CIRCULATION RESEARCH

Localization of Islet-1–Positive Cells in the Healthy and Infarcted Adult Murine Heart

(2012) Florian Weinberger et al.   CIRCULATION RESEARCH

Epistatic Rescue of Nkx2.5 Adult Cardiac Conduction Disease Phenotypes by Prospero-Related Homeobox Protein 1 and HDAC3

(2012) Catherine A. Risebro et al.   CIRCULATION RESEARCH

Blocking Scn10a Channels in Heart Reduces Late Sodium Current and Is Antiarrhythmic

(2012) Tao Yang et al.   CIRCULATION RESEARCH

Functional Na V 1.8 Channels in Intracardiac Neurons

(2012) Arie O. Verkerk et al.   CIRCULATION RESEARCH

Gene Regulatory Networks in Cardiac Conduction System Development

(2012) Nikhil V. Munshi   CIRCULATION RESEARCH

Brugada Syndrome

(2012) Yuka Mizusawa et al.   Circulation-Arrhythmia and Electrophysiology

Spatiotemporal regulation of an Hcn4 enhancer defines a role for Mef2c and HDACs in cardiac electrical patterning

(2012) Vasanth Vedantham et al.   DEVELOPMENTAL BIOLOGY

Coordinating Tissue Interactions: Notch Signaling in Cardiac Development and Disease

(2012) José Luis de la Pompa et al.   DEVELOPMENTAL CELL

Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancer

(2012) Malou van den Boogaard et al.   JOURNAL OF CLINICAL INVESTIGATION

TBX5 drives Scn5a expression to regulate cardiac conduction system function

(2012) David E. Arnolds et al.   JOURNAL OF CLINICAL INVESTIGATION

Topological domains in mammalian genomes identified by analysis of chromatin interactions

(2012) Jesse R. Dixon et al.   NATURE

Direct conversion of quiescent cardiomyocytes to pacemaker cells by expression of Tbx18

(2012) Nidhi Kapoor et al.   NATURE BIOTECHNOLOGY

Identifying the Evolutionary Building Blocks of the Cardiac Conduction System

(2012) Bjarke Jensen et al.   PLoS One

Identification and Functional Characterization of Cardiac Pacemaker Cells in Zebrafish

(2012) Federico Tessadori et al.   PLoS One

Systematic Localization of Common Disease-Associated Variation in Regulatory DNA

(2012) M. T. Maurano et al.   SCIENCE

Transcriptional enhancers in development and disease

(2012) Noboru Sakabe et al.   GENOME BIOLOGY

Epigenetics and Cardiovascular Development

(2011) Ching-Pin Chang et al.   Annual Review of Physiology

Wnt signaling regulates atrioventricular canal formation upstream of BMP and Tbx2

(2011) Manon C. Verhoeven et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Tbx2 and Tbx3 induce atrioventricular myocardial development and endocardial cushion formation

(2011) Reena Singh et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Histone Deacetylase 3 Regulates Smooth Muscle Differentiation in Neural Crest Cells and Development of the Cardiac Outflow Tract

(2011) Nikhil Singh et al.   CIRCULATION RESEARCH

Chromatin Remodeling in Cardiovascular Development and Physiology

(2011) Pei Han et al.   CIRCULATION RESEARCH

Molecular Analysis of Patterning of Conduction Tissues in the Developing Human Heart

(2011) Aleksander Sizarov et al.   Circulation-Arrhythmia and Electrophysiology

Ectopic expression of Nkx2.5 suppresses the formation of the sinoatrial node in mice

(2011) Ramón A. Espinoza-Lewis et al.   DEVELOPMENTAL BIOLOGY

Funny current channel HCN4 delineates the developing cardiac conduction system in chicken heart

(2011) Rebecca Vicente-Steijn et al.   HEART RHYTHM

Transcriptional Suppression of Connexin43 byTBX18Undermines Cell-Cell Electrical Coupling in Postnatal Cardiomyocytes

(2011) Nidhi Kapoor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defective Tbx2-dependent patterning of the atrioventricular canal myocardium causes accessory pathway formation in mice

(2011) Wim T.J. Aanhaanen et al.   JOURNAL OF CLINICAL INVESTIGATION

Notch signaling regulates murine atrioventricular conduction and the formation of accessory pathways

(2011) Stacey Rentschler et al.   JOURNAL OF CLINICAL INVESTIGATION

Lethal arrhythmias in Tbx3-deficient mice reveal extreme dosage sensitivity of cardiac conduction system function and homeostasis

(2011) D. U. Frank et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Iroquois homeobox gene 3 establishes fast conduction in the cardiac His-Purkinje network

(2011) S.-S. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An evolutionarily conserved three-dimensional structure in the vertebrate Irx clusters facilitates enhancer sharing and coregulation

(2011) Juan J. Tena et al.   Nature Communications

Genome-Wide Association Studies of the PR Interval in African Americans

(2011) J. Gustav Smith et al.   PLoS Genetics

The sinus venosus progenitors separate and diversify from the first and second heart fields early in development

(2010) Mathilda T.M. Mommersteeg et al.   CARDIOVASCULAR RESEARCH

Biphasic Development of the Mammalian Ventricular Conduction System

(2010) Lucile Miquerol et al.   CIRCULATION RESEARCH

Developmental Origin, Growth, and Three-Dimensional Architecture of the Atrioventricular Conduction Axis of the Mouse Heart

(2010) Wim T.J. Aanhaanen et al.   CIRCULATION RESEARCH

Development of the Pacemaker Tissues of the Heart

(2010) Vincent M. Christoffels et al.   CIRCULATION RESEARCH

Contactin-2 Expression in the Cardiac Purkinje Fiber Network

(2010) Benedetta A. Pallante et al.   Circulation-Arrhythmia and Electrophysiology

Chromatin remodeling in heart development

(2010) Benoit G Bruneau   CURRENT OPINION IN GENETICS & DEVELOPMENT

Genome-wide association analysis identifies multiple loci related to resting heart rate

(2010) M. Eijgelsheim et al.   HUMAN MOLECULAR GENETICS

Shox2 mediates Tbx5 activity by regulating Bmp4 in the pacemaker region of the developing heart

(2010) Sandra Puskaric et al.   HUMAN MOLECULAR GENETICS

Electrical Activation of Sinus Venosus Myocardium and Expression Patterns of RhoA and Isl-1 in the Chick Embryo

(2010) REBECCA VICENTE-STEIJN et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

Several common variants modulate heart rate, PR interval and QRS duration

(2010) Hilma Holm et al.   NATURE GENETICS

Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction

(2010) Nona Sotoodehnia et al.   NATURE GENETICS

Genome-wide association study of PR interval

(2010) Arne Pfeufer et al.   NATURE GENETICS

Genetic variation in SCN10A influences cardiac conduction

(2010) John C Chambers et al.   NATURE GENETICS

The cardiac sodium channel displays differential distribution in the conduction system and transmural heterogeneity in the murine ventricular myocardium

(2009) C. A. Remme et al.   BASIC RESEARCH IN CARDIOLOGY

Tbx20 Interacts With Smads to Confine Tbx2 Expression to the Atrioventricular Canal

(2009) Reena Singh et al.   CIRCULATION RESEARCH

The Tbx2 + Primary Myocardium of the Atrioventricular Canal Forms the Atrioventricular Node and the Base of the Left Ventricle

(2009) Wim T.J. Aanhaanen et al.   CIRCULATION RESEARCH

Gene Expression Profiling of the Forming Atrioventricular Node Using a Novel Tbx3 -Based Node-Specific Transgenic Reporter

(2009) Thomas Horsthuis et al.   CIRCULATION RESEARCH

Development of the Cardiac Conduction System

(2009) Vincent M. Christoffels et al.   Circulation-Arrhythmia and Electrophysiology

Cx30.2 enhancer analysis identifies Gata4 as a novel regulator of atrioventricular delay

(2009) N. V. Munshi et al.   DEVELOPMENT

Shox2 is essential for the differentiation of cardiac pacemaker cells by repressing Nkx2-5

(2009) Ramón A. Espinoza-Lewis et al.   DEVELOPMENTAL BIOLOGY

Genetic fate mapping demonstrates contribution of epicardium-derived cells to the annulus fibrosis of the mammalian heart

(2009) Bin Zhou et al.   DEVELOPMENTAL BIOLOGY

Common variants at ten loci modulate the QT interval duration in the QTSCD Study

(2009) Arne Pfeufer et al.   NATURE GENETICS

Common variants at ten loci influence QT interval duration in the QTGEN Study

(2009) Christopher Newton-Cheh et al.   NATURE GENETICS

T-box 2, a mediator of Bmp-Smad signaling, induced hyaluronan synthase 2 and Tgf 2 expression and endocardial cushion formation

(2009) M. Shirai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome

(2009) E. Lieberman-Aiden et al.   SCIENCE

Msx1 and Msx2 are required for endothelial-mesenchymal transformation of the atrioventricular cushions and patterning of the atrioventricular myocardium

(2008) Yi-Hui Chen et al.   BMC DEVELOPMENTAL BIOLOGY

Msx1 and Msx2 are functional interacting partners of T-box factors in the regulation of Connexin43

(2008) Kees-Jan Boogerd et al.   CARDIOVASCULAR RESEARCH

Formation of the Sinus Node Head and Differentiation of Sinus Node Myocardium Are Independently Regulated by Tbx18 and Tbx3

(2008) Cornelia Wiese et al.   CIRCULATION RESEARCH

Foxn4 directly regulates tbx2b expression and atrioventricular canal formation

(2008) N. C. Chi et al.   GENES & DEVELOPMENT

Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice

(2008) Rusty L. Montgomery et al.   JOURNAL OF CLINICAL INVESTIGATION

Genesis and Regulation of the Heart Automaticity

(2008) Matteo E. Mangoni et al.   PHYSIOLOGICAL REVIEWS