A common genetic variant within SCN10A modulates cardiac SCN5A expression

Spatial transcriptional profile of the chick and mouse endocardial cushions identify novel regulators of endocardial EMT in vitro

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Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death

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Matrix eQTL: ultra fast eQTL analysis via large matrix operations

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Blocking Scn10a Channels in Heart Reduces Late Sodium Current and Is Antiarrhythmic

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Functional Na V 1.8 Channels in Intracardiac Neurons

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Whither Art Thou, SCN10A, and What Art Thou Doing?

(2012) Barry London   CIRCULATION RESEARCH

A decade of 3C technologies: insights into nuclear organization

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Dual transcriptional activator and repressor roles of TBX20 regulate adult cardiac structure and function

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Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancer

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TBX5 drives Scn5a expression to regulate cardiac conduction system function

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A map of the cis-regulatory sequences in the mouse genome

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Robust 4C-seq data analysis to screen for regulatory DNA interactions

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Truncations of Titin Causing Dilated Cardiomyopathy

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Systematic Localization of Common Disease-Associated Variation in Regulatory DNA

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Biology of cardiac sodium channel Nav1.5 expression

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Phenotypical Manifestations of Mutations in the Genes Encoding Subunits of the Cardiac Sodium Channel

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Characterization of the single-cell transcriptional landscape by highly multiplex RNA-seq

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An evolutionarily conserved three-dimensional structure in the vertebrate Irx clusters facilitates enhancer sharing and coregulation

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Genome-Wide Association Studies of the PR Interval in African Americans

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Identification of Genomic Predictors of Atrioventricular Conduction

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ChIP-Seq identification of weakly conserved heart enhancers

(2010) Matthew J Blow et al.   NATURE GENETICS

Several common variants modulate heart rate, PR interval and QRS duration

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Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction

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Genome-wide association study of PR interval

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Genetic variation in SCN10A influences cardiac conduction

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Variable Nav1.5 Protein Expression from the Wild-Type Allele Correlates with the Penetrance of Cardiac Conduction Disease in the Scn5a+/− Mouse Model

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The cardiac sodium channel displays differential distribution in the conduction system and transmural heterogeneity in the murine ventricular myocardium

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Inherited Cardiac Diseases Caused by Mutations in the Nav1.5 Sodium Channel

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Cardiac sodium channel Nav1.5 and interacting proteins: Physiology and pathophysiology

(2009) Hugues Abriel   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

ChIP-seq accurately predicts tissue-specific activity of enhancers

(2009) Axel Visel et al.   NATURE

Common variants at ten loci modulate the QT interval duration in the QTSCD Study

(2009) Arne Pfeufer et al.   NATURE GENETICS

A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits

(2009) Yoon Shin Cho et al.   NATURE GENETICS

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

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Genetic Mapping in Human Disease

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