Blocking Scn10a Channels in Heart Reduces Late Sodium Current and Is Antiarrhythmic

Ranolazine block of human Nav1.4 sodium channels and paramyotonia congenita mutants

(2011) Nesrine El-Bizri et al.   Channels

Striking In Vivo Phenotype of a Disease-Associated Human SCN5A Mutation Producing Minimal Changes in Vitro

(2011) Hiroshi Watanabe et al.   CIRCULATION

Phenotypical Manifestations of Mutations in the Genes Encoding Subunits of the Cardiac Sodium Channel

(2011) Arthur A.M. Wilde et al.   CIRCULATION RESEARCH

Localisation of SCN10A Gene Product Nav1.8 and Novel Pain-Related Ion Channels in Human Heart

(2011) Paul Facer et al.   International Heart Journal

Ranolazine selectively blocks persistent current evoked by epilepsy-associated NaV1.1 mutations

(2010) Kristopher M Kahlig et al.   BRITISH JOURNAL OF PHARMACOLOGY

REVIEW: Sodium Channel (Dys)Function and Cardiac Arrhythmias

(2010) Carol Ann Remme et al.   Cardiovascular Therapeutics

Identification of Genomic Predictors of Atrioventricular Conduction

(2010) Joshua C. Denny et al.   CIRCULATION

Late Na+Current Inhibition by Ranolazine Reduces Torsades de Pointes in the Chronic Atrioventricular Block Dog Model

(2010) Gudrun Antoons et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Effects of Ranolazine on Wild-Type and Mutant hNav1.7 Channels and on DRG Neuron Excitability

(2010) Mark Estacion et al.   Molecular Pain

Several common variants modulate heart rate, PR interval and QRS duration

(2010) Hilma Holm et al.   NATURE GENETICS

Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction

(2010) Nona Sotoodehnia et al.   NATURE GENETICS

Genome-wide association study of PR interval

(2010) Arne Pfeufer et al.   NATURE GENETICS

Genetic variation in SCN10A influences cardiac conduction

(2010) John C Chambers et al.   NATURE GENETICS

Genomewide Association Studies and Assessment of the Risk of Disease

(2010) Teri A. Manolio   NEW ENGLAND JOURNAL OF MEDICINE

A multi PDZ-domain protein Pdzd2 contributes to functional expression of sensory neuron-specific sodium channel NaV1.8

(2009) Dongmin Shao et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Tetrodotoxin-resistant voltage-gated sodium channels Nav1.8 and Nav1.9 are expressed in the retina

(2008) Brendan J. O'Brien et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Pathophysiology and pharmacology of the cardiac “late sodium current”

(2008) Antonio Zaza et al.   PHARMACOLOGY & THERAPEUTICS