Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death

Blocking Scn10a Channels in Heart Reduces Late Sodium Current and Is Antiarrhythmic

(2012) Tao Yang et al.   CIRCULATION RESEARCH

Functional Na V 1.8 Channels in Intracardiac Neurons

(2012) Arie O. Verkerk et al.   CIRCULATION RESEARCH

Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancer

(2012) Malou van den Boogaard et al.   JOURNAL OF CLINICAL INVESTIGATION

TBX5 drives Scn5a expression to regulate cardiac conduction system function

(2012) David E. Arnolds et al.   JOURNAL OF CLINICAL INVESTIGATION

Common genetic variation modulating cardiac ECG parameters and susceptibility to sudden cardiac death

(2012) Iris C.R.M. Kolder et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Spectrum and Prevalence of Mutations Involving BrS1- Through BrS12-Susceptibility Genes in a Cohort of Unrelated Patients Referred for Brugada Syndrome Genetic Testing

(2012) Lia Crotti et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Including known covariates can reduce power to detect genetic effects in case-control studies

(2012) Matti Pirinen et al.   NATURE GENETICS

Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma

(2012) Sophie Postel-Vinay et al.   NATURE GENETICS

Prevention of Ventricular Fibrillation Episodes in Brugada Syndrome by Catheter Ablation Over the Anterior Right Ventricular Outflow Tract Epicardium

(2011) Koonlawee Nademanee et al.   CIRCULATION

A linear complexity phasing method for thousands of genomes

(2011) Olivier Delaneau et al.   NATURE METHODS

Genotype Imputation with Thousands of Genomes

(2011) Bryan Howie et al.   G3-Genes Genomes Genetics

Prospective Evaluation of the Familial Prevalence of the Brugada Syndrome

(2010) Jean-Sylvain Hermida et al.   AMERICAN JOURNAL OF CARDIOLOGY

METAL: fast and efficient meta-analysis of genomewide association scans

(2010) C. J. Willer et al.   BIOINFORMATICS

Contactin-2 Expression in the Cardiac Purkinje Fiber Network

(2010) Benedetta A. Pallante et al.   Circulation-Arrhythmia and Electrophysiology

Genome-wide association analysis identifies multiple loci related to resting heart rate

(2010) M. Eijgelsheim et al.   HUMAN MOLECULAR GENETICS

The pathophysiological mechanism underlying Brugada syndrome

(2010) Arthur A.M. Wilde et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Several common variants modulate heart rate, PR interval and QRS duration

(2010) Hilma Holm et al.   NATURE GENETICS

Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction

(2010) Nona Sotoodehnia et al.   NATURE GENETICS

Genome-wide association study of PR interval

(2010) Arne Pfeufer et al.   NATURE GENETICS

Genetic variation in SCN10A influences cardiac conduction

(2010) John C Chambers et al.   NATURE GENETICS

The Genetic Interpretation of Area under the ROC Curve in Genomic Profiling

(2010) Naomi R. Wray et al.   PLoS Genetics

The cardiac sodium channel displays differential distribution in the conduction system and transmural heterogeneity in the murine ventricular myocardium

(2009) C. A. Remme et al.   BASIC RESEARCH IN CARDIOLOGY

SCN5A Mutations and the Role of Genetic Background in the Pathophysiology of Brugada Syndrome

(2009) Vincent Probst et al.   Circulation-Cardiovascular Genetics

A Genome-Wide Association Scan of RR and QT Interval Duration in 3 European Genetically Isolated Populations

(2009) Fabio Marroni et al.   Circulation-Cardiovascular Genetics

An international compendium of mutations in the SCN5A-encoded cardiac sodium channel in patients referred for Brugada syndrome genetic testing

(2009) Jamie D. Kapplinger et al.   HEART RHYTHM

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Common variants at ten loci modulate the QT interval duration in the QTSCD Study

(2009) Arne Pfeufer et al.   NATURE GENETICS

Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations

(2009) David Meyre et al.   NATURE GENETICS

Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure

(2009) Christopher Newton-Cheh et al.   NATURE GENETICS

Incidence and outcome of osteoporotic fractures in 2004 in Sado City, Niigata Prefecture, Japan

(2008) Mayumi Sakuma et al.   JOURNAL OF BONE AND MINERAL METABOLISM