Journal
TRENDS IN CARDIOVASCULAR MEDICINE
Volume 24, Issue 1, Pages 23-31Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcm.2013.06.001
Keywords
-
Categories
Funding
- Junta de Andalucia Regional Council [CVI-6556]
- National Centre of Cardiovascular Research [CNIC-08-2009]
Ask authors/readers for more resources
The homeobox transcription factor Pitx2 displays a highly specific expression pattern during embryogenesis. Gain and loss of function experiments have unraveled its pivotal role in left-right signaling. Conditional deletion in mice has demonstrated a complex and intricate role for Pitx2 in distinct aspects of cardiac development and more recently a link to atrial fibrillation has been proposed based on genome-wide association studies. In this review we will revise the role of Pitx2 in the developing heart, starting from the early events of left-right determination followed by its role in cardiac morphogenesis and ending with its role in cardiac arrhythmogenesis. (C) 2013 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available