YAP1 and its fusion proteins in cancer initiation, progression and therapeutic resistance

Recurrent Fusions Between YAP1 and KMT2A in Morphologically Distinct Neoplasms Within the Spectrum of Low-grade Fibromyxoid Sarcoma and Sclerosing Epithelioid Fibrosarcoma

(2020) Florian Puls et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

YAP/TAZ: Drivers of Tumor Growth, Metastasis, and Resistance to Therapy

(2020) Barry J. Thompson   BIOESSAYS

Reprogramming normal cells into tumour precursors requires ECM stiffness and oncogene-mediated changes of cell mechanical properties

(2020) Tito Panciera et al.   NATURE MATERIALS

Yap suppresses T-cell function and infiltration in the tumor microenvironment

(2020) Eleni Stampouloglou et al.   PLOS BIOLOGY

The regulation of Yorkie, YAP and TAZ: new insights into the Hippo pathway

(2020) Samuel A. Manning et al.   DEVELOPMENT

Regulation of GPCR activation of the Hippo pathway in metastatic breast cancer

(2020) Aleena K. S. Arakaki et al.   FASEB JOURNAL

YAP1/TAZ drives ependymoma-like tumour formation in mice

(2020) Noreen Eder et al.   Nature Communications

YAP Attenuates CD8 T Cell-Mediated Anti-tumor Response

(2020) Andriana Lebid et al.   Frontiers in Immunology

Comparison of tumor-associated YAP1 fusions identifies a recurrent set of functions critical for oncogenesis

(2020) Frank Szulzewsky et al.   GENES & DEVELOPMENT

Multimodal single‐cell analysis reveals distinct radioresistant stem‐like and progenitor cell populations in murine glioma

(2020) Jes Alexander et al.   GLIA

Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine

(2020) Anwesha Dey et al.   NATURE REVIEWS DRUG DISCOVERY

MicroRNA-18a targeting of the STK4/MST1 tumour suppressor is necessary for transformation in HPV positive cervical cancer

(2020) Ethan L. Morgan et al.   PLoS Pathogens

A Potential Role of YAP/TAZ in the Interplay Between Metastasis and Metabolic Alterations

(2020) Hirohito Yamaguchi et al.   Frontiers in Oncology

YAP1-FAM118B Fusion Defines a Rare Subset of Childhood and Young Adulthood Meningiomas

(2020) Kathleen M. Schieffer et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Recurrent YAP1 and MAML2 Gene Rearrangements in Retiform and Composite Hemangioendothelioma

(2020) Cristina R. Antonescu et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Phenotypic characterization with somatic genome editing and gene transfer reveals the diverse oncogenicity of ependymoma fusion genes

(2020) Mutsumi Takadera et al.   Acta Neuropathologica Communications

Somatic hypermutation of the YAP oncogene in a human cutaneous melanoma

(2019) Xiaomeng Zhang et al.   MOLECULAR CANCER RESEARCH

YAP/TAZ Inhibition Induces Metabolic and Signaling Rewiring Resulting in Targetable Vulnerabilities in NF2-Deficient Tumor Cells

(2019) Shannon M. White et al.   DEVELOPMENTAL CELL

Analysis of the role of the Hippo pathway in cancer

(2019) Yanyan Han   Journal of Translational Medicine

PI3K-Yap activity drives cortical gyrification and hydrocephalus in mice

(2019) Achira Roy et al.   eLife

GPCR-Hippo Signaling in Cancer

(2019) Luo et al.   Cells

Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma

(2019) Peiwen Chen et al.   CANCER CELL

The emerging role of YAP/TAZ in tumor immunity

(2019) Yiqing Tian et al.   MOLECULAR CANCER RESEARCH

Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR-Cas9 screening

(2019) Gabriele Picco et al.   Nature Communications

Hippo Kinase Loss Contributes to Del(20q) Hematologic Malignancies through Chronic Innate Immune Activation

(2019) Samuel A. Stoner et al.   BLOOD

The Hippo Signaling Pathway in Development and Disease

(2019) Yonggang Zheng et al.   DEVELOPMENTAL CELL

Recurrent YAP1-MAML2 and YAP1-NUTM1 fusions in poroma and porocarcinoma

(2019) Shigeki Sekine et al.   JOURNAL OF CLINICAL INVESTIGATION

Prognostic stratification of clinical and molecular epithelioid hemangioendothelioma subsets

(2019) Evan Rosenbaum et al.   MODERN PATHOLOGY

YAP1-fusions in pediatric NF2-wildtype meningioma

(2019) Philipp Sievers et al.   ACTA NEUROPATHOLOGICA

Recurrent YAP1 and KMT2A Gene Rearrangements in a Subset of MUC4-negative Sclerosing Epithelioid Fibrosarcoma

(2019) Yu-Chien Kao et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis

(2019) Kristian W. Pajtler et al.   Nature Communications

The Role of Merlin/NF2 Loss in Meningioma Biology

(2019) Sungho Lee et al.   Cancers

Induction of AP-1 by YAP/TAZ contributes to cell proliferation and organ growth

(2019) Ja Hyun Koo et al.   GENES & DEVELOPMENT

miR-624-5p promoted tumorigenesis and metastasis by suppressing hippo signaling through targeting PTPRB in osteosarcoma cells

(2019) Yongjun Luo et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The Hippo Pathway Component TAZ Promotes Immune Evasion in Human Cancer through PD-L1

(2018) Helena J. Janse van Rensburg et al.   CANCER RESEARCH

Oncogenic Signaling Pathways in The Cancer Genome Atlas

(2018) Francisco Sanchez-Vega et al.   CELL

GPCRs: Emerging anti-cancer drug targets

(2018) Ainhoa Nieto Gutierrez et al.   CELLULAR SIGNALLING

Glutamine‐utilizing transaminases are a metabolic vulnerability of TAZ/YAP‐activated cancer cells

(2018) Chih‐Sheng Yang et al.   EMBO REPORTS

The α-arrestin ARRDC3 suppresses breast carcinoma invasion by regulating G protein–coupled receptor lysosomal sorting and signaling

(2018) Aleena K. S. Arakaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Hippo pathway effector proteins YAP and TAZ have both distinct and overlapping functions in the cell

(2018) Steven W. Plouffe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of yes-associated protein down-regulates PD-L1 (CD274) expression in human malignant pleural mesothelioma

(2018) Ping-Chih Hsu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

YAP/TAZ upstream signals and downstream responses

(2018) Antonio Totaro et al.   NATURE CELL BIOLOGY

YAP1 contributes to NSCLC invasion and migration by promoting Slug transcription via the transcription co-factor TEAD

(2018) Mengxue Yu et al.   Cell Death & Disease

miR-375 is involved in Hippo pathway by targeting YAP1/TEAD4-CTGF axis in gastric carcinogenesis

(2018) Wei Kang et al.   Cell Death & Disease

Regulation of Yki/Yap subcellular localization and Hpo signaling by a nuclear kinase PRP4K

(2018) Yong suk Cho et al.   Nature Communications

YAP Is Essential for Treg-Mediated Suppression of Antitumor Immunity

(2018) Xuhao Ni et al.   Cancer Discovery

YAP-Induced PD-L1 Expression Drives Immune Evasion in BRAFi-Resistant Melanoma

(2018) Min Hwan Kim et al.   Cancer Immunology Research

Interplay between YAP/TAZ and Metabolism

(2018) Ja Hyun Koo et al.   Cell Metabolism

miR-665 promotes hepatocellular carcinoma cell migration, invasion, and proliferation by decreasing Hippo signaling through targeting PTPRB

(2018) Yuanchang Hu et al.   Cell Death & Disease

The Hippo Pathway: Biology and Pathophysiology

(2018) Shenghong Ma et al.   Annual Review of Biochemistry

The Ambivalent Function of YAP in Apoptosis and Cancer

(2018) Xianbin Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

SRC tyrosine kinase activates the YAP/TAZ axis and thereby drives tumor growth and metastasis

(2018) John M. Lamar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mediated nuclear import and export of TAZ and the underlying molecular requirements

(2018) Michael Kofler et al.   Nature Communications

Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer

(2018) Yumeng Wang et al.   Cell Reports

Yap1 safeguards mouse embryonic stem cells from excessive apoptosis during differentiation

(2018) Lucy LeBlanc et al.   eLife

Crosstalk between Hippo signalling and miRNAs in tumour progression

(2017) Nianshuang Li et al.   FEBS Journal

Transcriptional integration of mitogenic and mechanical signals by Myc and YAP

(2017) Ottavio Croci et al.   GENES & DEVELOPMENT

A Novel YAP1 Inhibitor Targets CSC-Enriched Radiation-Resistant Cells and Exerts Strong Antitumor Activity in Esophageal Adenocarcinoma

(2017) Shumei Song et al.   MOLECULAR CANCER THERAPEUTICS

Regulation of the Hippo-YAP Pathway by Glucose Sensor O-GlcNAcylation

(2017) Changmin Peng et al.   MOLECULAR CELL

TumorFusions: an integrative resource for cancer-associated transcript fusions

(2017) Xin Hu et al.   NUCLEIC ACIDS RESEARCH

Hippo pathway mediates resistance to cytotoxic drugs

(2017) Taranjit S. Gujral et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The receptor tyrosine kinase EphA2 promotes glutamine metabolism in tumors by activating the transcriptional coactivators YAP and TAZ

(2017) Deanna N. Edwards et al.   Science Signaling

Cell Junctions in Hippo Signaling

(2017) Ruchan Karaman et al.   Cold Spring Harbor Perspectives in Biology

The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis

(2017) Xiao Zhang et al.   Nature Communications

Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth

(2017) Chiara V. Ragni et al.   Nature Communications

YAP regulates PD-L1 expression in human NSCLC cells

(2017) Jinbai Miao et al.   Oncotarget

The Epithelial Circumferential Actin Belt Regulates YAP/TAZ through Nucleocytoplasmic Shuttling of Merlin

(2017) Kana T. Furukawa et al.   Cell Reports

The Hippo pathway in tissue homeostasis and regeneration

(2017) Yu Wang et al.   Protein & Cell

The receptor tyrosine kinase EphA2 promotes glutamine metabolism in tumors by activating the transcriptional coactivators YAP and TAZ

(2017) Deanna N. Edwards et al.   Science Signaling

Crystal structure of TAZ-TEAD complex reveals a distinct interaction mode from that of YAP-TEAD complex

(2017) Hung Yi Kristal Kaan et al.   Scientific Reports

YAP/TAZ at the Roots of Cancer

(2016) Francesca Zanconato et al.   CANCER CELL

YAP Mediates Tumorigenesis in Neurofibromatosis Type 2 by Promoting Cell Survival and Proliferation through a COX-2-EGFR Signaling Axis

(2016) W. Guerrant et al.   CANCER RESEARCH

Integrin signalling regulates YAP and TAZ to control skin homeostasis

(2016) Ahmed Elbediwy et al.   DEVELOPMENT

MRTF potentiates TEAD‐YAP transcriptional activity causing metastasis

(2016) Tackhoon Kim et al.   EMBO JOURNAL

Mechanisms of Hippo pathway regulation

(2016) Zhipeng Meng et al.   GENES & DEVELOPMENT

αE-catenin inhibits a Src–YAP1 oncogenic module that couples tyrosine kinases and the effector of Hippo signaling pathway

(2016) Peng Li et al.   GENES & DEVELOPMENT

Biphasic Regulation of Yes-associated Protein (YAP) Cellular Localization, Phosphorylation, and Activity by G Protein-coupled Receptor Agonists in Intestinal Epithelial Cells

(2016) Jia Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension

(2016) Thomas Bertero et al.   JOURNAL OF CLINICAL INVESTIGATION

Transformation by Polyomavirus Middle T Antigen Involves a Unique Bimodal Interaction with the Hippo Effector YAP

(2016) Cecile Rouleau et al.   JOURNAL OF VIROLOGY

Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow

(2016) Li Wang et al.   NATURE

Onco-miR-130 promotes cell proliferation and migration by targeting TGFβR2 in gastric cancer

(2016) Jingjing Duan et al.   Oncotarget

Analysis of the hippo transducers TAZ and YAP in cervical cancer and its microenvironment

(2016) Simonetta Buglioni et al.   OncoImmunology

The miR-130 family promotes cell migration and invasion in bladder cancer through FAK and Akt phosphorylation by regulating PTEN

(2016) Hiroshi Egawa et al.   Scientific Reports

Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups

(2015) Kristian W. Pajtler et al.   CANCER CELL

YAP Promotes Malignant Progression ofLkb1-Deficient Lung Adenocarcinoma through Downstream Regulation of Survivin

(2015) Wenjing Zhang et al.   CANCER RESEARCH

Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer

(2015) Fa-Xing Yu et al.   CELL

The Hippo pathway effectors YAP and TAZ promote cell growth by modulating amino acid signaling to mTORC1

(2015) Carsten Gram Hansen et al.   CELL RESEARCH

A miR-130a-YAP positive feedback loop promotes organ size and tumorigenesis

(2015) Shuying Shen et al.   CELL RESEARCH

Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway

(2015) Youjun Li et al.   CELL RESEARCH

The Hippo Coactivator YAP1 Mediates EGFR Overexpression and Confers Chemoresistance in Esophageal Cancer

(2015) S. Song et al.   CLINICAL CANCER RESEARCH

Identification of Happyhour/MAP4K as Alternative Hpo/Mst-like Kinases in the Hippo Kinase Cascade

(2015) Yonggang Zheng et al.   DEVELOPMENTAL CELL

Actin remodeling confers BRAF inhibitor resistance to melanoma cells through YAP/TAZ activation

(2015) M. H. Kim et al.   EMBO JOURNAL

Homeostatic control of Hippo signaling activity revealed by an endogenous activating mutation in YAP

(2015) Qian Chen et al.   GENES & DEVELOPMENT

Yes-associated protein 1 and transcriptional coactivator with PDZ-binding motif activate the mammalian target of rapamycin complex 1 pathway by regulating amino acid transporters in hepatocellular carcinoma

(2015) Yun-Yong Park et al.   HEPATOLOGY

The Hippo pathway transcriptional co-activator, YAP, confers resistance to cisplatin in human oral squamous cell carcinoma

(2015) KYOHEI YOSHIKAWA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Adhesion to fibronectin regulates Hippo signaling via the FAK–Src–PI3K pathway

(2015) Nam-Gyun Kim et al.   JOURNAL OF CELL BIOLOGY

Estrogen regulates Hippo signaling via GPER in breast cancer

(2015) Xin Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Thyroid development in zebrafish lacking Taz

(2015) Andrea Pappalardo et al.   MECHANISMS OF DEVELOPMENT

Microenvironment rigidity modulates responses to the HER2 receptor tyrosine kinase inhibitor lapatinib via YAP and TAZ transcription factors

(2015) Chun-Han Lin et al.   MOLECULAR BIOLOGY OF THE CELL

A YAP/TAZ-Regulated Molecular Signature Is Associated with Oral Squamous Cell Carcinoma

(2015) S. E. Hiemer et al.   MOLECULAR CANCER RESEARCH

YAP Drives Growth by Controlling Transcriptional Pause Release from Dynamic Enhancers

(2015) Giorgio G. Galli et al.   MOLECULAR CELL

A gp130–Src–YAP module links inflammation to epithelial regeneration

(2015) Koji Taniguchi et al.   NATURE

Inactivation of a Gα s –PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis

(2015) Ramiro Iglesias-Bartolome et al.   NATURE CELL BIOLOGY

Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth

(2015) Francesca Zanconato et al.   NATURE CELL BIOLOGY

Role of Merlin/NF2 inactivation in tumor biology

(2015) A M Petrilli et al.   ONCOGENE

Mechanism of action of a WWTR1(TAZ)-CAMTA1 fusion oncoprotein

(2015) M R Tanas et al.   ONCOGENE

Glutaminolysis as a target for cancer therapy

(2015) L Jin et al.   ONCOGENE

YAP activation protects urothelial cell carcinoma from treatment-induced DNA damage

(2015) E Ciamporcero et al.   ONCOGENE

Targeting the Central Pocket in Human Transcription Factor TEAD as a Potential Cancer Therapeutic Strategy

(2015) Ajaybabu V. Pobbati et al.   STRUCTURE

YAP and TAZ: a nexus for Hippo signaling and beyond

(2015) Carsten Gram Hansen et al.   TRENDS IN CELL BIOLOGY

MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway

(2015) Zhipeng Meng et al.   Nature Communications

YAP is a critical oncogene in human cholangiocarcinoma

(2015) Tiemin Pei et al.   Oncotarget

Repression of Intestinal Stem Cell Function and Tumorigenesis through Direct Phosphorylation of β-Catenin and Yap by PKCζ

(2015) Victoria Llado et al.   Cell Reports

YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers

(2015) Claudia Stein et al.   PLoS Genetics

A Review: Molecular Aberrations within Hippo Signaling in Bone and Soft-Tissue Sarcomas

(2015) Michael D. Deel et al.   Frontiers in Oncology

YAP1 acts as oncogenic target of 11q22 amplification in multiple cancer subtypes.

(2015) Erica Lorenzetto et al.   Oncotarget

The regulation and function of YAP transcription co-activator

(2014) C. Zhu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition

(2014) Marcel Kool et al.   CANCER CELL

Mutant Gq/11 Promote Uveal Melanoma Tumorigenesis by Activating YAP

(2014) Fa-Xing Yu et al.   CANCER CELL

Hippo-Independent Activation of YAP by the GNAQ Uveal Melanoma Oncogene through a Trio-Regulated Rho GTPase Signaling Circuitry

(2014) Xiaodong Feng et al.   CANCER CELL

YAP-Induced Resistance of Cancer Cells to Antitubulin Drugs Is Modulated by a Hippo-Independent Pathway

(2014) Y. Zhao et al.   CANCER RESEARCH

YAP/TAZ Incorporation in the β-Catenin Destruction Complex Orchestrates the Wnt Response

(2014) Luca Azzolin et al.   CELL

Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer

(2014) Avnish Kapoor et al.   CELL

Hippo Signaling Regulates Microprocessor and Links Cell-Density-Dependent miRNA Biogenesis to Cancer

(2014) Masaki Mori et al.   CELL

The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease

(2014) X. Varelas   DEVELOPMENT

The clinically used photosensitizer Verteporfin (VP) inhibits YAP-TEAD and human retinoblastoma cell growth in vitro without light activation

(2014) Katarzyna Brodowska et al.   EXPERIMENTAL EYE RESEARCH

Polyomavirus Small t Antigen Interacts with Yes-Associated Protein To Regulate Cell Survival and Differentiation

(2014) J. H. Hwang et al.   JOURNAL OF VIROLOGY

Angiomotins link F-actin architecture to Hippo pathway signaling

(2014) Sebastian Mana-Capelli et al.   MOLECULAR BIOLOGY OF THE CELL

microRNA 31 functions as an endometrial cancer oncogene by suppressing Hippo tumor suppressor pathway

(2014) Takashi Mitamura et al.   Molecular Cancer

Identification, Mechanism of Action, and Antitumor Activity of a Small Molecule Inhibitor of Hippo, TGF- , and Wnt Signaling Pathways

(2014) D. Basu et al.   MOLECULAR CANCER THERAPEUTICS

Metabolic control of YAP and TAZ by the mevalonate pathway

(2014) Giovanni Sorrentino et al.   NATURE CELL BIOLOGY

Rescue of Hippo coactivator YAP1 triggers DNA damage–induced apoptosis in hematological cancers

(2014) Francesca Cottini et al.   NATURE MEDICINE

The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog−driven medulloblastoma

(2014) Xuelian He et al.   NATURE MEDICINE

Neuregulin 1-activated ERBB4 interacts with YAP to induce Hippo pathway target genes and promote cell migration

(2014) J. W. Haskins et al.   Science Signaling

Pax3 and Hippo Signaling Coordinate Melanocyte Gene Expression in Neural Crest

(2014) Lauren J. Manderfield et al.   Cell Reports

Yorkie Promotes Transcription by Recruiting a Histone Methyltransferase Complex

(2014) Hyangyee Oh et al.   Cell Reports

Viral Small T Oncoproteins Transform Cells by Alleviating Hippo-Pathway-Mediated Inhibition of the YAP Proto-oncogene

(2014) Hung Thanh Nguyen et al.   Cell Reports

The Hippo Transducer TAZ Interacts with the SWI/SNF Complex to Regulate Breast Epithelial Lineage Commitment

(2014) Adam Skibinski et al.   Cell Reports

Mutation analysis of large tumor suppressor genes LATS1 and LATS2 supports a tumor suppressor role in human cancer

(2014) Tian Yu et al.   Protein & Cell

The Hippo effector Yorkie activates transcription by interacting with a histone methyltransferase complex through Ncoa6

(2014) Yun Qing et al.   eLife

Mutual interaction between YAP and c-Myc is critical for carcinogenesis in liver cancer

(2013) Weifan Xiao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Spatial Organization of Hippo Signaling at the Plasma Membrane Mediated by the Tumor Suppressor Merlin/NF2

(2013) Feng Yin et al.   CELL

Control of Nutrient Stress-Induced Metabolic Reprogramming by PKCζ in Tumorigenesis

(2013) Li Ma et al.   CELL

A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors

(2013) Mariaceleste Aragona et al.   CELL

The role of LPA and YAP signaling in long-term migration of human ovarian cancer cells

(2013) Hui Cai et al.   Cell Communication and Signaling

Regulation of Hippo Signaling by EGFR-MAPK Signaling through Ajuba Family Proteins

(2013) B.V.V.G. Reddy et al.   DEVELOPMENTAL CELL

NovelYAP1-TFE3fusion defines a distinct subset of epithelioid hemangioendothelioma

(2013) Cristina R. Antonescu et al.   GENES CHROMOSOMES & CANCER

Pro-Invasive Activity of the Hippo Pathway Effectors YAP and TAZ in Cutaneous Melanoma

(2013) Flore Nallet-Staub et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Regulation of Hippo pathway by mitogenic growth factors via phosphoinositide 3-kinase and phosphoinositide-dependent kinase-1

(2013) R. Fan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-135b promotes lung cancer metastasis by regulating multiple targets in the Hippo pathway and LZTS1

(2013) Ching-Wen Lin et al.   Nature Communications

Loss of NF2/Merlin expression in advanced sporadic colorectal cancer

(2013) Tamara Čačev et al.   CELLULAR ONCOLOGY

Genome-wide Association of Yorkie with Chromatin and Chromatin-Remodeling Complexes

(2013) Hyangyee Oh et al.   Cell Reports

Differentially Expressed Genes Regulating the Progression of Ductal Carcinoma In Situ to Invasive Breast Cancer

(2012) S. Lee et al.   CANCER RESEARCH

Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling

(2012) Fa-Xing Yu et al.   CELL

β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis

(2012) Joseph Rosenbluh et al.   CELL

A molecular mechanism that links Hippo signalling to the inhibition of Wnt/β-catenin signalling

(2012) Masamichi Imajo et al.   EMBO JOURNAL

Regulation of the Hippo-YAP pathway by protease-activated receptors (PARs)

(2012) J.-S. Mo et al.   GENES & DEVELOPMENT

Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP

(2012) Y. Liu-Chittenden et al.   GENES & DEVELOPMENT

Function and cancer genomics of FAT family genes

(2012) MASARU KATOH   INTERNATIONAL JOURNAL OF ONCOLOGY

The N-terminal Phosphodegron Targets TAZ/WWTR1 Protein for SCFβ-TrCP-dependent Degradation in Response to Phosphatidylinositol 3-Kinase Inhibition

(2012) Wei Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wnt/β-Catenin Signaling Regulates Yes-associated Protein (YAP) Gene Expression in Colorectal Carcinoma Cells

(2012) Wesley M. Konsavage et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

YAP mediates crosstalk between the Hippo and PI(3)K–TOR pathways by suppressing PTEN via miR-29

(2012) Karen Tumaneng et al.   NATURE CELL BIOLOGY

LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker

(2012) Dahu Chen et al.   NATURE MEDICINE

Transduction of mechanical and cytoskeletal cues by YAP and TAZ

(2012) Georg Halder et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

YAP induces malignant mesothelioma cell proliferation by upregulating transcription of cell cycle-promoting genes

(2012) T Mizuno et al.   ONCOGENE

Merlin Is a Negative Regulator of Human Melanoma Growth

(2012) Lucas B. Murray et al.   PLoS One

The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain

(2012) J. M. Lamar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Premetazoan Origin of the Hippo Signaling Pathway

(2012) Arnau Sebé-Pedrós et al.   Cell Reports

Yap1 Acts Downstream of α-Catenin to Control Epidermal Proliferation

(2011) Karin Schlegelmilch et al.   CELL

Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila

(2011) B. G. Fernandez et al.   DEVELOPMENT

Modulating F-actin organization induces organ growth by affecting the Hippo pathway

(2011) Leticia Sansores-Garcia et al.   EMBO JOURNAL

Cooperation between dE2F1 and Yki/Sd defines a distinct transcriptional program necessary to bypass cell cycle exit

(2011) B. N. Nicolay et al.   GENES & DEVELOPMENT

A novel WWTR1-CAMTA1 gene fusion is a consistent abnormality in epithelioid hemangioendothelioma of different anatomic sites

(2011) Costantino Errani et al.   GENES CHROMOSOMES & CANCER

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Oncogenic YAP promotes radioresistance and genomic instability in medulloblastoma through IGF2-mediated Akt activation

(2011) A Fernandez-L et al.   ONCOGENE

E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components

(2011) N.-G. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hippo Pathway Inhibits Wnt Signaling to Restrain Cardiomyocyte Proliferation and Heart Size

(2011) T. Heallen et al.   SCIENCE

 -Catenin Is a Tumor Suppressor That Controls Cell Accumulation by Regulating the Localization and Activity of the Transcriptional Coactivator Yap1

(2011) M. R. Silvis et al.   Science Signaling

Identification of a Disease-Defining Gene Fusion in Epithelioid Hemangioendothelioma

(2011) M. R. Tanas et al.   Science Translational Medicine

Functional complexes between YAP2 and ZO-2 are PDZ domain-dependent, and regulate YAP2 nuclear localization and signalling

(2010) Tsutomu Oka et al.   BIOCHEMICAL JOURNAL

YAP is a candidate oncogene for esophageal squamous cell carcinoma

(2010) Tomoki Muramatsu et al.   CARCINOGENESIS

LATS tumor suppressor: A new governor of cellular homeostasis

(2010) Stacy Visser et al.   CELL CYCLE

The Hippo Pathway Regulates Wnt/β-Catenin Signaling

(2010) Xaralabos Varelas et al.   DEVELOPMENTAL CELL

The Hippo Signaling Pathway in Development and Cancer

(2010) Duojia Pan   DEVELOPMENTAL CELL

The Crumbs Complex Couples Cell Density Sensing to Hippo-Dependent Control of the TGF-β-SMAD Pathway

(2010) Xaralabos Varelas et al.   DEVELOPMENTAL CELL

Structural basis of YAP recognition by TEAD4 in the Hippo pathway

(2010) L. Chen et al.   GENES & DEVELOPMENT

Structural insights into the YAP and TEAD complex

(2010) Z. Li et al.   GENES & DEVELOPMENT

The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version

(2010) B. Zhao et al.   GENES & DEVELOPMENT

A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF -TRCP

(2010) B. Zhao et al.   GENES & DEVELOPMENT

The Hippo Tumor Pathway Promotes TAZ Degradation by Phosphorylating a Phosphodegron and Recruiting the SCFβ-TrCPE3 Ligase

(2010) Chen-Ying Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors

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TEAD Transcription Factors Mediate the Function of TAZ in Cell Growth and Epithelial-Mesenchymal Transition

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Structure-Activity Relationship Studies of Fostriecin, Cytostatin, and Key Analogs, with PP1, PP2A, PP5, and ( 12- 13)-Chimeras (PP1/PP2A and PP5/PP2A), Provide Further Insight into the Inhibitory Actions of Fostriecin Family Inhibitors

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Yap1 Phosphorylation by c-Abl Is a Critical Step in Selective Activation of Proapoptotic Genes in Response to DNA Damage

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Clonal Integration of a Polyomavirus in Human Merkel Cell Carcinoma

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