Article
Oncology
Qian Lu, Yongli Wang, Xuesheng Jiang, Sheng Huang
Summary: This research revealed that miR-584-5p inhibits the proliferation, migration, and invasion of osteosarcoma cells and promotes apoptosis by targeting CTGF. Additionally, miR-584-5p also inactivated the Hippo pathway through CTGF in osteosarcoma.
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
(2023)
Article
Multidisciplinary Sciences
Shuhong Dai, Ning Li, Ming Zhou, Yue Yuan, Ding Yue, Tao Li, Xiaowei Zhang
Summary: The study investigated the role of EBLN3P in osteosarcoma progression by modulating the miR-224-5p/Rab10 pathway, leading to enhanced cell proliferation, migration, and invasion. This finding suggests a potential new approach to diagnosing and treating osteosarcoma.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Ruiqi Chen, Yichong Ning, Guirong Zeng, Hao Zhou, Lin Zhou, Pei Xiao, Zhihong Li, Jianlin Zhou
Summary: MiR-193a-5p is upregulated in osteosarcoma tissues and promotes colony formation, migration, invasion, and EMT in osteosarcoma cells by targeting NCX2, leading to the progression of osteosarcoma.
Article
Medicine, Research & Experimental
Hongtao He, Muliang Ding, Tao Li, Wenzhi Zhao, Lu Zhang, Peng Yin, Wei Zhang
Summary: This study discovers that NORAD, a non-coding RNA highly expressed in osteosarcoma cells, can be delivered to osteosarcoma cells through extracellular vesicles (EVs) released by bone mesenchymal stem cells (BMSCs), thereby promoting proliferation and invasion of osteosarcoma. NORAD is found to interact with miR-30c-5p and KLF10, and regulates the miR-30c-5p/KLF10 axis to influence the development and metastasis of osteosarcoma.
LABORATORY INVESTIGATION
(2022)
Article
Environmental Sciences
Guanghui Wang, Xiyuan Wei, Shan Gao, Wenheng Chen, Yang Geng, Jia Liu, Hongya Guan
Summary: Circ_LRP6 plays a role in the occurrence and development of osteosarcoma by affecting the proliferation, migration, and invasion of osteosarcoma cells. It interacts with miR-122-5p and miR-204-5p and modulates their target gene HMGB1. The downregulation of miR-122-5p and miR-204-5p and the overexpression of HMGB1 partially restore and weaken the inhibitory effect of circ_LRP6 on osteosarcoma progression.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Chemistry, Medicinal
Clement Veys, Manon Jammes, Francoise Redini, Laurent Poulain, Christophe Denoyelle, Florence Legendre, Philippe Galera
Summary: This study identifies the tumor-suppressive activity of miR-342-5p and miR-491-5p in osteosarcoma cells. Both miRNAs induce apoptosis and target different proteins, offering potential for therapeutic intervention in osteosarcomas.
Article
Biotechnology & Applied Microbiology
Heidi M. Namlos, Magne Skarn, Deeqa Ahmed, Iwona Grad, Kim Andresen, Stine H. Kresse, Else Munthe, Massimo Serra, Katia Scotlandi, Antonio Llombart-Bosch, Ola Myklebost, Guro E. Lind, Leonardo A. Meza-Zepeda
Summary: miR-486-5p is an epigenetically regulated miRNA in osteosarcoma, playing a significant role in the biology of the disease.
Article
Oncology
Xiaohui Pan, Jingxue Tan, Tao Tao, Xiuwen Zhang, Yiping Weng, Xiaokun Weng, Jingwen Xu, Haibo Li, Yuqing Jiang, Dong Zhou, Yifei Shen
Summary: LINC01123, acting as an oncogene, is highly expressed in osteosarcoma. It enhances tumor cell proliferation and metastasis by interacting with miR-516b-5p to increase Gli1 expression.
Article
Materials Science, Multidisciplinary
Wenyi Wang, Junli Chang, Hongfeng Ruan, Xingyuan Sun, Fulai Zhao, Peng Zhao, Chujie Zhou, Junjie Tong, Suxia Guo, Qi Shi, Yongjun Wang, Weian Zhang, Yanping Yang
Summary: This study designed a near-infrared light-activated nanoplatform that successfully inhibited carcinogenesis and pulmonary metastasis of osteosarcoma by activating the HIPPO signaling pathway. The study identified a novel molecular mechanism of PDT and provided new insights for designing nanoplatforms for future cancer therapies.
MATERIALS & DESIGN
(2023)
Article
Cell Biology
Kai Guan, Shizhang Liu, Keke Duan, Xiaoxia Zhang, Huitong Liu, Bingqiang Xu, Xi Wang, Xin Jin
Summary: This study revealed that circ_0008259 suppresses the progression of osteosarcoma by regulating the miR-21-5p/PDCD4 axis, demonstrating the important role of circ_0008259 in osteosarcoma.
Article
Biochemistry & Molecular Biology
Taiping Wang, Yong Xu, Xin Liu, Yong Zeng, Lei Liu
Summary: The study identified that MiR-96-5p is upregulated in osteosarcoma tissues and cells, and can inhibit proliferation, adhesion, and migration of osteosarcoma cells while promoting apoptosis. Furthermore, MiR-96-5p targets SYK to exert its function in osteosarcoma treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Hallgeir Selven, Sigve Andersen, Mona Pedersen, Ana Paola Giometti Lombardi, Lill-Tove Rasmussen Busund, Thomas Karsten Kilvaer
Summary: This study investigated the prognostic impact of miR-17-5p and miR-20a-5p in colon cancer. The results showed that high expression of both miR-17-5p and miR-20a-5p is associated with a favorable prognosis and inhibits cell migration.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Lei Yang, Wenliang Tan, Yingcheng Wei, Zhiqin Xie, Wenxin Li, Xiaowu Ma, Qingbin Wang, Huilong Li, Ziyu Zhang, Changzhen Shang, Yajin Chen
Summary: This study demonstrates the tumor-suppressive role of circLIFR in hepatocellular carcinoma (HCC) by regulating miR-624-5p and inactivating the GSK-3 beta/beta-catenin signaling pathway.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Jingbing Lou, Hongliang Zhang, Jiuhui Xu, Tingting Ren, Yi Huang, Xiaodong Tang, Wei Guo
Summary: Osteosarcoma (OS) is a primary and highly malignant mesenchymal tissue tumor with unclear pathological mechanisms. This study found that circUSP34 promotes the proliferation, migration, and invasion of OS by sponging miR-16-5p, suggesting it as a potential therapeutic target and biomarker.
Article
Oncology
Lu Zhang, Hongxin Cao, Guanghui Gu, Dehui Hou, Yunhao You, Xiang Li, Yunzhen Chen, Guangjun Jiao
Summary: miR-199a-5p can be transported from osteosarcoma cells to HUVECs through exosomes, subsequently targeting VEGFA and inhibiting the growth and angiogenesis of osteosarcoma. Therefore, miR-199a-5p may act as a biomarker in the diagnosis and treatment of osteosarcoma.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yuhao Hu, Aiting Cai, Jing Xu, Wei Feng, Anqi Wu, Ruoyu Liu, Weihua Cai, Lin Chen, Feng Wang
Summary: A class of small noncoding RNAs, tRNA-derived fragments (tRFs), derived from mature tRNAs or pre-tRNAs, have been increasingly studied for their roles in human diseases, particularly in cancer and other diseases. These tRFs exhibit important biological functions and regulatory mechanisms in disease pathogenesis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Yuluo Rong, Jin Fan, Chengyue Ji, Zhuanghui Wang, Xuhui Ge, Jiaxing Wang, Wu Ye, Guoyong Yin, Weihua Cai, Wei Liu
Summary: This study reveals the involvement of ferroptosis in spinal cord ischemia-reperfusion injury (SCIRI) and the key role of USP11 in regulating ferroptosis, as well as promoting autophagy activation. Targeting USP11-mediated autophagy-dependent ferroptosis could be a promising approach for the treatment of SCIRI.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Infectious Diseases
Renfei Lu, Jian Wang, Min Li, Jing He, Yaqi Wang, Jia Dong, Weihua Cai
Summary: By retrospectively evaluating cases in Nantong city, China, we found that digital PCR provides more accurate detection of coronavirus infection and viral load than reverse-transcription PCR, especially for specimens with low viral load.
JOURNAL OF INFECTION IN DEVELOPING COUNTRIES
(2022)
Article
Chemistry, Physical
Chaoqi Wang, Rui Wang, Zhongyuan Huang, Mihai Chu, Wenhai Ji, Ziwei Chen, Taolue Zhang, Jingjun Zhai, Huaile Lu, Sihao Deng, Jie Chen, Lunhua He, Tianjiao Liang, Fangwei Wang, Jun Wang, Yonghong Deng, Weihua Cai, Yinguo Xiao
Summary: Utilizing in operando neutron diffraction technique, structural characteristics and lithium ion migration pathways of electrodes in LiNi0.5Co0.2Mn0.3O2 /Graphite full cell were revealed. The competition effect between delithiation and magnetic frustration affects the concentration of Li/Ni antisite defects in the cathode, while lithium ions diffuse via different hopping paths in different stages of charge. The study provides insights for designing an optimized pathway for achieving high-performance Li-ion batteries.
ENERGY STORAGE MATERIALS
(2022)
Article
Cell Biology
Zhiqi Lu, Jiaojiao Shen, Xubin Chen, Zhihua Ruan, Weihua Cai, Shuyun Cai, Minjun Li, Yihui Yang, Jian Mo, Guixi Mo, Yan Lu, Jing Tang, Liangqing Zhang
Summary: The study reveals that propofol protects cells by suppressing excessive autophagy induced by hypoxia/reoxygenation. It was found that miR-30b, which is downregulated by H/R treatment, is significantly upregulated by propofol after H/R treatment. miR-30b inhibits H/R-induced autophagy activation by targeting Beclin-1.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Multidisciplinary Sciences
Shannon Tansley, Ning Gu, Alba Urena Guzman, Weihua Cai, Calvin Wong, Kevin C. Lister, Einer Munoz-Pino, Noosha Yousefpour, R. Brian Roome, Jordyn Heal, Neil Wu, Annie Castonguay, Graham Lean, Elizabeth M. Muir, Artur Kania, Masha Prager-Khoutorsky, Ji Zhang, Christos G. Gkogkas, James W. Fawcett, Luda Diatchenko, Alfredo Ribeiro-da-Silva, Yves De Koninck, Jeffrey S. Mogil, Arkady Khoutorsky
Summary: After peripheral nerve injury, microglia degrade extracellular matrix structures (PNNs) in the spinal cord dorsal horn, enhancing the output of spinal nociceptive circuits and causing pain hypersensitivity.
Article
Clinical Neurology
Zhuanghui Wang, Wu Ye, Yufeng Zhu, Pengyu Tang, Weihua Cai
Summary: The study found that LSI > 10 is associated with recurrence of lumbar symptoms in TSS patients following cervical surgery.
EUROPEAN SPINE JOURNAL
(2022)
Article
Neurosciences
Xuhui Ge, Wu Ye, Yufeng Zhu, Min Cui, Jiawen Zhou, Chenyu Xiao, Dongdong Jiang, Pengyu Tang, Jiaxing Wang, Zhuanghui Wang, Chengyue Ji, Xuhui Zhou, Xiaojian Cao, Wei Liu, Weihua Cai
Summary: RNA N6-methyladenosine (m6A) modification plays an important role in spinal cord injury (SCI). Increased m6A level and upregulated METTL3 in reactive astrocytes are observed after SCI. The USP1/UAF1 complex stabilizes METTL3 by removing its K48-linked ubiquitination. Conditional knockout of astrocytic METTL3 suppresses reactive astrogliosis after SCI, leading to detrimental effects on functional recovery. METTL3 selectively methylates the YAP1 transcript and maintains its stability in an IGF2BP2-dependent manner. Overexpression of YAP1 partly reverses the effects of METTL3 knockout on functional recovery after SCI. Additionally, METTL3's methyltransferase activity is essential for reactive astrogliosis and motor repair.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Computer Science, Interdisciplinary Applications
Shan Ren, Lichun Shi, Yang Liu, Weihua Cai, Yingfeng Zhang
Summary: This study proposes a personalized maintenance approach (POMA-CP) to improve the accuracy and applicability of maintenance schemes for industrial products by establishing a refined maintenance model. The approach includes a multi-level case library, dynamic equipment portrait model, and case-pushing mechanism. Through this approach, active pushing of the best similar cases and automatic generation of service schemes can be achieved, resulting in higher accuracy and applicability for maintenance schemes.
ROBOTICS AND COMPUTER-INTEGRATED MANUFACTURING
(2023)
Article
Biochemistry & Molecular Biology
Xuhui Ge, Zheng Zhou, Siting Yang, Wu Ye, Zhuanghui Wang, Jiaxing Wang, Chenyu Xiao, Min Cui, Jiawen Zhou, Yufeng Zhu, Rixiao Wang, Yu Gao, Haofan Wang, Pengyu Tang, Xuhui Zhou, Ce Wang, Weihua Cai
Summary: Spinal cord injury (SCI) often leads to irreversible sensory and motor disabilities without effective treatment options. This study aimed to investigate the role of vascular endothelial cells in the polarization of microglia/macrophages and the underlying mechanism. The findings demonstrated that microglia/macrophages were shifted towards the M2 phenotype, mitochondrial impairment was alleviated, and reactive oxygen species (ROS) production was reduced by the administration of conditioned medium from microvascular endothelial cells. Exosomes derived from these endothelial cells were shown to promote motor rehabilitation and M2 polarization of microglia/macrophages in vivo. The study suggested that exosomes could be a promising therapeutic strategy for SCI treatment.
CELL AND BIOSCIENCE
(2023)
Article
Neurosciences
Xinying Guo, Gaolong Zhang, Weihua Cai, Fa Huang, Jingwen Qin, Xingrong Song
Summary: This study reveals the role of Rmst, a lncRNA, in damaged DRG neurons under neuropathic pain (NP) condition. Rmst is specifically expressed in injured DRG neurons and is upregulated following peripheral nerve damage. Overexpression of Rmst causes neuropathic symptoms, while blocking Rmst expression alleviates pain hypersensitivities and downregulates Dnmt3a expression. The study also shows that peripheral nerve damage-induced Rmst increase interacts with HuR to stabilize Dnmt3a mRNA. Overall, this research provides insight into the mechanism of NP and identifies Rmst as a potential target for drug development.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Engineering, Biomedical
Yuluo Rong, Zhuanghui Wang, Pengyu Tang, Jiaxing Wang, Chengyue Ji, Jie Chang, Yufeng Zhu, Wu Ye, Jianling Bai, Wei Liu, Guoyong Yin, Lipeng Yu, Xuhui Zhou, Weihua Cai
Summary: In this study, a drug delivery system using engineered extracellular vesicles (EVs) carrying CAQK-modified peptide and loaded siRNA (C-EVs-siRNA) was designed for targeted therapy of spinal cord injury (SCI). The modified EVs effectively delivered siRNA to the SCI region and showed favorable therapeutic effects. The combination of targeted modified EVs and siRNA enhanced the anti-inflammatory and neuroreparative functions of EVs, promoting functional recovery in mice after SCI. This study highlights the potential of engineered EVs as a feasible and efficacious treatment for SCI and possibly other diseases.
BIOACTIVE MATERIALS
(2023)
Article
Medicine, General & Internal
Tao Hang, Jian Lu, Aiyan Fu, Weihua Cai
Summary: This study investigated the diagnostic value of Gd-EOB-DTPA MRI for hepatocellular carcinoma (HCC) associated with hepatitis B cirrhosis. The results showed that Gd-EOB-DTPA-enhanced MRI can improve the diagnostic accuracy of HCC in patients with hepatitis B cirrhosis.
ACTA MEDICA MEDITERRANEA
(2023)
Article
Immunology
Jinfeng Huang, Hao Bai, Quanchang Tan, Dingjun Hao, Aimin Wu, Qingde Wang, Bing Wang, Linfeng Wang, Hao Liu, Xiongsheng Chen, Zhengsong Jiang, Xiaoming Ma, Xinyu Liu, Peng Liu, Weihua Cai, Ming Lu, Ningfang Mao, Yong Wang, Suochao Fu, Shuai Zhao, Xiaofang Zang, Youzhuan Xie, Haiyang Yu, Ruixian Song, Jiangbo Sun, Liangbi Xiang, Xiang Liu, Songkai Li, Bo Liao, Zixiang Wu
Summary: The risk of instantaneous death is relatively high in patients with AS and cervical fracture, especially in the first 6 months. However, this risk gradually decreases over time. Delayed surgery is associated with a decreased incidence of complications. Patients with ASIA A and B demonstrate improved conditional survival over time.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Calvin Wong, Omer Barkai, Feng Wang, Carolina Thorn Perez, Shaya Lev, Weihua Cai, Shannon Tansley, Noosha Yousefpour, Mehdi Hooshmandi, Kevin C. Lister, Mariam Latif, A. Claudio Cuello, Masha Prager-Khoutorsky, Jeffrey S. Mogil, Philippe Seguela, Yves De Koninck, Alfredo Ribeiro-da-Silva, Alexander M. Binshtok, Arkady Khoutorsky
Summary: The activation of mTORC2 triggered by tissue inflammation causes structural changes in nociceptive free nerve endings, leading to inflammatory pain. Inhibiting the regulatory protein Rictor of mTORC2 can prevent the elongation and branching of nociceptive fibers, reducing inflammatory pain hypersensitivity.
JOURNAL OF CLINICAL INVESTIGATION
(2022)