Role of Merlin/NF2 inactivation in tumor biology

Inhibition of SIRT2 in merlin/NF2-mutant Schwann cells triggers necrosis

(2015) Alejandra M. Petrilli et al.   Oncotarget

The Neurofibromatosis 2 Tumor Suppressor Gene Product, Merlin, Regulates Human Meningioma Cell Growth by Signaling through YAP

(2015) Katherine Striedinger et al.   NEOPLASIA

Multistep Phosphorylation by Oncogenic Kinases Enhances the Degradation of the NF2 Tumor Suppressor Merlin

(2015) Minja Laulajainen et al.   NEOPLASIA

Merlin-Deficient Human Tumors Show Loss of Contact Inhibition and Activation of Wnt/β-Catenin Signaling Linked to the PDGFR/Src and Rac/PAK Pathways

(2015) Lu Zhou et al.   NEOPLASIA

Functional interdependence of NHE1 and merlin in human melanoma cells

(2014) Fabian Frontzek et al.   Biochemistry and Cell Biology

Merlin/NF2 Loss-Driven Tumorigenesis Linked to CRL4DCAF1-Mediated Inhibition of the Hippo Pathway Kinases Lats1 and 2 in the Nucleus

(2014) Wei Li et al.   CANCER CELL

The mammalian Hippo pathway: regulation and function of YAP1 and TAZ

(2014) Manami Kodaka et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

YAP/TAZ as mechanosensors and mechanotransducers in regulating organ size and tumor growth

(2014) Boon Chuan Low et al.   FEBS LETTERS

Structural basis of DDB1-and-Cullin 4-associated Factor 1 (DCAF1) recognition by merlin/NF2 and its implication in tumorigenesis by CD44-mediated inhibition of merlin suppression of DCAF1 function

(2014) Tomoyuki Mori et al.   GENES TO CELLS

A murine model of neurofibromatosis type 2 that accurately phenocopies human schwannoma formation

(2014) Jeffrey R. Gehlhausen et al.   HUMAN MOLECULAR GENETICS

Molecular Conformation of the Full-Length Tumor Suppressor NF2/Merlin—A Small-Angle Neutron Scattering Study

(2014) Jahan Ali Khajeh et al.   JOURNAL OF MOLECULAR BIOLOGY

Gene-expression profiling elucidates molecular signaling networks that can be therapeutically targeted in vestibular schwannoma

(2014) Sameer Agnihotri et al.   JOURNAL OF NEUROSURGERY

The p53/mouse double minute 2 homolog complex deregulation in merlin-deficient tumours

(2014) Sylwia Ammoun et al.   Molecular Oncology

Proteomic screening identifies a YAP-driven signaling network linked to tumor cell proliferation in human schwannomas

(2014) Alizée Boin et al.   NEURO-ONCOLOGY

mTORC1 inhibition delays growth of neurofibromatosis type 2 schwannoma

(2014) Marco Giovannini et al.   NEURO-ONCOLOGY

The Biology of YAP/TAZ: Hippo Signaling and Beyond

(2014) Stefano Piccolo et al.   PHYSIOLOGICAL REVIEWS

Nf2/Merlin Controls Spinal Cord Neural Progenitor Function in a Rac1/ErbB2-Dependent Manner

(2014) Cynthia Garcia et al.   PLoS One

NCI-60 Whole Exome Sequencing and Pharmacological CellMiner Analyses

(2014) William C. Reinhold et al.   PLoS One

A neuronal function of the tumor suppressor protein merlin

(2014) Alexander Schulz et al.   Acta Neuropathologica Communications

Intracranial meningiomas and neurofibromatosis type 2

(2013) Rabih Aboukais et al.   ACTA NEUROCHIRURGICA

Neuronal merlin influences ERBB2 receptor expression on Schwann cells through neuregulin 1 type III signalling

(2013) Alexander Schulz et al.   BRAIN

High Incidence of ActivatingTERTPromoter Mutations in Meningiomas Undergoing Malignant Progression

(2013) Stéphane Goutagny et al.   BRAIN PATHOLOGY

Chromosomal structural variations during progression of a prostate epithelial cell line to a malignant metastatic state inactivate the NF2, NIPSNAP1, UGT2B17, and LPIN2 genes

(2013) Ankit Malhotra et al.   CANCER BIOLOGY & THERAPY

Tumor Suppressor NF2/Merlin Is a Microtubule Stabilizer

(2013) Z. Smole et al.   CANCER RESEARCH

Spatial Organization of Hippo Signaling at the Plasma Membrane Mediated by the Tumor Suppressor Merlin/NF2

(2013) Feng Yin et al.   CELL

A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors

(2013) Mariaceleste Aragona et al.   CELL

Merlin isoform 2 in neurofibromatosis type 2–associated polyneuropathy

(2013) Alexander Schulz et al.   NATURE NEUROSCIENCE

Axl/Gas6/NFκB signalling in schwannoma pathological proliferation, adhesion and survival

(2013) S Ammoun et al.   ONCOGENE

LIM domain kinases as potential therapeutic targets for neurofibromatosis type 2

(2013) A Petrilli et al.   ONCOGENE

Regulation of Son of sevenless by the membrane-actin linker protein ezrin

(2013) K. J. Geissler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

The p130 Isoform of Angiomotin Is Required for Yap-Mediated Hepatic Epithelial Cell Proliferation and Tumorigenesis

(2013) C. Yi et al.   Science Signaling

Multiple primary intramedullary ependymomas: a case report and review of the literature

(2013) Mohamad Bydon et al.   Spine Journal

Loss of NF2/Merlin expression in advanced sporadic colorectal cancer

(2013) Tamara Čačev et al.   CELLULAR ONCOLOGY

Stem cell regulation by the Hippo pathway

(2012) Samantha E. Hiemer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Histone Deacetylase Inhibitor AR-42 Differentially Affects Cell-cycle Transit in Meningeal and Meningioma Cells, Potently Inhibiting NF2-Deficient Meningioma Growth

(2012) S. S. Burns et al.   CANCER RESEARCH

Growth Control by Committee: Intercellular Junctions, Cell Polarity, and the Cytoskeleton Regulate Hippo Signaling

(2012) Julian C. Boggiano et al.   DEVELOPMENTAL CELL

The Tumor Suppressor Merlin Controls Growth in Its Open State, and Phosphorylation Converts It to a Less-Active More-Closed State

(2012) Ifat Sher et al.   DEVELOPMENTAL CELL

The role of insulin-like growth factors signaling in merlin-deficient human schwannomas

(2012) Sylwia Ammoun et al.   GLIA

Regulation of mTOR Complex 2 Signaling in Neurofibromatosis 2-Deficient Target Cell Types

(2012) M. F. James et al.   MOLECULAR CANCER RESEARCH

Systematic identification of genomic markers of drug sensitivity in cancer cells

(2012) Mathew J. Garnett et al.   NATURE

Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells

(2012) Wanjuan Yang et al.   NUCLEIC ACIDS RESEARCH

Lack of Neurofibromatosis Type 2 Gene Promoter Methylation in Sporadic Vestibular Schwannomas

(2012) D. Koutsimpelas et al.   ORL-Journal for Oto-Rhino-Laryngology Head and Neck Surgery

Investigation of the In Vitro Therapeutic Efficacy of Nilotinib in Immortalized Human NF2-Null Vestibular Schwannoma Cells

(2012) Nesrin Sabha et al.   PLoS One

Merlin Is a Negative Regulator of Human Melanoma Growth

(2012) Lucas B. Murray et al.   PLoS One

Regulation of the Hippo pathway by cell architecture and mechanical signals

(2012) Molly C. Schroeder et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Hippo signaling pathway and stem cell biology

(2012) Azucena Ramos et al.   TRENDS IN CELL BIOLOGY

A Tight Junction-Associated Merlin-Angiomotin Complex Mediates Merlin's Regulation of Mitogenic Signaling and Tumor Suppressive Functions

(2011) Chunling Yi et al.   CANCER CELL

LATS2 Is a Tumor Suppressor Gene of Malignant Mesothelioma

(2011) H. Murakami et al.   CANCER RESEARCH

Cell–Cell Junctions: α-Catenin and E-Cadherin Help Fence In Yap1

(2011) Brian S. Robinson et al.   CURRENT BIOLOGY

Hippo pathway regulation by cell morphology and stress fibers

(2011) K.-I. Wada et al.   DEVELOPMENT

Spinal ependymomas in neurofibromatosis Type 2: a retrospective analysis of 55 patients

(2011) Scott R. Plotkin et al.   JOURNAL OF NEUROSURGERY-SPINE

Preclinical validation of AR42, a novel histone deacetylase inhibitor, as treatment for vestibular schwannomas

(2011) Abraham Jacob et al.   LARYNGOSCOPE

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal

(2011) Bin Zhao et al.   NATURE CELL BIOLOGY

Nilotinib alone or in combination with selumetinib is a drug candidate for neurofibromatosis type 2

(2011) S. Ammoun et al.   NEURO-ONCOLOGY

AR42, a novel histone deacetylase inhibitor, as a potential therapy for vestibular schwannomas and meningiomas

(2011) M. L. Bush et al.   NEURO-ONCOLOGY

PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signaling

(2011) Y Shrestha et al.   ONCOGENE

Mutational analysis of tumour suppressor gene NF2 in common solid cancers and acute leukaemias

(2011) Nam Jin Yoo et al.   PATHOLOGY

Unfurling of the band 4.1, ezrin, radixin, moesin (FERM) domain of the merlin tumor suppressor

(2011) S. D. Yogesha et al.   PROTEIN SCIENCE

Merlin/NF2 Functions Upstream of the Nuclear E3 Ubiquitin Ligase CRL4DCAF1 to Suppress Oncogenic Gene Expression

(2011) J. Cooper et al.   Science Signaling

Merlin/NF2 Suppresses Tumorigenesis by Inhibiting the E3 Ubiquitin Ligase CRL4DCAF1 in the Nucleus

(2010) Wei Li et al.   CELL

Ependymomas in Adults

(2010) Mark R. Gilbert et al.   Current Neurology and Neuroscience Reports

Merlin, a “Magic” Linker Between the Extracellular Cues and Intracellular Signaling Pathways that Regulate Cell Motility, Proliferation, and Survival

(2010) Ivan Stamenkovic et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

The Merlin/NF2 Tumor Suppressor Functions through the YAP Oncoprotein to Regulate Tissue Homeostasis in Mammals

(2010) Nailing Zhang et al.   DEVELOPMENTAL CELL

The Hippo Signaling Pathway in Development and Cancer

(2010) Duojia Pan   DEVELOPMENTAL CELL

Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver

(2010) S. Benhamouche et al.   GENES & DEVELOPMENT

Meningioma mouse models

(2010) Michel Kalamarides et al.   JOURNAL OF NEURO-ONCOLOGY

Epidemiology and etiology of meningioma

(2010) Joseph Wiemels et al.   JOURNAL OF NEURO-ONCOLOGY

Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

(2010) Ramin Nazarian et al.   NATURE

ErbB/HER receptor activation and preclinical efficacy of lapatinib in vestibular schwannoma

(2010) S. Ammoun et al.   NEURO-ONCOLOGY

Overexpression of ezrin inactivates NF2 tumor suppressor in glioblastoma

(2010) F. C. Morales et al.   NEURO-ONCOLOGY

NF2-deficient cells depend on the Rac1-canonical Wnt signaling pathway to promote the loss of contact inhibition of proliferation

(2010) E E Bosco et al.   ONCOGENE

Merlin Knockdown in Human Schwann Cells

(2010) Zana Ahmad et al.   OTOLOGY & NEUROTOLOGY

Microtubule-mediated transport of the tumor-suppressor protein Merlin and its mutants

(2010) L. B. Bensenor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression

(2010) H. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver

(2010) L. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 Oncogene

(2009) Dawang Zhou et al.   CANCER CELL

Human Schwannomas Express Activated Platelet-Derived Growth Factor Receptors and c-kit and Are Growth Inhibited by Gleevec (Imatinib Mesylate)

(2009) J. Mukherjee et al.   CANCER RESEARCH

Growth inhibitory and anti-tumour activities of OSU-03012, a novel PDK-1 inhibitor, on vestibular schwannoma and malignant schwannoma cells

(2009) Tina X. Lee et al.   EUROPEAN JOURNAL OF CANCER

Activation of ERK, AKT and JNK signalling pathways in human schwannomasin situ

(2009) David A Hilton et al.   HISTOPATHOLOGY

Neurofibromatosis type 2

(2009) Ashok R Asthagiri et al.   LANCET

Fluorescence Resonance Energy Transfer Analysis of Merlin Conformational Changes

(2009) R. F. Hennigan et al.   MOLECULAR AND CELLULAR BIOLOGY

Loss of the Tumor Suppressor Gene NF2, Encoding Merlin, Constitutively Activates Integrin-Dependent mTORC1 Signaling

(2009) M. A. Lopez-Lago et al.   MOLECULAR AND CELLULAR BIOLOGY

NF2/Merlin Is a Novel Negative Regulator of mTOR Complex 1, and Activation of mTORC1 Is Associated with Meningioma and Schwannoma Growth

(2009) M. F. James et al.   MOLECULAR AND CELLULAR BIOLOGY

Neurofibromatosis type 2 (NF2): A clinical and molecular review

(2009) D Gareth R Evans   Orphanet Journal of Rare Diseases

Phosphatidylinositol 3-Kinase/AKT Pathway Activation in Human Vestibular Schwannoma

(2009) Abraham Jacob et al.   OTOLOGY & NEUROTOLOGY

Altered Adhesive Structures and Their Relation to RhoGTPase Activation in Merlin-Deficient Schwannoma

(2008) Christine Flaiz et al.   BRAIN PATHOLOGY

Dissecting and Targeting the Growth Factor-Dependent and Growth Factor-Independent Extracellular Signal-Regulated Kinase Pathway in Human Schwannoma

(2008) S. Ammoun et al.   CANCER RESEARCH

Merlin Is a Potent Inhibitor of Glioma Growth

(2008) Y.-K. I. Lau et al.   CANCER RESEARCH

YAP1 is involved in mesothelioma development and negatively regulated by Merlin through phosphorylation

(2008) Toshihiko Yokoyama et al.   CARCINOGENESIS

Nf2/Merlin Regulates Hematopoietic Stem Cell Behavior by Altering Microenvironmental Architecture

(2008) Jonas Larsson et al.   Cell Stem Cell

Impaired intercellular adhesion and immature adherens junctions in merlin-deficient human primary schwannoma cells

(2008) C. Flaiz et al.   GLIA

Functional inactivation of NF2/merlin in human mesothelioma

(2008) Claudio Thurneysen et al.   LUNG CANCER

The Neurofibromatosis 2 Protein, Merlin, Regulates Glial Cell Growth in an ErbB2- and Src-Dependent Manner

(2008) S. S. Houshmandi et al.   MOLECULAR AND CELLULAR BIOLOGY

Merlin regulates transmembrane receptor accumulation and signaling at the plasma membrane in primary mouse Schwann cells and in human schwannomas

(2008) D Lallemand et al.   ONCOGENE

Inactivation of the NF2 tumor suppressor protein merlin in DU145 prostate cancer cells

(2008) Akio Horiguchi et al.   PROSTATE

Antitumor Activity of Rapamycin in a Phase I Trial for Patients with Recurrent PTEN-Deficient Glioblastoma

(2008) Tim F Cloughesy et al.   PLOS MEDICINE