Protection against Alzheimer's disease by luteolin: Role of brain glucose regulation, anti‐inflammatory activity, and the gut microbiota‐liver‐brain axis

An Update of Palmitoylethanolamide and Luteolin Effects in Preclinical and Clinical Studies of Neuroinflammatory Events

(2020) Marika Cordaro et al.   Antioxidants

A story of liver and gut microbes: how does the intestinal flora affect liver disease? A review of the literature

(2020) Mauro Giuffrè et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Luteolin and Apigenin Attenuate LPS-Induced Astrocyte Activation and Cytokine Production by Targeting MAPK, STAT3, and NF-κB Signaling Pathways

(2020) Denis Nchang Che et al.   INFLAMMATION

Looking for a Treatment for the Early Stage of Alzheimer’s Disease: Preclinical Evidence with Co-Ultramicronized Palmitoylethanolamide and Luteolin

(2020) Roberta Facchinetti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

LRP1 is a master regulator of tau uptake and spread

(2020) Jennifer N. Rauch et al.   NATURE

Role of Gut Microbiota in Neuroendocrine Regulation of Carbohydrate and Lipid Metabolism via the Microbiota-Gut-Brain-Liver Axis

(2020) Shu-Zhi Wang et al.   Microorganisms

Brain Insulin Signaling, Alzheimer Disease Pathology, and Cognitive Function

(2020) Zoe Arvanitakis et al.   ANNALS OF NEUROLOGY

Role of tau protein in Alzheimer's disease: The prime pathological player

(2020) Shibi Muralidar et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Luteolin reduces fluid hypersecretion by inhibiting TMEM16A in interleukin-4 treated Calu-3 airway epithelial cells

(2020) Hyun Jong Kim et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

How May GIP Enhance the Therapeutic Efficacy of GLP-1?

(2020) Ricardo J. Samms et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The Role of Astrocytes in CNS Inflammation

(2020) Federico Giovannoni et al.   TRENDS IN IMMUNOLOGY

Interaction of Polyphenols as Antioxidant and Anti-Inflammatory Compounds in Brain–Liver–Gut Axis

(2020) Amritpal Singh et al.   Antioxidants

Canine atopic dermatitis: Role of luteolin as new natural treatment

(2020) Enrico Gugliandolo et al.   Veterinary Medicine and Science

Neuroprotective effects of flavone luteolin in neuroinflammation and neurotrauma

(2020) Duraisamy Kempuraj et al.   BIOFACTORS

A network pharmacology strategy to investigate the anti-inflammatory mechanism of luteolin combined with in vitro transcriptomics and proteomics

(2020) Xiu-Fang Huang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Interplay between Peripheral and Central Inflammation in Obesity-Promoted Disorders: The Impact on Synaptic Mitochondrial Functions

(2020) Marianna Crispino et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gut Microbiota and Dysbiosis in Alzheimer’s Disease: Implications for Pathogenesis and Treatment

(2020) Shan Liu et al.   MOLECULAR NEUROBIOLOGY

Early-Stage Alzheimer’s Disease Is Associated with Simultaneous Systemic and Central Nervous System Dysregulation of Insulin-Linked Metabolic Pathways

(2019) Suzanne M. de la Monte et al.   JOURNAL OF ALZHEIMERS DISEASE

Luteolin protects PC-12 cells from H2O2-induced injury by up-regulation of microRNA-21

(2019) Zhiti Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity

(2019) Alberto Mantovani et al.   IMMUNITY

Luteolin Attenuates Cardiac Ischemia/Reperfusion Injury in Diabetic Rats by Modulating Nrf2 Antioxidative Function

(2019) Chi Xiao et al.   Oxidative Medicine and Cellular Longevity

Changes in the gut microbiome and fermentation products concurrent with enhanced longevity in acarbose-treated mice

(2019) Byron J Smith et al.   BMC MICROBIOLOGY

Effects of metformin, acarbose, and sitagliptin monotherapy on gut microbiota in Zucker diabetic fatty rats

(2019) Minchun Zhang et al.   BMJ Open Diabetes Research & Care

Discovery of a series of selective and cell permeable beta-secretase (BACE1) inhibitors by fragment linking with the assistance of STD-NMR

(2019) Wei-Shuo Fang et al.   BIOORGANIC CHEMISTRY

Anti-inflammatory effects of flavonoids

(2019) Soheila J. Maleki et al.   FOOD CHEMISTRY

Systemic and central nervous system metabolic alterations in Alzheimer’s disease

(2019) Vera van der Velpen et al.   Alzheimers Research & Therapy

Recent Trends in the Application of Chromatographic Techniques in the Analysis of Luteolin and Its Derivatives

(2019) Juszczak et al.   Biomolecules

Low-dose brain estrogen prevents menopausal syndrome while maintaining the diversity of the gut microbiomes in estrogen-deficient rats

(2018) Sunmin Park et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The role of insulin at brain-liver axis in the control of glucose production

(2018) Izabela MR Ribeiro et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Randomized Trial of Verubecestat for Mild-to-Moderate Alzheimer’s Disease

(2018) Michael F. Egan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Trial of Solanezumab for Mild Dementia Due to Alzheimer’s Disease

(2018) Lawrence S. Honig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structure-Dependent Modulation of Aryl Hydrocarbon Receptor-Mediated Activities by Flavonoids

(2018) Un-Ho Jin et al.   TOXICOLOGICAL SCIENCES

Effects of Natural Flavonoid Isoorientin on Growth Performance and Gut Microbiota of Mice

(2018) Li Yuan et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Relevance of gutmicrobiota in cognition, behaviour and Alzheimer’s disease

(2018) Vanessa de J.R. De-Paula et al.   PHARMACOLOGICAL RESEARCH

Influence of microglia and astrocyte activation in the neuroinflammatory pathogenesis of Alzheimer’s disease: Rational insights for the therapeutic approaches

(2018) Mir Hilal Ahmad et al.   JOURNAL OF CLINICAL NEUROSCIENCE

The combination of luteolin and l-theanine improved Alzheimer disease–like symptoms by potentiating hippocampal insulin signaling and decreasing neuroinflammation and norepinephrine degradation in amyloid-β–infused rats

(2018) Sunmin Park et al.   NUTRITION RESEARCH

Luteolin Targets the Toll-Like Receptor Signaling Pathway in Prevention of Hepatic and Adipocyte Fibrosis and Insulin Resistance in Diet-Induced Obese Mice

(2018) Eun-Young Kwon et al.   Nutrients

Pleiotropic Effects of GLP-1 and Analogs on Cell Signaling, Metabolism, and Function

(2018) Jordan Rowlands et al.   Frontiers in Endocrinology

Alzheimer's disease

(2017) C. A. Lane et al.   EUROPEAN JOURNAL OF NEUROLOGY

Luteolin as a potential preventive and therapeutic candidate for Alzheimer's disease

(2017) Youngjoo Kwon   EXPERIMENTAL GERONTOLOGY

Luteolin Inhibits Fibrillary β-Amyloid1–40-Induced Inflammation in a Human Blood-Brain Barrier Model by Suppressing the p38 MAPK-Mediated NF-κB Signaling Pathways

(2017) Jun-Xia Zhang et al.   MOLECULES

Bidirectional interactions between diabetes and Alzheimer's disease

(2017) Mitsuru Shinohara et al.   NEUROCHEMISTRY INTERNATIONAL

Mast Cell Activation in Brain Injury, Stress, and Post-traumatic Stress Disorder and Alzheimer's Disease Pathogenesis

(2017) Duraisamy Kempuraj et al.   Frontiers in Neuroscience

Luteolin: A Flavonoid that Has Multiple Cardio-Protective Effects and Its Molecular Mechanisms

(2017) Yuanyuan Luo et al.   Frontiers in Pharmacology

The role of metabolism (and the microbiome) in defining the clinical efficacy of dietary flavonoids

(2016) Aedín Cassidy et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Anti-diabetic effects of luteolin and luteolin-7-O-glucoside on KK-Aymice

(2016) Yanqing Zang et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Luteolin reduces obesity-associated insulin resistance in mice by activating AMPKα1 signalling in adipose tissue macrophages

(2016) Lei Zhang et al.   DIABETOLOGIA

Luteolin rescues pentylenetetrazole-induced cognitive impairment in epileptic rats by reducing oxidative stress and activating PKA/CREB/BDNF signaling

(2016) Jun-Li Zhen et al.   EPILEPSY & BEHAVIOR

Dietary luteolin activates browning and thermogenesis in mice through an AMPK/PGC1α pathway-mediated mechanism

(2016) X Zhang et al.   INTERNATIONAL JOURNAL OF OBESITY

Therapeutic anti-inflammatory effects of luteolin on endotoxin-induced uveitis in Lewis rats

(2016) Kazutaka KANAI et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Dietary Luteolin Reduces Proinflammatory Microglia in the Brain of Senescent Mice

(2016) Michael D. Burton et al.   REJUVENATION RESEARCH

Isolation of Luteolin and Luteolin-7-O-glucoside from Dendranthema morifolium Ramat Tzvel and Their Pharmacokinetics in Rats

(2015) Lie-Chwen Lin et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Acarbose treatment affects the serum levels of inflammatory cytokines and the gut content of bifidobacteria in Chinese patients with type 2 diabetes mellitus

(2015) Benli Su et al.   Journal of Diabetes

Luteolin protects against high fat diet-induced cognitive deficits in obesity mice

(2014) Yi Liu et al.   BEHAVIOURAL BRAIN RESEARCH

Luteolin Attenuates Hepatic Steatosis and Insulin Resistance Through the Interplay Between the Liver and Adipose Tissue in Mice with Diet-Induced Obesity

(2014) Eun-Young Kwon et al.   DIABETES

Luteolin Reduces Alzheimer’s Disease Pathologies Induced by Traumatic Brain Injury

(2014) Darrell Sawmiller et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Protective role of luteolin against cognitive dysfunction induced by chronic cerebral hypoperfusion in rats

(2014) Xiaobin Fu et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Luteolin attenuates diabetes-associated cognitive decline in rats

(2013) Yi Liu et al.   BRAIN RESEARCH BULLETIN

α-Glucosidase inhibition by luteolin: Kinetics, interaction and molecular docking

(2013) Jiakai Yan et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Proinflammatory Cytokines, Aging, and Age-Related Diseases

(2013) Martin Michaud et al.   Journal of the American Medical Directors Association

β-Amyloid-induced cognitive dysfunction impairs glucose homeostasis by increasing insulin resistance and decreasing β-cell mass in non-diabetic and diabetic rats

(2013) Sunmin Park et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Linking Inflammation to the Brain-Liver Axis

(2012) P. I. Mighiu et al.   DIABETES

Widespread Tau and Amyloid-Beta Pathology Many Years After a Single Traumatic Brain Injury in Humans

(2011) Victoria E. Johnson et al.   BRAIN PATHOLOGY

Effects of Insulin on Brain Glucose Metabolism in Impaired Glucose Tolerance

(2011) J. Hirvonen et al.   DIABETES

Accumulation of orally administered quercetin in brain tissue and its antioxidative effects in rats

(2011) Akari Ishisaka et al.   FREE RADICAL BIOLOGY AND MEDICINE

Luteolin Inhibits Microglia and Alters Hippocampal-Dependent Spatial Working Memory in Aged Mice

(2010) Saebyeol Jang et al.   JOURNAL OF NUTRITION

Postischemic administration of liposome-encapsulated luteolin prevents against ischemia-reperfusion injury in a rat middle cerebral artery occlusion model

(2010) Gang Zhao et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

A role for the CREB co-activator CRTC2 in the hypothalamic mechanisms linking glucose sensing with gene regulation

(2009) Robin G Lerner et al.   EMBO REPORTS

Luteolin promotes long-term potentiation and improves cognitive functions in chronic cerebral hypoperfused rats

(2009) Bei Xu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Luteolin as a therapeutic option for multiple sclerosis

(2009) Theoharis C Theoharides   Journal of Neuroinflammation

CD14 and Toll-Like Receptors 2 and 4 Are Required for Fibrillar A -Stimulated Microglial Activation

(2009) E. G. Reed-Geaghan et al.   JOURNAL OF NEUROSCIENCE

Luteolin enhances insulin sensitivity via activation of PPARγ transcriptional activity in adipocytes

(2009) Li Ding et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Distribution and Biological Activities of the Flavonoid Luteolin

(2009) Miguel Lopez-Lazaro   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Long-Term Intracerebroventricular Infusion of Insulin, but Not Glucose, Modulates Body Weight and Hepatic Insulin Sensitivity by Modifying the Hypothalamic Insulin Signaling Pathway in Type 2 Diabetic Rats

(2009) Sunmin Park et al.   NEUROENDOCRINOLOGY

The anti-amnesic effects of luteolin against amyloid β25–35 peptide-induced toxicity in mice involve the protection of neurovascular unit

(2009) R. Liu et al.   NEUROSCIENCE

Luteolin, a Flavonoid with Potential for Cancer Prevention and Therapy

(2008) Yong Lin et al.   CURRENT CANCER DRUG TARGETS

The gut-brain-liver axis: A new option to treat obesity and diabetes?

(2008) Naiara Beraza et al.   HEPATOLOGY

Flavonoid-mediated presenilin-1 phosphorylation reduces Alzheimer's disease β-amyloid production

(2008) Kavon Rezai-Zadeh et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Quercetin and interferon-β modulate immune response(s) in peripheral blood mononuclear cells isolated from multiple sclerosis patients

(2008) Zohara Sternberg et al.   JOURNAL OF NEUROIMMUNOLOGY