Mast Cell Activation in Brain Injury, Stress, and Post-traumatic Stress Disorder and Alzheimer's Disease Pathogenesis

Post-traumatic stress disorder and risk of dementia among members of a health care delivery system

(2018) Jason D. Flatt et al.   Alzheimers & Dementia

Human mast cells as antigen-presenting cells: When is this role important in vivo ?

(2018) Stephen J. Galli et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The anti-inflammatory mechanism of antidepressants – SSRIs, SNRIs

(2018) Piotr Gałecki et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Alzheimer's Disease: Evidence for the Expression of Interleukin-33 and Its Receptor ST2 in the Brain

(2018) Zhi Xiong et al.   JOURNAL OF ALZHEIMERS DISEASE

Emerging role of amyloid beta in stress response: Implication for depression and diabetes

(2017) Maria Grazia Morgese et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Neuroendocrinology of mast cells: Challenges and controversies

(2017) Theoharis C. Theoharides   EXPERIMENTAL DERMATOLOGY

Co-Localization of Glia Maturation Factor with NLRP3 Inflammasome and Autophagosome Markers in Human Alzheimer’s Disease Brain

(2017) Mohammad Ejaz Ahmed et al.   JOURNAL OF ALZHEIMERS DISEASE

What is the Relationship of Traumatic Brain Injury to Dementia?

(2017) Mario F. Mendez   JOURNAL OF ALZHEIMERS DISEASE

The Implication of Combat Stress and PTSD Trajectories in Metabolic Syndrome and Elevated C-Reactive Protein Levels

(2017) Zahava Solomon et al.   JOURNAL OF CLINICAL PSYCHIATRY

Repeated water avoidance stress induces visceral hypersensitivity: Role of interleukin-1, interleukin-6, and peripheral corticotropin-releasing factor

(2017) Tsukasa Nozu et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Frontline Science: Corticotropin-releasing factor receptor subtype 1 is a critical modulator of mast cell degranulation and stress-induced pathophysiology

(2017) Saravanan Ayyadurai et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Cross-Talk between Glia, Neurons and Mast Cells in Neuroinflammation Associated with Parkinson’s Disease

(2017) Duraisamy Kempuraj et al.   Journal of Neuroimmune Pharmacology

Peripheral inflammatory markers in Alzheimer’s disease: a systematic review and meta-analysis of 175 studies

(2017) Ka Sing P Lai et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Insights Into the Neuroinflammatory Responses After Neonatal Hypoxia-Ischemia

(2017) Malgorzata Ziemka-Nalecz et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The Role of Inflammation in Late-Life Post-Traumatic Stress Disorder

(2017) Kenneth Miller et al.   MILITARY MEDICINE

Stress injuries and autophagy in mouse hippocampus after chronic cold exposure

(2017) Lai Wang et al.   Neural Regeneration Research

The Role of Mast Cells in Intracerebral Hemorrhage

(2017) Mustafa Yehya et al.   Neurocritical Care

Psychosocial stress on neuroinflammation and cognitive dysfunctions in Alzheimer's disease: the emerging role for microglia?

(2017) Sami Piirainen et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Mast cells in neuroinflammation and brain disorders

(2017) Erik Hendriksen et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Mast Cells and KIT as Potential Therapeutic Targets in Severe Asthma

(2017) Stephen J. Galli   NEW ENGLAND JOURNAL OF MEDICINE

Corticotropin-releasing factor receptor-1 modulates biomarkers of DNA oxidation in Alzheimer’s disease mice

(2017) Cheng Zhang et al.   PLoS One

Neuroinflammatory genes associated with post-traumatic stress disorder

(2017) Lyndon J. Zass et al.   PSYCHIATRIC GENETICS

Positive and Negative Signals in Mast Cell Activation

(2017) Silvia Bulfone-Paus et al.   TRENDS IN IMMUNOLOGY

Brain and Peripheral Atypical Inflammatory Mediators Potentiate Neuroinflammation and Neurodegeneration

(2017) Duraisamy Kempuraj et al.   Frontiers in Cellular Neuroscience

Role of neuroinflammation in neurodegeneration: new insights

(2017) Róisín M. McManus et al.   Alzheimers Research & Therapy

Glia Maturation Factor and Mitochondrial Uncoupling Proteins 2 and 4 Expression in the Temporal Cortex of Alzheimer’s Disease Brain

(2017) Ramasamy Thangavel et al.   Frontiers in Aging Neuroscience

Molecular indicators of stress-induced neuroinflammation in a mouse model simulating features of post-traumatic stress disorder

(2017) S Muhie et al.   Translational Psychiatry

Influenza Infection in Mice Induces Accumulation of Lung Mast Cells through the Recruitment and Maturation of Mast Cell Progenitors

(2017) Behdad Zarnegar et al.   Frontiers in Immunology

Amyloid β Peptides Trigger CD47-Dependent Mast Cell Secretory and Phagocytic Responses

(2017) N. Niederhoffer et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Corticotropin-Releasing Hormone, Microglia and Mental Disorders

(2017) S.K. Kritas et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Nerve Growth Factor Interactions with Mast Cells

(2017) S.K. Kritas et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Neuroinflammation in Alzheimer's Disease and Mild Cognitive Impairment: A Field in Its Infancy

(2017) Edith G. McGeer et al.   JOURNAL OF ALZHEIMERS DISEASE

Regulation of plasma histamine levels by the mast cell clock and its modulation by stress

(2017) Yuki Nakamura et al.   Scientific Reports

Mast cell involvement in glucose tolerance impairment caused by chronic mild stress with sleep disturbance

(2017) Sachiko Chikahisa et al.   Scientific Reports

NF-κB as a Key Mediator of Brain Inflammation in Alzheimer’s Disease

(2017) Chul Ju Hwang et al.   CNS & Neurological Disorders-Drug Targets

Blast traumatic brain injury–induced cognitive deficits are attenuated by preinjury or postinjury treatment with the glucagon-like peptide-1 receptor agonist, exendin-4

(2016) David Tweedie et al.   Alzheimers & Dementia

Role of reactive oxygen species in mast cell degranulation

(2016) M. A. Chelombitko et al.   BIOCHEMISTRY-MOSCOW

Responses of dural mast cells in concussive and blast models of mild traumatic brain injury in mice: Potential implications for post-traumatic headache

(2016) Dan Levy et al.   CEPHALALGIA

New Developments in Mast Cell Biology

(2016) Greer Arthur et al.   CHEST

Mast Cell - Glia Dialogue in Chronic Pain and Neuropathic Pain: Blood-Brain Barrier Implications

(2016) Stephen D. Skaper   CNS & Neurological Disorders-Drug Targets

The Anti-Inflammatory Role of Minocycline in Alzheimers Disease

(2016) J. Budni et al.   Current Alzheimer Research

Mast cells in rheumatic disease

(2016) Jolien Suurmond et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The impact of mast cells on cardiovascular diseases

(2016) Eva Kritikou et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mast cells, brain inflammation and autism

(2016) Theoharis C. Theoharides et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inflammation, Antiinflammatory Agents, and Alzheimer’s Disease: The Last 22 Years

(2016) Patrick L. McGeer et al.   JOURNAL OF ALZHEIMERS DISEASE

Different activation signals induce distinct mast cell degranulation strategies

(2016) Nicolas Gaudenzio et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular Anti-inflammatory Mechanisms of Retinoids and Carotenoids in Alzheimer’s Disease: a Review of Current Evidence

(2016) Niyaz Mohammadzadeh Honarvar et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Neurogenic inflammation after traumatic brain injury and its potentiation of classical inflammation

(2016) Frances Corrigan et al.   Journal of Neuroinflammation

Contribution of mast cells to injury mechanisms in a mouse model of pediatric traumatic brain injury

(2016) Raffaella Moretti et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Altered Neuroinflammation and Behavior after Traumatic Brain Injury in a Mouse Model of Alzheimer's Disease

(2016) Olga Kokiko-Cochran et al.   JOURNAL OF NEUROTRAUMA

Role of neuroinflammation and sex hormones in war-related PTSD

(2016) Cristhian Mendoza et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Role of neuroinflammation in neurodegenerative diseases (Review)

(2016) WEI-WEI CHEN et al.   Molecular Medicine Reports

Mast cells' involvement in inflammation pathways linked to depression: evidence in mastocytosis

(2016) S Georgin-Lavialle et al.   MOLECULAR PSYCHIATRY

Interleukin 33 is a guardian of barriers and a local alarmin

(2016) Nikolas T Martin et al.   NATURE IMMUNOLOGY

Microglia Priming with Aging and Stress

(2016) Anzela Niraula et al.   NEUROPSYCHOPHARMACOLOGY

Traumatic brain injury accelerates amyloid-β deposition and impairs spatial learning in the triple-transgenic mouse model of Alzheimer’s disease

(2016) Hajime Shishido et al.   NEUROSCIENCE LETTERS

IL-33 ameliorates Alzheimer’s disease-like pathology and cognitive decline

(2016) Amy K. Y. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Posttraumatic stress disorder influences the nociceptive and intrathecal cytokine response to a painful stimulus in combat veterans

(2016) Imanuel Lerman et al.   PSYCHONEUROENDOCRINOLOGY

Stress and neuroinflammation: a systematic review of the effects of stress on microglia and the implications for mental illness

(2016) Marilia A. Calcia et al.   PSYCHOPHARMACOLOGY

Traumatic brain injury: a risk factor for neurodegenerative diseases

(2016) Rajaneesh Gupta et al.   REVIEWS IN THE NEUROSCIENCES

IgE and mast cells in host defense against parasites and venoms

(2016) Kaori Mukai et al.   Seminars in Immunopathology

Astrocytes: Key Regulators of Neuroinflammation

(2016) Emanuela Colombo et al.   TRENDS IN IMMUNOLOGY

The Role of Mast Cells in Alzheimer’s Disease

(2016) Yasdani Shaik-Dasthagirisaheb et al.   Advances in Clinical and Experimental Medicine

The Impact of Traumatic Brain Injury on the Aging Brain

(2016) Jacob S. Young et al.   Current Psychiatry Reports

Association of Traumatic Brain Injury With Late-Life Neurodegenerative Conditions and Neuropathologic Findings

(2016) Paul K. Crane et al.   JAMA Neurology

Emotion Dysregulation and Inflammation in African-American Women with Type 2 Diabetes

(2016) Abigail Powers et al.   NEURAL PLASTICITY

Effects of a Moderately Lower Temperature on the Proliferation and Degranulation of Rat Mast Cells

(2016) Ruoyu Wang et al.   Journal of Immunology Research

Mast Cell: A Multi-Functional Master Cell

(2016) Melissa Krystel-Whittemore et al.   Frontiers in Immunology

Neuron–Microglia Interactions in Mental Health Disorders: “For Better, and For Worse”

(2016) Eric S. Wohleb   Frontiers in Immunology

PTSD, a Disorder with an Immunological Component

(2016) Zhewu Wang et al.   Frontiers in Immunology

Oxidative stress markers are increased in patients with mastocytosis

(2015) S. Gangemi et al.   ALLERGY

Role of mast cells in trauma and neuroinflammation in allergy immunology

(2015) Marianne Frieri et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Elevated Risk for Autoimmune Disorders in Iraq and Afghanistan Veterans with Posttraumatic Stress Disorder

(2015) Aoife O’Donovan et al.   BIOLOGICAL PSYCHIATRY

How microglia kill neurons

(2015) Guy C. Brown et al.   BRAIN RESEARCH

Neuroinflammation, Microglia and Mast Cells in the Pathophysiology of Neurocognitive Disorders: A Review

(2015) Stephen Skaper et al.   CNS & Neurological Disorders-Drug Targets

Update on TBI and Cognitive Impairment in Military Veterans

(2015) Gregory A. Elder   Current Neurology and Neuroscience Reports

The crucial role of mast cells in blood–brain barrier alterations

(2015) Domenico Ribatti   EXPERIMENTAL CELL RESEARCH

Mast Cells Promote Blood Brain Barrier Breakdown and Neutrophil Infiltration in a Mouse Model of Focal Cerebral Ischemia

(2015) Craig M McKittrick et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The mitochondrial uncoupling protein-2 is a master regulator of both M1 and M2 microglial responses

(2015) Roberta De Simone et al.   JOURNAL OF NEUROCHEMISTRY

Short-term modern life-like stress exacerbates Aβ-pathology and synapse loss in 3xTg-AD mice

(2015) David Baglietto-Vargas et al.   JOURNAL OF NEUROCHEMISTRY

Posttraumatic Stress Disorder-Like Induction Elevates  -Amyloid Levels, Which Directly Activates Corticotropin-Releasing Factor Neurons to Exacerbate Stress Responses

(2015) N. J. Justice et al.   JOURNAL OF NEUROSCIENCE

Hemichannels Are Required for Amyloid  -Peptide-Induced Degranulation and Are Activated in Brain Mast Cells of APPswe/PS1dE9 Mice

(2015) P. A. Harcha et al.   JOURNAL OF NEUROSCIENCE

The effect of environmental humidity and temperature on skin barrier function and dermatitis

(2015) K.A. Engebretsen et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Mast Cells Release Chemokine CCL2 in Response to Parkinsonian Toxin 1-Methyl-4-Phenyl-Pyridinium (MPP+)

(2015) Duraisamy Kempuraj et al.   NEUROCHEMICAL RESEARCH

Microglia in neuronal plasticity: Influence of stress

(2015) Jean-Christophe Delpech et al.   NEUROPHARMACOLOGY

Role of Translocator Protein Density, a Marker of Neuroinflammation, in the Brain During Major Depressive Episodes

(2015) Elaine Setiawan et al.   JAMA Psychiatry

Vascular and Inflammatory Factors in the Pathophysiology of Blast-Induced Brain Injury

(2015) Gregory A. Elder et al.   Frontiers in Neurology

Dopaminergic Toxin 1-Methyl-4-Phenylpyridinium, Proteins α-Synuclein and Glia Maturation Factor Activate Mast Cells and Release Inflammatory Mediators

(2015) Duraisamy Kempuraj et al.   PLoS One

Role of Histaminergic System in Blood–Brain Barrier Dysfunction Associated with Neurological Disorders

(2014) Ivette Bañuelos-Cabrera et al.   ARCHIVES OF MEDICAL RESEARCH

Relationship of PTSD Symptoms With Combat Exposure, Stress, and Inflammation in American Soldiers

(2014) M. W. Groer et al.   Biological Research for Nursing

Targeting microglia for the treatment of Alzheimer’s disease

(2014) Patrick L McGeer et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Spectrum of mast cell activation disorders

(2014) Anastasia I Petra et al.   Expert Review of Clinical Immunology

Mast cells in chronic inflammation, pelvic pain and depression in women

(2014) Alessandra Graziottin et al.   GYNECOLOGICAL ENDOCRINOLOGY

Risk of Dementia Among Patients With Asthma: A Nationwide Longitudinal Study

(2014) Mu-Hong Chen et al.   Journal of the American Medical Directors Association

Histamine Induces Upregulated Expression of Histamine Receptors and Increases Release of Inflammatory Mediators from Microglia

(2014) Hongquan Dong et al.   MOLECULAR NEUROBIOLOGY

Microglial priming in neurodegenerative disease

(2014) V. Hugh Perry et al.   Nature Reviews Neurology

Traumatic brain injury and risk of dementia in older veterans

(2014) D. E. Barnes et al.   NEUROLOGY

Chronic stress as a risk factor for Alzheimer’s disease

(2014) Alberto Machado et al.   REVIEWS IN THE NEUROSCIENCES

Effect of stress on brain inflammation and multiple sclerosis

(2013) Anna Karagkouni et al.   AUTOIMMUNITY REVIEWS

Genetic interactions found between calcium channel genes modulate amyloid load measured by positron emission tomography

(2013) Mary Ellen I. Koran et al.   HUMAN GENETICS

Innate and adaptive immune responses in neurodegeneration and repair

(2013) Sandra Amor et al.   IMMUNOLOGY

Focal brain inflammation and autism

(2013) Theoharis C Theoharides et al.   Journal of Neuroinflammation

Glia Maturation Factor Expression in Hippocampus of Human Alzheimer’s Disease

(2013) Deirdre Stolmeier et al.   NEUROCHEMICAL RESEARCH

Glia Maturation Factor Expression in Entorhinal Cortex of Alzheimer’s Disease Brain

(2013) Ramasamy Thangavel et al.   NEUROCHEMICAL RESEARCH

Histamine from Brain Resident MAST Cells Promotes Wakefulness and Modulates Behavioral States

(2013) Sachiko Chikahisa et al.   PLoS One

Contribution of stress to asthma worsening through mast cell activation

(2012) Theoharis C. Theoharides et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Microglia and mast cells: two tracks on the road to neuroinflammation

(2012) Stephen D. Skaper et al.   FASEB JOURNAL

IgE and mast cells in allergic disease

(2012) Stephen J Galli et al.   NATURE MEDICINE

Stress and the developing adolescent brain

(2012) L. Eiland et al.   NEUROSCIENCE

Neurotensin and CRH Interactions Augment Human Mast Cell Activation

(2012) Konstantinos–Dionysios Alysandratos et al.   PLoS One

Posttraumatic Stress Disorder in Children and Adolescents: Neuroendocrine Perspectives

(2012) P. Pervanidou et al.   Science Signaling

Inflammatory Factors Contribute to Depression and Its Comorbid Conditions

(2012) H. Anisman et al.   Science Signaling

Mast Cells Respond to Cell Injury through the Recognition of IL-33

(2012) Carolina Lunderius-Andersson et al.   Frontiers in Immunology

Widespread Tau and Amyloid-Beta Pathology Many Years After a Single Traumatic Brain Injury in Humans

(2011) Victoria E. Johnson et al.   BRAIN PATHOLOGY

Production and functions of IL-33 in the central nervous system

(2011) Satoko Yasuoka et al.   BRAIN RESEARCH

Cytokine Levels as Potential Biomarkers for Predicting the Development of Posttraumatic Stress Symptoms in Casualties of Accidents

(2011) Miri Cohen et al.   INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE

Cutting Edge: Mast Cells Regulate Disease Severity in a Relapsing-Remitting Model of Multiple Sclerosis

(2011) B. A. Sayed et al.   JOURNAL OF IMMUNOLOGY

Signal pathways in astrocytes activated by cross-talk between of astrocytes and mast cells through CD40-CD40L

(2011) Dae Kim et al.   Journal of Neuroinflammation

Work-Related Stress May Increase the Risk of Vascular Dementia

(2011) Ross Andel et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Augmented expression of glia maturation factor in Alzheimer's disease

(2011) S. Zaheer et al.   NEUROSCIENCE

Toward an Anti-Inflammatory Strategy for Depression

(2011) Shawn Hayley   Frontiers in Behavioral Neuroscience

Mast cells and inflammation

(2010) Theoharis C. Theoharides et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Brain metastases of mouse mammary adenocarcinoma is increased by acute stress

(2010) Jacek J. Rozniecki et al.   BRAIN RESEARCH

Suppression of neuro inflammation in experimental autoimmune encephalomyelitis by glia maturation factor antibody

(2010) Smita Zaheer et al.   BRAIN RESEARCH

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Modern Approaches to the Diagnosis and Treatment of Cold Contact Urticaria

(2010) Karoline Krause et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Therapeutic potential of some stress mediators in early Alzheimer's disease

(2010) Marie-Christine Pardon   EXPERIMENTAL GERONTOLOGY

Microglia in neurodegenerative disease

(2010) V. Hugh Perry et al.   Nature Reviews Neurology

IL-33 augments substance P-induced VEGF secretion from human mast cells and is increased in psoriatic skin

(2010) T. C. Theoharides et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An emerging role of mast cells in cerebral ischemia and hemorrhage

(2009) Daniel Strbian et al.   ANNALS OF MEDICINE

Mitochondrial Uncoupling Protein 2 Inhibits Mast Cell Activation and Reduces Histamine Content

(2009) M. Tagen et al.   JOURNAL OF IMMUNOLOGY

Role of mast cell activation in inducing microglial cells to release neurotrophin

(2009) Hongbin Yuan et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Glia maturation factor modulates β-amyloid-induced glial activation, inflammatory cytokine/chemokine production and neuronal damage

(2008) Asgar Zaheer et al.   BRAIN RESEARCH

Induction of IL-33 expression and activity in central nervous system glia

(2008) Chad A. Hudson et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Impact of stress and mast cells on brain metastases

(2008) Theoharis C. Theoharides et al.   JOURNAL OF NEUROIMMUNOLOGY

New developments in mast cell biology

(2008) Janet Kalesnikoff et al.   NATURE IMMUNOLOGY

Brain mast cells link the immune system to anxiety-like behavior

(2008) K. M. Nautiyal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA