Development of a pancreas-liver organ-on-chip coculture model for organ-to-organ interaction studies

Tubular bile duct structure mimicking bile duct morphogenesis for prospective in vitro liver metabolite recovery

(2020) Astia Rizki-Safitri et al.   Journal of Biological Engineering

Microwell-based pancreas-on-chip model enhances genes expression and functionality of rat islets of Langerhans

(2020) Amal Essaouiba et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Diabetes Mellitus and Its Cardiovascular Complications: New Insights into an Old Disease

(2019) Celestino Sardu et al.   Journal of Diabetes Research

Non-invasive marker-independent high content analysis of a microphysiological human pancreas-on-a-chip model

(2019) Aline Zbinden et al.   MATRIX BIOLOGY

In vivo–mimicking microfluidic perfusion culture of pancreatic islet spheroids

(2019) Yesl Jun et al.   Science Advances

Organ/body-on-a-chip based on microfluidic technology for drug discovery

(2018) Hiroshi Kimura et al.   Drug Metabolism and Pharmacokinetics

The molecular functions of hepatocyte nuclear factors – In and beyond the liver

(2018) Hwee Hui Lau et al.   JOURNAL OF HEPATOLOGY

Stem-cell based organ-on-a-chip models for diabetes research

(2018) Julia Rogal et al.   ADVANCED DRUG DELIVERY REVIEWS

Insulin Secretion Depends on Intra-islet Glucagon Signaling

(2018) Berit Svendsen et al.   Cell Reports

3D-templated, fully automated microfluidic input/output multiplexer for endocrine tissue culture and secretion sampling

(2017) Xiangpeng Li et al.   LAB ON A CHIP

Microphysiological Analysis Platform of Pancreatic Islet β-Cell Spheroids

(2017) Sang Hun Lee et al.   Advanced Healthcare Materials

Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model

(2017) Sophie Bauer et al.   Scientific Reports

Macro-to-micro interfacing to microfluidic channels using 3D-printed templates: application to time-resolved secretion sampling of endocrine tissue

(2016) Jessica C. Brooks et al.   ANALYST

Animal models for diabetes: Understanding the pathogenesis and finding new treatments

(2016) Aileen King et al.   BIOCHEMICAL PHARMACOLOGY

Long-term human primary hepatocyte cultures in a microfluidic liver biochip show maintenance of mRNA levels and higher drug metabolism compared with Petri cultures

(2016) Rachid Jellali et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Liver and kidney cells cultures in a new perfluoropolyether biochip

(2016) Rachid Jellali et al.   SENSORS AND ACTUATORS B-CHEMICAL

Investigation of omeprazole and phenacetin first-pass metabolism in humans using a microscale bioreactor and pharmacokinetic models

(2015) Thibault Bricks et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Nonalcoholic Fatty Liver Disease and Type 2 Diabetes: Common Pathophysiologic Mechanisms

(2015) Chiara Saponaro et al.   Current Diabetes Reports

The Basic Helix-Loop-Helix Transcription Factor NEUROG3 Is Required for Development of the Human Endocrine Pancreas

(2015) Patrick S. McGrath et al.   DIABETES

New physiologically-relevant liver tissue model based on hierarchically cocultured primary rat hepatocytes with liver endothelial cells

(2015) Wenjin Xiao et al.   Integrative Biology

Insulin Is Required to Maintain Albumin Expression by Inhibiting Forkhead Box O1 Protein

(2015) Qing Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Type 2 diabetes mellitus

(2015) Ralph A. DeFronzo et al.   Nature Reviews Disease Primers

Pdx1 Maintains β Cell Identity and Function by Repressing an α Cell Program

(2014) Tao Gao et al.   Cell Metabolism

Organs-on-a-chip: a new tool for drug discovery

(2014) Alessandro Polini et al.   Expert Opinion on Drug Discovery

Approaching the in vitro clinical trial: engineering organs on chips

(2014) A. K. Capulli et al.   LAB ON A CHIP

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

(2014) Rachel J. Perry et al.   NATURE

Investigation of expression and activity levels of primary rat hepatocyte detoxication genes under various flow rates and cell densities in microfluidic biochips

(2013) Régis Baudoin et al.   BIOTECHNOLOGY PROGRESS

Metabolic Characterization of Primary Rat Hepatocytes Cultivated in Parallel Microfluidic Biochips

(2013) Audrey Legendre et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Mechanisms of Diabetic Complications

(2013) Josephine M. Forbes et al.   PHYSIOLOGICAL REVIEWS

Biomimetic tissues on a chip for drug discovery

(2011) Amir M. Ghaemmaghami et al.   DRUG DISCOVERY TODAY

Behavior of HepG2/C3A cell cultures in a microfluidic bioreactor

(2010) Régis Baudoin et al.   BIOCHEMICAL ENGINEERING JOURNAL

Pancreatic β Cells Require NeuroD to Achieve and Maintain Functional Maturity

(2010) Chunyan Gu et al.   Cell Metabolism

Defects in Insulin Secretion and Action in the Pathogenesis of Type 2 Diabetes Mellitus

(2010) Devjit Tripathy et al.   Current Diabetes Reports

Relationship between insulin resistance, inflammation and liver cell apoptosis in patients with severe obesity

(2010) M. Civera et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Hepatocyte nuclear factor 4α regulation of bile acid and drug metabolism

(2009) John YL Chiang   Expert Opinion on Drug Metabolism & Toxicology

Down-Regulation of Hepatic HNF4α Gene Expression during Hyperinsulinemia via SREBPs

(2009) Xuefen Xie et al.   MOLECULAR ENDOCRINOLOGY

Crosstalk between angiogenesis, cytokeratin-18, and insulinresistance in the progression of non-alcoholic steatohepatitis

(2009) Mitsuteru Kitade et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Pck1 Gene Silencing in the Liver Improves Glycemia Control, Insulin Sensitivity, and Dyslipidemia in db/db Mice

(2008) A. G. Gomez-Valades et al.   DIABETES