The roles of signaling pathways in SARS-CoV-2 infection; lessons learned from SARS-CoV and MERS-CoV

Circular RNA circRHOBTB3 acts as a sponge for miR-654-3p inhibiting gastric cancer growth

(2020) Guangxu Deng et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

U1 snRNP regulates cancer cell migration and invasion in vitro

(2020) Jung-Min Oh et al.   Nature Communications

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

(2020) Zhe Xu et al.   Lancet Respiratory Medicine

Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses

(2020) Michael Letko et al.   Nature Microbiology

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

(2020) Daniel Blanco-Melo et al.   CELL

Weak Induction of Interferon Expression by SARS-CoV-2 Supports Clinical Trials of Interferon Lambda to Treat Early COVID-19

(2020) Thomas R O’Brien et al.   CLINICAL INFECTIOUS DISEASES

Middle East respiratory syndrome coronavirus nucleocapsid protein suppresses type I and type III interferon induction by targeting RIG-I signaling

(2020) Chi-You Chang et al.   JOURNAL OF VIROLOGY

Should we try the antiinflammatory natural product, celastrol, for COVID ‐19?

(2020) Solomon Habtemariam et al.   PHYTOTHERAPY RESEARCH

Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors

(2020) Linlin Zhang et al.   SCIENCE

Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19)

(2020) Bo Diao et al.   Frontiers in Immunology

COVID-19 Infection in Cancer Patients: How Can Oncologists Deal With These Patients?

(2020) Oronzo Brunetti et al.   Frontiers in Oncology

Antiviral activities of type I interferons to SARS-CoV-2 infection

(2020) Emily Mantlo et al.   ANTIVIRAL RESEARCH

Type 1 interferons as a potential treatment against COVID-19

(2020) Erwan Sallard et al.   ANTIVIRAL RESEARCH

A cytokine super cyclone in COVID-19 patients with risk factors: the therapeutic potential of BCG immunization

(2020) Betcy Susan Johnson et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Metformin in COVID-19: A possible role beyond diabetes

(2020) Swati Sharma et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Inhibition of SARS-CoV-2 by type I and type III interferons

(2020) Ulrike Felgenhauer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p38 MAPK inhibition: A promising therapeutic approach for COVID-19

(2020) Joseph M. Grimes et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Repurposing of Kinase Inhibitors for Treatment of COVID-19

(2020) Ellen Weisberg et al.   PHARMACEUTICAL RESEARCH

Lianhuaqingwen exerts anti-viral and anti-inflammatory activity against novel coronavirus (SARS-CoV-2)

(2020) Li Runfeng et al.   PHARMACOLOGICAL RESEARCH

Double-Membrane Vesicles as Platforms for Viral Replication

(2020) Georg Wolff et al.   TRENDS IN MICROBIOLOGY

Neutrophils, Crucial, or Harmful Immune Cells Involved in Coronavirus Infection: A Bioinformatics Study

(2020) Nima Hemmat et al.   Frontiers in Genetics

Extrapulmonary Clinical Manifestations in COVID-19 Patients

(2020) Aila Sarkesh et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

In vitro evaluation of antiviral activity of single and combined repurposable drugs against SARS-CoV-2

(2020) Andrés Pizzorno et al.   ANTIVIRAL RESEARCH

Virtual screening of approved drugs as potential SARS-CoV-2 main protease inhibitors

(2020) Alicia Jiménez-Alberto et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

The ORF6, ORF8 and nucleocapsid proteins of SARS-CoV-2 inhibit type I interferon signaling pathway

(2020) Jin-Yan Li et al.   VIRUS RESEARCH

On-target versus off-target effects of drugs inhibiting the replication of SARS-CoV-2

(2020) Allan Sauvat et al.   Cell Death & Disease

Evasion of Type I Interferon by SARS-CoV-2

(2020) Hongjie Xia et al.   Cell Reports

Severe acute respiratory syndrome coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of ASC

(2019) Kam-Leung Siu et al.   FASEB JOURNAL

Coronavirus envelope protein: current knowledge

(2019) Dewald Schoeman et al.   Virology Journal

Middle East respiratory syndrome coronavirus-encoded ORF8b strongly antagonizes IFN-β promoter activation: its implication for vaccine design

(2019) Jeong Yoon Lee et al.   JOURNAL OF MICROBIOLOGY

Middle East Respiratory Syndrome Coronavirus-Encoded Accessory Proteins Impair MDA5-and TBK1-Mediated Activation of NF-��B

(2019) Jeong Yoon Lee et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

A Perspective on the Development of TGF-β Inhibitors for Cancer Treatment

(2019) Huynh et al.   Biomolecules

Mutant p53 as a therapeutic target for the treatment of triple-negative breast cancer: Preclinical investigation with the anti-p53 drug, PK11007

(2018) Naoise C. Synnott et al.   CANCER LETTERS

Porcine Epidemic Diarrhea Virus-Induced Epidermal Growth Factor Receptor Activation Impairs the Antiviral Activity of Type I Interferon

(2018) Lijun Yang et al.   JOURNAL OF VIROLOGY

Respiratory syncytial virus activates epidermal growth factor receptor to suppress interferon regulatory factor 1-dependent interferon-lambda and antiviral defense in airway epithelium

(2018) A Kalinowski et al.   Mucosal Immunology

Viruses as key modulators of the TGF-β pathway; a double-edged sword involved in cancer

(2018) Habibollah Mirzaei et al.   REVIEWS IN MEDICAL VIROLOGY

Accessory proteins 8b and 8ab of severe acute respiratory syndrome coronavirus suppress the interferon signaling pathway by mediating ubiquitin-dependent rapid degradation of interferon regulatory factor 3

(2018) Hui Hui Wong et al.   VIROLOGY

Epidermal growth factor receptor is a co-factor for transmissible gastroenteritis virus entry

(2018) Weiwei Hu et al.   VIROLOGY

MERS-CoV 4b protein interferes with the NF-κB-dependent innate immune response during infection

(2018) Javier Canton et al.   PLoS Pathogens

The Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Inhibits Type I Interferon Production by Interfering with TRIM25-Mediated RIG-I Ubiquitination

(2017) Yong Hu et al.   JOURNAL OF VIROLOGY

Overactive Epidermal Growth Factor Receptor Signaling Leads to Increased Fibrosis after Severe Acute Respiratory Syndrome Coronavirus Infection

(2017) Thiagarajan Venkataraman et al.   JOURNAL OF VIROLOGY

MERS, SARS and other coronaviruses as causes of pneumonia

(2017) Yudong Yin et al.   RESPIROLOGY

SARS coronavirus papain-like protease up-regulates the collagen expression through non-Samd TGF-β1 signaling

(2017) Ching-Ying Wang et al.   VIRUS RESEARCH

Activation of the c-Jun NH2-terminal kinase pathway by coronavirus infectious bronchitis virus promotes apoptosis independently of c-Jun

(2017) To Sing Fung et al.   Cell Death & Disease

Triptolide inhibits the function of TNF-α in osteoblast differentiation by inhibiting the NF-κB signaling pathway

(2017) Shen-Peng Liu et al.   Experimental and Therapeutic Medicine

Early endonuclease-mediated evasion of RNA sensing ensures efficient coronavirus replication

(2017) Eveline Kindler et al.   PLoS Pathogens

Berberine Restricts Coxsackievirus B Type 3 Replication via Inhibition of c-Jun N-Terminal Kinase (JNK) and p38 MAPK Activation In Vitro

(2017) Qian Dai et al.   MEDICAL SCIENCE MONITOR

JNK, p38, ERK, and SGK1 Inhibitors in Cancer

(2017) Jonas Cicenas et al.   Cancers

Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness

(2017) Michiru Nishita et al.   Scientific Reports

The p53 Pathway: Origins, Inactivation in Cancer, and Emerging Therapeutic Approaches

(2016) Andreas C. Joerger et al.   Annual Review of Biochemistry

The effect of inhibition of PP1 and TNFα signaling on pathogenesis of SARS coronavirus

(2016) Jason E. McDermott et al.   BMC Systems Biology

The p38 MAPK inhibitor BIRB796 enhances the antitumor effects of VX680 in cervical cancer

(2016) Xin Jin et al.   CANCER BIOLOGY & THERAPY

Identification of Interferon-Stimulated Genes with Antiretroviral Activity

(2016) Melissa Kane et al.   Cell Host & Microbe

Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice

(2016) Rudragouda Channappanavar et al.   Cell Host & Microbe

Clinical Progression and Cytokine Profiles of Middle East Respiratory Syndrome Coronavirus Infection

(2016) Eu Suk Kim et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Next-generation epidermal growth factor receptor tyrosine kinase inhibitors in epidermal growth factor receptor -mutant non-small cell lung cancer

(2016) Chee-Seng Tan et al.   LUNG CANCER

SARS and MERS: recent insights into emerging coronaviruses

(2016) Emmie de Wit et al.   NATURE REVIEWS MICROBIOLOGY

p53 down-regulates SARS coronavirus replication and is targeted by the SARS-unique domain and PLprovia E3 ubiquitin ligase RCHY1

(2016) Yue Ma-Lauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MERS-CoV vaccine candidates in development: The current landscape

(2016) Kayvon Modjarrad   VACCINE

SARS coronavirus papain-like protease induces Egr-1-dependent up-regulation of TGF-β1 via ROS/p38 MAPK/STAT3 pathway

(2016) Shih-Wein Li et al.   Scientific Reports

Middle East respiratory syndrome coronavirus M protein suppresses type I interferon expression through the inhibition of TBK1-dependent phosphorylation of IRF3

(2016) Pak-Yin Lui et al.   Emerging Microbes & Infections

Viral Evasion Strategies in Type I IFN Signaling – A Summary of Recent Developments

(2016) Katharina S. Schulz et al.   Frontiers in Immunology

Novel TGF-β inhibitors ready for prime time in onco-immunology

(2016) Armand de Gramont et al.   OncoImmunology

MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2

(2016) Man-Lung Yeung et al.   Nature Microbiology

Metformin is a novel suppressor for transforming growth factor (TGF)-β1

(2016) Han Xiao et al.   Scientific Reports

The c-Jun N-terminal kinase inhibitor SP600125 inhibits human cytomegalovirus replication

(2015) Huiping Zhang et al.   JOURNAL OF MEDICAL VIROLOGY

Ginsenoside Rg1 Ameliorates Motor Function in an Animal Model of Parkinson's Disease

(2015) Wenda Jiang et al.   PHARMACOLOGY

Severe acute respiratory syndrome coronavirus E protein transports calcium ions and activates the NLRP3 inflammasome

(2015) Jose L. Nieto-Torres et al.   VIROLOGY

Middle East respiratory syndrome coronavirus ORF4b protein inhibits type I interferon production through both cytoplasmic and nuclear targets

(2015) Yang Yang et al.   Scientific Reports

State of the art paper Tumor necrosis factor inhibitors – state of knowledge

(2015) Krzysztof Lis et al.   Archives of Medical Science

Targeting JNK-interacting-protein-1 (JIP1) sensitises osteosarcoma to doxorubicin

(2015) Jantine PosthumadeBoer et al.   Oncotarget

Antiviral Potential of ERK/MAPK and PI3K/AKT/mTOR Signaling Modulation for Middle East Respiratory Syndrome Coronavirus Infection as Identified by Temporal Kinome Analysis

(2014) Jason Kindrachuk et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Severe acute respiratory syndrome vs. the Middle East respiratory syndrome

(2014) David S. Hui et al.   CURRENT OPINION IN PULMONARY MEDICINE

Targeting EGFR signalling in chronic lung disease: therapeutic challenges and opportunities

(2014) S. Vallath et al.   EUROPEAN RESPIRATORY JOURNAL

p53 Degradation by a Coronavirus Papain-like Protease Suppresses Type I Interferon Signaling

(2014) Lin Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nidovirus papain-like proteases: Multifunctional enzymes with protease, deubiquitinating and deISGylating activities

(2014) Anna M. Mielech et al.   VIRUS RESEARCH

The Coronavirus Nucleocapsid Is a Multifunctional Protein

(2014) Ruth McBride et al.   Viruses-Basel

Coronaviruses Induce Entry-Independent, Continuous Macropinocytosis

(2014) M. C. Freeman et al.   mBio

The PDZ-Binding Motif of Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Is a Determinant of Viral Pathogenesis

(2014) Jose M. Jimenez-Guardeño et al.   PLoS Pathogens

SARS coronavirus papain-like protease inhibits the type I interferon signaling pathway through interaction with the STING-TRAF3-TBK1 complex

(2014) Xiaojuan Chen et al.   Protein & Cell

Peripheral Injection of SB203580 Inhibits the Inflammatory-Dependent Synthesis of Proinflammatory Cytokines in the Hypothalamus

(2014) Andrzej P. Herman et al.   Biomed Research International

JNK signalling in cancer: in need of new, smarter therapeutic targets

(2013) Concetta Bubici et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibition of NF- B-Mediated Inflammation in Severe Acute Respiratory Syndrome Coronavirus-Infected Mice Increases Survival

(2013) M. L. DeDiego et al.   JOURNAL OF VIROLOGY

Middle East Respiratory Syndrome Coronavirus (MERS-CoV): Announcement of the Coronavirus Study Group

(2013) R. J. de Groot et al.   JOURNAL OF VIROLOGY

Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC

(2013) V. Stalin Raj et al.   NATURE

Make Yourself at Home: Viral Hijacking of the PI3K/Akt Signaling Pathway

(2013) Nora Diehl et al.   Viruses-Basel

Cell Host Response to Infection with Novel Human Coronavirus EMC Predicts Potential Antivirals and Important Differences with SARS Coronavirus

(2013) L. Josset et al.   mBio

Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

(2012) Ali M. Zaki et al.   NEW ENGLAND JOURNAL OF MEDICINE

Distinct Regulation of Host Responses by ERK and JNK MAP Kinases in Swine Macrophages Infected with Pandemic (H1N1) 2009 Influenza Virus

(2012) Wei Gao et al.   PLoS One

Up-Regulation of Mcl-1 and Bak by Coronavirus Infection of Human, Avian and Animal Cells Modulates Apoptosis and Viral Replication

(2012) Yanxin Zhong et al.   PLoS One

Respiratory Syncytial Virus Matrix Protein Induces Lung Epithelial Cell Cycle Arrest through a p53 Dependent Pathway

(2012) Tao Bian et al.   PLoS One

Genome guardian p53 and viral infections

(2012) Yoshitaka Sato et al.   REVIEWS IN MEDICAL VIROLOGY

AS601245, an Anti-Inflammatory JNK Inhibitor, and Clofibrate Have a Synergistic Effect in Inducing Cell Responses and in Affecting the Gene Expression Profile in CaCo-2 Colon Cancer Cells

(2012) Angelo Cerbone et al.   PPAR Research

SARS coronavirus pathogenesis: host innate immune responses and viral antagonism of interferon

(2012) Allison L Totura et al.   Current Opinion in Virology

SARS-CoV Accessory Protein 3b Induces AP-1 Transcriptional Activity through Activation of JNK and ERK Pathways

(2011) Bhavna Varshney et al.   BIOCHEMISTRY

Regulation of the p38 mitogen-activated protein kinase and dual-specificity phosphatase 1 feedback loop modulates the induction of interleukin 6 and 8 in cells infected with coronavirus infectious bronchitis virus

(2011) Ying Liao et al.   VIROLOGY

Mechanisms and functions of p38 MAPK signalling

(2010) Ana Cuadrado et al.   BIOCHEMICAL JOURNAL

Identification of known drugs that act as inhibitors of NF-κB signaling and their mechanism of action

(2010) Susanne C. Miller et al.   BIOCHEMICAL PHARMACOLOGY

To kill or be killed: how viruses interact with the cell death machinery

(2010) V. Kaminskyy et al.   JOURNAL OF INTERNAL MEDICINE

The Ubiquitin-Proteasome System Plays an Important Role during Various Stages of the Coronavirus Infection Cycle

(2010) M. Raaben et al.   JOURNAL OF VIROLOGY

Deubiquitinating and Interferon Antagonism Activities of Coronavirus Papain-Like Proteases

(2010) M. A. Clementz et al.   JOURNAL OF VIROLOGY

EGFR Signaling and Drug Discovery

(2010) Georg Lurje et al.   ONCOLOGY

Dual Role of p53 in Innate Antiviral Immunity

(2010) Carmen Rivas et al.   Viruses-Basel

p53 Research: The Past Thirty Years and the Next Thirty Years

(2010) D. Lane et al.   Cold Spring Harbor Perspectives in Biology

The Epidermal Growth Factor Receptor (EGFR) Promotes Uptake of Influenza A Viruses (IAV) into Host Cells

(2010) Thorsten Eierhoff et al.   PLoS Pathogens

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

Critical role of p38 mitogen-activated protein kinase signaling in septic lung injury*

(2009) Muhammad Asaduzzaman et al.   CRITICAL CARE MEDICINE

Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites

(2009) S. Belouzard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A SARS-CoV protein, ORF-6, induces caspase-3 mediated, ER stress and JNK-dependent apoptosis

(2008) Zhongde Ye et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Roles of TNF-α gene polymorphisms in the occurrence and progress of SARS-Cov infection: A case-control study

(2008) Shixin Wang et al.   BMC INFECTIOUS DISEASES

Transcriptional role of p53 in interferon-mediated antiviral immunity

(2008) César Muñoz-Fontela et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Severe acute respiratory syndrome coronavirus 3a protein activates the mitochondrial death pathway through p38 MAP kinase activation

(2008) K. Padhan et al.   JOURNAL OF GENERAL VIROLOGY

Global trends in emerging infectious diseases

(2008) Kate E. Jones et al.   NATURE

TGF-β1 targets the GSK-3β/β-catenin pathway via ERK activation in the transition of human lung fibroblasts into myofibroblasts

(2008) F CARACI et al.   PHARMACOLOGICAL RESEARCH

Modulation of TNF- -converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF-  production and facilitates viral entry

(2008) S. Haga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of human coronavirus 229E infection in human epithelial lung cells (L132) by chloroquine: Involvement of p38 MAPK and ERK

(2007) Masakazu Kono et al.   ANTIVIRAL RESEARCH