Apicobasal polarity of brain endothelial cells

Cerebral Cavernous Malformation-1 Protein Controls DLL4-Notch3 Signaling Between the Endothelium and Pericytes

(2015) G. B. Schulz et al.   STROKE

Phosphoinositide 3-kinase p110δ promotes lumen formation through the enhancement of apico-basal polarity and basal membrane organization

(2015) Juan Peng et al.   Nature Communications

Integrin β1 controls VE-cadherin localization and blood vessel stability

(2015) Hiroyuki Yamamoto et al.   Nature Communications

GPR124 Functions as a WNT7-Specific Coactivator of Canonical β-Catenin Signaling

(2015) Ekaterina Posokhova et al.   Cell Reports

Permeability Analysis of Neuroactive Drugs Through a Dynamic Microfluidic In Vitro Blood–Brain Barrier Model

(2014) R. Booth et al.   ANNALS OF BIOMEDICAL ENGINEERING

Protein kinase C restricts transport of carnitine by amino acid transporter ATB0,+ apically localized in the blood–brain barrier

(2014) Katarzyna Michalec et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Endophilin-1 regulates blood–brain barrier permeability by controlling ZO-1 and occludin expression via the EGFR–ERK1/2 pathway

(2014) Wenjing Liu et al.   BRAIN RESEARCH

Picking up the threads: extracellular matrix signals in epithelial morphogenesis

(2014) Alejo E Rodriguez-Fraticelli et al.   CURRENT OPINION IN CELL BIOLOGY

Differential Apicobasal VEGF Signaling at Vascular Blood-Neural Barriers

(2014) Natalie Hudson et al.   DEVELOPMENTAL CELL

Cerebral cavernous malformation proteins at a glance

(2014) Kyle M. Draheim et al.   JOURNAL OF CELL SCIENCE

Enhanced sphingosine-1-phosphate receptor 2 expression underlies female CNS autoimmunity susceptibility

(2014) Lillian Cruz-Orengo et al.   JOURNAL OF CLINICAL INVESTIGATION

Mfsd2a is critical for the formation and function of the blood–brain barrier

(2014) Ayal Ben-Zvi et al.   NATURE

Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid

(2014) Long N. Nguyen et al.   NATURE

Endophilin marks and controls a clathrin-independent endocytic pathway

(2014) Emmanuel Boucrot et al.   NATURE

Molecular mechanisms of de novo lumen formation

(2014) Sara Sigurbjörnsdóttir et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Organization and execution of the epithelial polarity programme

(2014) Enrique Rodriguez-Boulan et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Rewiring cell polarity signaling in cancer

(2014) R Halaoui et al.   ONCOGENE

Cargo Sorting in the Endocytic Pathway: A Key Regulator of Cell Polarity and Tissue Dynamics

(2014) S. Eaton et al.   Cold Spring Harbor Perspectives in Biology

Rap1 signaling in endothelial barrier control

(2014) Willem-Jan Pannekoek et al.   Cell Adhesion & Migration

RhoA and Membrane Fluidity Mediates the Spatially Polarized Src/FAK Activation in Response to Shear Stress

(2014) Bo Liu et al.   Scientific Reports

Cellular and molecular mechanisms underlying blood vessel lumen formation

(2013) Marta S. Charpentier et al.   BIOESSAYS

The Polarity Protein Scrib Is Essential for Directed Endothelial Cell Migration

(2013) U. Ruth Michaelis et al.   CIRCULATION RESEARCH

Complexities of Crumbs Function and Regulation in Tissue Morphogenesis

(2013) Shirin Meher Pocha et al.   CURRENT BIOLOGY

Polarizing pathways: Balancing endothelial polarity, permeability, and lumen formation

(2013) Carlos O. Lizama et al.   EXPERIMENTAL CELL RESEARCH

Glial influence on the blood brain barrier

(2013) Jorge Ivan Alvarez et al.   GLIA

Discs Large 1 (Dlg1) Scaffolding Protein Participates with Clathrin and Adaptator Protein Complex 1 (AP-1) in Forming Weibel-Palade Bodies of Endothelial Cells

(2013) Monique Philippe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Wnt/Planar Cell Polarity Signaling Pathway Contributes to the Integrity of Tight Junctions in Brain Endothelial Cells

(2013) Cédric Artus et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

CLN3 Loss Disturbs Membrane Microdomain Properties and Protein Transport in Brain Endothelial Cells

(2013) L. Tecedor et al.   JOURNAL OF NEUROSCIENCE

Quantitative Atlas of Blood–Brain Barrier Transporters, Receptors, and Tight Junction Proteins in Rats and Common Marmoset

(2013) Yutaro Hoshi et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

The endothelial glycocalyx in syndecan-1 deficient mice

(2013) Michele D. Savery et al.   MICROVASCULAR RESEARCH

Spatial regulation of VEGF receptor endocytosis in angiogenesis

(2013) Masanori Nakayama et al.   NATURE CELL BIOLOGY

Identification of an essential endogenous regulator of blood-brain barrier integrity, and its pathological and therapeutic implications

(2013) E. Cristante et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polarity in Mammalian Epithelial Morphogenesis

(2013) J. Roignot et al.   Cold Spring Harbor Perspectives in Biology

VEGF and Angiopoietin-1 exert opposing effects on cell junctions by regulating the Rho GEF Syx

(2012) Siu P. Ngok et al.   JOURNAL OF CELL BIOLOGY

P-glycoprotein trafficking at the blood-brain barrier altered by peripheral inflammatory hyperalgesia

(2012) Gwen McCaffrey et al.   JOURNAL OF NEUROCHEMISTRY

Relocalization of Junctional Adhesion Molecule A during Inflammatory Stimulation of Brain Endothelial Cells

(2012) S. M. Stamatovic et al.   MOLECULAR AND CELLULAR BIOLOGY

Localization Microscopy (SPDM) Reveals Clustered Formations of P-Glycoprotein in a Human Blood-Brain Barrier Model

(2012) Olga Huber et al.   PLoS One

Targeting blood-brain barrier sphingolipid signaling reduces basal P-glycoprotein activity and improves drug delivery to the brain

(2012) R. E. Cannon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Apical Polarity Protein Network in Drosophila Epithelial Cells: Regulation of Polarity, Junctions, Morphogenesis, Cell Growth, and Survival

(2011) Ulrich Tepass   Annual Review of Cell and Developmental Biology

The role of shear stress in Blood-Brain Barrier endothelial physiology

(2011) Luca Cucullo et al.   BMC NEUROSCIENCE

Epithelial polarity and morphogenesis

(2011) Daniel St Johnston et al.   CURRENT OPINION IN CELL BIOLOGY

Ccm3 functions in a manner distinct from Ccm1 and Ccm2 in a zebrafish model of CCM vascular disease

(2011) Bilge Yoruk et al.   DEVELOPMENTAL BIOLOGY

Blood Vessel Tubulogenesis Requires Rasip1 Regulation of GTPase Signaling

(2011) Ke Xu et al.   DEVELOPMENTAL CELL

Differential axial localization along the mouse brain vascular tree of luminal sodium-dependent glutamine transporters Snat1 and Snat3

(2011) Nadine Ruderisch et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice

(2011) Aubrey C. Chan et al.   JOURNAL OF CLINICAL INVESTIGATION

Developmental timing of CCM2 loss influences cerebral cavernous malformations in mice

(2011) Gwénola Boulday et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by luminal microvessel IL-6 and GM-CSF

(2011) Shinya Dohgu et al.   Journal of Neuroinflammation

Willin and Par3 cooperatively regulate epithelial apical constriction through aPKC-mediated ROCK phosphorylation

(2011) Takashi Ishiuchi et al.   NATURE CELL BIOLOGY

Molecular mechanism and physiological functions of clathrin-mediated endocytosis

(2011) Harvey T. McMahon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RhoA and NF-κB are involved in lipopolysaccharide-induced brain microvascular cell line hyperpermeability

(2011) F. He et al.   NEUROSCIENCE

The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence

(2011) J. I. Alvarez et al.   SCIENCE

Phosphoinositides in Cell Architecture

(2011) A. Shewan et al.   Cold Spring Harbor Perspectives in Biology

Myosin light chain kinase in microvascular endothelial barrier function

(2010) Q. Shen et al.   CARDIOVASCULAR RESEARCH

β1 Integrin Establishes Endothelial Cell Polarity and Arteriolar Lumen Formation via a Par3-Dependent Mechanism

(2010) Ann C. Zovein et al.   DEVELOPMENTAL CELL

Tuba, a Cdc42 GEF, is required for polarized spindle orientation during epithelial cyst formation

(2010) Yi Qin et al.   JOURNAL OF CELL BIOLOGY

CCM1 regulates vascular-lumen organization by inducing endothelial polarity

(2010) M. G. Lampugnani et al.   JOURNAL OF CELL SCIENCE

CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation

(2010) M. Fidalgo et al.   JOURNAL OF CELL SCIENCE

17-β-Estradiol: A Powerful Modulator of Blood–Brain Barrier BCRP Activity

(2010) Anika MS Hartz et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

CCM3 signaling through sterile 20–like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations

(2010) Xiangjian Zheng et al.   JOURNAL OF CLINICAL INVESTIGATION

Expression and clinical significance of multidrug resistance proteins in brain tumors

(2010) Zhenhua Guo et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity

(2010) Rebecca A. Stockton et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cellular localization of the organic cation transporters, OCT1 and OCT2, in brain microvessel endothelial cells and its implication for MPTP transport across the blood-brain barrier and MPTP-induced dopaminergic toxicity in rodents

(2010) Chun-Jung Lin et al.   JOURNAL OF NEUROCHEMISTRY

Regulation of CCL2 and CCL3 expression in human brain endothelial cells by cytokines and lipopolysaccharide

(2010) Ray Chui et al.   Journal of Neuroinflammation

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging

(2010) Robert D. Bell et al.   NEURON

The Mouse Blood-Brain Barrier Transcriptome: A New Resource for Understanding the Development and Function of Brain Endothelial Cells

(2010) Richard Daneman et al.   PLoS One

Apolipoprotein E Controls ATP-Binding Cassette Transporters in the Ischemic Brain

(2010) A. ElAli et al.   Science Signaling

Nipah virus infection and glycoprotein targeting in endothelial cells

(2010) Stephanie Erbar et al.   Virology Journal

Cerebral microvascular endothelial cell Na/H exchange: evidence for the presence of NHE1 and NHE2 isoforms and regulation by arginine vasopressin

(2009) Tina I. Lam et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Polarized P-glycoprotein expression by the immortalised human brain endothelial cell line, hCMEC/D3, restricts apical-to-basolateral permeability to rhodamine 123

(2009) Leon M. Tai et al.   BRAIN RESEARCH

Angiomotin-Like Protein 1 Controls Endothelial Polarity and Junction Stability During Sprouting Angiogenesis

(2009) Yujuan Zheng et al.   CIRCULATION RESEARCH

The Molecular Basis of Vascular Lumen Formation in the Developing Mouse Aorta

(2009) Boris Strilić et al.   DEVELOPMENTAL CELL

Rap1 and its effector KRIT1/CCM1 regulate  -catenin signaling

(2009) A. J. Glading et al.   Disease Models & Mechanisms

A Primary Role for Golgi Positioning in Directed Secretion, Cell Polarity, and Wound Healing

(2009) Smita Yadav et al.   MOLECULAR BIOLOGY OF THE CELL

Molecular signatures of disease brain endothelia provide new sites for CNS-directed enzyme therapy

(2009) Yong Hong Chen et al.   NATURE MEDICINE

The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases

(2009) Kevin J Whitehead et al.   NATURE MEDICINE

LKB1 and AMPK Family Signaling: The Intimate Link Between Cell Polarity and Energy Metabolism

(2009) Marnix Jansen et al.   PHYSIOLOGICAL REVIEWS

Wnt/ -catenin signaling is required for CNS, but not non-CNS, angiogenesis

(2009) R. Daneman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Meningococcal Type IV Pili Recruit the Polarity Complex to Cross the Brain Endothelium

(2009) Mathieu Coureuil et al.   SCIENCE

Syx, a RhoA Guanine Exchange Factor, Is Essential for Angiogenesis In Vivo

(2008) Maija K. Garnaas et al.   CIRCULATION RESEARCH

Rho-Kinase Phosphorylates PAR-3 and Disrupts PAR Complex Formation

(2008) Masanori Nakayama et al.   DEVELOPMENTAL CELL

All vertebrates started out with a glial blood-brain barrier 4-500 million years ago

(2008) Magnus Bundgaard et al.   GLIA

Cdc42- and Rac1-mediated endothelial lumen formation requires Pak2, Pak4 and Par3, and PKC-dependent signaling

(2008) W. Koh et al.   JOURNAL OF CELL SCIENCE

Coordinated Nuclear Receptor Regulation of the Efflux Transporter, Mrp2, and the Phase-Ii Metabolizing Enzyme, GSTπ, at the Blood—Brain Barrier

(2008) Björn Bauer et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Subcellular localization of transporters along the rat blood–brain barrier and blood–cerebral-spinal fluid barrier by in vivo biotinylation

(2008) L.M. Roberts et al.   NEUROSCIENCE

Control of tumourigenesis by the Scribble/Dlg/Lgl polarity module

(2008) P O Humbert et al.   ONCOGENE

Canonical Wnt Signaling Regulates Organ-Specific Assembly and Differentiation of CNS Vasculature

(2008) J. M. Stenman et al.   SCIENCE

Seizure-Induced Up-Regulation of P-Glycoprotein at the Blood-Brain Barrier through Glutamate and Cyclooxygenase-2 Signaling

(2007) B. Bauer et al.   MOLECULAR PHARMACOLOGY