A mini-review on ion fluxes that regulate NLRP3 inflammasome activation

Disulfiram suppresses NLRP3 inflammasome activation to treat peritoneal and gouty inflammation

(2020) Wenmin Deng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Balance between asymmetry and abundance in multi-domain DNA-binding proteins may regulate the kinetics of their binding to DNA

(2020) Arumay Pal et al.   PLoS Computational Biology

Cathepsin B Is Required for NLRP3 Inflammasome Activation in Macrophages, Through NLRP3 Interaction

(2020) Angélique Chevriaux et al.   Frontiers in Cell and Developmental Biology

Signaling pathways targeting mitochondrial potassium channels

(2020) Daria Rotko et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Recent advances in the NEK7-licensed NLRP3 inflammasome activation: Mechanisms, role in diseases and related inhibitors

(2020) Ni Zhao et al.   JOURNAL OF AUTOIMMUNITY

Chronic Manganese Administration with Longer Intervals Between Injections Produced Neurotoxicity and Hepatotoxicity in Rats

(2020) Xi-Min Fan et al.   NEUROCHEMICAL RESEARCH

Mucosal Abnormalities in Children With Congenital Chloride Diarrhea—An Underestimated Phenotypic Feature?

(2020) Elena Kurteva et al.   Frontiers in Pediatrics

Key Mechanisms and Potential Targets of the NLRP3 Inflammasome in Neurodegenerative Diseases

(2020) Yadi Guan et al.   Frontiers in Integrative Neuroscience

The gut microbiota attenuate neuroinflammation in manganese exposure by inhibiting cerebral NLRP3 inflammasome

(2020) Hui Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Anemia Severity Associated with Increased Healthcare Utilization and Costs in Inflammatory Bowel Disease

(2020) Hanna Blaney et al.   DIGESTIVE DISEASES AND SCIENCES

Manganese-induced neurodegenerative diseases and possible therapeutic approaches

(2020) Airton C. Martins et al.   Expert Review of Neurotherapeutics

Calcium-sensing receptor-mediated NLRP3 inflammasome response to calciprotein particles drives inflammation in rheumatoid arthritis

(2020) Elisabeth Jäger et al.   Nature Communications

Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells

(2019) Souvarish Sarkar et al.   Science Signaling

Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein

(2019) Dilshan S. Harischandra et al.   Science Signaling

Winning the war with iron

(2019) Suzy V. Torti et al.   Nature Nanotechnology

MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition

(2019) Rebecca C. Coll et al.   Nature Chemical Biology

MCC950 closes the active conformation of NLRP3 to an inactive state

(2019) Ana Tapia-Abellán et al.   Nature Chemical Biology

The chloride anion as a signalling effector

(2019) Ángel G. Valdivieso et al.   BIOLOGICAL REVIEWS

Magnesium protects against sepsis by blocking gasdermin D N-terminal-induced pyroptosis

(2019) Dingyu Wang et al.   CELL DEATH AND DIFFERENTIATION

The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

(2019) Nathan Kelley et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The role of magnesium in different inflammatory diseases

(2019) Abbas Shahi et al.   INFLAMMOPHARMACOLOGY

ENaC-mediated sodium influx exacerbates NLRP3-dependent inflammation in cystic fibrosis

(2019) Thomas Scambler et al.   eLife

Target of MCC950 in Inhibition of NLRP3 Inflammasome Activation: a Literature Review

(2019) Danbin Wu et al.   INFLAMMATION

Impact of dietary manganese on experimental colitis in mice

(2019) Eun‐Kyung Choi et al.   FASEB JOURNAL

Hypocalcemic disorders

(2018) Erin Bove-Fenderson et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Mechanistic insights into the protective impact of zinc on sepsis

(2018) Jolien Souffriau et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses

(2018) Chenguang Wang et al.   IMMUNITY

The TWIK2 Potassium Efflux Channel in Macrophages Mediates NLRP3 Inflammasome-Induced Inflammation

(2018) Anke Di et al.   IMMUNITY

Effects of MgSO 4 on inhibiting Nod-like receptor protein 3 inflammasome involve decreasing intracellular calcium

(2018) Ya-Ying Chang et al.   JOURNAL OF SURGICAL RESEARCH

The Essential Element Manganese, Oxidative Stress, and Metabolic Diseases: Links and Interactions

(2018) Longman Li et al.   Oxidative Medicine and Cellular Longevity

SLC39A14 deficiency alters manganese homeostasis and excretion resulting in brain manganese accumulation and motor deficits in mice

(2018) Supak Jenkitkasemwong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Orchestration of NLRP3 Inflammasome Activation by Ion Fluxes

(2018) Tao Gong et al.   TRENDS IN IMMUNOLOGY

Mitochondria-associated membranes in aging and senescence: structure, function, and dynamics

(2018) Justyna Janikiewicz et al.   Cell Death & Disease

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

(2018) Zhenyu Zhong et al.   NATURE

Chloride regulates dynamic NLRP3-dependent ASC oligomerization and inflammasome priming

(2018) Jack P. Green et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Magnesium isoglycyrrhizinate blocks fructose-induced hepatic NF-κB/NLRP3 inflammasome activation and lipid metabolism disorder

(2017) Xiao-Juan Zhao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Overview of iron metabolism in health and disease

(2017) Som Dev et al.   Hemodialysis International

The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1β transcription and activate the NLRP3 inflammasome

(2017) Raquel Domingo-Fernández et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Zinc inhibits high glucose-induced NLRP3 inflammasome activation in human peritoneal mesothelial cells

(2017) Yi Fan et al.   Molecular Medicine Reports

CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation

(2017) Tiantian Tang et al.   Nature Communications

Magnesium lithospermate B acts against dextran sodiumsulfate-induced ulcerative colitis by inhibiting activation of the NRLP3/ASC/Caspase-1 pathway

(2016) Xiaoyun Jiang et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Activation of the NLRP3 inflammasome by cellular labile iron

(2016) Kyohei Nakamura et al.   EXPERIMENTAL HEMATOLOGY

PKA Has the Gall to Oppose NLRP3

(2016) Christina J. Groß et al.   IMMUNITY

K + Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria

(2016) Christina J. Groß et al.   IMMUNITY

Emerging biological roles of Cl−intracellular channel proteins

(2016) Elisabetta Argenzio et al.   JOURNAL OF CELL SCIENCE

Vitamin D 3 transactivates the zinc and manganese transporter SLC30A10 via the Vitamin D receptor

(2016) Tatiana Claro da Silva et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Coordinated Control of ENaC and Na+,K+-ATPase in Renal Collecting Duct

(2016) E. Feraille et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

(2016) Yuan He et al.   NATURE

Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer’s disease in rodent models

(2016) Michael J. D. Daniels et al.   Nature Communications

Disruption of glycolytic flux is a signal for inflammasome signaling and pyroptotic cell death

(2016) Laura E Sanman et al.   eLife

Zinc and its role in immunity and inflammation

(2015) Paola Bonaventura et al.   AUTOIMMUNITY REVIEWS

Low zinc and selenium concentrations in sepsis are associated with oxidative damage and inflammation

(2015) K. Mertens et al.   BRITISH JOURNAL OF ANAESTHESIA

K+Efflux Agonists Induce NLRP3 Inflammasome Activation Independently of Ca2+Signaling

(2015) Michael A. Katsnelson et al.   JOURNAL OF IMMUNOLOGY

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

K+ regulates Ca2+ to drive inflammasome signaling: dynamic visualization of ion flux in live cells

(2015) J R Yaron et al.   Cell Death & Disease

NLRP3 inflammasome activation and interleukin-1β release in macrophages require calcium but are independent of calcium-activated NADPH oxidases

(2014) Balázs Rada et al.   INFLAMMATION RESEARCH

Lysosomes Integrate Metabolic-Inflammatory Cross-talk in Primary Macrophage Inflammasome Activation

(2014) Kassandra Weber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Environmental manganese compounds accumulate as Mn(ii) within the Golgi apparatus of dopamine cells: relationship between speciation, subcellular distribution, and cytotoxicity

(2014) Asuncion Carmona et al.   Metallomics

Mitochondrial Calcium Uniporter MCU Supports Cytoplasmic Ca2+ Oscillations, Store-Operated Ca2+ Entry and Ca2+-Dependent Gene Expression in Response to Receptor Stimulation

(2014) Krishna Samanta et al.   PLoS One

Zinc depletion regulates the processing and secretion of IL-1β

(2014) H Summersgill et al.   Cell Death & Disease

Labile iron in cells and body fluids: physiology, pathology, and pharmacology

(2014) Zvi Ioav Cabantchik   Frontiers in Pharmacology

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

The complement membrane attack complex triggers intracellular Ca2+ fluxes leading to NLRP3 inflammasome activation

(2013) K. Triantafilou et al.   JOURNAL OF CELL SCIENCE

Cutting Edge: The NLRP3 Inflammasome Links Complement-Mediated Inflammation and IL-1  Release

(2013) F. Laudisi et al.   JOURNAL OF IMMUNOLOGY

The role of iron and reactive oxygen species in cell death

(2013) Scott J Dixon et al.   Nature Chemical Biology

Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome

(2013) Takuma Misawa et al.   NATURE IMMUNOLOGY

Receptor interacting protein kinase 2–mediated mitophagy regulates inflammasome activation during virus infection

(2013) Christopher Lupfer et al.   NATURE IMMUNOLOGY

TRPM2 links oxidative stress to NLRP3 inflammasome activation

(2013) Zhenyu Zhong et al.   Nature Communications

Cell Volume Regulation Modulates NLRP3 Inflammasome Activation

(2012) Vincent Compan et al.   IMMUNITY

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP

(2012) Geun-Shik Lee et al.   NATURE

Inducible NOS-induced chloride intracellular channel 4 (CLIC4) nuclear translocation regulates macrophage deactivation

(2012) M. Malik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Critical role for calcium mobilization in activation of the NLRP3 inflammasome

(2012) T. Murakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors

(2012) Manuela Rossol et al.   Nature Communications

Non-transferrin bound iron: A key role in iron overload and iron toxicity

(2011) Pierre Brissot et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Hepcidin and iron regulation, 10 years later

(2011) T. Ganz   BLOOD

Magnesium in a signalling role

(2011) Ning Wu et al.   NATURE

Subclinical Zinc Deficiency in Alzheimer’s Disease and Parkinson’s Disease

(2010) George J. Brewer et al.   American Journal of Alzheimers Disease and Other Dementias

The enigma of the CLIC proteins: Ion channels, redox proteins, enzymes, scaffolding proteins?

(2010) Dene R. Littler et al.   FEBS LETTERS

Sodium Overload and Water Influx Activate the NALP3 Inflammasome

(2010) Christine Schorn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

(2010) Edward A Miao et al.   NATURE IMMUNOLOGY

APLP1, Alzheimer's-like pathology and neurodegeneration in the frontal cortex of manganese-exposed non-human primates

(2010) Tomás R. Guilarte   NEUROTOXICOLOGY

SR/ER–mitochondrial local communication: Calcium and ROS

(2009) György Csordás et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA

(2009) Irving C. Allen et al.   IMMUNITY

A Mutation in the Nlrp3 Gene Causing Inflammasome Hyperactivation Potentiates Th17 Cell-Dominant Immune Responses

(2009) Guangxun Meng et al.   IMMUNITY

The Intracellular Sensor NLRP3 Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1

(2009) Paul G. Thomas et al.   IMMUNITY

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

(2009) Olaf Gross et al.   NATURE

Iron homoeostasis in rheumatic disease

(2009) J. F. Baker et al.   RHEUMATOLOGY

Update on the assessment of magnesium status

(2008) Maurice J. Arnaud   BRITISH JOURNAL OF NUTRITION

CLIC1 Function Is Required for  -Amyloid-Induced Generation of Reactive Oxygen Species by Microglia

(2008) R. H. Milton et al.   JOURNAL OF NEUROSCIENCE

Intracellular labile iron

(2007) William Breuer et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY