Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility

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Mitoapocynin Treatment Protects Against Neuroinflammation and Dopaminergic Neurodegeneration in a Preclinical Animal Model of Parkinson’s Disease

(2016) Anamitra Ghosh et al.   Journal of Neuroimmune Pharmacology

Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease

(2016) Richard Gordon et al.   NEUROBIOLOGY OF DISEASE

Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinsons disease

(2016) A. Ghosh et al.   Science Translational Medicine

“Manganese-induced neurotoxicity: a review of its behavioral consequences and neuroprotective strategies”

(2016) Tanara V. Peres et al.   BMC Pharmacology & Toxicology

Lysosomal storage and impaired autophagy lead to inflammasome activation in Gaucher macrophages

(2015) Elma Aflaki et al.   AGING CELL

Manganese Is Essential for Neuronal Health

(2015) Kyle J. Horning et al.   Annual Review of Nutrition

Molecular mechanisms regulating NLRP3 inflammasome activation

(2015) Eun-Kyeong Jo et al.   Cellular & Molecular Immunology

Fyn Kinase Regulates Microglial Neuroinflammatory Responses in Cell Culture and Animal Models of Parkinson's Disease

(2015) N. Panicker et al.   JOURNAL OF NEUROSCIENCE

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Parkinson's disease–associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes

(2015) Wenzhang Wang et al.   NATURE MEDICINE

T1 Relaxation Rate (R1) Indicates Nonlinear Mn Accumulation in Brain Tissue of Welders With Low-Level Exposure

(2015) Eun-Young Lee et al.   TOXICOLOGICAL SCIENCES

Manganese-Induced Parkinsonism Is Not Idiopathic Parkinson’s Disease: Environmental and Genetic Evidence

(2015) Tomás R. Guilarte et al.   TOXICOLOGICAL SCIENCES

Inflammation in Parkinson’s disease: role of glucocorticoids

(2015) María-Trinidad Herrero et al.   Frontiers in Neuroanatomy

VPS35 Deficiency or Mutation Causes Dopaminergic Neuronal Loss by Impairing Mitochondrial Fusion and Function

(2015) Fu-Lei Tang et al.   Cell Reports

Mfn2 downregulation in excitotoxicity causes mitochondrial dysfunction and delayed neuronal death

(2014) A. Martorell-Riera et al.   EMBO JOURNAL

MFN2 Couples Glutamate Excitotoxicity and Mitochondrial Dysfunction in Motor Neurons

(2014) Wenzhang Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosomes as mediators of neuroinflammation

(2014) Archana Gupta et al.   Journal of Neuroinflammation

Pharmacological chaperones stabilize retromer to limit APP processing

(2014) Vincent J Mecozzi et al.   Nature Chemical Biology

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

(2014) Bernardo S Franklin et al.   NATURE IMMUNOLOGY

Role of mitochondria ROS generation in ethanol-induced NLRP3 inflammasome activation and cell death in astroglial cells

(2014) Silvia Alfonso-Loeches et al.   Frontiers in Cellular Neuroscience

Mitochondrial Reactive Oxygen Species Induces NLRP3-Dependent Lysosomal Damage and Inflammasome Activation

(2013) M. E. Heid et al.   JOURNAL OF IMMUNOLOGY

Mitochondrial dysfunction and the inflammatory response

(2013) María J. López-Armada et al.   MITOCHONDRION

Triggering of Inflammasome by Aggregated α–Synuclein, an Inflammatory Response in Synucleinopathies

(2013) Gaia Codolo et al.   PLoS One

The Vps35 D620N Mutation Linked to Parkinson's Disease Disrupts the Cargo Sorting Function of Retromer

(2013) Jordan Follett et al.   TRAFFIC

Manganese neurotoxicity: new perspectives from behavioral, neuroimaging, and neuropathological studies in humans and non-human primates

(2013) Tomás R. Guilarte   Frontiers in Aging Neuroscience

Anti-inflammatory and neuroprotective effects of an orally active apocynin derivative in pre-clinical models of Parkinson’s disease

(2012) Anamitra Ghosh et al.   Journal of Neuroinflammation

Genetic risk for Parkinson's disease correlates with alterations in neuronal manganese sensitivity between two human subjects

(2012) Asad A. Aboud et al.   NEUROTOXICOLOGY

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

Functional human regulatory T cells fail to control autoimmune inflammation due to PKB/c-akt hyperactivation in effector cells

(2011) E. J. Wehrens et al.   BLOOD

Understanding the mechanism of IL-1β secretion

(2011) Gloria Lopez-Castejon et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Retromer disruption promotes amyloidogenic APP processing

(2011) Christopher P. Sullivan et al.   NEUROBIOLOGY OF DISEASE

Pathophysiology of manganese-associated neurotoxicity

(2011) Brad A. Racette et al.   NEUROTOXICOLOGY

Mutations in PINK1 and Parkin Impair Ubiquitination of Mitofusins in Human Fibroblasts

(2011) Aleksandar Rakovic et al.   PLoS One

VPS29 Is Not an Active Metallo-Phosphatase but Is a Rigid Scaffold Required for Retromer Interaction with Accessory Proteins

(2011) James D. Swarbrick et al.   PLoS One

Protective effects of antioxidants and anti-inflammatory agents against manganese-induced oxidative damage and neuronal injury

(2011) Dejan Milatovic et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Manganese and Parkinson’s Disease: A Critical Review and New Findings

(2010) Tomás R. Guilarte   ENVIRONMENTAL HEALTH PERSPECTIVES

A simple magnetic separation method for high-yield isolation of pure primary microglia

(2010) Richard Gordon et al.   JOURNAL OF NEUROSCIENCE METHODS

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Manganese exposure induces microglia activation and dystrophy in the substantia nigra of non-human primates

(2010) Tatyana Verina et al.   NEUROTOXICOLOGY

Manganese disrupts astrocyte glutamine transporter expression and function

(2009) Marta Sidoryk-Węgrzynowicz et al.   JOURNAL OF NEUROCHEMISTRY

Manganese and its Role in Parkinson’s Disease: From Transport to Neuropathology

(2009) Michael Aschner et al.   NEUROMOLECULAR MEDICINE

Developmental Exposure to Manganese Increases Adult Susceptibility to Inflammatory Activation of Glia and Neuronal Protein Nitration

(2009) Julie A. Moreno et al.   TOXICOLOGICAL SCIENCES

Mitochondrial-dependent manganese neurotoxicity in rat primary astrocyte cultures

(2008) Zhaoobao Yin et al.   BRAIN RESEARCH

Manganese potentiates nuclear factor‐κB‐dependent expression of nitric oxide synthase 2 in astrocytes by activating soluble guanylate cyclase and extracellular responsive kinase signaling pathways

(2008) Julie A. Moreno et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE

Manganese Induces Dopaminergic Neurodegeneration via Microglial Activation in a Rat Model of Manganism

(2008) Fang Zhao et al.   TOXICOLOGICAL SCIENCES

Manganese-induced potentiation of in vitro proinflammatory cytokine production by activated microglial cells is associated with persistent activation of p38 MAPK

(2007) P.L. Crittenden et al.   TOXICOLOGY IN VITRO