Journal
BIOLOGICAL REVIEWS
Volume 94, Issue 5, Pages 1839-1856Publisher
WILEY
DOI: 10.1111/brv.12536
Keywords
chloride anion; Cl-; second messenger; inflammation; proinflammatory signal; oxidative stress; intracellular signalling; signal transduction; CFTR
Categories
Funding
- National Agency for the Promotion of Science and Technology (ANPCYT) [PICT-2015-1031]
- National Scientific and Technical Research Council (CONICET) [PIP-2015-11220150100227, PUE-2016-22920160100129CO]
- Pontifical Catholic University of Argentina (UCA)
Ask authors/readers for more resources
The specific role of the chloride anion (Cl-) as a signalling effector or second messenger has been increasingly recognized in recent years. It could represent a key factor in the regulation of cellular homeostasis. Changes in intracellular Cl- concentration affect diverse cellular functions such as gene and protein expression and activities, post-translational modifications of proteins, cellular volume, cell cycle, cell proliferation and differentiation, membrane potential, reactive oxygen species levels, and intracellular/extracellular pH. Cl- also modulates functions in different organelles, including endosomes, phagosomes, lysosomes, endoplasmic reticulum, and mitochondria. A better knowledge of Cl- signalling could help in understanding the molecular and metabolic changes seen in pathologies with altered Cl- transport or under physiological conditions. Here we review relevant evidence supporting the role of Cl- as a signalling effector.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available