Lipid Players of Cellular Senescence

CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors

(2020) Haiping Wang et al.   NATURE IMMUNOLOGY

Metabolomic and Lipidomic Signatures of Metabolic Syndrome and its Physiological Components in Adults: A Systematic Review

(2020) Stéphanie Monnerie et al.   Scientific Reports

Alteration of fatty acid oxidation by increased CPT1A on replicative senescence of placenta-derived mesenchymal stem cells

(2020) Jin Seok et al.   Stem Cell Research & Therapy

DNA Damage Regulates Senescence-Associated Extracellular Vesicle Release via the Ceramide Pathway to Prevent Excessive Inflammatory Responses

(2020) Kazuhiro Hitomi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Untargeted Lipidomics Highlight the Depletion of Deoxyceramides during Therapy‐Induced Senescence

(2020) Alec Millner et al.   PROTEOMICS

Phospholipid Membrane Fluidity Alters Ligand Binding Activity of a G Protein-Coupled Receptor by Shifting the Conformational Equilibrium

(2019) Kouhei Yoshida et al.   BIOCHEMISTRY

Very Long-Chain C24:1 Ceramide Is Increased in Serum Extracellular Vesicles with Aging and Can Induce Senescence in Bone-Derived Mesenchymal Stem Cells

(2019) Andrew Khayrullin et al.   Cells

Molecular mechanism of lysophosphatidic acid-induced hypertensive response

(2019) Kuniyuki Kano et al.   Scientific Reports

Phosphorylation-mediated activation of mouse Xkr8 scramblase for phosphatidylserine exposure

(2019) Takaharu Sakuragi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An integrative systems genetic analysis of mammalian lipid metabolism

(2019) Benjamin L. Parker et al.   NATURE

Tumor Cell Escape from Therapy-Induced Senescence as a Model of Disease Recurrence after Dormancy

(2019) Tareq Saleh et al.   CANCER RESEARCH

Membrane Lipid Composition: Effect on Membrane and Organelle Structure, Function and Compartmentalization and Therapeutic Avenues

(2019) Doralicia Casares et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

FASN activity is important for the initial stages of the induction of senescence

(2019) Juan Fafián-Labora et al.   Cell Death & Disease

Role of lysophosphatidic acid in proliferation and differentiation of intestinal epithelial cells

(2019) Tasuku Konno et al.   PLoS One

The role of lipid metabolism in aging, lifespan regulation, and age‐related disease

(2019) Adiv A. Johnson et al.   AGING CELL

Deoxysphingolipids and ether-linked diacylglycerols accumulate in the tissues of aged mice

(2019) Ayumi Ando et al.   Cell and Bioscience

Lipid Cell Biology: A Focus on Lipids in Cell Division

(2018) Elisabeth M. Storck et al.   Annual Review of Biochemistry

CD36 initiates the secretory phenotype during the establishment of cellular senescence

(2018) Mengyang Chong et al.   EMBO REPORTS

Role of sphingolipids in senescence: implication in aging and age-related diseases

(2018) Magali Trayssac et al.   JOURNAL OF CLINICAL INVESTIGATION

CD36 palmitoylation disrupts free fatty acid metabolism and promotes tissue inflammation in non-alcoholic steatohepatitis

(2018) Lei Zhao et al.   JOURNAL OF HEPATOLOGY

Hallmarks of Cellular Senescence

(2018) Alejandra Hernandez-Segura et al.   TRENDS IN CELL BIOLOGY

Endothelial cell CD36 optimizes tissue fatty acid uptake

(2018) Ni-Huiping Son et al.   JOURNAL OF CLINICAL INVESTIGATION

Author Correction: Sphingolipids and their metabolism in physiology and disease

(2018) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The dynamic nature of senescence in cancer

(2018) Soyoung Lee et al.   NATURE CELL BIOLOGY

Dynamics and functions of lipid droplets

(2018) James A. Olzmann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Prostaglandins D2and E2have opposite effects on alveolar macrophages infected withHistoplasma capsulatum

(2017) Priscilla A. T. Pereira et al.   JOURNAL OF LIPID RESEARCH

Regulation of lipids is central to replicative senescence

(2017) Darleny Y. Lizardo et al.   Molecular BioSystems

The Dual Role of Cellular Senescence in Developing Tumors and Their Response to Cancer Therapy

(2017) Markus Schosserer et al.   Frontiers in Oncology

Specific Triacylglycerols Accumulate via Increased Lipogenesis During 5-FU-Induced Apoptosis

(2016) Nasi Li et al.   ACS Chemical Biology

Senescence associated secretory phenotype profile from primary lung mice fibroblasts depends on the senescence induction stimuli

(2016) L. A. Maciel-Barón et al.   AGE

Post-translational modifications of CD36 (SR-B2): Implications for regulation of myocellular fatty acid uptake

(2016) Joost J.F.P. Luiken et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Emerging roles for lipids in non-apoptotic cell death

(2016) L Magtanong et al.   CELL DEATH AND DIFFERENTIATION

Exposure of phosphatidylserine on the cell surface

(2016) S Nagata et al.   CELL DEATH AND DIFFERENTIATION

A senescence secretory switch mediated by PI3K/AKT/mTOR activation controls chemoprotective endothelial secretory responses

(2016) Eric H. Bent et al.   GENES & DEVELOPMENT

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

ATF6α regulates morphological changes associated with senescence in human fibroblasts

(2016) Clémentine Druelle et al.   Oncotarget

Lysophosphatidylcholine plays critical role in allergic airway disease manifestation

(2016) Preeti Bansal et al.   Scientific Reports

Age-associated changes in long-chain fatty acid profile during healthy aging promote pro-inflammatory monocyte polarization via PPARγ

(2015) Chathyan Pararasa et al.   AGING CELL

The Macrophage Phagocytic Receptor CD36 Promotes Fibrogenic Pathways on Removal of Apoptotic Cells during Chronic Kidney Injury

(2015) Subramaniam Pennathur et al.   AMERICAN JOURNAL OF PATHOLOGY

Dynamics and Membrane Interactions of Protein Kinase C

(2015) Tatyana I. Igumenova   BIOCHEMISTRY

Glial Lipid Droplets and ROS Induced by Mitochondrial Defects Promote Neurodegeneration

(2015) Lucy Liu et al.   CELL

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation

(2015) Shanmugam Panneer Selvam et al.   Science Signaling

Lipid Profiles and Signals for Long Life

(2015) Elizabeth A. Schroeder et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Lysophosphatidic acid enhances survival of human CD34+ cells in ischemic conditions

(2015) Ivana Kostic et al.   Scientific Reports

Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation

(2015) Shanmugam Panneer Selvam et al.   Science Signaling

Structure-Function of CD36 and Importance of Fatty Acid Signal Transduction in Fat Metabolism

(2014) Marta Yanina Pepino et al.   Annual Review of Nutrition

Biophysical Properties of Novel 1-Deoxy-(Dihydro)ceramides Occurring in Mammalian Cells

(2014) Noemi Jiménez-Rojo et al.   BIOPHYSICAL JOURNAL

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

Lipid Catabolism via CPT1 as a Therapeutic Target for Prostate Cancer

(2014) I. R. Schlaepfer et al.   MOLECULAR CANCER THERAPEUTICS

Prostaglandin E2 Promotes Features of Replicative Senescence in Chronically Activated Human CD8+ T Cells

(2014) Jennifer P. Chou et al.   PLoS One

Sphingosine-1-phosphate receptor 2

(2013) Mohamad Adada et al.   FEBS Journal

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

Removal of sphingomyelin headgroup inhibits the ligand binding function of hippocampal serotonin1A receptors

(2012) Pushpendra Singh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Apoptosis-induced mitochondrial dysfunction causes cytoplasmic lipid droplet formation

(2012) J Boren et al.   CELL DEATH AND DIFFERENTIATION

Sphingolipid Signaling in Metabolic Disorders

(2012) Timothy Hla et al.   Cell Metabolism

Molecular recognition of a single sphingolipid species by a protein’s transmembrane domain

(2012) F.-Xabier Contreras et al.   NATURE

Mechanisms of lysophosphatidylcholine-induced hepatocyte lipoapoptosis

(2011) Keisuke Kakisaka et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Lipid classification, structures and tools

(2011) Eoin Fahy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Sphingosine 1-phosphate stimulates proliferation and migration of satellite cells

(2011) Serena Calise et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Sterols Have Higher Affinity for Sphingomyelin than for Phosphatidylcholine Bilayers even at Equal Acyl-Chain Order

(2011) Max Lönnfors et al.   BIOPHYSICAL JOURNAL

Mammalian Triacylglycerol Metabolism: Synthesis, Lipolysis, and Signaling

(2011) Rosalind A. Coleman et al.   CHEMICAL REVIEWS

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

(2011) Tae-Won Kang et al.   NATURE

Defining a role for sphingosine kinase 1 in p53-dependent tumors

(2011) L A Heffernan-Stroud et al.   ONCOGENE

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

A CD36-dependent pathway enhances macrophage and adipose tissue inflammation and impairs insulin signalling

(2010) David J. Kennedy et al.   CARDIOVASCULAR RESEARCH

Protein kinase C in heart failure: a therapeutic target?

(2009) S. S. Palaniyandi et al.   CARDIOVASCULAR RESEARCH

Ceramide induces endothelial cell senescence

(2009) Mark E. Venable et al.   CELL BIOCHEMISTRY AND FUNCTION

The Human Scavenger Receptor CD36

(2009) Sarah J. Hoosdally et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Soluble CD36 Ectodomain Binds Negatively Charged Diacylglycerol Ligands and Acts as a Co-Receptor for TLR2

(2009) Maximiliano J. Jimenez-Dalmaroni et al.   PLoS One

CD36, a Scavenger Receptor Involved in Immunity, Metabolism, Angiogenesis, and Behavior

(2009) R. L. Silverstein et al.   Science Signaling

Transport through the Golgi Apparatus by Rapid Partitioning within a Two-Phase Membrane System

(2008) George H. Patterson et al.   CELL

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence

(2008) Juan C. Acosta et al.   CELL

Involvement of very long fatty acid-containing lactosylceramide in lactosylceramide-mediated superoxide generation and migration in neutrophils

(2008) Kazuhisa Iwabuchi et al.   GLYCOCONJUGATE JOURNAL

Opposite Regulation of CD36 Ubiquitination by Fatty Acids and Insulin

(2008) Jill Smith et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phospholipase A2structure/function, mechanism, and signaling

(2008) John E. Burke et al.   JOURNAL OF LIPID RESEARCH

Lipid activation of protein kinases

(2008) Alexandra C. Newton   JOURNAL OF LIPID RESEARCH

Bioactive sphingolipids: metabolism and function

(2008) Nana Bartke et al.   JOURNAL OF LIPID RESEARCH

Fatty acid metabolism: target for metabolic syndrome

(2008) Salih J. Wakil et al.   JOURNAL OF LIPID RESEARCH

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural Basis of Protein Kinase C Isoform Function

(2008) Susan F. Steinberg   PHYSIOLOGICAL REVIEWS