Sphingosine-1-phosphate receptor 2

S1PR5 is pivotal for the homeostasis of patrolling monocytes

(2013) Emilie Debien et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Epidermal growth factor-induced cellular invasion requires sphingosine-1-phosphate/sphingosine-1-phosphate 2 receptor-mediated ezrin activation

(2013) K. Alexa Orr Gandy et al.   FASEB JOURNAL

Sphingosine-1–Phosphate Receptor–3 Is a Novel Biomarker in Acute Lung Injury

(2012) Xiaoguang Sun et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis

(2012) Suriyan Ponnusamy et al.   EMBO Molecular Medicine

S1P2 receptor mediates sphingosine-1-phosphate-induced fibronectin expression via MAPK signaling pathway in mesangial cells under high glucose condition

(2012) Weihua Liu et al.   EXPERIMENTAL CELL RESEARCH

Dendritic Cell Sphingosine 1-Phosphate Receptor-3 Regulates Th1-Th2 Polarity in Kidney Ischemia-Reperfusion Injury

(2012) A. Bajwa et al.   JOURNAL OF IMMUNOLOGY

Sphingosine 1-phosphate receptor 5 mediates the immune quiescence of the human brain endothelial barrier

(2012) Ruben van Doorn et al.   Journal of Neuroinflammation

LPS and TNF-α induce expression of sphingosine-1-phosphate receptor-2 in human microvascular endothelial cells

(2012) Jing Du et al.   PATHOLOGY RESEARCH AND PRACTICE

Sphingosine-1-Phosphate Enhances Satellite Cell Activation in Dystrophic Muscles through a S1PR2/STAT3 Signaling Pathway

(2012) Kenneth C. Loh et al.   PLoS One

Mouse SPNS2 Functions as a Sphingosine-1-Phosphate Transporter in Vascular Endothelial Cells

(2012) Yu Hisano et al.   PLoS One

Fingolimod: an oral disease-modifying therapy for relapsing multiple sclerosis

(2011) E. Ann Yeh et al.   ADVANCES IN THERAPY

Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A

(2011) A. Salas et al.   BLOOD

Sequential desensitization of CXCR4 and S1P5 controls natural killer cell trafficking

(2011) K. Mayol et al.   BLOOD

Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy

(2011) Christopher R. Gault et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Frequent spontaneous seizures followed by spatial working memory/anxiety deficits in mice lacking sphingosine 1-phosphate receptor 2

(2011) Noriyuki Akahoshi et al.   EPILEPSY & BEHAVIOR

Sphingosine-1-phospate receptor 4 (S1P4) deficiency profoundly affects dendritic cell function and TH17-cell differentiation in a murine model

(2011) Tobias Schulze et al.   FASEB JOURNAL

Conjugated bile acids activate the sphingosine-1-phosphate receptor 2 in primary rodent hepatocytes

(2011) Elaine Studer et al.   HEPATOLOGY

Many Ceramides

(2011) Yusuf A. Hannun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dissecting the Role of the S1P/S1PR Axis in Health and Disease

(2011) J.J. Aarthi et al.   JOURNAL OF DENTAL RESEARCH

FTY720 Blocks Egress of T Cells in Part by Abrogation of Their Adhesion on the Lymph Node Sinus

(2011) L. Zhi et al.   JOURNAL OF IMMUNOLOGY

Inhibition of Sphingosine 1-Phosphate Receptor 2 Protects against Renal Ischemia-Reperfusion Injury

(2011) S. Won Park et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Role of sphingosine-1-phosphate (S1P) and S1P receptor 2 in the phagocytosis of Cryptococcus neoformans by alveolar macrophages

(2011) T. McQuiston et al.   MICROBIOLOGY-SGM

Senescent endothelial dysfunction is attributed to the up-regulation of sphingosine-1-phosphate receptor-2 in aged rats

(2011) Hongwei Lu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Sphingosine Kinase 1 and Sphingosine 1-Phosphate Receptor 3 Are Functionally Upregulated on Astrocytes under Pro-Inflammatory Conditions

(2011) Iris Fischer et al.   PLoS One

Glycosphingolipid Functions

(2011) C. A. Lingwood   Cold Spring Harbor Perspectives in Biology

Selectivity and Specificity of Sphingosine-1-Phosphate Receptor Ligands: Caveats and Critical Thinking in Characterizing Receptor-Mediated Effects

(2011) Salvatore Salomone et al.   Frontiers in Pharmacology

Sphingosine 1-Phosphate Receptor 2 Signals Through Leukemia-Associated RhoGEF (LARG), to Promote Smooth Muscle Cell Differentiation

(2010) Matt D. Medlin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Blockade of sphingosine 1-phosphate receptor 2 signaling attenuates streptozotocin-induced apoptosis of pancreatic β-cells

(2010) Toshiyuki Imasawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sphingosine-1-Phosphate–Dependent Activation of p38 MAPK Maintains Elevated Peripheral Resistance in Heart Failure Through Increased Myogenic Vasoconstriction

(2010) Judith Hoefer et al.   CIRCULATION RESEARCH

Sphingosine-1-Phosphate Receptor 3 Promotes Recruitment of Monocyte/Macrophages in Inflammation and Atherosclerosis

(2010) Petra Keul et al.   CIRCULATION RESEARCH

Shaping of terminal megakaryocyte differentiation and proplatelet development by sphingosine-1-phosphate receptor S1P4

(2010) Sven Golfier et al.   FASEB JOURNAL

Sphingosine 1-Phosphate Receptor 4 Uses HER2 (ERBB2) to Regulate Extracellular Signal Regulated Kinase-1/2 in MDA-MB-453 Breast Cancer Cells

(2010) Jaclyn S. Long et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hereditary Sensory Neuropathy Type 1 Is Caused by the Accumulation of Two Neurotoxic Sphingolipids

(2010) Anke Penno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingosine kinase 1 and sphingosine-1-phosphate receptor 2 are vital to recovery from anaphylactic shock in mice

(2010) Ana Olivera et al.   JOURNAL OF CLINICAL INVESTIGATION

Essential roles of sphingosine-1–phosphate receptor 2 in human mast cell activation, anaphylaxis, and pulmonary edema

(2010) Carole A. Oskeritzian et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sphingosine 1-Phosphate (S1P) Regulates Vascular Contraction via S1P3 Receptor: Investigation Based on a New S1P3 Receptor Antagonist

(2010) A. Murakami et al.   MOLECULAR PHARMACOLOGY

Downregulation of sphingosine-1-phosphate receptors in bronchial smooth muscle of mouse experimental asthma

(2010) Yoshihiko Chiba et al.   PHARMACOLOGICAL RESEARCH

Effect of S1P5 on proliferation and migration of human esophageal cancer cells

(2010) Wei-Min Hu   WORLD JOURNAL OF GASTROENTEROLOGY

S1P5 is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells

(2009) Chi-Lun Chang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Sphingosine-1-Phosphate Receptor-2 Regulates Expression of Smooth Muscle Alpha-Actin After Arterial Injury

(2009) Allison D. Grabski et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

S1P/S1P1 signaling stimulates cell migration and invasion in Wilms tumor

(2009) Mei-Hong Li et al.   CANCER LETTERS

Targeted Disruption of the S1P2 Sphingosine 1-Phosphate Receptor Gene Leads to Diffuse Large B-Cell Lymphoma Formation

(2009) G. Cattoretti et al.   CANCER RESEARCH

T-bet–dependent S1P5expression in NK cells promotes egress from lymph nodes and bone marrow

(2009) Craig N. Jenne et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inhibitory Role of Sphingosine 1-Phosphate Receptor 2 in Macrophage Recruitment during Inflammation

(2009) J. Michaud et al.   JOURNAL OF IMMUNOLOGY

Sphingosine-1-phosphate promotes lymphangiogenesis by stimulating S1P1/Gi/PLC/Ca2+ signaling pathways

(2008) C. M. Yoon et al.   BLOOD

G12/13 and Gq mediate S1P2-induced inhibition of Rac and migration in vascular smooth muscle in a manner dependent on Rho but not Rho kinase

(2008) Shin-ichiro Takashima et al.   CARDIOVASCULAR RESEARCH

Up-regulating Sphingosine 1-Phosphate Receptor-2 Signaling Impairs Chemotactic, Wound-healing, and Morphogenetic Responses in Senescent Endothelial Cells

(2008) Rosendo Estrada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ceramide Synthase Inhibition by Fumonisin B1Causes Accumulation of 1-Deoxysphinganine

(2008) Nicholas C. Zitomer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2

(2008) Hitoshi Ikeda et al.   JOURNAL OF LIPID RESEARCH

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

"Inside-Out" Signaling of Sphingosine-1-Phosphate: Therapeutic Targets

(2008) K. Takabe et al.   PHARMACOLOGICAL REVIEWS

Antagonism of Sphingosine 1-Phosphate Receptor-2 Enhances Migration of Neural Progenitor Cells Toward an Area of Brain Infarction

(2008) Atsushi Kimura et al.   STROKE