Regulation of Adult Neurogenesis in Mammalian Brain

Metabolic regulation of neurodifferentiation in the adult brain

(2020) Camilla Maffezzini et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The C terminus of p73 is essential for hippocampal development

(2020) Ivano Amelio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhancing folic acid metabolism suppresses defects associated with loss of Drosophila mitofusin

(2019) Juan Garrido-Maraver et al.   Cell Death & Disease

Adult neurogenesis in mammals

(2019) Fred H. Gage   SCIENCE

More than just Stem Cells: Functional Roles of the Transcription Factor Sox2 in Differentiated Glia and Neurons

(2019) Sara Mercurio et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tissue-specific roles of p73 in development and homeostasis

(2019) Alice Nemajerova et al.   JOURNAL OF CELL SCIENCE

p53 mitotic centrosome localization preserves centrosome integrity and works as sensor for the mitotic surveillance pathway

(2019) Claudia Contadini et al.   Cell Death & Disease

Do Mutations Turn p53 into an Oncogene?

(2019) Consuelo Pitolli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

p53-Mediated Tumor Suppression: DNA-Damage Response and Alternative Mechanisms

(2019) Consuelo Pitolli et al.   Cancers

The p53 Family in Brain Disease

(2018) Massimiliano Agostini et al.   ANTIOXIDANTS & REDOX SIGNALING

The stiff RhoAd from mevalonate to mutant p53

(2018) Giovanni Sorrentino et al.   CELL DEATH AND DIFFERENTIATION

Alterations in neuronal metabolism contribute to the pathogenesis of prion disease

(2018) Julie-Myrtille Bourgognon et al.   CELL DEATH AND DIFFERENTIATION

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

p73 Alternative Splicing: Exploring a Biological Role for the C-Terminal Isoforms

(2018) Polina Vikhreva et al.   JOURNAL OF MOLECULAR BIOLOGY

Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults

(2018) Shawn F. Sorrells et al.   NATURE

The chromatin basis of neurodevelopmental disorders: Rethinking dysfunction along the molecular and temporal axes

(2018) Michele Gabriele et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Epigenetic modifiers promote mitochondrial biogenesis and oxidative metabolism leading to enhanced differentiation of neuroprogenitor cells

(2018) Martine Uittenbogaard et al.   Cell Death & Disease

Class I histone deacetylase (HDAC) inhibitor CI-994 promotes functional recovery following spinal cord injury

(2018) Suxiang Zhang et al.   Cell Death & Disease

ATP-Dependent Chromatin Remodeling During Cortical Neurogenesis

(2018) Godwin Sokpor et al.   Frontiers in Neuroscience

Histone Deacetylase Inhibitors: A Therapeutic Key in Neurological Disorders?

(2018) Malgorzata Ziemka-Nalecz et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Presenilin 1 deficiency suppresses autophagy in human neural stem cells through reducing γ-secretase-independent ERK/CREB signaling

(2018) Cheong-Meng Chong et al.   Cell Death & Disease

Phosphorylation of the neurogenic transcription factor SOX11 on serine 133 modulates neuronal morphogenesis

(2018) Elli-Anna Balta et al.   Scientific Reports

Mutant p53 as a guardian of the cancer cell

(2018) Fiamma Mantovani et al.   CELL DEATH AND DIFFERENTIATION

p53 mutants cooperate with HIF-1 in transcriptional regulation of extracellular matrix components to promote tumor progression

(2018) Ivano Amelio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromatin-remodeling factor, RSF1, controls p53-mediated transcription in apoptosis upon DNA strand breaks

(2018) Sunwoo Min et al.   Cell Death & Disease

p73 regulates ependymal planar cell polarity by modulating actin and microtubule cytoskeleton

(2018) Sandra Fuertes-Alvarez et al.   Cell Death & Disease

MicroRNAs Engage in Complex Circuits Regulating Adult Neurogenesis

(2018) Laura Stappert et al.   Frontiers in Neuroscience

Adaptive responses of neuronal mitochondria to bioenergetic challenges: Roles in neuroplasticity and disease resistance

(2017) Sophia M. Raefsky et al.   FREE RADICAL BIOLOGY AND MEDICINE

The metabolic programming of stem cells

(2017) Ng Shyh-Chang et al.   GENES & DEVELOPMENT

New Insights in Thyroid Cancer and p53 Family Proteins

(2017) Livia Manzella et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

p73 Regulates Primary Cortical Neuron Metabolism: a Global Metabolic Profile

(2017) Massimiliano Agostini et al.   MOLECULAR NEUROBIOLOGY

Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes

(2017) Cedric R. Clapier et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

p53 pathway dysfunction in AML: beyond TP53 mutations

(2017) Sean M. Post et al.   Oncotarget

Chromatin Remodeling BAF (SWI/SNF) Complexes in Neural Development and Disorders

(2017) Godwin Sokpor et al.   Frontiers in Molecular Neuroscience

Transcription factor NRF2 controls the fate of neural stem cells in the subgranular zone of the hippocampus

(2017) Natalia Robledinos-Antón et al.   Redox Biology

Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior

(2016) J. Tiago Gonçalves et al.   CELL

p53 family members regulate cancer stem cells

(2016) Subhasree Basu et al.   CELL CYCLE

Metabolic reprogramming during neuronal differentiation

(2016) M Agostini et al.   CELL DEATH AND DIFFERENTIATION

p53 family interactions and yeast: together in anticancer therapy

(2016) Sara Gomes et al.   DRUG DISCOVERY TODAY

Structure-function integrity of the adult hippocampus depends on the transcription factor Bcl11b/Ctip2

(2016) R. Simon et al.   GENES BRAIN AND BEHAVIOR

High prevalence and allele burden-independent prognostic importance of p53 mutations in an inner-city MDS/AML cohort

(2016) S Goel et al.   LEUKEMIA

Ablation of BAF170 in Developing and Postnatal Dentate Gyrus Affects Neural Stem Cell Proliferation, Differentiation, and Learning

(2016) Tran Tuoc et al.   MOLECULAR NEUROBIOLOGY

Epigenetic mechanisms in neurogenesis

(2016) Bing Yao et al.   NATURE REVIEWS NEUROSCIENCE

The role of mTOR signalling in neurogenesis, insights from tuberous sclerosis complex

(2016) Andrew R. Tee et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The dominant-negative interplay between p53, p63 and p73: A family affair

(2016) Olivier Billant et al.   Oncotarget

Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation

(2016) Xinde Zheng et al.   eLife

Mapping gene regulatory circuitry of Pax6 during neurogenesis

(2016) Sudhir Thakurela et al.   Cell Discovery

Oncogenic Intra-p53 Family Member Interactions in Human Cancers

(2016) Maria Ferraiuolo et al.   Frontiers in Oncology

How Does p73 Cause Neuronal Defects?

(2015) Maria Victoria Niklison-Chirou et al.   MOLECULAR NEUROBIOLOGY

Function and information content of DNA methylation

(2015) Dirk Schübeler   NATURE

p53 mutations cooperate with oncogenic Kras to promote adenocarcinoma from pancreatic ductal cells

(2015) J M Bailey et al.   ONCOGENE

Connecting Mitochondria, Metabolism, and Stem Cell Fate

(2015) Anaïs Wanet et al.   STEM CELLS AND DEVELOPMENT

The p53 family and the hypoxia-inducible factors (HIFs): determinants of cancer progression

(2015) Ivano Amelio et al.   TRENDS IN BIOCHEMICAL SCIENCES

Activity Dependency and Aging in the Regulation of Adult Neurogenesis

(2015) Gerd Kempermann   Cold Spring Harbor Perspectives in Biology

Noncanonical Sites of Adult Neurogenesis in the Mammalian Brain

(2015) David M. Feliciano et al.   Cold Spring Harbor Perspectives in Biology

TAp73 promotes anabolism

(2015) Ivano Amelio et al.   Oncotarget

The roles and regulation of Polycomb complexes in neural development

(2014) Matthew Corley et al.   CELL AND TISSUE RESEARCH

Roles of chromatin remodeling BAF complex in neural differentiation and reprogramming

(2014) Ramanathan Narayanan et al.   CELL AND TISSUE RESEARCH

Glycine receptors control the generation of projection neurons in the developing cerebral cortex

(2014) A Avila et al.   CELL DEATH AND DIFFERENTIATION

Programmed cell death during neuronal development: the sympathetic neuron model

(2014) M Kristiansen et al.   CELL DEATH AND DIFFERENTIATION

A single allele of Hdac2 but not Hdac1 is sufficient for normal mouse brain development in the absence of its paralog

(2014) A. Hagelkruys et al.   DEVELOPMENT

Pluripotent stem cell energy metabolism: an update

(2014) T. Teslaa et al.   EMBO JOURNAL

How theTP53Family ProteinsTP63andTP73Contribute to Tumorigenesis: Regulators and Effectors

(2014) Eleonora Candi et al.   HUMAN MUTATION

Histone Deacetylase 3 Is Necessary for Proper Brain Development

(2014) Jordan Norwood et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of genomic imprinting in biology and disease: an expanding view

(2014) Jo Peters   NATURE REVIEWS GENETICS

Analysis of Mll1 Deficiency Identifies Neurogenic Transcriptional Modules and Brn4 as a Factor for Direct Astrocyte-to-Neuron Reprogramming

(2014) Matthew B. Potts et al.   NEUROSURGERY

TAp73 opposes tumor angiogenesis by promoting hypoxia-inducible factor 1α degradation

(2014) Ivano Amelio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Serine and glycine metabolism in cancer

(2014) Ivano Amelio et al.   TRENDS IN BIOCHEMICAL SCIENCES

Activation of Neuronal Gene Expression by the JMJD3 Demethylase Is Required for Postnatal and Adult Brain Neurogenesis

(2014) Dae Hwi Park et al.   Cell Reports

Distinct and separable roles for EZH2 in neurogenic astroglia

(2014) William W Hwang et al.   eLife

Aerobic glycolysis in the primate brain: reconsidering the implications for growth and maintenance

(2013) Amy L. Bauernfeind et al.   Brain Structure & Function

The BAF Complex Interacts with Pax6 in Adult Neural Progenitors to Establish a Neurogenic Cross-Regulatory Transcriptional Network

(2013) Jovica Ninkovic et al.   Cell Stem Cell

Tet1 Regulates Adult Hippocampal Neurogenesis and Cognition

(2013) Run-Rui Zhang et al.   Cell Stem Cell

TAp73 knockout mice show morphological and functional nervous system defects associated with loss of p75 neurotrophin receptor

(2013) M. V. Niklison-Chirou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR Inhibition Alleviates Mitochondrial Disease in a Mouse Model of Leigh Syndrome

(2013) S. C. Johnson et al.   SCIENCE

Mature neurons: equipped for survival

(2013) A J Kole et al.   Cell Death & Disease

Septins promote dendrite and axon development by negatively regulating microtubule stability via HDAC6-mediated deacetylation

(2013) Natsumi Ageta-Ishihara et al.   Nature Communications

Tissue-specific expression of p73 C-terminal isoforms in mice

(2012) Francesca Grespi et al.   CELL CYCLE

Translational Control of Mitochondrial Energy Production Mediates Neuron Morphogenesis

(2012) Aparna Oruganty-Das et al.   Cell Metabolism

Prox1 postmitotically defines dentate gyrus cells by specifying granule cell identity over CA3 pyramidal cell fate in the hippocampus

(2012) T. Iwano et al.   DEVELOPMENT

A dual function of Bcl11b/Ctip2 in hippocampal neurogenesis

(2012) Ruth Simon et al.   EMBO JOURNAL

Role of DNMT3B in the regulation of early neural and neural crest specifiers

(2012) Kristen Martins-Taylor et al.   Epigenetics

TAp73 depletion accelerates aging through metabolic dysregulation

(2012) A. Rufini et al.   GENES & DEVELOPMENT

Orchestrating transcriptional control of adult neurogenesis

(2012) J. Hsieh   GENES & DEVELOPMENT

Querkopf is a key marker of self-renewal and multipotency of adult neural stem cells

(2012) B. N. Sheikh et al.   JOURNAL OF CELL SCIENCE

Foxg1 Has an Essential Role in Postnatal Development of the Dentate Gyrus

(2012) C. Tian et al.   JOURNAL OF NEUROSCIENCE

SoxC Transcription Factors Are Required for Neuronal Differentiation in Adult Hippocampal Neurogenesis

(2012) L. Mu et al.   JOURNAL OF NEUROSCIENCE

Involvement of PGC-1α in the formation and maintenance of neuronal dendritic spines

(2012) Aiwu Cheng et al.   Nature Communications

Nucleus-encoded regulators of mitochondrial function: Integration of respiratory chain expression, nutrient sensing and metabolic stress

(2011) Richard C. Scarpulla   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

SOX after SOX: SOXession regulates neurogenesis

(2011) M. Wegner   GENES & DEVELOPMENT

SRY-box-containing Gene2Regulation of Nuclear Receptor Tailless (Tlx) Transcription in Adult Neural Stem Cells

(2011) Koji Shimozaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Master Negative Regulator REST/NRSF Controls Adult Neurogenesis by Restraining the Neurogenic Program in Quiescent Stem Cells

(2011) Z. Gao et al.   JOURNAL OF NEUROSCIENCE

p73: A Multifunctional Protein in Neurobiology

(2011) Richard Killick et al.   MOLECULAR NEUROBIOLOGY

Fighting neurodegeneration with rapamycin: mechanistic insights

(2011) Jordi Bové et al.   NATURE REVIEWS NEUROSCIENCE

Transcriptional Regulation of Neuronal Polarity and Morphogenesis in the Mammalian Brain

(2011) Luis de la Torre-Ubieta et al.   NEURON

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions

(2011) Guo-li Ming et al.   NEURON

Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets

(2011) M. Agostini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

microRNA-34a regulates neurite outgrowth, spinal morphology, and function

(2011) M. Agostini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p73 regulates maintenance of neural stem cell

(2010) Massimiliano Agostini et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

miR-7 and miR-214 are specifically expressed during neuroblastoma differentiation, cortical development and embryonic stem cells differentiation, and control neurite outgrowth in vitro

(2010) Hailan Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

p73 is an essential regulator of neural stem cell maintenance in embryonal and adult CNS neurogenesis

(2010) F Talos et al.   CELL DEATH AND DIFFERENTIATION

TAp73 Acts via the bHLH Hey2 to Promote Long-Term Maintenance of Neural Precursors

(2010) Masashi Fujitani et al.   CURRENT BIOLOGY

Isoform-specific p73 knockout mice reveal a novel role for  Np73 in the DNA damage response pathway

(2010) M. T. Wilhelm et al.   GENES & DEVELOPMENT

RBPJ -Dependent Signaling Is Essential for Long-Term Maintenance of Neural Stem Cells in the Adult Hippocampus

(2010) O. Ehm et al.   JOURNAL OF NEUROSCIENCE

Histone Demethylase LSD1 Regulates Neural Stem Cell Proliferation

(2010) G. Sun et al.   MOLECULAR AND CELLULAR BIOLOGY

Epigenetic mechanisms underlying human epileptic disorders and the process of epileptogenesis

(2010) Irfan A. Qureshi et al.   NEUROBIOLOGY OF DISEASE

Differential control of TAp73 and  Np73 protein stability by the ring finger ubiquitin ligase PIR2

(2010) B. S. Sayan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p73 deficiency results in impaired self renewal and premature neuronal differentiation of mouse neural progenitors independently of p53

(2010) L Gonzalez-Cano et al.   Cell Death & Disease

Prox1 Is Required for Granule Cell Maturation and Intermediate Progenitor Maintenance During Brain Neurogenesis

(2010) Alfonso Lavado et al.   PLOS BIOLOGY

The non-apoptotic role of p53 in neuronal biology: enlightening the dark side of the moon

(2009) Andrea Tedeschi et al.   EMBO REPORTS

Expression of Sox11 in adult neurogenic niches suggests a stage-specific role in adult neurogenesis

(2009) Anja Haslinger et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

GABA-cAMP Response Element-Binding Protein Signaling Regulates Maturation and Survival of Newly Generated Neurons in the Adult Hippocampus

(2009) R. Jagasia et al.   JOURNAL OF NEUROSCIENCE

Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells

(2009) Daniel A. Lim et al.   NATURE

Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh

(2009) Rebecca Favaro et al.   NATURE NEUROSCIENCE

Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis

(2009) Tomoko Kuwabara et al.   NATURE NEUROSCIENCE

Neurod1 is essential for the survival and maturation of adult-born neurons

(2009) Zhengliang Gao et al.   NATURE NEUROSCIENCE

Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development

(2009) R. L. Montgomery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TAp73 regulates the spindle assembly checkpoint by modulating BubR1 activity

(2009) Richard Tomasini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal Activity-Induced Gadd45b Promotes Epigenetic DNA Demethylation and Adult Neurogenesis

(2009) D. K. Ma et al.   SCIENCE

The Level of the Transcription Factor Pax6 Is Essential for Controlling the Balance between Neural Stem Cell Self-Renewal and Neurogenesis

(2009) Stephen N. Sansom et al.   PLoS Genetics

Mechanisms and Functional Implications of Adult Neurogenesis

(2008) Chunmei Zhao et al.   CELL

Neurogenin 2 has an essential role in development of the dentate gyrus

(2008) C. Galichet et al.   DEVELOPMENT

Histone deacetylases 1 and 2 are expressed at distinct stages of neuro-glial development

(2008) Jessica L. MacDonald et al.   DEVELOPMENTAL DYNAMICS

Adult neural stem cells and their role in brain pathology

(2008) G Yadirgi et al.   JOURNAL OF PATHOLOGY

Lineage-Specific Polycomb Targets and De Novo DNA Methylation Define Restriction and Potential of Neuronal Progenitors

(2008) Fabio Mohn et al.   MOLECULAR CELL

Directed differentiation of hippocampal stem/progenitor cells in the adult brain

(2008) Sebastian Jessberger et al.   NATURE NEUROSCIENCE

Therapeutic application of histone deacetylase inhibitors for central nervous system disorders

(2008) Aleksey G. Kazantsev et al.   NATURE REVIEWS DRUG DISCOVERY

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS

p53 regulates the self-renewal and differentiation of neural precursors

(2008) A. Armesilla-Diaz et al.   NEUROSCIENCE

Leigh and Leigh-Like Syndrome in Children and Adults

(2008) Josef Finsterer   PEDIATRIC NEUROLOGY

The Histone H3 Lysine 27-Specific Demethylase Jmjd3 Is Required for Neural Commitment

(2008) Thomas Burgold et al.   PLoS One

The impact of p53 and p73 on aneuploidy and cancer

(2008) Richard Tomasini et al.   TRENDS IN CELL BIOLOGY