From Seeds to Fibrils and Back: Fragmentation as an Overlooked Step in the Propagation of Prions and Prion-Like Proteins

Autophagy participates in, well, just about everything

(2020) Daniel J. Klionsky   CELL DEATH AND DIFFERENTIATION

Discriminating α-synuclein strains in Parkinson’s disease and multiple system atrophy

(2020) Mohammad Shahnawaz et al.   NATURE

A single ultrasensitive assay for detection and discrimination of tau aggregates of Alzheimer and Pick diseases

(2020) Michael A. Metrick et al.   Acta Neuropathologica Communications

Early-onset impairment of the ubiquitin-proteasome system in dopaminergic neurons caused by α-synuclein

(2020) Chris McKinnon et al.   Acta Neuropathologica Communications

The molecular processes underpinning prion-like spreading and seed amplification in protein aggregation

(2020) Georg Meisl et al.   CURRENT OPINION IN NEUROBIOLOGY

The HSP110/HSP70 disaggregation system generates spreading‐competent toxic α‐synuclein species

(2020) Jessica Tittelmeier et al.   EMBO JOURNAL

Promiscuous Roles of Autophagy and Proteasome in Neurodegenerative Proteinopathies

(2020) Fiona Limanaqi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species

(2020) Eliana Nachman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How Do Yeast Cells Contend with Prions?

(2020) Reed B. Wickner et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Biological Functions of Autophagy Genes: A Disease Perspective

(2019) Beth Levine et al.   CELL

Anti-prion systems in yeast

(2019) Reed B. Wickner   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy pathways in the treatment of prion diseases

(2019) Dalia H Abdelaziz et al.   CURRENT OPINION IN PHARMACOLOGY

Secondary nucleation and elongation occur at different sites on Alzheimer’s amyloid-β aggregates

(2019) Tom Scheidt et al.   Science Advances

Prion disease is accelerated in mice lacking stress-induced heat shock protein 70 (HSP70)

(2019) Charles E. Mays et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amplification techniques and diagnosis of prion diseases

(2019) J.-P. Brandel et al.   REVUE NEUROLOGIQUE

Autophagy in Synucleinopathy: The Overwhelmed and Defective Machinery

(2019) Marie-Laure Arotcarena et al.   Cells

α‐synuclein oligomers and fibrils: a spectrum of species, a spectrum of toxicities

(2019) Parvez Alam et al.   JOURNAL OF NEUROCHEMISTRY

Targeting Autophagy for the Treatment of Alzheimer’s Disease: Challenges and Opportunities

(2019) Jie Liu et al.   Frontiers in Molecular Neuroscience

Small Heat Shock Proteins, Big Impact on Protein Aggregation in Neurodegenerative Disease

(2019) Jack M. Webster et al.   Frontiers in Pharmacology

Hsp110 mitigates α-synuclein pathology in vivo

(2019) Yumiko V. Taguchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular quality control by the ubiquitin-proteasome system and autophagy

(2019) Christian Pohl et al.   SCIENCE

Prion-Like Propagation of Protein Misfolding and Aggregation in Amyotrophic Lateral Sclerosis

(2019) Luke McAlary et al.   Frontiers in Molecular Neuroscience

Invited Review: The role of prion‐like mechanisms in neurodegenerative diseases

(2019) Z. Jaunmuktane et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Autophagy regulates exosomal release of prions in neuronal cells

(2018) Basant A. Abdulrahman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid toxicity in Alzheimer’s disease

(2018) Allison B. Reiss et al.   REVIEWS IN THE NEUROSCIENCES

Protein Disaggregation in Multicellular Organisms

(2018) Nadinath B. Nillegoda et al.   TRENDS IN BIOCHEMICAL SCIENCES

A common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers

(2018) Tiffany A. Thibaudeau et al.   Nature Communications

Are We Ready for Detecting α-Synuclein Prone to Aggregation in Patients? The Case of “Protein-Misfolding Cyclic Amplification” and “Real-Time Quaking-Induced Conversion” as Diagnostic Tools

(2018) Silvia Paciotti et al.   Frontiers in Neurology

Rapid and ultra-sensitive quantitation of disease-associated α-synuclein seeds in brain and cerebrospinal fluid by αSyn RT-QuIC

(2018) Bradley R. Groveman et al.   Acta Neuropathologica Communications

Amyloid-β Secretion, Generation, and Lysosomal Sequestration in Response to Proteasome Inhibition: Involvement of Autophagy

(2018) Lotta Agholme et al.   JOURNAL OF ALZHEIMERS DISEASE

Seeding selectivity and ultrasensitive detection of tau aggregate conformers of Alzheimer disease

(2018) Allison Kraus et al.   ACTA NEUROPATHOLOGICA

Cell-free prion protein conversion assays in screening for anti-prion drug candidates

(2018) Natália do Carmo Ferreira et al.   CURRENT OPINION IN PHARMACOLOGY

Pathways of cellular proteostasis in aging and disease

(2017) Courtney L. Klaips et al.   JOURNAL OF CELL BIOLOGY

Secondary nucleation of monomers on fibril surface dominates α-synuclein aggregation and provides autocatalytic amyloid amplification

(2017) Ricardo Gaspar et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Tau Oligomers: Cytotoxicity, Propagation, and Mitochondrial Damage

(2017) Scott S. Shafiei et al.   Frontiers in Aging Neuroscience

Development of a Biochemical Diagnosis of Parkinson Disease by Detection of α-Synuclein Misfolded Aggregates in Cerebrospinal Fluid

(2017) Mohammad Shahnawaz et al.   JAMA Neurology

The celecoxib derivatives AR-12 and AR-14 induce autophagy and clear prion-infected cells from prions

(2017) Basant A. Abdulrahman et al.   Scientific Reports

Alpha-synuclein structure, functions, and interactions

(2016) FatemehNouri Emamzadeh   Journal of Research in Medical Sciences

Decoding ALS: from genes to mechanism

(2016) J. Paul Taylor et al.   NATURE

The real-time quaking-induced conversion assay for detection of human prion disease and study of other protein misfolding diseases

(2016) Matthias Schmitz et al.   Nature Protocols

Extended survival of misfolded G85R SOD1-linked ALS mice by transgenic expression of chaperone Hsp110

(2016) Maria Nagy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prions, Chaperones, and Proteostasis in Yeast

(2016) Tatiana A. Chernova et al.   Cold Spring Harbor Perspectives in Biology

Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies

(2016) Graham Fairfoul et al.   Annals of Clinical and Translational Neurology

Role of autophagy in the pathogenesis of amyotrophic lateral sclerosis

(2015) Jae Keun Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The multivesicular body is the major internal site of prion conversion

(2015) Y.-I. Yim et al.   JOURNAL OF CELL SCIENCE

Yeast Prions: Structure, Biology, and Prion-Handling Systems

(2015) Reed B. Wickner et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Human Hsp70 Disaggregase Reverses Parkinson’s-Linked α-Synuclein Amyloid Fibrils

(2015) Xuechao Gao et al.   MOLECULAR CELL

Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation

(2015) Nadinath B. Nillegoda et al.   NATURE

Strain-Dependent Effect of Macroautophagy on Abnormally Folded Prion Protein Degradation in Infected Neuronal Cells

(2015) Daisuke Ishibashi et al.   PLoS One

Experimental transmissibility of mutant SOD1 motor neuron disease

(2014) Jacob I. Ayers et al.   ACTA NEUROPATHOLOGICA

Apolipoprotein E in Alzheimer's Disease: An Update

(2014) Jin-Tai Yu et al.   Annual Review of Neuroscience

BAG3 induces the sequestration of proteasomal clients into cytoplasmic puncta

(2014) Melania Minoia et al.   Autophagy

Amplification of Tau Fibrils from Minute Quantities of Seeds

(2014) Virginia Meyer et al.   BIOCHEMISTRY

Proteasome Dysfunction Activates Autophagy and the Keap1-Nrf2 Pathway

(2014) Shun Kageyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteasome inhibitor-induced autophagy in PC12 cells overexpressing A53T mutant α-synuclein

(2014) DANMEI LAN et al.   Molecular Medicine Reports

Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms

(2014) Leslie I. Grad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteostasis impairment in protein-misfolding and -aggregation diseases

(2014) Mark S. Hipp et al.   TRENDS IN CELL BIOLOGY

Detection of Misfolded Aβ Oligomers for Sensitive Biochemical Diagnosis of Alzheimer’s Disease

(2014) Natalia Salvadores et al.   Cell Reports

mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies

(2013) Antonella Caccamo et al.   AGING CELL

An Overview of Autophagy: Morphology, Mechanism, and Regulation

(2013) Katherine R. Parzych et al.   ANTIOXIDANTS & REDOX SIGNALING

FK506 reduces abnormal prion protein through the activation of autolysosomal degradation and prolongs survival in prion-infected mice

(2013) Takehiro Nakagaki et al.   Autophagy

Proliferation of amyloid- 42 aggregates occurs through a secondary nucleation mechanism

(2013) S. I. A. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy

(2012) Véronique Schaeffer et al.   BRAIN

An Interdomain Energetic Tug-of-War Creates the Allosterically Active State in Hsp70 Molecular Chaperones

(2012) Anastasia Zhuravleva et al.   CELL

Metazoan Hsp70 machines use Hsp110 to power protein disaggregation

(2012) Heike Rampelt et al.   EMBO JOURNAL

Evidence for the Existence of a Secondary Pathway for Fibril Growth during the Aggregation of Tau

(2012) Gayathri Ramachandran et al.   JOURNAL OF MOLECULAR BIOLOGY

Rapamycin Delays Disease Onset and Prevents PrP Plaque Deposition in a Mouse Model of Gerstmann-Straussler-Scheinker Disease

(2012) C. J. Cortes et al.   JOURNAL OF NEUROSCIENCE

Exosomal cell-to-cell transmission of alpha synuclein oligomers

(2012) Karin M Danzer et al.   Molecular Neurodegeneration

Trans-Synaptic Spread of Tau Pathology In Vivo

(2012) Li Liu et al.   PLoS One

Involvement of members of the Rab family and related small GTPases in autophagosome formation and maturation

(2011) Christelle En Lin Chua et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Misfolded PrP impairs the UPS by interaction with the 20S proteasome and inhibition of substrate entry

(2011) Pelagia Deriziotis et al.   EMBO JOURNAL

Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion

(2011) Ryuichiro Atarashi et al.   NATURE MEDICINE

The Mammalian Disaggregase Machinery: Hsp110 Synergizes with Hsp70 and Hsp40 to Catalyze Protein Disaggregation and Reactivation in a Cell-Free System

(2011) James Shorter   PLoS One

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

(2010) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapamycin Protects against Neuron Death in In Vitro andIn Vivo Models of Parkinson's Disease

(2010) C. Malagelada et al.   JOURNAL OF NEUROSCIENCE

Loss of Hsp110 Leads to Age-Dependent Tau Hyperphosphorylation and Early Accumulation of Insoluble Amyloid  

(2010) B. Eroglu et al.   MOLECULAR AND CELLULAR BIOLOGY

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Superoxide Dismutase 1 and tgSOD1G93A Mouse Spinal Cord Seed Fibrils, Suggesting a Propagative Cell Death Mechanism in Amyotrophic Lateral Sclerosis

(2010) Ruth Chia et al.   PLoS One

The Physical Relationship between Infectivity and Prion Protein Aggregates Is Strain-Dependent

(2010) Philippe Tixador et al.   PLoS Pathogens

Autophagy induction by trehalose counter-acts cellular prion-infection

(2009) Yasmine Aguib et al.   Autophagy

Inhibition of cholesterol recycling impairs cellular PrPSc propagation

(2009) Sabine Gilch et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Lithium induces clearance of protease resistant prion protein in prion-infected cells by induction of autophagy

(2009) Andreas Heiseke et al.   JOURNAL OF NEUROCHEMISTRY

Loss of Hsp70 Exacerbates Pathogenesis But Not Levels of Fibrillar Aggregates in a Mouse Model of Huntington's Disease

(2009) J. L. Wacker et al.   JOURNAL OF NEUROSCIENCE

Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in  -Synuclein Models of Parkinson's and Lewy Body Diseases

(2009) B. Spencer et al.   JOURNAL OF NEUROSCIENCE

Prion-like mechanisms in neurodegenerative diseases

(2009) Bess Frost et al.   NATURE REVIEWS NEUROSCIENCE

Human variant Creutzfeldt-Jakob disease and sheep scrapie PrPres detection using seeded conversion of recombinant prion protein

(2009) C. D. Orru et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6

(2009) C. Vance et al.   SCIENCE

Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis

(2009) T. J. Kwiatkowski et al.   SCIENCE

Identification of an Intracellular Site of Prion Conversion

(2009) Zrinka Marijanovic et al.   PLoS Pathogens

Genes contributing to prion pathogenesis

(2008) G. Tamguney et al.   JOURNAL OF GENERAL VIROLOGY

Simplified ultrasensitive prion detection by recombinant PrP conversion with shaking

(2008) Ryuichiro Atarashi et al.   NATURE METHODS

The yeast Sup35NM domain propagates as a prion in mammalian cells

(2008) C. Krammer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Initiation and elongation in fibrillation of ALS-linked superoxide dismutase

(2008) M. Chattopadhyay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Regulation of Dynein and Kinesin Motor Proteins by Tau

(2008) R. Dixit et al.   SCIENCE