The HSP110/HSP70 disaggregation system generates spreading‐competent toxic α‐synuclein species

Modulation of Amyloid States by Molecular Chaperones

(2019) Anne Wentink et al.   Cold Spring Harbor Perspectives in Biology

Cell-Nonautonomous Regulation of Proteostasis in Aging and Disease

(2019) Richard I. Morimoto   Cold Spring Harbor Perspectives in Biology

Reducing INS-IGF1 signaling protects against non-cell autonomous vesicle rupture caused by SNCA spreading

(2019) Carl Alexander Sandhof et al.   Autophagy

Cellular Handling of Protein Aggregates by Disaggregation Machines

(2018) Axel Mogk et al.   MOLECULAR CELL

Coordinated Hsp110 and Hsp104 Activities Power Protein Disaggregation in Saccharomyces cerevisiae

(2017) Jayasankar Mohanakrishnan Kaimal et al.   MOLECULAR AND CELLULAR BIOLOGY

A bacterial global regulator forms a prion

(2017) Andy H. Yuan et al.   SCIENCE

Enhanced neuroinvasion by smaller, soluble prions

(2017) Cyrus Bett et al.   Acta Neuropathologica Communications

DnaJ/Hsc70 chaperone complexes control the extracellular release of neurodegenerative‐associated proteins

(2016) Sarah N Fontaine et al.   EMBO JOURNAL

Quantitative gene expression analysis in Caenorhabditis elegans using single molecule RNA FISH

(2016) Jitka Bolková et al.   METHODS

Extended survival of misfolded G85R SOD1-linked ALS mice by transgenic expression of chaperone Hsp110

(2016) Maria Nagy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The HSP70 co-chaperone DNAJC14 targets misfolded pendrin for unconventional protein secretion

(2016) Jinsei Jung et al.   Nature Communications

Widespread Proteome Remodeling and Aggregation in Aging C. elegans

(2015) Dirk M. Walther et al.   CELL

Streamlined Genome Engineering with a Self-Excising Drug Selection Cassette

(2015) Daniel J. Dickinson et al.   GENETICS

Human Hsp70 Disaggregase Reverses Parkinson’s-Linked α-Synuclein Amyloid Fibrils

(2015) Xuechao Gao et al.   MOLECULAR CELL

Yeast prions are useful for studying protein chaperones and protein quality control

(2015) Daniel C Masison et al.   Prion

Streamlined Genome Engineering with a Self-Excising Drug Selection Cassette

(2015) Daniel J. Dickinson et al.   GENETICS

Remodeling of Proteostasis Upon Transition to Adulthood is Linked to Reproduction Onset

(2014) Nadav Shai et al.   CURRENT GENOMICS

HSPA8/HSC70 chaperone protein

(2013) François Stricher et al.   Autophagy

Amyloids and Yeast Prion Biology

(2013) Reed B. Wickner et al.   BIOCHEMISTRY

Hsp110 Is aBona FideChaperone Using ATP to Unfold Stable Misfolded Polypeptides and Reciprocally Collaborate with Hsp70 to Solubilize Protein Aggregates

(2013) Rayees U. H. Mattoo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Life cycle of cytosolic prions

(2013) Julia Hofmann et al.   Prion

Cell-to-cell propagation of infectious cytosolic protein aggregates

(2013) J. P. Hofmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spreading of a Prion Domain from Cell-to-Cell by Vesicular Transport in Caenorhabditis elegans

(2013) Carmen I. Nussbaum-Krammer et al.   PLoS Genetics

Metazoan Hsp70 machines use Hsp110 to power protein disaggregation

(2012) Heike Rampelt et al.   EMBO JOURNAL

Chaperone networks in protein disaggregation and prion propagation

(2012) Juliane Winkler et al.   JOURNAL OF STRUCTURAL BIOLOGY

A Unifying Role for Prions in Neurodegenerative Diseases

(2012) S. B. Prusiner   SCIENCE

Firefly luciferase mutants as sensors of proteome stress

(2011) Rajat Gupta et al.   NATURE METHODS

The Mammalian Disaggregase Machinery: Hsp110 Synergizes with Hsp70 and Hsp40 to Catalyze Protein Disaggregation and Reactivation in a Cell-Free System

(2011) James Shorter   PLoS One

A Genetic Screening Strategy Identifies Novel Regulators of the Proteostasis Network

(2011) M. Catarina Silva et al.   PLoS Genetics

Prion-like disorders: blurring the divide between transmissibility and infectivity

(2010) M. Cushman et al.   JOURNAL OF CELL SCIENCE

The HSP70 chaperone machinery: J proteins as drivers of functional specificity

(2010) Harm H. Kampinga et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Prion-like propagation of cytosolic protein aggregates

(2010) Carmen Krammer et al.   Prion

Widespread Protein Aggregation as an Inherent Part of Aging in C. elegans

(2010) Della C. David et al.   PLOS BIOLOGY

An efficient one-step site-directed deletion, insertion, single and multiple-site plasmid mutagenesis protocol

(2009) Huanting Liu et al.   BMC BIOTECHNOLOGY

The Transcellular Spread of Cytosolic Amyloids, Prions, and Prionoids

(2009) Adriano Aguzzi et al.   NEURON

Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging

(2009) A. Ben-Zvi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Analytical Solution to the Kinetics of Breakable Filament Assembly

(2009) T. P. J. Knowles et al.   SCIENCE

Structural Basis for the Cooperation of Hsp70 and Hsp110 Chaperones in Protein Folding

(2008) Sigrun Polier et al.   CELL

Hsp110 Is a Nucleotide-activated Exchange Factor for Hsp70

(2008) Claes Andréasson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substrate threading through the central pore of the Hsp104 chaperone as a common mechanism for protein disaggregation and prion propagation

(2008) Peter Tessarz et al.   MOLECULAR MICROBIOLOGY

Simplified ultrasensitive prion detection by recombinant PrP conversion with shaking

(2008) Ryuichiro Atarashi et al.   NATURE METHODS

The yeast Sup35NM domain propagates as a prion in mammalian cells

(2008) C. Krammer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

C. elegans Model Identifies Genetic Modifiers of α-Synuclein Inclusion Formation During Aging

(2008) Tjakko J. van Ham et al.   PLoS Genetics