Role of Ubiquitination in PTEN Cellular Homeostasis and Its Implications in GB Drug Resistance

Improved prognostication of glioblastoma beyond molecular subtyping by transcriptional profiling of the tumor microenvironment

(2020) Marine Jeanmougin et al.   Molecular Oncology

Downregulation of the Ubiquitin-E3 Ligase RNF123 Promotes Upregulation of the NF-κB1 Target SerpinE1 in Aggressive Glioblastoma Tumors

(2020) Xiaowen Wang et al.   Cancers

FAK Inhibition Induces Glioblastoma Cell Senescence-Like State through p62 and p27

(2020) Lía Alza et al.   Cancers

Oncogenic Smurf1 promotes PTEN wild-type glioblastoma growth by mediating PTEN ubiquitylation

(2020) Qin Xia et al.   ONCOGENE

PTEN Mutations Trigger Resistance to Immunotherapy

(2019) Feixiong Cheng et al.   TRENDS IN MOLECULAR MEDICINE

Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair

(2019) Jianhui Ma et al.   CANCER CELL

Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway

(2019) Yu-Ru Lee et al.   SCIENCE

Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma

(2019) Peiwen Chen et al.   CANCER CELL

ZFYVE21 is a complement-induced Rab5 effector that activates non-canonical NF-κB via phosphoinosotide remodeling of endosomes

(2019) Caodi Fang et al.   Nature Communications

The PTEN–PI3K Axis in Cancer

(2019) Papa et al.   Biomolecules

LINC01198 promotes proliferation and temozolomide resistance in a NEDD4-1-dependent manner, repressing PTEN expression in glioma

(2019) Wei-Lin Chen et al.   Aging-US

The protein arginine methyltransferase PRMT5 confers therapeutic resistance to mTOR inhibition in glioblastoma

(2019) Brent Holmes et al.   JOURNAL OF NEURO-ONCOLOGY

The Protein Neddylation Inhibitor MLN4924 Suppresses Patient-Derived Glioblastoma Cells via Inhibition of ERK and AKT Signaling

(2019) Suji Han et al.   Cancers

Regulating the human HECT E3 ligases

(2018) Jasper Sluimer et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

HRD1-mediated PTEN degradation promotes cell proliferation and hepatocellular carcinoma progression

(2018) Liu Liu et al.   CELLULAR SIGNALLING

The functions and regulation of the PTEN tumour suppressor: new modes and prospects

(2018) Yu-Ru Lee et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MicroRNA-300 Regulates the Ubiquitination of PTEN through the CRL4B DCAF13 E3 Ligase in Osteosarcoma Cells

(2018) Zhi Chen et al.   Molecular Therapy-Nucleic Acids

Attenuation of Tumor Suppressive Function of FBXO16 Ubiquitin Ligase Activates Wnt Signaling In Glioblastoma

(2018) Mohsina Khan et al.   NEOPLASIA

Role for loss of nuclear PTEN in a harbinger of brain metastases

(2017) Ryo Nosaka et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Expression and function of ABCG2 and XIAP in glioblastomas

(2017) Ivette F. Emery et al.   JOURNAL OF NEURO-ONCOLOGY

PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation

(2017) Amit Gupta et al.   MOLECULAR CELL

A Tunable Brake for HECT Ubiquitin Ligases

(2017) Zan Chen et al.   MOLECULAR CELL

Characterization of PTEN mutations in brain cancer reveals that pten mono-ubiquitination promotes protein stability and nuclear localization

(2017) Jr-M Yang et al.   ONCOGENE

PTEN regulates glioblastoma oncogenesis through chromatin-associated complexes of DAXX and histone H3.3

(2017) Jorge A. Benitez et al.   Nature Communications

Enzymatic Analysis of PTEN Ubiquitylation by WWP2 and NEDD4-1 E3 Ligases

(2016) Zan Chen et al.   BIOCHEMISTRY

MiR-200c is a cMyc-activated miRNA that promotes nasopharyngeal carcinoma by downregulating PTEN

(2016) Pan Chen et al.   Oncotarget

Cdh1 inhibits WWP2-mediated ubiquitination of PTEN to suppress tumorigenesis in an APC-independent manner

(2016) Jia Liu et al.   Cell Discovery

The intrinsically disordered tails of PTEN and PTEN-L have distinct roles in regulating substrate specificity and membrane activity

(2015) G. R. Masson et al.   BIOCHEMICAL JOURNAL

Bcl-2 family member Mcl-1 expression is reduced under hypoxia by the E3 ligase FBW7 contributing to BNIP3 induced cell death in glioma cells

(2015) Yongqiang Chen et al.   CANCER BIOLOGY & THERAPY

Genomic and Functional Analysis of the E3 Ligase PARK2 in Glioma

(2015) D.-C. Lin et al.   CANCER RESEARCH

NEDD4: The founding member of a family of ubiquitin-protein ligases

(2015) Natasha Anne Boase et al.   GENE

TRIM28 as an independent prognostic marker plays critical roles in glioma progression

(2015) Zeng-Xin Qi et al.   JOURNAL OF NEURO-ONCOLOGY

Kinases, tails and more: Regulation of PTEN function by phosphorylation

(2015) Rita Fragoso et al.   METHODS

Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis

(2015) Lin Yuan et al.   NATURE CELL BIOLOGY

SLUG is a direct transcriptional repressor of PTEN tumor suppressor

(2015) Berna Uygur et al.   PROSTATE

The PTEN Tumor Suppressor Forms Homodimers in Solution

(2015) Frank Heinrich et al.   STRUCTURE

PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis

(2015) Min-Sik Lee et al.   Nature Communications

PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype

(2015) Shunlei Duan et al.   Nature Communications

The Roles of Post-translational Modifications in the Context of Protein Interaction Networks

(2015) Guangyou Duan et al.   PLoS Computational Biology

PTEN: Multiple Functions in Human Malignant Tumors

(2015) Michele Milella et al.   Frontiers in Oncology

CHIP is a novel tumor suppressor in pancreatic cancer and inhibits tumor growth through targeting EGFR

(2015) Tianxiao Wang et al.   Oncotarget

SCFβ-TRCP-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway

(2015) Jia Liu et al.   Oncotarget

Small-Molecule XIAP Inhibitors Enhance γ-Irradiation-Induced Apoptosis in Glioblastoma

(2015) Sri Hari Krishna Vellanki et al.   NEOPLASIA

Regulation of EGFR Protein Stability by the HECT-type Ubiquitin Ligase SMURF2

(2015) Dipankar Ray et al.   NEOPLASIA

Epidemiologic and Molecular Prognostic Review of Glioblastoma

(2014) J. P. Thakkar et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

CBP Loss Cooperates with PTEN Haploinsufficiency to Drive Prostate Cancer: Implications for Epigenetic Therapy

(2014) L. Ding et al.   CANCER RESEARCH

Cancer-Associated PTEN Mutants Act in a Dominant-Negative Manner to Suppress PTEN Protein Function

(2014) Antonella Papa et al.   CELL

Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth

(2014) Nan Li et al.   GENES & DEVELOPMENT

PTEN is a protein tyrosine phosphatase for IRS1

(2014) Yuji Shi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

WWP1 as a potential tumor oncogene regulates PTEN-Akt signaling pathway in human gastric carcinoma

(2014) Li Zhang et al.   TUMOR BIOLOGY

Smurf2 E3 ubiquitin ligase modulates proliferation and invasiveness of breast cancer cells in a CNKSR2 dependent manner

(2014) Diana David et al.   Cell Division

Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers

(2014) Shingo Nakahata et al.   Nature Communications

Characterization of Dual PTEN and p53-Targeting MicroRNAs Identifies MicroRNA-638/Dnm2 as a Two-Hit Oncogenic Locus

(2014) Yvonne Tay et al.   Cell Reports

The Somatic Genomic Landscape of Glioblastoma

(2013) Cameron W. Brennan et al.   CELL

RFP-mediated ubiquitination of PTEN modulates its effect on AKT activation

(2013) James T Lee et al.   CELL RESEARCH

Pharmaceutical Perspectives of HECT-TYPE Ubiquitin Ligase Smurf1

(2013) Yu Cao et al.   CURRENT PHARMACEUTICAL DESIGN

MC1R Is a Potent Regulator of PTEN after UV Exposure in Melanocytes

(2013) Juxiang Cao et al.   MOLECULAR CELL

Deubiquitylation and stabilization of PTEN by USP13

(2013) Jinsong Zhang et al.   NATURE CELL BIOLOGY

Nuclear PTEN Controls DNA Repair and Sensitivity to Genotoxic Stress

(2013) C. Bassi et al.   SCIENCE

Proteolysis of MOB1 by the ubiquitin ligase praja2 attenuates Hippo signalling and supports glioblastoma growth

(2013) Luca Lignitto et al.   Nature Communications

Functional analysis of the protein phosphatase activity of PTEN

(2012) Xiaoqun Catherine Zhang et al.   BIOCHEMICAL JOURNAL

Systemic Elevation of PTEN Induces a Tumor-Suppressive Metabolic State

(2012) Isabel Garcia-Cao et al.   CELL

The Chaperone-assisted E3 Ligase C Terminus of Hsc70-interacting Protein (CHIP) Targets PTEN for Proteasomal Degradation

(2012) Syed Feroj Ahmed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HECT and RING finger families of E3 ubiquitin ligases at a glance

(2012) M. B. Metzger et al.   JOURNAL OF CELL SCIENCE

The mitogen-activated protein kinase (MAPK) cascade controls phosphatase and tensin homolog (PTEN) expression through multiple mechanisms

(2012) Ludovica Ciuffreda et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

(2012) Jeremy Schwartzentruber et al.   NATURE

Androgen receptor degradation by the E3 ligase CHIP modulates mitotic arrest in prostate cancer cells

(2012) S Sarkar et al.   ONCOGENE

Sensitization of Glioma Cells by X-Linked Inhibitor of Apoptosis Protein Knockdown

(2012) Patricia L.C. Lopez et al.   ONCOLOGY

Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240

(2012) T. R. Fenton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PTEN Protein Phosphatase Activity Correlates with Control of Gene Expression and Invasion, a Tumor-Suppressing Phenotype, But Not with AKT Activity

(2012) P. Tibarewal et al.   Science Signaling

Regulation of the tumor suppressor PTEN by SUMO

(2012) J González-Santamaría et al.   Cell Death & Disease

SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane

(2012) Jian Huang et al.   Nature Communications

E3 Ubiquitin Ligase Cbl-b Regulates Pten via Nedd4 in T Cells Independently of Its Ubiquitin Ligase Activity

(2012) Hui Guo et al.   Cell Reports

PTEN Level in Tumor Suppression: How Much Is Too Little?

(2011) A. Carracedo et al.   CANCER RESEARCH

CREB Is a Novel Nuclear Target of PTEN Phosphatase

(2011) T. Gu et al.   CANCER RESEARCH

Carboxyl terminus of Hsp70-interacting protein (CHIP) contributes to human glioma oncogenesis

(2011) Tao Xu et al.   CANCER SCIENCE

Nuclear PTEN Regulates the APC-CDH1 Tumor-Suppressive Complex in a Phosphatase-Independent Manner

(2011) Min Sup Song et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Genomic Profiles of Glioma

(2011) Cameron Brennan   Current Neurology and Neuroscience Reports

Mislocalization of the E3 Ligase, β-Transducin Repeat-containing Protein 1 (β-TrCP1), in Glioblastoma Uncouples Negative Feedback between the Pleckstrin Homology Domain Leucine-rich Repeat Protein Phosphatase 1 (PHLPP1) and Akt

(2011) Noel A. Warfel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A continuum model for tumour suppression

(2011) Alice H. Berger et al.   NATURE

WWP2 is an E3 ubiquitin ligase for PTEN

(2011) Subbareddy Maddika et al.   NATURE CELL BIOLOGY

On-off system for PI3-kinase-Akt signaling through S-nitrosylation of phosphatase with sequence homology to tensin (PTEN)

(2011) N. Numajiri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

FoxM1B Regulates NEDD4-1 Expression, Leading to Cellular Transformation and Full Malignant Phenotype in Immortalized Human Astrocytes

(2010) Bingbing Dai et al.   CANCER RESEARCH

MicroRNA-21 (miR-21) represses tumor suppressor PTEN and promotes growth and invasion in non-small cell lung cancer (NSCLC)

(2010) Ji-guang Zhang et al.   CLINICA CHIMICA ACTA

Differential Regulation of Protrusion and Polarity by PI(3)K during Neutrophil Motility in Live Zebrafish

(2010) Sa Kan Yoo et al.   DEVELOPMENTAL CELL

A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis

(2010) Andrea Alimonti et al.   JOURNAL OF CLINICAL INVESTIGATION

Surgical outcomes for older patients with glioblastoma multiforme: preoperative factors associated with decreased survival

(2010) Kaisorn L. Chaichana et al.   JOURNAL OF NEUROSURGERY

Molecular pathology in adult gliomas: diagnostic, prognostic, and predictive markers

(2010) Michael Jansen et al.   LANCET NEUROLOGY

NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration

(2010) Young-Don Kwak et al.   Molecular Neurodegeneration

Subtle variations in Pten dose determine cancer susceptibility

(2010) Andrea Alimonti et al.   NATURE GENETICS

Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2

(2010) T. Mund et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allele-specific tumor spectrum in Pten knockin mice

(2010) H. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of NF- B Signaling by A20 Through Disruption of Ubiquitin Enzyme Complexes

(2010) N. Shembade et al.   SCIENCE

Identification of the miR-106b 25 MicroRNA Cluster as a Proto-Oncogenic PTEN-Targeting Intron That Cooperates with Its Host Gene MCM7 in Transformation

(2010) L. Poliseno et al.   Science Signaling

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Genetic dissection of the miR-17 92 cluster of microRNAs in Myc-induced B-cell lymphomas

(2009) P. Mu et al.   GENES & DEVELOPMENT

X-linked Inhibitor of Apoptosis Protein (XIAP) Regulates PTEN Ubiquitination, Content, and Compartmentalization

(2009) Céline Van Themsche et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

C Terminus of Hsc70-interacting Protein Promotes Smooth Muscle Cell Proliferation and Survival through Ubiquitin-mediated Degradation of FoxO1

(2009) Fang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells

(2009) Li-Bing Song et al.   JOURNAL OF CLINICAL INVESTIGATION

The ubiquitin ligase CHIP acts as an upstream regulator of oncogenic pathways

(2009) Masashi Kajiro et al.   NATURE CELL BIOLOGY

Somatic mutations of the Parkinson's disease–associated gene PARK2 in glioblastoma and other human malignancies

(2009) Selvaraju Veeriah et al.   NATURE GENETICS

Suppression of cellular proliferation and invasion by the concerted lipid and protein phosphatase activities of PTEN

(2009) L Davidson et al.   ONCOGENE

Stem Cell Factor SALL4 Represses the Transcriptions of PTEN and SALL1 through an Epigenetic Repressor Complex

(2009) Jiayun Lu et al.   PLoS One

Phosphorylation keeps PTEN phosphatase closed for business

(2009) A. H. Ross et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of the PI3K Pathway in Cancer Through Inhibition of PTEN by Exchange Factor P-REX2a

(2009) B. Fine et al.   SCIENCE

Crucial role of the C-terminus of PTEN in antagonizing NEDD4-1-mediated PTEN ubiquitination and degradation

(2008) Xinjiang Wang et al.   BIOCHEMICAL JOURNAL

The HECT Family of E3 Ubiquitin Ligases: Multiple Players in Cancer Development

(2008) Francesca Bernassola et al.   CANCER CELL

PTEN Acetylation Modulates Its Interaction with PDZ Domain

(2008) T. Ikenoue et al.   CANCER RESEARCH

MicroRNA Expression Profiling in Human Ovarian Cancer: miR-214 Induces Cell Survival and Cisplatin Resistance by Targeting PTEN

(2008) H. Yang et al.   CANCER RESEARCH

Pten Haploinsufficiency Accelerates Formation of High-Grade Astrocytomas

(2008) C.-H. Kwon et al.   CANCER RESEARCH

The nuclear affairs of PTEN

(2008) S. M. Planchon et al.   JOURNAL OF CELL SCIENCE

PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability

(2008) Ana Silva et al.   JOURNAL OF CLINICAL INVESTIGATION

Repression of PTEN Phosphatase by Snail1 Transcriptional Factor during Gamma Radiation-Induced Apoptosis

(2008) M. Escriva et al.   MOLECULAR AND CELLULAR BIOLOGY

The deubiquitinylation and localization of PTEN are regulated by a HAUSP–PML network

(2008) Min Sup Song et al.   NATURE

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes

(2008) Changchun Xiao et al.   NATURE IMMUNOLOGY

PTEN functions to 'prioritize' chemotactic cues and prevent 'distraction' in migrating neutrophils

(2008) Bryan Heit et al.   NATURE IMMUNOLOGY

A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN

(2008) M. Rahdar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA