FAK Inhibition Induces Glioblastoma Cell Senescence-Like State through p62 and p27

Inhibition of FAK Signaling Elicits Lamin A/C-Associated Nuclear Deformity and Cellular Senescence

(2019) Hsiang-Hao Chuang et al.   Frontiers in Oncology

Mechanisms, Hallmarks, and Implications of Stem Cell Quiescence

(2019) Inchul J. Cho et al.   Stem Cell Reports

SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence

(2019) Gloria Salazar et al.   Autophagy

Cellular Senescence: Defining a Path Forward

(2019) Vassilis Gorgoulis et al.   CELL

The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy

(2019) Caroline Kumsta et al.   Nature Communications

Inhibition of WNT-CTNNB1 signaling upregulates SQSTM1 and sensitizes glioblastoma cells to autophagy blockers

(2018) Mireia Nàger et al.   Autophagy

Sequestosome 1 protects esophageal squamous carcinoma cells from apoptosis via stabilizing SKP2 under serum starvation condition

(2018) Chao Shi et al.   ONCOGENE

Hallmarks of Cellular Senescence

(2018) Alejandra Hernandez-Segura et al.   TRENDS IN CELL BIOLOGY

Quinacrine upregulates p21/p27 independent of p53 through autophagy-mediated downregulation of p62-Skp2 axis in ovarian cancer

(2018) DeokBeom Jung et al.   Scientific Reports

Chronic p27Kip1 Induction by Dexamethasone Causes Senescence Phenotype and Permanent Cell Cycle Blockade in Lung Adenocarcinoma Cells Over-expressing Glucocorticoid Receptor

(2018) Mugdha Patki et al.   Scientific Reports

Ki67 is a Graded Rather than a Binary Marker of Proliferation versus Quiescence

(2018) Iain Miller et al.   Cell Reports

p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors

(2018) Panagiotis Karras et al.   CANCER CELL

Developments in Blood-Brain Barrier Penetrance and Drug Repurposing for Improved Treatment of Glioblastoma

(2018) Bryan G. Harder et al.   Frontiers in Oncology

Is the blood–brain barrier really disrupted in all glioblastomas? A critical assessment of existing clinical data

(2017) Jann N Sarkaria et al.   NEURO-ONCOLOGY

Techniques to Induce and Quantify Cellular Senescence

(2017) Nicole Noren Hooten et al.   Jove-Journal of Visualized Experiments

p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells

(2016) Atsushi Umemura et al.   CANCER CELL

p62 in Cancer: Signaling Adaptor Beyond Autophagy

(2016) Jorge Moscat et al.   CELL

GlioVis data portal for visualization and analysis of brain tumor expression datasets

(2016) Robert L. Bowman et al.   NEURO-ONCOLOGY

Cell cycle arrest is not senescence

(2016) Mikhail V. Blagosklonny   Aging-US

Autophagy mediates degradation of nuclear lamina

(2015) Zhixun Dou et al.   NATURE

Cytotoxic and radiosensitizing effects of FAK targeting in human glioblastoma cells in vitro

(2015) KATJA STORCH et al.   ONCOLOGY REPORTS

FAK signaling in human cancer as a target for therapeutics

(2015) Brian Y. Lee et al.   PHARMACOLOGY & THERAPEUTICS

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

(2015) C. Kang et al.   SCIENCE

Emerging Roles of Focal Adhesion Kinase in Cancer

(2015) Yu-Ling Tai et al.   Biomed Research International

BIS targeting induces cellular senescence through the regulation of 14-3-3 zeta/STAT3/SKP2/p27 in glioblastoma cells

(2014) J-J Lee et al.   Cell Death & Disease

FAK and paxillin dynamics at focal adhesions in the protrusions of migrating cells

(2014) Ying-Li Hu et al.   Scientific Reports

Nanog Increases Focal Adhesion Kinase (FAK) Promoter Activity and Expression and Directly Binds to FAK Protein to Be Phosphorylated

(2012) Baotran Ho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lamin B1 loss is a senescence-associated biomarker

(2012) Adam Freund et al.   MOLECULAR BIOLOGY OF THE CELL

Pharmacologic Blockade of FAK Autophosphorylation Decreases Human Glioblastoma Tumor Growth and Synergizes with Temozolomide

(2012) V. M. Golubovskaya et al.   MOLECULAR CANCER THERAPEUTICS

Phosphorylation of p62 by cdk1 Controls the Timely Transit of Cells through Mitosis and Tumor Cell Proliferation

(2011) J. F. Linares et al.   MOLECULAR AND CELLULAR BIOLOGY

Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling

(2011) Emma Sandilands et al.   NATURE CELL BIOLOGY

Expression of NANOG in human gliomas and its relationship with undifferentiated glioma cells

(2011) Chao-Shi Niu   ONCOLOGY REPORTS

NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with GLI1 and p53

(2010) Marie Zbinden et al.   EMBO JOURNAL

Nucleocytoplasmic Shuttling of p62/SQSTM1 and Its Role in Recruitment of Nuclear Polyubiquitinated Proteins to Promyelocytic Leukemia Bodies

(2009) Serhiy Pankiv et al.   JOURNAL OF BIOLOGICAL CHEMISTRY