Journal
ONCOTARGET
Volume 8, Issue 3, Pages 5206-5218Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.14123
Keywords
miRNA-200c; c-Myc; PTEN; nasopharyngeal carcinoma
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Funding
- 111 Project [111-2-12]
- National Nature Scientific Foundation of China [81071644, 81101509, 81402307]
- Natural Science Foundation of Hunan Province, China [2015JJ6061]
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The c-Myc transcription factor regulates a complex transcriptional program that leads to cellular transformation by targeting a large number of protein-encoding genes and non-coding RNAs. In this study, we show that a microRNA, miR-200c, is a novel c-Myc target that promotes cellular transformation and metastasis in nasopharyngeal carcinoma. MiR-200c achieves this oncogenic effect, at least in part, by targeting and inhibiting the tumor suppressor gene PTEN (phosphatase and tensin homolog), which is a key inhibitor of the AKT kinase signaling that promotes tumorigenesis in nasopharyngeal carcinoma. Our study thus identifies cMyc-miR-200c-PTEN-AKT as a functional module that promotes cellular transformation in nasopharyngeal carcinoma.
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