ELAVL1 Role in Cell Fusion and Tunneling Membrane Nanotube Formations with Implication to Treat Glioma Heterogeneity

Biological effects of selective COX-2 inhibitor NS398 on human glioblastoma cell lines

(2020) Paola Palumbo et al.   Cancer Cell International

Tumor-Cell–Macrophage Fusion Cells as Liquid Biomarkers and Tumor Enhancers in Cancer

(2020) Yariswamy Manjunath et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Astrocytes rescue neuronal health after cisplatin treatment through mitochondrial transfer

(2020) Krystal English et al.   Acta Neuropathologica Communications

Therapeutic Targeting of Autophagy for Renal Cell Carcinoma Therapy

(2020) Trace M. Jones et al.   Cancers

Tunneling Nanotubes and Tumor Microtubes in Cancer

(2020) Cora Roehlecke et al.   Cancers

Tunneling nanotubes, a novel mode of tumor cell-macrophage communication in tumor cell invasion

(2019) Samer J. Hanna et al.   JOURNAL OF CELL SCIENCE

RNA binding protein HuR promotes autophagosome formation by regulating expressions of autophagy-related protein 5, 12, and 16 in human hepatocellular carcinoma cells.

(2019) Eunbyul Ji et al.   MOLECULAR AND CELLULAR BIOLOGY

Novel compounds targeting the RNA-binding protein HuR. Struc-ture-based design, synthesis and interaction studies.

(2019) Serena Della Volpe et al.   ACS Medicinal Chemistry Letters

The chaperone ERp29 is required for tunneling nanotube formation by stabilizing MSec.

(2019) Rajaiah Pergu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-cancer effects of the HuR inhibitor, MS-444, in malignant glioma cells

(2019) Jiping Wang et al.   CANCER BIOLOGY & THERAPY

Methyl-β-cyclodextrin, an actin depolymerizer augments the antiproliferative potential of microtubule-targeting agents

(2019) Nikita Mundhara et al.   Scientific Reports

An Inflammatory Landscape for Preoperative Neurologic Deficits in Glioblastoma

(2019) Amal Katrib et al.   Frontiers in Genetics

Deletion of the RNA regulator HuR in tumor‐associated microglia and macrophages stimulates anti‐tumor immunity and attenuates glioma growth

(2019) Jiping Wang et al.   GLIA

Pre-Clinical Drug Testing in 2D and 3D Human In Vitro Models of Glioblastoma Incorporating Non-Neoplastic Astrocytes: Tunneling Nano Tubules and Mitochondrial Transfer Modulates Cell Behavior and Therapeutic Respons

(2019) Prospero Civita et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Immune biology of glioma associated macrophages and microglia: Functional and therapeutic implications

(2019) Jun Wei et al.   NEURO-ONCOLOGY

Mesenchymal stem cells promote glioma neovascularization in vivo by fusing with cancer stem cells

(2019) Chao Sun et al.   BMC CANCER

Expression of cytosolic phospholipase A2 alpha in glioblastoma is associated with resistance to chemotherapy

(2018) Lei Yang et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Cystathionine γ Lyase Sulfhydrates the RNA Binding Protein HuR to Preserve Endothelial Cell Function and Delay Atherogenesis

(2018) Sofia-Iris Bibli et al.   CIRCULATION

Fusogens

(2018) Nadav Segev et al.   CURRENT BIOLOGY

RalGPS2 is involved in tunneling nanotubes formation in 5637 bladder cancer cells

(2018) A. D’Aloia et al.   EXPERIMENTAL CELL RESEARCH

Role of Macrophages in Brain Tumor Growth and Progression

(2018) Elia Guadagno et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CAR T-cell therapy for glioblastoma: recent clinical advances and future challenges

(2018) Stephen J Bagley et al.   NEURO-ONCOLOGY

HuR (Elavl1) and HuB (Elavl2) Stabilize Matrix Metalloproteinase-9 mRNA During Seizure-Induced Mmp-9 Expression in Neurons

(2018) Katarzyna Zybura-Broda et al.   Frontiers in Neuroscience

RNA-binding Protein HuR Regulates Both Mutant and Wild-type IDH1 in IDH1-mutated Cancer

(2018) Mahsa Zarei et al.   MOLECULAR CANCER RESEARCH

RBPs Play Important Roles in Vascular Endothelial Dysfunction Under Diabetic Conditions

(2018) Chunbo Yang et al.   Frontiers in Physiology

Perspective on nanochannels as cellular mediators in different disease conditions

(2018) Eshna Jash et al.   Cell Communication and Signaling

RNA-binding protein, human antigen R regulates hypoxia-induced autophagy by targeting ATG7/ATG16L1 expressions and autophagosome formation

(2018) Kalaiselvi Palanisamy et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Tumour treating fields in a combinational therapeutic approach

(2018) Joshua Branter et al.   Oncotarget

Suramin, screened from an approved drug library, inhibits HuR functions and attenuates malignant phenotype of oral cancer cells

(2018) Wataru Kakuguchi et al.   Cancer Medicine

Hybrids by tumor-associated macrophages × glioblastoma cells entail nuclear reprogramming and glioblastoma invasion

(2018) Mian-Fu Cao et al.   CANCER LETTERS

Hu antigen R (HuR) multimerization contributes to glioma disease progression

(2017) Natalia Filippova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of connexin 43 in different forms of intercellular communication – gap junctions, extracellular vesicles and tunnelling nanotubes

(2017) Teresa M. Ribeiro-Rodrigues et al.   JOURNAL OF CELL SCIENCE

Tweety-Homolog 1 Drives Brain Colonization of Gliomas

(2017) Erik Jung et al.   JOURNAL OF NEUROSCIENCE

T Cell-Macrophage Fusion Triggers Multinucleated Giant Cell Formation for HIV-1 Spreading

(2017) Lucie Bracq et al.   JOURNAL OF VIROLOGY

Tumor microtubes convey resistance to surgical lesions and chemotherapy in gliomas

(2017) Sophie Weil et al.   NEURO-ONCOLOGY

Radiation plus Temozolomide in Patients with Glioblastoma

(2017)   NEW ENGLAND JOURNAL OF MEDICINE

COX-2 expression in ovarian cancer: an updated meta-analysis

(2017) Haiming Sun et al.   Oncotarget

Blocking epithelial-to-mesenchymal transition in glioblastoma with a sextet of repurposed drugs: the EIS regimen

(2017) Richard E. Kast et al.   Oncotarget

The Role of Rho-GTPases and actin polymerization during Macrophage Tunneling Nanotube Biogenesis

(2017) Samer J. Hanna et al.   Scientific Reports

Role of Modulator of Inflammation Cyclooxygenase-2 in Gammaherpesvirus Mediated Tumorigenesis

(2017) Jaya Gandhi et al.   Frontiers in Microbiology

The fungal natural product azaphilone-9 binds to HuR and inhibits HuR-RNA interaction in vitro

(2017) Kawaljit Kaur et al.   PLoS One

HuR-targeted small molecule inhibitor exhibits cytotoxicity towards human lung cancer cells

(2017) Ranganayaki Muralidharan et al.   Scientific Reports

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

The role of neural connexins in HeLa cell mobility and intercellular communication through tunneling tubes

(2016) Lina Rimkutė et al.   BMC CELL BIOLOGY

Tunneling nanotubes spread fibrillar α‐synuclein by intercellular trafficking of lysosomes

(2016) Saïda Abounit et al.   EMBO JOURNAL

Linked in: immunologic membrane nanotube networks

(2016) C. R. Zaccard et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A malignant cellular network in gliomas: potential clinical implications

(2016) Matthias Osswald et al.   NEURO-ONCOLOGY

Inhibiting cytoplasmic accumulation of HuR synergizes genotoxic agents in urothelial carcinoma of the bladder

(2016) Jiawei Guo et al.   Oncotarget

Tunneling nanotube formation is stimulated by hypoxia in ovarian cancer cells

(2016) Snider Desir et al.   Oncotarget

Differential identity of Filopodia and Tunneling Nanotubes revealed by the opposite functions of actin regulatory complexes

(2016) Elise Delage et al.   Scientific Reports

Identification and Validation of Novel Small Molecule Disruptors of HuR-mRNA Interaction

(2015) Xiaoqing Wu et al.   ACS Chemical Biology

Oligodendroglioma: pathology, molecular mechanisms and markers

(2015) Pieter Wesseling et al.   ACTA NEUROPATHOLOGICA

Post-transcriptional regulation of connexins: Figure 1

(2015) Clàudia Salat-Canela et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Cyclooxygenase-2 promotes tumor growth and suppresses tumor immunity

(2015) Bing Liu et al.   Cancer Cell International

Radiation-induced homotypic cell fusions of innately resistant glioblastoma cells mediate their sustained survival and recurrence

(2015) E. Kaur et al.   CARCINOGENESIS

Eribulin Mesylate: Mechanism of Action of a Unique Microtubule-Targeting Agent

(2015) N. F. Dybdal-Hargreaves et al.   CLINICAL CANCER RESEARCH

Rescue of Brain Function Using Tunneling Nanotubes Between Neural Stem Cells and Brain Microvascular Endothelial Cells

(2015) Xiaoqing Wang et al.   MOLECULAR NEUROBIOLOGY

Brain tumour cells interconnect to a functional and resistant network

(2015) Matthias Osswald et al.   NATURE

Fusion of cancer stem cells and mesenchymal stem cells contributes to glioma neovascularization

(2015) CHAO SUN et al.   ONCOLOGY REPORTS

Tunneling nanotubes between rat primary astrocytes and C6 glioma cells alter proliferation potential of glioma cells

(2015) Lei Zhang et al.   Neuroscience Bulletin

Lipid droplets as a novel cargo of tunnelling nanotubes in endothelial cells

(2015) Ksenia Astanina et al.   Scientific Reports

Dihydrotanshinone-I interferes with the RNA-binding activity of HuR affecting its post-transcriptional function

(2015) Vito Giuseppe D’Agostino et al.   Scientific Reports

Endothelial Cell Self-fusion during Vascular Pruning

(2015) Anna Lenard et al.   PLOS BIOLOGY

Molecular Heterogeneity in Glioblastoma: Potential Clinical Implications

(2015) Nicole Renee Parker et al.   Frontiers in Oncology

Identification of Small-Molecule Inhibitors of the HuR/RNA Interaction Using a Fluorescence Polarization Screening Assay Followed by NMR Validation

(2015) Zhonghua Wang et al.   PLoS One

Miro1 regulates intercellular mitochondrial transport & enhances mesenchymal stem cell rescue efficacy

(2014) Tanveer Ahmad et al.   EMBO JOURNAL

Chemokine-coupled β2integrin–induced macrophage Rac2–Myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesis

(2014) Alan R. Morrison et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Role of Sphingolipids in Arachidonic Acid Metabolism

(2014) Hiroyuki Nakamura et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Tumor and Endothelial Cell Hybrids Participate in Glioblastoma Vasculature

(2014) Soufiane El Hallani et al.   Biomed Research International

Chloroquine in Cancer Therapy: A Double-Edged Sword of Autophagy

(2013) T. Kimura et al.   CANCER RESEARCH

Preferential transfer of mitochondria from endothelial to cancer cells through tunneling nanotubes modulates chemoresistance

(2013) Jennifer Pasquier et al.   Journal of Translational Medicine

HuR and miR-1192 regulate myogenesis by modulating the translation of HMGB1 mRNA

(2013) Virginie Dormoy-Raclet et al.   Nature Communications

Macrophage β2 Integrin–Mediated, HuR-Dependent Stabilization of Angiogenic Factor–Encoding mRNAs in Inflammatory Angiogenesis

(2012) Jiange Zhang et al.   AMERICAN JOURNAL OF PATHOLOGY

Tunneling nanotubes, an emerging intercellular communication route in development

(2012) Hans-Hermann Gerdes et al.   MECHANISMS OF DEVELOPMENT

Tunneling-nanotube direction determination in neurons and astrocytes

(2012) X Sun et al.   Cell Death & Disease

Regulation of cyclooxygenase-2 and cytosolic phospholipase A2gene expression by lipopolysaccharide through the RNA-binding protein HuR: involvement of NADPH oxidase, reactive oxygen species and mitogen-activated protein kinases

(2011) Wei-Ning Lin et al.   BRITISH JOURNAL OF PHARMACOLOGY

The intrinsic fusogenicity of glioma cells as a factor of transformation and progression in the tumor microenvironment

(2011) Javier Mercapide et al.   INTERNATIONAL JOURNAL OF CANCER

Horizontal transmission and retention of malignancy, as well as functional human genes, after spontaneous fusion of human glioblastoma and hamster host cells in vivo

(2011) David M. Goldenberg et al.   INTERNATIONAL JOURNAL OF CANCER

The RNA-binding Protein HuR Stabilizes Cytosolic Phospholipase A2α mRNA under Interleukin-1β Treatment in Non-small Cell Lung Cancer A549 Cells

(2011) Wan-Lin Liao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genomic Analyses of the RNA-binding Protein Hu Antigen R (HuR) Identify a Complex Network of Target Genes and Novel Characteristics of Its Binding Sites

(2011) Philip J. Uren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mRNA stability alterations mediated by HuR are necessary to sustain the fast growth of glioma cells

(2011) Federico Bolognani et al.   JOURNAL OF NEURO-ONCOLOGY

Projections of the Cost of Cancer Care in the United States: 2010-2020

(2011) A. B. Mariotto et al.   JNCI-Journal of the National Cancer Institute

The RNA-binding protein ELAVL1/HuR is essential for mouse spermatogenesis, acting both at meiotic and postmeiotic stages

(2011) Mai Nguyen Chi et al.   MOLECULAR BIOLOGY OF THE CELL

The RNA-Binding Protein HuR Promotes Glioma Growth and Treatment Resistance

(2011) N. Filippova et al.   MOLECULAR CANCER RESEARCH

Cytoplasmic accumulation of the RNA binding protein HuR is central to tamoxifen resistance in estrogen receptor positive breast cancer cells

(2010) Christine Hostetter et al.   CANCER BIOLOGY & THERAPY

Interaction between activated chemokine receptor 1 and FcεRI at membrane rafts promotes communication and F-actin-rich cytoneme extensions between mast cells

(2010) Nimita H. Fifadara et al.   INTERNATIONAL IMMUNOLOGY

Cytosolic Phospholipase A2 and Lysophospholipids in Tumor Angiogenesis

(2010) A. G. Linkous et al.   JNCI-Journal of the National Cancer Institute

Evidence Report: The efficacy and safety of mitoxantrone (Novantrone) in the treatment of multiple sclerosis: Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology

(2010) J. J. Marriott et al.   NEUROLOGY

Posttranscriptional regulation of cancer traits by HuR

(2010) Kotb Abdelmohsen et al.   Wiley Interdisciplinary Reviews-RNA

Cell Fusion as a Hidden Force in Tumor Progression

(2009) X. Lu et al.   CANCER RESEARCH

Ubiquitin-mediated proteolysis of HuR by heat shock

(2009) Kotb Abdelmohsen et al.   EMBO JOURNAL

Chemical inhibitors destabilize HuR binding to the AU-rich element of TNF-α mRNA

(2009) Min-Ju Chae et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Selective block of tunneling nanotube (TNT) formation inhibits intercellular organelle transfer between PC12 cells

(2009) Nickolay V. Bukoreshtliev et al.   FEBS LETTERS

HuR regulates gap junctional intercellular communication by controlling β-catenin levels and adherens junction integrity

(2009) Niloofar Ale-Agha et al.   HEPATOLOGY

The RNA-Binding Protein Elavl1/HuR Is Essential for Placental Branching Morphogenesis and Embryonic Development

(2009) V. Katsanou et al.   MOLECULAR AND CELLULAR BIOLOGY

M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex

(2009) Koji Hase et al.   NATURE CELL BIOLOGY

Viral and Developmental Cell Fusion Mechanisms: Conservation and Divergence

(2008) Amir Sapir et al.   DEVELOPMENTAL CELL

Membrane nanotubes physically connect T cells over long distances presenting a novel route for HIV-1 transmission

(2008) Stefanie Sowinski et al.   NATURE CELL BIOLOGY

Mechanics of membrane fusion

(2008) Leonid V Chernomordik et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Inhibition of cyclooxygenase activity blocks cell-to-cell spread of human cytomegalovirus

(2008) J. Schroer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA