Therapeutic Targeting of Autophagy for Renal Cell Carcinoma Therapy
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Title
Therapeutic Targeting of Autophagy for Renal Cell Carcinoma Therapy
Authors
Keywords
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Journal
Cancers
Volume 12, Issue 5, Pages 1185
Publisher
MDPI AG
Online
2020-05-08
DOI
10.3390/cancers12051185
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Related references
Note: Only part of the references are listed.- Cancer statistics, 2019
- (2019) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Autophagy inhibition to augment mTOR inhibition: A phase I/II trial of everolimus and hydroxychloroquine in patients with previously treated renal cell carcinoma
- (2019) Naomi B. Haas et al. CLINICAL CANCER RESEARCH
- Avelumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma
- (2019) Robert J. Motzer et al. NEW ENGLAND JOURNAL OF MEDICINE
- Pembrolizumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma
- (2019) Brian I. Rini et al. NEW ENGLAND JOURNAL OF MEDICINE
- STF-62247 accumulates in lysosomes and blocks late stages of autophagy to selectively target VHL-inactivated cells
- (2019) Nadia Bouhamdani et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- The novel autophagy inhibitor ROC-325 augments the antileukemic activity of azacitidine
- (2019) Steffan T. Nawrocki et al. LEUKEMIA
- A phase I trial of MK-2206 and hydroxychloroquine in patients with advanced solid tumors
- (2019) Janice M. Mehnert et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Moving beyond hydroxychloroquine: the novel lysosomal autophagy inhibitor ROC-325 shows significant potential in preclinical studies
- (2019) Trace M. Jones et al. Cancer Communications
- ATG4B inhibitor FMK-9a induces autophagy independent on its enzyme inhibition
- (2018) Jiaqi Chu et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- B1a B cells require autophagy for metabolic homeostasis and self-renewal
- (2018) Alexander J. Clarke et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Preliminary results for avelumab plus axitinib as first-line therapy in patients with advanced clear-cell renal-cell carcinoma (JAVELIN Renal 100): an open-label, dose-finding and dose-expansion, phase 1b trial
- (2018) Toni K Choueiri et al. LANCET ONCOLOGY
- Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma
- (2018) Robert J. Motzer et al. NEW ENGLAND JOURNAL OF MEDICINE
- Cancer immunotherapy using checkpoint blockade
- (2018) Antoni Ribas et al. SCIENCE
- Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype
- (2018) Degao Chen et al. Nature Communications
- The small molecule STF-62247 induces apoptotic and autophagic cell death in leukemic cells
- (2018) Tomohiro Kozako et al. Oncotarget
- The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma
- (2018) Christopher J. Ricketts et al. Cell Reports
- Nanovaccine Incorporated with Hydroxychloroquine Enhances Antigen Cross-Presentation and Promotes Antitumor Immune Responses
- (2018) Jiale Liu et al. ACS Applied Materials & Interfaces
- Discovery of a small molecule targeting autophagy via ATG4B inhibition and cell death of colorectal cancer cells in vitro and in vivo
- (2018) Yuanyuan Fu et al. Autophagy
- Outcomes based on prior therapy in the phase 3 METEOR trial of cabozantinib versus everolimus in advanced renal cell carcinoma
- (2018) Thomas Powles et al. BRITISH JOURNAL OF CANCER
- Targeting autophagy by small molecule inhibitors of vacuolar protein sorting 34 (Vps34) improves the sensitivity of breast cancer cells to Sunitinib
- (2018) Matheus Dyczynski et al. CANCER LETTERS
- Epacadostat Plus Pembrolizumab in Patients With Advanced Solid Tumors: Phase I Results From a Multicenter, Open-Label Phase I/II Trial (ECHO-202/KEYNOTE-037)
- (2018) Tara C. Mitchell et al. JOURNAL OF CLINICAL ONCOLOGY
- Loperamide, pimozide, and STF-62247 trigger autophagy-dependent cell death in glioblastoma cells
- (2018) Svenja Zielke et al. Cell Death & Disease
- PPT1 promotes tumor growth and is the molecular target of chloroquine derivatives in cancer.
- (2018) Vito W Rebecca et al. Cancer Discovery
- A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles
- (2017) Vito W. Rebecca et al. Cancer Discovery
- Disruption of Autophagic Degradation with ROC-325 Antagonizes Renal Cell Carcinoma Pathogenesis
- (2016) Jennifer S. Carew et al. CLINICAL CANCER RESEARCH
- Antitumor adaptive immunity remains intact following inhibition of autophagy and antimalarial treatment
- (2016) Hanna Starobinets et al. JOURNAL OF CLINICAL INVESTIGATION
- Resistance to Targeted Therapies in Renal Cancer: The Importance of Changing the Mechanism of Action
- (2016) I. Duran et al. Targeted Oncology
- Melanoma cell lysosome secretory burst neutralizes the CTL-mediated cytotoxicity at the lytic synapse
- (2016) Roxana Khazen et al. Nature Communications
- SAR405, a PIK3C3/Vps34 inhibitor that prevents autophagy and synergizes with MTOR inhibition in tumor cells
- (2015) Benoit Pasquier Autophagy
- MiRNA-30a-mediated autophagy inhibition sensitizes renal cell carcinoma cells to sorafenib
- (2015) Bing Zheng et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Lenvatinib, everolimus, and the combination in patients with metastatic renal cell carcinoma: a randomised, phase 2, open-label, multicentre trial
- (2015) Robert J Motzer et al. LANCET ONCOLOGY
- Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates
- (2015) Daniel F. Egan et al. MOLECULAR CELL
- Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma
- (2015) Robert J. Motzer et al. NEW ENGLAND JOURNAL OF MEDICINE
- Combined autophagy and HDAC inhibition
- (2014) Devalingam Mahalingam et al. Autophagy
- A novel ATG4B antagonist inhibits autophagy and has a negative impact on osteosarcoma tumors
- (2014) Debra Akin et al. Autophagy
- Targeting SQSTM1/p62 Induces Cargo Loading Failure and Converts Autophagy to Apoptosis via NBK/Bik
- (2014) S. Chen et al. MOLECULAR AND CELLULAR BIOLOGY
- A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy
- (2014) Baptiste Ronan et al. Nature Chemical Biology
- Autophagy is essential for effector CD8+ T cell survival and memory formation
- (2014) Xiaojin Xu et al. NATURE IMMUNOLOGY
- Granzyme B degradation by autophagy decreases tumor cell susceptibility to natural killer-mediated lysis under hypoxia
- (2013) J. Baginska et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lys05
- (2012) Ravi K. Amaravadi et al. Autophagy
- A novel method for autophagy detection in primary cells
- (2012) Kanchan Phadwal et al. Autophagy
- Inhibition of autophagy enhances apoptosis induced by the PI3K/AKT/mTor inhibitor NVP-BEZ235 in renal cell carcinoma cells
- (2012) Hongyan Li et al. CELL BIOCHEMISTRY AND FUNCTION
- Autophagy modulation as a potential therapeutic target for diverse diseases
- (2012) David C. Rubinsztein et al. NATURE REVIEWS DRUG DISCOVERY
- Autophagy Suppresses RIP Kinase-Dependent Necrosis Enabling Survival to mTOR Inhibition
- (2012) Kevin Bray et al. PLoS One
- Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency
- (2012) Q. McAfee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Radiosensitization of renal cell carcinoma in vitro through the induction of autophagy
- (2012) Selvakumar Anbalagan et al. RADIOTHERAPY AND ONCOLOGY
- Autophagy as a target for cancer therapy: new developments
- (2012) Steffan Nawrocki et al. Cancer Management and Research
- Blocking Hypoxia-Induced Autophagy in Tumors Restores Cytotoxic T-Cell Activity and Promotes Regression
- (2011) M. Z. Noman et al. CANCER RESEARCH
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Principles and Current Strategies for Targeting Autophagy for Cancer Treatment
- (2011) R. K. Amaravadi et al. CLINICAL CANCER RESEARCH
- Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial
- (2011) Brian I Rini et al. LANCET
- AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
- (2011) Joungmok Kim et al. NATURE CELL BIOLOGY
- Autophagy as a target for anticancer therapy
- (2011) Filip Janku et al. Nature Reviews Clinical Oncology
- Lucanthone Is a Novel Inhibitor of Autophagy That Induces Cathepsin D-mediated Apoptosis
- (2010) Jennifer S. Carew et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Pazopanib in Locally Advanced or Metastatic Renal Cell Carcinoma: Results of a Randomized Phase III Trial
- (2010) Cora N. Sternberg et al. JOURNAL OF CLINICAL ONCOLOGY
- Autophagy: assays and artifacts
- (2010) Sandra Barth et al. JOURNAL OF PATHOLOGY
- Improved Survival with Ipilimumab in Patients with Metastatic Melanoma
- (2010) F. Stephen Hodi et al. NEW ENGLAND JOURNAL OF MEDICINE
- Regulation Mechanisms and Signaling Pathways of Autophagy
- (2009) Congcong He et al. Annual Review of Genetics
- Mammalian autophagy: core molecular machinery and signaling regulation
- (2009) Zhifen Yang et al. CURRENT OPINION IN CELL BIOLOGY
- The structure of Atg4B–LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy
- (2009) Kenji Satoo et al. EMBO JOURNAL
- Resistance to targeted therapy in renal-cell carcinoma
- (2009) Brian I Rini et al. LANCET ONCOLOGY
- A Molecule Targeting VHL-Deficient Renal Cell Carcinoma that Induces Autophagy
- (2008) Sandra Turcotte et al. CANCER CELL
- Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial
- (2008) Robert J Motzer et al. LANCET
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