Role of Macrophages in Brain Tumor Growth and Progression

A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases

(2018) Livia Garzia et al.   CELL

Advances in meningioma genetics: novel therapeutic opportunities

(2018) Matthias Preusser et al.   Nature Reviews Neurology

Trajectory of inflammatory and microglial activation markers in the postnatal rabbit brain following intrauterine endotoxin exposure

(2018) Zhi Zhang et al.   NEUROBIOLOGY OF DISEASE

WHO 2016 Classification of gliomas

(2018) P. Wesseling et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Macrophages orchestrate breast cancer early dissemination and metastasis

(2018) Nina Linde et al.   Nature Communications

VEGF as a modulator of the innate immune response in glioblastoma

(2017) Kati Turkowski et al.   GLIA

Innate immunity in cardiac myxomas and its pathological and clinical correlations

(2017) Anna Di Vito et al.   Innate Immunity

Innate immunity may play a role in growth and relapse of chordoid meningioma

(2017) Ivan Presta et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis

(2017) Felix Sahm et al.   LANCET ONCOLOGY

The contribution of tumor-associated macrophages in glioma neo-angiogenesis and implications for anti-angiogenic strategies

(2017) Changbin Zhu et al.   NEURO-ONCOLOGY

Is the blood–brain barrier really disrupted in all glioblastomas? A critical assessment of existing clinical data

(2017) Jann N Sarkaria et al.   NEURO-ONCOLOGY

The 2016 WHO Classification of Tumours of the Central Nervous System: The Major Points of Revision

(2017) Takashi KOMORI   NEUROLOGIA MEDICO-CHIRURGICA

Tumour-associated microglia/macrophages predict poor prognosis in high-grade gliomas and correlate with an aggressive tumour subtype

(2017) M. D. Sørensen et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

The JAK2/STAT3 inhibitor pacritinib effectively inhibits patient-derived GBM brain tumor initiating cells in vitro and when used in combination with temozolomide increases survival in an orthotopic xenograft model

(2017) Katharine Victoria Jensen et al.   PLoS One

Microglia Polarization with M1/M2 Phenotype Changes in rd1 Mouse Model of Retinal Degeneration

(2017) Tian Zhou et al.   Frontiers in Neuroanatomy

EGF stimulates glioblastoma metastasis by induction of matrix metalloproteinase-9 in an EGFR-dependent mechanism

(2017) Xing-Chen Chen et al.   Oncotarget

Tumor-associated macrophages promote tumor metastasis via the TGF-β/SOX9 axis in non-small cell lung cancer

(2017) Shuai Zhang et al.   Oncotarget

Advances in Immunotherapy for Glioblastoma Multiforme

(2017) Boyuan Huang et al.   Journal of Immunology Research

SDF-1 Blockade Enhances Anti-VEGF Therapy of Glioblastoma and Can Be Monitored by MRI

(2017) Lei Deng et al.   NEOPLASIA

Expression site of P2RY12 in residential microglial cells in astrocytomas correlates with M1 and M2 marker expression and tumor grade

(2017) Changbin Zhu et al.   Acta Neuropathologica Communications

Macrophage Activation and Patterns of Inflammation in Obese and Non-Obese Women with Breast Carcinoma

(2017) M. Renne et al.   European Journal of Inflammation

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

Cycling hypoxia: A key feature of the tumor microenvironment

(2016) Carine Michiels et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Non-invasive real-time biopsy of intracranial lesions using short time expanded circulating tumor cells on glass slide: report of two cases

(2016) N. Malara et al.   BMC Neurology

Tumor infiltrating immune cells in gliomas and meningiomas

(2016) Patrícia Domingues et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglioma in a child – a further case in support of the microglioma entity and distinction from histiocytic sarcoma

(2016) Anitha Mathews et al.   CLINICAL NEUROPATHOLOGY

Relapsed Glioblastoma: Treatment Strategies for Initial and Subsequent Recurrences

(2016) Alicia Tosoni et al.   CURRENT TREATMENT OPTIONS IN ONCOLOGY

Inflammation and macrophage polarization in cutaneous melanoma: Histopathological and immunohistochemical study

(2016) Elisabetta Scali et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

The impact of hypoxia on tumor-associated macrophages

(2016) Anne-Theres Henze et al.   JOURNAL OF CLINICAL INVESTIGATION

A polarizing question: do M1 and M2 microglia exist?

(2016) Richard M Ransohoff   NATURE NEUROSCIENCE

Decrease of VEGF-A in myeloid cells attenuates glioma progression and prolongs survival in an experimental glioma model

(2016) Nadja Osterberg et al.   NEURO-ONCOLOGY

Biological Significance of Mutant Isocitrate Dehydrogenase 1 and 2 in Gliomagenesis

(2016) Shigeo OHBA et al.   NEUROLOGIA MEDICO-CHIRURGICA

A reappraisal of macrophage polarization in glioblastoma: Histopathological and immunohistochemical findings and review of the literature

(2016) Chiara Mignogna et al.   PATHOLOGY RESEARCH AND PRACTICE

Circulating tumor cell is a common property of brain glioma and promotes the monitoring system

(2016) Faliang Gao et al.   Oncotarget

Targeting the CCL2-CCR2 signaling axis in cancer metastasis

(2016) Su Yin Lim et al.   Oncotarget

Immunological Evasion in Glioblastoma

(2016) Roxana Magaña-Maldonado et al.   Biomed Research International

Glioma Stem Cells: Signaling, Microenvironment, and Therapy

(2016) Brandon D. Liebelt et al.   Stem Cells International

Resident microglia rather than peripheral macrophages promote vascularization in brain tumors and are source of alternative pro-angiogenic factors

(2015) Susan Brandenburg et al.   ACTA NEUROPATHOLOGICA

Macrophage traits in cancer cells are induced by macrophage-cancer cell fusion and cannot be explained by cellular interaction

(2015) Ivan Shabo et al.   BMC CANCER

CCL2-induced chemokine cascade promotes breast cancer metastasis by enhancing retention of metastasis-associated macrophages

(2015) Takanori Kitamura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Isocitrate dehydrogenase mutations in gliomas

(2015) Matthew S. Waitkus et al.   NEURO-ONCOLOGY

The Molecular Constituents of the Blood–Brain Barrier

(2015) Brian Wai Chow et al.   TRENDS IN NEUROSCIENCES

Hypoxia induces macrophage polarization and re-education toward an M2 phenotype in U87 and U251 glioblastoma models

(2015) Marine M Leblond et al.   OncoImmunology

Proinflammatory-Activated Glioma Cells Induce a Switch in Microglial Polarization and Activation Status, From a Predominant M2b Phenotype to a Mixture of M1 and M2a/B Polarized Cells

(2014) Lucia Lisi et al.   ASN Neuro

Mechanisms of intimate and long-distance cross-talk between glioma and myeloid cells: How to break a vicious cycle

(2014) Thomas Wurdinger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

RAGE Expression in Tumor-Associated Macrophages Promotes Angiogenesis in Glioma

(2014) X. Chen et al.   CANCER RESEARCH

Expression of Tumor-Associated Macrophage in Progression of Human Glioma

(2014) Peng Ding et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Tumor-Associated Macrophages in SHH Subgroup of Medulloblastomas

(2014) A. S. Margol et al.   CLINICAL CANCER RESEARCH

Therapeutic implications of CD1d expression and tumor-infiltrating macrophages in pediatric medulloblastomas

(2014) Wan-Yee Teo et al.   JOURNAL OF NEURO-ONCOLOGY

Isocitrate dehydrogenase 1and2mutations in gliomas

(2014) Magdalena Megova et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

The mTOR signaling pathway and neuronal stem/progenitor cell proliferation in the hippocampus are altered during the development of absence epilepsy in a genetic animal model

(2014) Emilio Russo et al.   NEUROLOGICAL SCIENCES

Chordoid meningiomas: Incidence and clinicopathological features of a case series over 18 years

(2014) Antonio Di Ieva et al.   NEUROPATHOLOGY

Chemokine expression profile of freshly isolated human glioblastoma-associated macrophages/microglia

(2014) KIRSTEN HATTERMANN et al.   ONCOLOGY REPORTS

Circulating giant macrophages as a potential biomarker of solid tumors

(2014) Daniel L. Adams et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brain Tumor Cells in Circulation Are Enriched for Mesenchymal Gene Expression

(2014) J. P. Sullivan et al.   Cancer Discovery

Does the Immune System Naturally Protect Against Cancer?

(2014) Alexandre Corthay   Frontiers in Immunology

Phenotypic profile of alternative activation marker CD163 is different in Alzheimer’s and Parkinson’s disease

(2014) Peixuan Pey et al.   Acta Neuropathologica Communications

Tumor Hypoxia Does Not Drive Differentiation of Tumor-Associated Macrophages but Rather Fine-Tunes the M2-like Macrophage Population

(2013) D. Laoui et al.   CANCER RESEARCH

The Controversial Role of Microglia in Malignant Gliomas

(2013) Jun Wei et al.   Clinical & Developmental Immunology

Dose-Dense Temozolomide for Newly Diagnosed Glioblastoma: A Randomized Phase III Clinical Trial

(2013) Mark R. Gilbert et al.   JOURNAL OF CLINICAL ONCOLOGY

Elevated CD3+ and CD8+ tumor-infiltrating immune cells correlate with prolonged survival in glioblastoma patients despite integrated immunosuppressive mechanisms in the tumor microenvironment and at the systemic level

(2013) Justyna Kmiecik et al.   JOURNAL OF NEUROIMMUNOLOGY

Expression of CD163 prevents apoptosis through the production of granulocyte colony-stimulating factor in meningioma

(2013) H. Kanno et al.   NEURO-ONCOLOGY

Genomic Analysis of Non-NF2 Meningiomas Reveals Mutations in TRAF7, KLF4, AKT1, and SMO

(2013) V. E. Clark et al.   SCIENCE

Immunophenotypic Identification and Characterization of Tumor Cells and Infiltrating Cell Populations in Meningiomas

(2012) Patrícia H. Domingues et al.   AMERICAN JOURNAL OF PATHOLOGY

18F-Fluoromisonidazole positron emission tomography may differentiate glioblastoma multiforme from less malignant gliomas

(2012) Kenji Hirata et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

The immune score as a new possible approach for the classification of cancer

(2012) Jérôme Galon et al.   Journal of Translational Medicine

Capture, crawl, cross: the T cell code to breach the blood–brain barriers

(2012) Britta Engelhardt et al.   TRENDS IN IMMUNOLOGY

Molecular subgroups of medulloblastoma: the current consensus

(2011) Michael D. Taylor et al.   ACTA NEUROPATHOLOGICA

Hypothesis: Are Neoplastic Macrophages/Microglia Present in Glioblastoma Multiforme?

(2011) Leanne C Huysentruyt et al.   ASN Neuro

Relative survival of childhood and adult medulloblastomas and primitive neuroectodermal tumors (PNETs)

(2011) Nicolas R. Smoll   CANCER

A dialog between glioma and microglia that promotes tumor invasiveness through the CCL2/CCR2/interleukin-6 axis

(2011) J. Zhang et al.   CARCINOGENESIS

Analysis of UbcH10 expression represents a useful tool for the diagnosis and therapy of astrocytic tumors

(2011) G. Donato et al.   CLINICAL NEUROPATHOLOGY

Rare Phenomenon: Liver Metastases From Glioblastoma Multiforme

(2011) Stefan S. Schönsteiner et al.   JOURNAL OF CLINICAL ONCOLOGY

The chemokine CXCL12 and its receptor CXCR4 promote glioma stem cell-mediated VEGF production and tumour angiogenesis via PI3K/AKT signalling

(2011) Yi-fang Ping et al.   JOURNAL OF PATHOLOGY

Identification and manipulation of tumor associated macrophages in human cancers

(2011) Moniek Heusinkveld et al.   Journal of Translational Medicine

Les cellules de la microglie

(2011) Florent Ginhoux et al.   M S-MEDECINE SCIENCES

Glutathione S-transferase polymorphisms are associated with survival in anaplastic glioma patients

(2010) Lindsay Kilburn et al.   CANCER

The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype

(2010) John M. Heddleston et al.   CELL CYCLE

Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice

(2010) Mitomu Kioi et al.   JOURNAL OF CLINICAL INVESTIGATION

CD8+ T-cell infiltrate in newly diagnosed glioblastoma is associated with long-term survival

(2010) Isaac Yang et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells

(2010) Lucia Ricci-Vitiani et al.   NATURE

Glioma cancer stem cells induce immunosuppressive macrophages/microglia

(2010) Adam Wu et al.   NEURO-ONCOLOGY

The Multifaceted Profile of Activated Microglia

(2009) Marina A. Lynch   MOLECULAR NEUROBIOLOGY

CD163, a Marker of Perivascular Macrophages, Is Up-Regulated by Microglia in Simian Immunodeficiency Virus Encephalitis after Haptoglobin-Hemoglobin Complex Stimulation and Is Suggestive of Breakdown of the Blood-Brain Barrier

(2008) Juan T. Borda et al.   AMERICAN JOURNAL OF PATHOLOGY

HIF1α Induces the Recruitment of Bone Marrow-Derived Vascular Modulatory Cells to Regulate Tumor Angiogenesis and Invasion

(2008) Rose Du et al.   CANCER CELL

Macrophages and cancer

(2008) Alessandra Nardin   Frontiers in Bioscience-Landmark

The microglial/macrophagic response at the tumour-brain border of invasive meningiomas

(2008) S. Grund et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Macrophage polarization in tumour progression

(2008) Antonio Sica et al.   SEMINARS IN CANCER BIOLOGY

CD98 immunoreactivity in multinucleated giant cells of glioblastomas: An immunohistochemical double labeling study

(2007) Hiroaki Takeuchi et al.   NEUROPATHOLOGY