Role of connexin 43 in different forms of intercellular communication – gap junctions, extracellular vesicles and tunnelling nanotubes

The E3 ubiquitin ligase NEDD4 induces endocytosis and lysosomal sorting of connexin 43 to promote loss of gap junctions

(2017) Max Z. Totland et al.   JOURNAL OF CELL SCIENCE

Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications

(2017) Luc Leybaert et al.   PHARMACOLOGICAL REVIEWS

Inhibitors of connexin and pannexin channels as potential therapeutics

(2017) Joost Willebrords et al.   PHARMACOLOGY & THERAPEUTICS

The Role of Rho-GTPases and actin polymerization during Macrophage Tunneling Nanotube Biogenesis

(2017) Samer J. Hanna et al.   Scientific Reports

Influenza virus exploits tunneling nanotubes for cell-to-cell spread

(2017) Amrita Kumar et al.   Scientific Reports

Regulation of connexins by the ubiquitin system: Implications for intercellular communication and cancer

(2016) Edward Leithe   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

The role of neural connexins in HeLa cell mobility and intercellular communication through tunneling tubes

(2016) Lina Rimkutė et al.   BMC CELL BIOLOGY

Regulation of gap junction channels and hemichannels by phosphorylation and redox changes: a revision

(2016) Kristin Pogoda et al.   BMC CELL BIOLOGY

Tumor Exosomal RNAs Promote Lung Pre-metastatic Niche Formation by Activating Alveolar Epithelial TLR3 to Recruit Neutrophils

(2016) Yanfang Liu et al.   CANCER CELL

Communication of Ca2+ signals via tunneling membrane nanotubes is mediated by transmission of inositol trisphosphate through gap junctions

(2016) Jeffrey T. Lock et al.   CELL CALCIUM

Mitotic cells form actin-based bridges with adjacent cells to provide intercellular communication during rounding

(2016) Tone A. Fykerud et al.   CELL CYCLE

Connexins and their channels in inflammation

(2016) Joost Willebrords et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Structural Studies of the Nedd4 WW Domains and Their Selectivity for the Connexin43 (Cx43) Carboxyl Terminus

(2016) Gaelle Spagnol et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular vesicles: masters of intercellular communication and potential clinical interventions

(2016) Jonathan M. Pitt et al.   JOURNAL OF CLINICAL INVESTIGATION

Connectosomes for Direct Molecular Delivery to the Cellular Cytoplasm

(2016) Avinash K. Gadok et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Specific functional pathologies of Cx43 mutations associated with oculodentodigital dysplasia

(2016) John J. Kelly et al.   MOLECULAR BIOLOGY OF THE CELL

Electrotonic coupling of excitable and nonexcitable cells in the heart revealed by optogenetics

(2016) T. Alexander Quinn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Connexin channels in congenital skin disorders

(2016) Evelyn Lilly et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Connexins in skeletal muscle development and disease

(2016) Peter A. Merrifield et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The cardiac connexome: Non-canonical functions of connexin43 and their role in cardiac arrhythmias

(2016) Alejandra Leo-Macias et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Next-Generation Connexin and Pannexin Cell Biology

(2016) Jessica L. Esseltine et al.   TRENDS IN CELL BIOLOGY

The missing link: does tunnelling nanotube-based supercellularity provide a new understanding of chronic and lifestyle diseases?

(2016) Amin Rustom   Open Biology

Tetherin is an exosomal tether

(2016) James R Edgar et al.   eLife

Differential identity of Filopodia and Tunneling Nanotubes revealed by the opposite functions of actin regulatory complexes

(2016) Elise Delage et al.   Scientific Reports

Degradation of gap junction connexins is regulated by the interaction with Cx43-interacting protein of 75 kDa (CIP75)

(2015) Jennifer L. Kopanic et al.   BIOCHEMICAL JOURNAL

Ischaemia-induced autophagy leads to degradation of gap junction protein connexin43 in cardiomyocytes

(2015) Tania Martins-Marques et al.   BIOCHEMICAL JOURNAL

Connexin 43 ubiquitination determines the fate of gap junctions: restrict to survive: Figure 1

(2015) Teresa M. Ribeiro-Rodrigues et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Gap junctions–guards of excitability

(2015) Line Waring Stroemlund et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Heart ischemia results in connexin43 ubiquitination localized at the intercalated discs

(2015) Tânia Martins-Marques et al.   BIOCHIMIE

Transfer of mitochondria via tunneling nanotubes rescues apoptotic PC12 cells

(2015) X Wang et al.   CELL DEATH AND DIFFERENTIATION

Role of connexins and pannexins in cardiovascular physiology

(2015) Merlijn J. Meens et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Gap junctional shuttling of miRNA — A novel pathway of intercellular gene regulation and its prospects in clinical application

(2015) Heiko Lemcke et al.   CELLULAR SIGNALLING

Emerging physiological and pathological implications of tunneling nanotubes formation between cells

(2015) Sajjad Sisakhtnezhad et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Intercellular communication lessons in heart failure

(2015) Claudia Bang et al.   EUROPEAN JOURNAL OF HEART FAILURE

Interacting Network of the Gap Junction (GJ) Protein Connexin43 (Cx43) is Modulated by Ischemia and Reperfusion in the Heart

(2015) Tania Martins-Marques et al.   MOLECULAR & CELLULAR PROTEOMICS

Brain tumour cells interconnect to a functional and resistant network

(2015) Matthias Osswald et al.   NATURE

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

(2015) Bruno Costa-Silva et al.   NATURE CELL BIOLOGY

Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines

(2015) Ikrame Lazar et al.   Pigment Cell & Melanoma Research

Cellular Small Talk

(2015) Dale W. Laird et al.   SCIENTIFIC AMERICAN

Diseases associated with leaky hemichannels

(2015) Mauricio A. Retamal et al.   Frontiers in Cellular Neuroscience

Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes

(2015) Shivakumar Keerthikumar et al.   Oncotarget

Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel

(2015) Pedram Kharaziha et al.   Oncotarget

Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells

(2015) Ana Rosa Soares et al.   Scientific Reports

Intravitreal injection of lipoamino acid-modified connexin43 mimetic peptide enhances neuroprotection after retinal ischemia

(2015) Ying-Shan Chen et al.   Drug Delivery and Translational Research

Mutations in cardiovascular connexin genes

(2014) Filippo Molica et al.   BIOLOGY OF THE CELL

Preliminary characterisation of nanotubes connecting T-cells and their use by HIV-1

(2014) Simon Lachambre et al.   BIOLOGY OF THE CELL

Super-resolution imaging reveals that loss of the C-terminus of connexin43 limits microtubule plus-end capture and NaV1.5 localization at the intercalated disc

(2014) Esperanza Agullo-Pascual et al.   CARDIOVASCULAR RESEARCH

Mechanisms linking connexin mutations to human diseases

(2014) John J. Kelly et al.   CELL AND TISSUE RESEARCH

Connexins and gap junctions in the inner ear – it’s not just about K+ recycling

(2014) Daniel J. Jagger et al.   CELL AND TISSUE RESEARCH

AMSH-mediated deubiquitination of Cx43 regulates internalization and degradation of gap junctions

(2014) Teresa M. Ribeiro-Rodrigues et al.   FASEB JOURNAL

Specific Cx43 phosphorylation events regulate gap junction turnover in vivo

(2014) Joell L. Solan et al.   FEBS LETTERS

Hunting for connexin hemichannels

(2014) Juan C. Sáez et al.   FEBS LETTERS

Cardiac to cancer: Connecting connexins to clinical opportunity

(2014) Christina L. Grek et al.   FEBS LETTERS

Syndromic and non-syndromic disease-linked Cx43 mutations

(2014) Dale W. Laird   FEBS LETTERS

Cardiac fibroblast–derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy

(2014) Claudia Bang et al.   JOURNAL OF CLINICAL INVESTIGATION

Cutting Edge: Membrane Nanotubes In Vivo: A Feature of MHC Class II + Cells in the Mouse Cornea

(2014) Holly R. Chinnery et al.   JOURNAL OF IMMUNOLOGY

Cardioprotection by remote ischemic preconditioning of the rat heart is mediated by extracellular vesicles

(2014) Zoltán Giricz et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Influenza A Virus Uses Intercellular Connections To Spread to Neighboring Cells

(2014) Kari L. Roberts et al.   JOURNAL OF VIROLOGY

Long-Distance Communication between Laryngeal Carcinoma Cells

(2014) Ieva Antanavičiūtė et al.   PLoS One

A 14-3-3 Mode-1 Binding Motif Initiates Gap Junction Internalization During Acute Cardiac Ischemia

(2014) James W. Smyth et al.   TRAFFIC

Regulation of gap junction channels by infectious agents and inflammation in the CNS

(2014) Paul Castellano et al.   Frontiers in Cellular Neuroscience

Deletion of the last five C-terminal amino acid residues of connexin43 leads to lethal ventricular arrhythmias in mice without affecting coupling via gap junction channels

(2013) Indra Lübkemeier et al.   BASIC RESEARCH IN CARDIOLOGY

Regulation of connexin- and pannexin-based channels by post-translational modifications

(2013) Catheleyne D'hondt et al.   BIOLOGY OF THE CELL

Super-resolution fluorescence microscopy of the cardiac connexome reveals plakophilin-2 inside the connexin43 plaque

(2013) Esperanza Agullo-Pascual et al.   CARDIOVASCULAR RESEARCH

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Antiadrenergic effect of adenosine involves connexin 43 turn-over in H9c2 cells

(2013) Ada Popolo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Transfer of polyglutamine aggregates in neuronal cells occurs in tunneling nanotubes

(2013) M. Costanzo et al.   JOURNAL OF CELL SCIENCE

14-3-3  facilitates plasma membrane delivery and function of mechanosensitive connexin 43 hemichannels

(2013) N. Batra et al.   JOURNAL OF CELL SCIENCE

Injury-triggered Akt phosphorylation of Cx43: a ZO-1-driven molecular switch that regulates gap junction size

(2013) C. A. Dunn et al.   JOURNAL OF CELL SCIENCE

MicroRNAs Transfer from Human Macrophages to Hepato-Carcinoma Cells and Inhibit Proliferation

(2013) A. Aucher et al.   JOURNAL OF IMMUNOLOGY

Cytotoxicity and Vitreous Stability of Chemically Modified Connexin43 Mimetic Peptides for the Treatment of Optic Neuropathy

(2013) Ying-Shan Chen et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Characterization and proteomic analysis of ovarian cancer-derived exosomes

(2013) Bing Liang et al.   Journal of Proteomics

Connexin43 mimetic peptide is neuroprotective and improves function following spinal cord injury

(2013) Simon J. O’Carroll et al.   NEUROSCIENCE RESEARCH

Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte–Neuron Communication

(2013) Carsten Frühbeis et al.   PLOS BIOLOGY

Managing the complexity of communication: regulation of gap junctions by post-translational modification

(2013) Lene N. Axelsen et al.   Frontiers in Pharmacology

Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury

(2012) Nan Wang et al.   BASIC RESEARCH IN CARDIOLOGY

Connexin43 mimetic peptide reduces vascular leak and retinal ganglion cell death following retinal ischaemia

(2012) Helen V. Danesh-Meyer et al.   BRAIN

Connexin43 ablation in foetal atrial myocytes decreases electrical coupling, partner connexins, and sodium current

(2012) Thomas Desplantez et al.   CARDIOVASCULAR RESEARCH

Toward tailored exosomes: The exosomal tetraspanin web contributes to target cell selection

(2012) Sanyukta Rana et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Permeation of Calcium through Purified Connexin 26 Hemichannels

(2012) Mariana C. Fiori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Gap Junction Channel Protein Connexin 43 Is Covalently Modified and Regulated by SUMOylation

(2012) Ane Kjenseth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wiring through tunneling nanotubes - from electrical signals to organelle transfer

(2012) S. Abounit et al.   JOURNAL OF CELL SCIENCE

Tunneling nanotubes, an emerging intercellular communication route in development

(2012) Hans-Hermann Gerdes et al.   MECHANISMS OF DEVELOPMENT

Structure and functional studies of N-terminal Cx43 mutants linked to oculodentodigital dysplasia

(2012) Qing Shao et al.   MOLECULAR BIOLOGY OF THE CELL

Autophagy modulates dynamics of connexins at the plasma membrane in a ubiquitin-dependent manner

(2012) Eloy Bejarano et al.   MOLECULAR BIOLOGY OF THE CELL

Multi-Level Communication of Human Retinal Pigment Epithelial Cells via Tunneling Nanotubes

(2012) Dierk Wittig et al.   PLoS One

Tunneling Nanotubes Provide a Unique Conduit for Intercellular Transfer of Cellular Contents in Human Malignant Pleural Mesothelioma

(2012) Emil Lou et al.   PLoS One

Developing Neurons Form Transient Nanotubes Facilitating Electrical Coupling and Calcium Signaling with Distant Astrocytes

(2012) Xiang Wang et al.   PLoS One

Tunneling-nanotube direction determination in neurons and astrocytes

(2012) X Sun et al.   Cell Death & Disease

Long-distance electrical coupling via tunneling nanotubes

(2011) Xiang Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Active Generation and Propagation of Ca2+ Signals within Tunneling Membrane Nanotubes

(2011) Ian F. Smith et al.   BIOPHYSICAL JOURNAL

The natural cardioprotective particle HDL modulates connexin43 gap junction channels

(2011) Sandrine Morel et al.   CARDIOVASCULAR RESEARCH

Long-distance intercellular connectivity between cardiomyocytes and cardiofibroblasts mediated by membrane nanotubes

(2011) Kangmin He et al.   CARDIOVASCULAR RESEARCH

Ischemia Induces Closure of Gap Junctional Channels and Opening of Hemichannels in Heart-derived Cells and Tissue

(2011) David Johansen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Interactions Between Ankyrin-G, Plakophilin-2, and Connexin43 at the Cardiac Intercalated Disc

(2011) Priscila Y. Sato et al.   CIRCULATION RESEARCH

The molecular mechanisms of gap junction remodeling

(2011) Heather S. Duffy   HEART RHYTHM

Reduced heterogeneous expression of Cx43 results in decreased Nav1.5 expression and reduced sodium current that accounts for arrhythmia vulnerability in conditional Cx43 knockout mice

(2011) John A. Jansen et al.   HEART RHYTHM

The perinexus: A new feature of Cx43 gap junction organization

(2011) Joshua Matthew Rhett et al.   HEART RHYTHM

Activation of Akt, Not Connexin 43 Protein Ubiquitination, Regulates Gap Junction Stability

(2011) Clarence A. Dunn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intercellular Bridges in Vertebrate Gastrulation

(2011) Luca Caneparo et al.   PLoS One

N -lysine acetylation determines dissociation from GAP junctions and lateralization of connexin 43 in normal and dystrophic heart

(2011) C. Colussi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Connexin 43 hemichannels mediate the Ca2+ influx induced by extracellular alkalinization

(2010) Kurt A. Schalper et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mesenchymal stem cells rescue cardiomyoblasts from cell death in an in vitro ischemia model via direct cell-to-cell connections

(2010) Attila Cselenyák et al.   BMC CELL BIOLOGY

Functional MicroRNA Is Transferred between Glioma Cells

(2010) M. Katakowski et al.   CANCER RESEARCH

Cell Surface Tetraspanin Tspan8 Contributes to Molecular Pathways of Exosome-Induced Endothelial Cell Activation

(2010) I. Nazarenko et al.   CANCER RESEARCH

Cancer Exosomes Trigger Fibroblast to Myofibroblast Differentiation

(2010) J. Webber et al.   CANCER RESEARCH

Tunneling-nanotube development in astrocytes depends on p53 activation

(2010) Y Wang et al.   CELL DEATH AND DIFFERENTIATION

Dynamic imaging of mammalian neural tube closure

(2010) Christina Pyrgaki et al.   DEVELOPMENTAL BIOLOGY

Mutations in connexin genes and disease

(2010) Anna Pfenniger et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Ubiquitin-independent Proteasomal Degradation of Endoplasmic Reticulum-localized Connexin43 Mediated by CIP75

(2010) Vivian Su et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane nanotubes facilitate long-distance interactions between natural killer cells and target cells

(2010) A. Chauveau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Animal cells connected by nanotubes can be electrically coupled through interposed gap-junction channels

(2010) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Presence of connexin 43 in subsarcolemmal, but not in interfibrillar cardiomyocyte mitochondria

(2009) Kerstin Boengler et al.   BASIC RESEARCH IN CARDIOLOGY

Ca2+ regulation of connexin 43 hemichannels in C6 glioma and glial cells

(2009) Elke De Vuyst et al.   CELL CALCIUM

Fas stimulation of T lymphocytes promotes rapid intercellular exchange of death signals via membrane nanotubes

(2009) Peter D Arkwright et al.   CELL RESEARCH

Eps15 interacts with ubiquitinated Cx43 and mediates its internalization

(2009) Henrique Girão et al.   EXPERIMENTAL CELL RESEARCH

Prions hijack tunnelling nanotubes for intercellular spread

(2009) Karine Gousset et al.   NATURE CELL BIOLOGY

M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex

(2009) Koji Hase et al.   NATURE CELL BIOLOGY

HIV-1 hijacks tunneling nanotubes and secretory microvesicles for intercellular spread in monocyte-derived macrophages

(2009) Irena Kadiu et al.   Retrovirology

Tunneling nanotubes (TNT) are induced by HIV-infection of macrophages: A potential mechanism for intercellular HIV trafficking

(2008) E.A. Eugenin et al.   CELLULAR IMMUNOLOGY

Membrane nanotubes physically connect T cells over long distances presenting a novel route for HIV-1 transmission

(2008) Stefanie Sowinski et al.   NATURE CELL BIOLOGY