Tumor-Cell–Macrophage Fusion Cells as Liquid Biomarkers and Tumor Enhancers in Cancer

Tunneling nanotubes, a novel mode of tumor cell-macrophage communication in tumor cell invasion

(2019) Samer J. Hanna et al.   JOURNAL OF CELL SCIENCE

Cell Fusion in Human Cancer: The Dark Matter Hypothesis

(2019) Julian Weiler et al.   Cells

Leukocyte–Cancer Cell Fusion—Genesis of a Deadly Journey

(2019) Greggory Laberge et al.   Cells

Liquid biopsy and minimal residual disease — latest advances and implications for cure

(2019) Klaus Pantel et al.   Nature Reviews Clinical Oncology

Cancer cell fusion: a potential target to tackle drug-resistant and metastatic cancer cells

(2019) Clara Fernandes et al.   DRUG DISCOVERY TODAY

Mechanisms of immunotherapy resistance: lessons from glioblastoma

(2019) Christopher M. Jackson et al.   NATURE IMMUNOLOGY

PD-L1 Expression with Epithelial Mesenchymal Transition of Circulating Tumor Cells Is Associated with Poor Survival in Curatively Resected Non-Small Cell Lung Cancer

(2019) Yariswamy Manjunath et al.   Cancers

Fusion of macrophages promotes breast cancer cell proliferation, migration and invasion through activating epithelial-mesenchymal transition and Wnt/β-catenin signaling pathway

(2019) Li-Na Zhang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Tunneling Nanotubes: A Versatile Target for Cancer Therapy

(2018) Pragyaparamita Sahu et al.   CURRENT CANCER DRUG TARGETS

Chemotherapy-Induced Tunneling Nanotubes Mediate Intercellular Drug Efflux in Pancreatic Cancer

(2018) Snider Desir et al.   Scientific Reports

The hypoxic tumour microenvironment

(2018) Varvara Petrova et al.   Oncogenesis

Tunneling Nanotubes: Intimate Communication between Myeloid Cells

(2018) Maeva Dupont et al.   Frontiers in Immunology

Specialized Intercellular Communications via Cytonemes and Nanotubes

(2018) Yukiko M. Yamashita et al.   Annual Review of Cell and Developmental Biology

Emerging role of contact-mediated cell communication in tissue development and diseases

(2018) Benjamin Mattes et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Cell fusion potentiates tumor heterogeneity and reveals circulating hybrid cells that correlate with stage and survival

(2018) Charles E. Gast et al.   Science Advances

Blood‐based biopsies—clinical utility beyond circulating tumor cells

(2018) Cha‐Mei Tang et al.   CYTOMETRY PART A

Immune regulation of metastasis: mechanistic insights and therapeutic opportunities

(2018) Olga S. Blomberg et al.   Disease Models & Mechanisms

The epithelial-to-mesenchymal transition induced by tumor-associated macrophages confers chemoresistance in peritoneally disseminated pancreatic cancer

(2018) Kazuya Kuwada et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The Fate of Fusions

(2018) Gary Clawson   Cells

Tunneling Nanotubes and Gap Junctions–Their Role in Long-Range Intercellular Communication during Development, Health, and Disease Conditions

(2017) Jennifer Ariazi et al.   Frontiers in Molecular Neuroscience

Promotion of Tumor Invasion by Tumor-Associated Macrophages: The Role of CSF-1-Activated Phosphatidylinositol 3 Kinase and Src Family Kinase Motility Signaling

(2017) Amy Dwyer et al.   Cancers

A Melanoma Lymph Node Metastasis with a Donor-Patient Hybrid Genome following Bone Marrow Transplantation: A Second Case of Leucocyte-Tumor Cell Hybridization in Cancer Metastasis

(2017) Greggory S. LaBerge et al.   PLoS One

"Stealth dissemination" of macrophage-tumor cell fusions cultured from blood of patients with pancreatic ductal adenocarcinoma

(2017) Gary A. Clawson et al.   PLoS One

Perioperative circulating tumor cell detection: Current perspectives

(2016) Jussuf T. Kaifi et al.   CANCER BIOLOGY & THERAPY

Circulating Cancer-Associated Macrophage-Like Cells Differentiate Malignant Breast Cancer and Benign Breast Conditions

(2016) D. L. Adams et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Cancer Stem Cells and Macrophages: Implications in Tumor Biology and Therapeutic Strategies

(2016) Bruno Sainz et al.   MEDIATORS OF INFLAMMATION

An In Vitro Inverted Vertical Invasion Assay to Avoid Manipulation of Rare or Sensitive Cell Types

(2016) Tanner J. McArdle et al.   Journal of Cancer

Differential identity of Filopodia and Tunneling Nanotubes revealed by the opposite functions of actin regulatory complexes

(2016) Elise Delage et al.   Scientific Reports

Cell Fusion Connects Oncogenesis with Tumor Evolution

(2015) Xiaofeng Zhou et al.   AMERICAN JOURNAL OF PATHOLOGY

Structural and functional analysis of tunneling nanotubes (TnTs) usinggCW STED andgconfocal approaches

(2015) Magalie Bénard et al.   BIOLOGY OF THE CELL

Macrophage traits in cancer cells are induced by macrophage-cancer cell fusion and cannot be explained by cellular interaction

(2015) Ivan Shabo et al.   BMC CANCER

Circulating tumor cell isolation during resection of colorectal cancer lung and liver metastases: a prospective trial with different detection techniques

(2015) Jussuf T Kaifi et al.   CANCER BIOLOGY & THERAPY

Establishment and Characterization of a Cell Line from Human Circulating Colon Cancer Cells

(2015) L. Cayrefourcq et al.   CANCER RESEARCH

Transfer of mitochondria via tunneling nanotubes rescues apoptotic PC12 cells

(2015) X Wang et al.   CELL DEATH AND DIFFERENTIATION

Mechanical Tension Drives Cell Membrane Fusion

(2015) Ji Hoon Kim et al.   DEVELOPMENTAL CELL

Apoptosis-induced cancer cell fusion: a mechanism of breast cancer metastasis

(2015) Felicite K. Noubissi et al.   FASEB JOURNAL

Intercellular transfer of transferrin receptor by a contact-, Rab8-dependent mechanism involving tunneling nanotubes

(2015) Anne Burtey et al.   FASEB JOURNAL

Challenges in circulating tumor cell detection by the CellSearch system

(2015) Kiki C. Andree et al.   Molecular Oncology

Brain tumour cells interconnect to a functional and resistant network

(2015) Matthias Osswald et al.   NATURE

The detection of EpCAM+ and EpCAM– circulating tumor cells

(2015) Sanne de Wit et al.   Scientific Reports

Macrophage-Tumor Cell Fusions from Peripheral Blood of Melanoma Patients

(2015) Gary A. Clawson et al.   PLoS One

Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis

(2014) Nicola Aceto et al.   CELL

Cytometric characterization of Circulating Tumor Cells Captured by microfiltration and their correlation to the cellsearch®CTC test

(2014) Daniel L. Adams et al.   CYTOMETRY PART A

Fusion of HepG2 cells with mesenchymal stem cells increases cancer-associated and malignant properties: An in vivo metastasis model

(2014) HONG LI et al.   ONCOLOGY REPORTS

Circulating giant macrophages as a potential biomarker of solid tumors

(2014) Daniel L. Adams et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fusion-Derived Epithelial Cancer Cells Express Hematopoietic Markers and Contribute to Stem Cell and Migratory Phenotype in Ovarian Carcinoma

(2013) M. Ramakrishnan et al.   CANCER RESEARCH

Breast Cancer Expression of DAP12 is Associated With Skeletal and Liver Metastases and Poor Survival

(2013) Ivan Shabo et al.   Clinical Breast Cancer

Flexible Micro Spring Array Device for High-Throughput Enrichment of Viable Circulating Tumor Cells

(2013) R. A. Harouaka et al.   CLINICAL CHEMISTRY

The Dark Side of Stem Cells: Triggering Cancer Progression by Cell Fusion

(2013) T. Dittmar et al.   CURRENT MOLECULAR MEDICINE

Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion

(2013) Amelia E. Hochreiter-Hufford et al.   NATURE

Fusion of CCL21 Non-Migratory Active Breast Epithelial and Breast Cancer Cells Give Rise to CCL21 Migratory Active Tumor Hybrid Cell Lines

(2013) Benjamin Berndt et al.   PLoS One

A Melanoma Brain Metastasis with a Donor-Patient Hybrid Genome following Bone Marrow Transplantation: First Evidence for Fusion in Human Cancer

(2013) Rossitza Lazova et al.   PLoS One

Fusion for Moving

(2013) G. A. Clawson   SCIENCE

Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition

(2013) M. Yu et al.   SCIENCE

Genetic basis of cell–cell fusion mechanisms

(2013) Pablo S. Aguilar et al.   TRENDS IN GENETICS

Spontaneous Formation of Tumorigenic Hybrids between Breast Cancer and Multipotent Stromal Cells Is a Source of Tumor Heterogeneity

(2012) Germana Rappa et al.   AMERICAN JOURNAL OF PATHOLOGY

Pancreatic cancer circulating tumour cells express a cell motility gene signature that predicts survival after surgery

(2012) Gregory Sergeant et al.   BMC CANCER

Biologic Challenges in the Detection of Circulating Tumor Cells

(2012) S. A. Joosse et al.   CANCER RESEARCH

Targeting Tumor-Infiltrating Macrophages Decreases Tumor-Initiating Cells, Relieves Immunosuppression, and Improves Chemotherapeutic Responses

(2012) J. B. Mitchem et al.   CANCER RESEARCH

Hybrid cells derived from breast epithelial cell/breast cancer cell fusion events show a differential RAF-AKT crosstalk

(2012) Cem Özel et al.   Cell Communication and Signaling

Macrophage migration inhibitory factor induces epithelial to mesenchymal transition, enhances tumor aggressiveness and predicts clinical outcome in resected pancreatic ductal adenocarcinoma

(2012) Naotake Funamizu et al.   INTERNATIONAL JOURNAL OF CANCER

Wiring through tunneling nanotubes - from electrical signals to organelle transfer

(2012) S. Abounit et al.   JOURNAL OF CELL SCIENCE

The landscape of cancer genes and mutational processes in breast cancer

(2012) Philip J. Stephens et al.   NATURE

Tunneling Nanotubes Provide a Unique Conduit for Intercellular Transfer of Cellular Contents in Human Malignant Pleural Mesothelioma

(2012) Emil Lou et al.   PLoS One

Tumor Associated Macrophage × Cancer Cell Hybrids May Acquire Cancer Stem Cell Properties in Breast Cancer

(2012) Jingxian Ding et al.   PLoS One

Circulating Tumor Cells in Melanoma Patients

(2012) Gary A. Clawson et al.   PLoS One

“Stealth” Melanoma Cells in Histology-negative Sentinel Lymph Nodes

(2011) Eijun Itakura et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Active Generation and Propagation of Ca2+ Signals within Tunneling Membrane Nanotubes

(2011) Ian F. Smith et al.   BIOPHYSICAL JOURNAL

Automated identification of circulating tumor cells by image cytometry

(2011) Tycho M. Scholtens et al.   CYTOMETRY PART A

The CD40-CD40L axis and IFN-  play critical roles in Langhans giant cell formation

(2011) H. Sakai et al.   INTERNATIONAL IMMUNOLOGY

Clinical Significance of Circulating Tumor Cells, Including Cancer Stem-Like Cells, in Peripheral Blood for Recurrence and Prognosis in Patients With Dukes' Stage B and C Colorectal Cancer

(2011) Hisae Iinuma et al.   JOURNAL OF CLINICAL ONCOLOGY

Macrophages at the Fetal-Maternal Interface Express Markers of Alternative Activation and Are Induced by M-CSF and IL-10

(2011) J. Svensson et al.   JOURNAL OF IMMUNOLOGY

Human Mesenchymal Stem Cells Reprogram Adult Cardiomyocytes Toward a Progenitor-Like State Through Partial Cell Fusion and Mitochondria Transfer

(2011) Adrien Acquistapace et al.   STEM CELLS

p-Glycoprotein ABCB5 and YB-1 expression plays a role in increased heterogeneity of breast cancer cells: correlations with cell fusion and doxorubicin resistance

(2010) Ji Yeon Yang et al.   BMC CANCER

Circulating tumor cells in metastatic colorectal cancer: Efficacy and feasibility of different enrichment methods

(2010) Robert Königsberg et al.   CANCER LETTERS

Tunneling-nanotube development in astrocytes depends on p53 activation

(2010) Y Wang et al.   CELL DEATH AND DIFFERENTIATION

Expression of the macrophage antigen CD163 in rectal cancer cells is associated with early local recurrence and reduced survival time

(2009) Ivan Shabo et al.   INTERNATIONAL JOURNAL OF CANCER

Intra-tumor heterogeneity of MLH1 promoter methylation revealed by deep single molecule bisulfite sequencing

(2009) Katherine E. Varley et al.   NUCLEIC ACIDS RESEARCH

Efficient acquisition of dual metastasis organotropism to bone and lung through stable spontaneous fusion between MDA-MB-231 variants

(2009) X. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis

(2008) Jing Yang et al.   DEVELOPMENTAL CELL

Cancer cell fusion with migratory bone marrow-derived cells as an explanation for metastasis: new therapeutic paradigms

(2008) John M Pawelek   Future Oncology

Myoblasts and macrophages share molecular components that contribute to cell–cell fusion

(2008) Kostandin V. Pajcini et al.   JOURNAL OF CELL BIOLOGY

Membrane nanotubes physically connect T cells over long distances presenting a novel route for HIV-1 transmission

(2008) Stefanie Sowinski et al.   NATURE CELL BIOLOGY

Cytonemes and tunneling nanotubules in cell–cell communication and viral pathogenesis

(2008) Nathan M. Sherer et al.   TRENDS IN CELL BIOLOGY