Antigen Recognition by MR1-Reactive T Cells; MAIT Cells, Metabolites, and Remaining Mysteries

The Chemical Synthesis, Stability, and Activity of MAIT Cell Prodrug Agonists That Access MR1 in Recycling Endosomes

(2020) Joshua Lange et al.   ACS Chemical Biology

MAIT Cells in Health and Disease

(2020) Nicholas M. Provine et al.   Annual Review of Immunology

Neutrophils suppress mucosal‐associated invariant T cells in humans

(2020) Marion Schneider et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Reconstitution of Circulating Mucosal-Associated Invariant T Cells after Allogeneic Hematopoietic Cell Transplantation: Its Association with the Riboflavin Synthetic Pathway of Gut Microbiota in Cord Blood Transplant Recipients

(2020) Takaaki Konuma et al.   JOURNAL OF IMMUNOLOGY

Human Mucosal-Associated Invariant T Cells in Older Individuals Display Expanded TCRαβ Clonotypes with Potent Antimicrobial Responses

(2020) Liyen Loh et al.   JOURNAL OF IMMUNOLOGY

Mucosal-associated invariant T-Cell (MAIT) activation is altered by chlorpyrifos- and glyphosate-treated commensal gut bacteria

(2020) Anne Mendler et al.   Journal of Immunotoxicology

IL-17 production by tissue-resident MAIT cells is locally induced in children with pneumonia

(2020) Bingtai Lu et al.   Mucosal Immunology

The molecular basis underpinning the potency and specificity of MAIT cell antigens

(2020) Wael Awad et al.   NATURE IMMUNOLOGY

Genome-wide CRISPR–Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1

(2020) Michael D. Crowther et al.   NATURE IMMUNOLOGY

Butyrophilin 2A1 is essential for phosphoantigen reactivity by γδ T cells

(2020) Marc Rigau et al.   SCIENCE

A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1

(2020) Jérôme Le Nours et al.   SCIENCE

Sustained IFN-I stimulation impairs MAIT cell responses to bacteria by inducing IL-10 during chronic HIV-1 infection

(2020) X. Tang et al.   Science Advances

MAIT Cells Come to the Rescue in Cancer Immunotherapy?

(2020) Zuzanna Lukasik et al.   Cancers

Ligand-dependent downregulation of MR1 cell surface expression

(2020) Mariolina Salio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MAIT Cells Upregulate α4β7 in Response to Acute Simian Immunodeficiency Virus/Simian HIV Infection but Are Resistant to Peripheral Depletion in Pigtail Macaques

(2019) Jennifer A. Juno et al.   JOURNAL OF IMMUNOLOGY

MAIT cells as attractive vaccine targets

(2019) A. Michael Downey et al.   FEBS LETTERS

Chronically stimulated human MAIT cells are unexpectedly potent IL‐13 producers

(2019) Jason Kelly et al.   IMMUNOLOGY AND CELL BIOLOGY

Diverse MR1-restricted T cells in mice and humans

(2019) Hui-Fern Koay et al.   Nature Communications

Mucosal-Associated Invariant T Cells Display Diminished Effector Capacity in Oesophageal Adenocarcinoma

(2019) Ashanty M. Melo et al.   Frontiers in Immunology

Computer modelling and synthesis of deoxy and monohydroxy analogues of a ribitylaminouracil bacterial metabolite that potently activates human T cells

(2019) David P Fairlie et al.   CHEMISTRY-A EUROPEAN JOURNAL

Inflammation drives an altered phenotype of mucosal-associated invariant T cells in chronic hepatitis D virus infection

(2019) Helenie Kefalakes et al.   JOURNAL OF HEPATOLOGY

The biology and functional importance of MAIT cells

(2019) Dale I. Godfrey et al.   NATURE IMMUNOLOGY

Molecular mechanisms of lineage decisions in metabolite-specific T cells

(2019) François Legoux et al.   NATURE IMMUNOLOGY

Microbial metabolites control the thymic development of mucosal-associated invariant T cells

(2019) François Legoux et al.   SCIENCE

Association Between Impaired Vα7.2+CD161++CD8+ (MAIT) and Vα7.2+CD161-CD8+ T-Cell Populations and Gut Dysbiosis in Chronically HIV- and/or HCV-Infected Patients

(2019) Esther Merlini et al.   Frontiers in Microbiology

Type I interferons are important co‐stimulatory signals during T cell receptor mediated human MAIT cell activation

(2019) Rajesh Lamichhane et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

(2019) Andrea Cossarizza et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

MR1-Independent Activation of Human Mucosal-Associated Invariant T Cells by Mycobacteria

(2019) Sara Suliman et al.   JOURNAL OF IMMUNOLOGY

Activation-Induced Cell Death of Mucosal-Associated Invariant T Cells Is Amplified by OX40 in Type 2 Diabetic Patients

(2019) Mei Zhang et al.   JOURNAL OF IMMUNOLOGY

MAIT Cells Are Major Contributors to the Cytokine Response in Group A Streptococcal Toxic Shock Syndrome

(2019) Johanna Emgård et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MAIT cells are imprinted by the microbiota in early life and promote tissue repair

(2019) Michael G. Constantinides et al.   SCIENCE

A TCR-Dependent Tissue Repair Potential of MAIT Cells

(2019) Marion Salou et al.   TRENDS IN IMMUNOLOGY

A Critical Role for Mucosal-Associated Invariant T Cells as Regulators and Therapeutic Targets in Systemic Lupus Erythematosus

(2019) Goh Murayama et al.   Frontiers in Immunology

Mucosal-Associated Invariant T Cell Features and TCR Repertoire Characteristics During the Course of Multiple Sclerosis

(2019) Edgar Carnero Contentti et al.   Frontiers in Immunology

IL-23 costimulates antigen-specific MAIT cell activation and enables vaccination against bacterial infection

(2019) Huimeng Wang et al.   Science Immunology

MAIT Cells Promote Tumor Initiation, Growth, and Metastases via Tumor MR1

(2019) Juming Yan et al.   Cancer Discovery

Graft-Derived Reconstitution of Mucosal-Associated Invariant T Cells after Allogeneic Hematopoietic Cell Transplantation

(2018) Abir Bhattacharyya et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Human blood MAIT cell subsets defined using MR1 tetramers

(2018) Nicholas A Gherardin et al.   IMMUNOLOGY AND CELL BIOLOGY

Mucosal-associated invariant T cell receptor recognition of small molecules presented by MR1

(2018) Wael Awad et al.   IMMUNOLOGY AND CELL BIOLOGY

An overview on the identification of MAIT cell antigens

(2018) Lars Kjer-Nielsen et al.   IMMUNOLOGY AND CELL BIOLOGY

Mucosal-associated invariant T cells in autoimmune and immune-mediated diseases

(2018) Ophélie Rouxel et al.   IMMUNOLOGY AND CELL BIOLOGY

Interleukin-18 Is Critical for Mucosa-Associated Invariant T Cell Gamma Interferon Responses to Francisella Species In Vitro but Not In Vivo

(2018) Eric Jesteadt et al.   INFECTION AND IMMUNITY

IL-12 and IL-7 synergize to control mucosal-associated invariant T-cell cytotoxic responses to bacterial infection

(2018) Joshua C. Wallington et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The immunobiology of mucosal-associated invariant T cell (MAIT) function in primary biliary cholangitis: Regulation by cholic acid-induced Interleukin-7

(2018) Xiang Jiang et al.   JOURNAL OF AUTOIMMUNITY

Recipient mucosal-associated invariant T cells control GVHD within the colon

(2018) Antiopi Varelias et al.   JOURNAL OF CLINICAL INVESTIGATION

Mucosal-Associated Invariant T Cells Augment Immunopathology and Gastritis in ChronicHelicobacter pyloriInfection

(2018) Criselle D’Souza et al.   JOURNAL OF IMMUNOLOGY

Production of IL-17 by MAIT Cells Is Increased in Multiple Sclerosis and Is Associated with IL-7 Receptor Expression

(2018) Anne Willing et al.   JOURNAL OF IMMUNOLOGY

Modulation of bacterial metabolism by the microenvironment controls MAIT cell stimulation

(2018) Mathias Schmaler et al.   Mucosal Immunology

Synthesis, stabilization, and characterization of the MR1 ligand precursor 5-amino-6-D-ribitylaminouracil (5-A-RU)

(2018) Kelin Li et al.   PLoS One

MAIT cell clonal expansion and TCR repertoire shaping in human volunteers challenged with Salmonella Paratyphi A

(2018) Lauren J. Howson et al.   Nature Communications

Mucosal-Associated Invariant T Cells in Autoimmune Diseases

(2018) Asako Chiba et al.   Frontiers in Immunology

Hyper-Expression of PD-1 Is Associated with the Levels of Exhausted and Dysfunctional Phenotypes of Circulating CD161++TCR iVα7.2+ Mucosal-Associated Invariant T Cells in Chronic Hepatitis B Virus Infection

(2018) Yean K. Yong et al.   Frontiers in Immunology

Revealing the protective and pathogenic potential of MAIT cells

(2018) Criselle D’Souza et al.   MOLECULAR IMMUNOLOGY

Tuning of human MAIT cell activation by commensal bacteria species and MR1-dependent T-cell presentation

(2018) Cihan Tastan et al.   Mucosal Immunology

MAIT cells protect against pulmonary Legionella longbeachae infection

(2018) Huimeng Wang et al.   Nature Communications

Activation of Human Mucosal-Associated Invariant T Cells Induces CD40L-Dependent Maturation of Monocyte-Derived and Primary Dendritic Cells

(2017) Mariolina Salio et al.   JOURNAL OF IMMUNOLOGY

Diverse Streptococcus pneumoniae Strains Drive a Mucosal-Associated Invariant T-Cell Response Through Major Histocompatibility Complex class I–Related Molecule–Dependent and Cytokine-Driven Pathways

(2017) Ayako Kurioka et al.   JOURNAL OF INFECTIOUS DISEASES

Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells

(2017) Jeffrey Y. W. Mak et al.   Nature Communications

MAIT cells launch a rapid, robust and distinct hyperinflammatory response to bacterial superantigens and quickly acquire an anergic phenotype that impedes their cognate antimicrobial function: Defining a novel mechanism of superantigen-induced immunopathology and immunosuppression

(2017) Christopher R. Shaler et al.   PLOS BIOLOGY

Functionally diverse human T cells recognize non-microbial antigens presented by MR1

(2017) Marco Lepore et al.   eLife

Shared and Distinct Phenotypes and Functions of Human CD161++ Vα7.2+ T Cell Subsets

(2017) Ayako Kurioka et al.   Frontiers in Immunology

IL-7 primes IL-17 in mucosal-associated invariant T (MAIT) cells, which contribute to the Th17-axis in ankylosing spondylitis

(2016) Eric Gracey et al.   ANNALS OF THE RHEUMATIC DISEASES

TLR signaling in human antigen-presenting cells regulates MR1-dependent activation of MAIT cells

(2016) James E. Ussher et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A polymorphism in human MR1 is associated with mRNA expression and susceptibility to tuberculosis

(2016) C Seshadri et al.   GENES AND IMMUNITY

Diversity of T Cells Restricted by the MHC Class I-Related Molecule MR1 Facilitates Differential Antigen Recognition

(2016) Nicholas A. Gherardin et al.   IMMUNITY

MAIT, MR1, microbes and riboflavin: a paradigm for the co-evolution of invariant TCRs and restricting MHCI-like molecules?

(2016) Stanislas Mondot et al.   IMMUNOGENETICS

The role of mucosal-associated invariant T cells in infectious diseases

(2016) Emily B. Wong et al.   IMMUNOLOGY

Engineering of Isogenic Cells Deficient for MR1 with a CRISPR/Cas9 Lentiviral System: Tools To Study Microbial Antigen Processing and Presentation to Human MR1-Restricted T Cells

(2016) Bruno Laugel et al.   JOURNAL OF IMMUNOLOGY

MAIT cells reside in the female genital mucosa and are biased towards IL-17 and IL-22 production in response to bacterial stimulation

(2016) A Gibbs et al.   Mucosal Immunology

MR1-restricted mucosal-associated invariant T (MAIT) cells respond to mycobacterial vaccination and infection in nonhuman primates

(2016) J M Greene et al.   Mucosal Immunology

Mucosal-associated invariant T-cell activation and accumulation after in vivo infection depends on microbial riboflavin synthesis and co-stimulatory signals

(2016) Z Chen et al.   Mucosal Immunology

A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage

(2016) Hui-Fern Koay et al.   NATURE IMMUNOLOGY

The intracellular pathway for the presentation of vitamin B–related antigens by the antigen-presenting molecule MR1

(2016) Hamish E G McWilliam et al.   NATURE IMMUNOLOGY

Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens

(2016) Erin W. Meermeier et al.   Nature Communications

MAIT cells are activated during human viral infections

(2016) Bonnie van Wilgenburg et al.   Nature Communications

Enhanced immune response of MAIT cells in tuberculous pleural effusions depends on cytokine signaling

(2016) Jing Jiang et al.   Scientific Reports

IL-15 dependent induction of IL-18 secretion as a feedback mechanism controlling human MAIT-cell effector functions

(2015) Arne Sattler et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

High expression of CD26 accurately identifies human bacteria-reactive MR1-restricted MAIT cells

(2015) Prabhat K. Sharma et al.   IMMUNOLOGY

Recognition of Vitamin B Precursors and Byproducts by Mucosal Associated Invariant T Cells

(2015) Sidonia B. G. Eckle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mucosal-associated invariant T cell–rich congenic mouse strain allows functional evaluation

(2015) Yue Cui et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant T cells using MR1 tetramers

(2015) Azad Rahimpour et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Functional Heterogeneity and Antimycobacterial Effects of Mouse Mucosal-Associated Invariant T Cells Specific for Riboflavin Metabolites

(2015) Isaac G. Sakala et al.   JOURNAL OF IMMUNOLOGY

In Vitro and In Vivo Analysis of the Gram-Negative Bacteria–Derived Riboflavin Precursor Derivatives Activating Mouse MAIT Cells

(2015) Claire Soudais et al.   JOURNAL OF IMMUNOLOGY

The burgeoning family of unconventional T cells

(2015) Dale I Godfrey et al.   NATURE IMMUNOLOGY

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Arming of MAIT Cell Cytolytic Antimicrobial Activity Is Induced by IL-7 and Defective in HIV-1 Infection

(2015) Edwin Leeansyah et al.   PLoS Pathogens

Mucosal-Associated Invariant T Cells in the Human Gastric Mucosa and Blood: Role in Helicobacter pylori Infection

(2015) Jayaum S. Booth et al.   Frontiers in Immunology

MAIT Cell Function is Modulated by PD-1 Signaling in Patients with Active Tuberculosis

(2014) Jing Jiang et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

MR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage

(2014) Marielle C. Gold et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A molecular basis underpinning the T cell receptor heterogeneity of mucosal-associated invariant T cells

(2014) Sidonia B.G. Eckle et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T-cell activation by transitory neo-antigens derived from distinct microbial pathways

(2014) Alexandra J. Corbett et al.   NATURE

CD161+ MAIT Cells Are Severely Reduced in Peripheral Blood and Lymph Nodes of HIV-Infected Individuals Independently of Disease Progression

(2014) Johanna Maria Eberhard et al.   PLoS One

Parallel T-cell cloning and deep sequencing of human MAIT cells reveal stable oligoclonal TCRβ repertoire

(2014) Marco Lepore et al.   Nature Communications

Circulating Mucosal Associated Invariant T Cells Are Activated in Vibrio cholerae O1 Infection and Associated with Lipopolysaccharide Antibody Responses

(2014) Daniel T. Leung et al.   PLoS Neglected Tropical Diseases

CD161++CD8+T cells, including the MAIT cell subset, are specifically activated by IL-12+IL-18 in a TCR-independent manner

(2013) James E. Ussher et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Specific MAIT cell behaviour among innate-like T lymphocytes in critically ill patients with severe infections

(2013) David Grimaldi et al.   INTENSIVE CARE MEDICINE

Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells

(2013) Rangsima Reantragoon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-7 Licenses Activation of Human Liver Intrasinusoidal Mucosal-Associated Invariant T Cells

(2013) X.-Z. Tang et al.   JOURNAL OF IMMUNOLOGY

The molecular basis for Mucosal-Associated Invariant T cell recognition of MR1 proteins

(2013) J. Lopez-Sagaseta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recognition of vitamin B metabolites by mucosal-associated invariant T cells

(2013) Onisha Patel et al.   Nature Communications

Activation, exhaustion, and persistent decline of the antimicrobial MR1-restricted MAIT-cell population in chronic HIV-1 infection

(2012) E. Leeansyah et al.   BLOOD

Structural insight into MR1-mediated recognition of the mucosal associated invariant T cell receptor

(2012) Rangsima Reantragoon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MR1 presents microbial vitamin B metabolites to MAIT cells

(2012) Lars Kjer-Nielsen et al.   NATURE

Human MR1 expression on the cell surface is acid sensitive, proteasome independent and increases after culturing at 26°C

(2011) Beatriz Abós et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Endogenous MHC-Related Protein 1 Is Transiently Expressed on the Plasma Membrane in a Conformation That Activates Mucosal-Associated Invariant T Cells

(2011) W.-J. Chua et al.   JOURNAL OF IMMUNOLOGY

Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells

(2010) M. Dusseaux et al.   BLOOD

The non-conventional MHC class I MR1 molecule controls infection by Klebsiella pneumoniae in mice

(2010) Philippe Georgel et al.   MOLECULAR IMMUNOLOGY

Towards a knowledge-based Human Protein Atlas

(2010) Mathias Uhlen et al.   NATURE BIOTECHNOLOGY

Antimicrobial activity of mucosal-associated invariant T cells

(2010) Lionel Le Bourhis et al.   NATURE IMMUNOLOGY

Human Mucosal Associated Invariant T Cells Detect Bacterially Infected Cells

(2010) Marielle C. Gold et al.   PLOS BIOLOGY

MR1 antigen presentation to mucosal-associated invariant T cells was highly conserved in evolution

(2009) S. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stepwise Development of MAIT Cells in Mouse and Human

(2009) Emmanuel Martin et al.   PLOS BIOLOGY

MR1 uses an endocytic pathway to activate mucosal-associated invariant T cells

(2008) Shouxiong Huang et al.   JOURNAL OF EXPERIMENTAL MEDICINE