IL-23 costimulates antigen-specific MAIT cell activation and enables vaccination against bacterial infection

Activation and In Vivo Evolution of the MAIT Cell Transcriptome in Mice and Humans Reveals Tissue Repair Functionality

(2019) Timothy S.C. Hinks et al.   Cell Reports

Riboflavin Metabolism Variation among Clinical Isolates of Streptococcus pneumoniae Results in Differential Activation of Mucosal-associated Invariant T Cells

(2018) Nadine Hartmann et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

4-1BB expression on MAIT cells is associated with enhanced IFN-γ production and depends on IL-2

(2018) Jing Jiang et al.   CELLULAR IMMUNOLOGY

Interleukin-18 Is Critical for Mucosa-Associated Invariant T Cell Gamma Interferon Responses to Francisella Species In Vitro but Not In Vivo

(2018) Eric Jesteadt et al.   INFECTION AND IMMUNITY

IL-12 and IL-7 synergize to control mucosal-associated invariant T-cell cytotoxic responses to bacterial infection

(2018) Joshua C. Wallington et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Tuning of human MAIT cell activation by commensal bacteria species and MR1-dependent T-cell presentation

(2018) Cihan Tastan et al.   Mucosal Immunology

MAIT cells protect against pulmonary Legionella longbeachae infection

(2018) Huimeng Wang et al.   Nature Communications

The Toll-like receptor 9 signalling pathway regulates MR1-mediated bacterial antigen presentation in B cells

(2017) Jianyun Liu et al.   IMMUNOLOGY

Diverse Streptococcus pneumoniae Strains Drive a Mucosal-Associated Invariant T-Cell Response Through Major Histocompatibility Complex class I–Related Molecule–Dependent and Cytokine-Driven Pathways

(2017) Ayako Kurioka et al.   JOURNAL OF INFECTIOUS DISEASES

Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells

(2017) Jeffrey Y. W. Mak et al.   Nature Communications

Swiss Army Pathogen: The Salmonella Entry Toolkit

(2017) Peter J. Hume et al.   Frontiers in Cellular and Infection Microbiology

IL-7 primes IL-17 in mucosal-associated invariant T (MAIT) cells, which contribute to the Th17-axis in ankylosing spondylitis

(2016) Eric Gracey et al.   ANNALS OF THE RHEUMATIC DISEASES

The Salmonella Effector SteD Mediates MARCH8-Dependent Ubiquitination of MHC II Molecules and Inhibits T Cell Activation

(2016) Ethel Bayer-Santos et al.   Cell Host & Microbe

Biliary epithelium and liver B cells exposed to bacteria activate intrahepatic MAIT cells through MR1

(2016) Hannah C. Jeffery et al.   JOURNAL OF HEPATOLOGY

Mucosal-associated invariant T-cell activation and accumulation after in vivo infection depends on microbial riboflavin synthesis and co-stimulatory signals

(2016) Z Chen et al.   Mucosal Immunology

A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage

(2016) Hui-Fern Koay et al.   NATURE IMMUNOLOGY

Cooperation between Monocyte-Derived Cells and Lymphoid Cells in the Acute Response to a Bacterial Lung Pathogen

(2016) Andrew S. Brown et al.   PLoS Pathogens

Endosomal MR1 Trafficking Plays a Key Role in Presentation of Mycobacterium tuberculosis Ligands to MAIT Cells

(2016) Melanie J. Harriff et al.   PLoS Pathogens

ICOS Co-Stimulation: Friend or Foe?

(2016) Daniel J. Wikenheiser et al.   Frontiers in Immunology

IL-15 dependent induction of IL-18 secretion as a feedback mechanism controlling human MAIT-cell effector functions

(2015) Arne Sattler et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function

(2015) Robert P. Wilson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant T cells using MR1 tetramers

(2015) Azad Rahimpour et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Inducible Costimulator Augments Tc17 Cell Responses to Self and Tumor Tissue

(2015) Michelle H. Nelson et al.   JOURNAL OF IMMUNOLOGY

Functional Heterogeneity and Antimycobacterial Effects of Mouse Mucosal-Associated Invariant T Cells Specific for Riboflavin Metabolites

(2015) Isaac G. Sakala et al.   JOURNAL OF IMMUNOLOGY

In Vitro and In Vivo Analysis of the Gram-Negative Bacteria–Derived Riboflavin Precursor Derivatives Activating Mouse MAIT Cells

(2015) Claire Soudais et al.   JOURNAL OF IMMUNOLOGY

T-cell activation by transitory neo-antigens derived from distinct microbial pathways

(2014) Alexandra J. Corbett et al.   NATURE

Human Lung Epithelial Cells Contain Mycobacterium tuberculosis in a Late Endosomal Vacuole and Are Efficiently Recognized by CD8+ T Cells

(2014) Melanie J. Harriff et al.   PLoS One

Parallel T-cell cloning and deep sequencing of human MAIT cells reveal stable oligoclonal TCRβ repertoire

(2014) Marco Lepore et al.   Nature Communications

Toll-Like Receptor 8 Agonist and Bacteria Trigger Potent Activation of Innate Immune Cells in Human Liver

(2014) Juandy Jo et al.   PLoS Pathogens

CD161++CD8+T cells, including the MAIT cell subset, are specifically activated by IL-12+IL-18 in a TCR-independent manner

(2013) James E. Ussher et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells

(2013) Rangsima Reantragoon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Characterization of innate responses to influenza virus infection in a novel lung type I epithelial cell model

(2013) C. M. Rosenberger et al.   JOURNAL OF GENERAL VIROLOGY

Double Positive Thymocytes Select Mucosal-Associated Invariant T Cells

(2013) N. Seach et al.   JOURNAL OF IMMUNOLOGY

MAIT cells are critical for optimal mucosal immune responses during in vivo pulmonary bacterial infection

(2013) A. Meierovics et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recognition of vitamin B metabolites by mucosal-associated invariant T cells

(2013) Onisha Patel et al.   Nature Communications

Polyclonal Mucosa-Associated Invariant T Cells Have Unique Innate Functions in Bacterial Infection

(2012) Wei-Jen Chua et al.   INFECTION AND IMMUNITY

Structural insight into MR1-mediated recognition of the mucosal associated invariant T cell receptor

(2012) Rangsima Reantragoon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Intravascular Staining Redefines Lung CD8 T Cell Responses

(2012) K. G. Anderson et al.   JOURNAL OF IMMUNOLOGY

MR1 presents microbial vitamin B metabolites to MAIT cells

(2012) Lars Kjer-Nielsen et al.   NATURE

Lymphotoxin regulates commensal responses to enable diet-induced obesity

(2012) Vaibhav Upadhyay et al.   NATURE IMMUNOLOGY

Human MAIT and CD8   cells develop from a pool of type-17 precommitted CD8+ T cells

(2011) L. J. Walker et al.   BLOOD

Lymphotoxin Controls the IL-22 Protection Pathway in Gut Innate Lymphoid Cells during Mucosal Pathogen Challenge

(2011) Alexei V. Tumanov et al.   Cell Host & Microbe

Roles of Interleukin-17 in an Experimental Legionella pneumophila Pneumonia Model

(2011) Yoshifumi Kimizuka et al.   INFECTION AND IMMUNITY

IL-23 in Infections, Inflammation, Autoimmunity and Cancer: Possible Role in HIV-1 and AIDS

(2011) Govardhana Rao Yannam et al.   Journal of Neuroimmune Pharmacology

Mucosal-associated invariant T cells: unconventional development and function

(2011) Lionel Le Bourhis et al.   TRENDS IN IMMUNOLOGY

Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells

(2010) M. Dusseaux et al.   BLOOD

Cutting Edge: MHC Class II Expression by Pulmonary Nonhematopoietic Cells Plays a Critical Role in Controlling Local Inflammatory Responses

(2010) D. Kreisel et al.   JOURNAL OF IMMUNOLOGY

The non-conventional MHC class I MR1 molecule controls infection by Klebsiella pneumoniae in mice

(2010) Philippe Georgel et al.   MOLECULAR IMMUNOLOGY

Antimicrobial activity of mucosal-associated invariant T cells

(2010) Lionel Le Bourhis et al.   NATURE IMMUNOLOGY

Human Mucosal Associated Invariant T Cells Detect Bacterially Infected Cells

(2010) Marielle C. Gold et al.   PLOS BIOLOGY

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

Cutting Edge: IL-23 Receptor GFP Reporter Mice Reveal Distinct Populations of IL-17-Producing Cells

(2009) Amit Awasthi et al.   JOURNAL OF IMMUNOLOGY

MR1 antigen presentation to mucosal-associated invariant T cells was highly conserved in evolution

(2009) S. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Salmonella regulates polyubiquitination and surface expression of MHC class II antigens

(2009) N. Lapaque et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stepwise Development of MAIT Cells in Mouse and Human

(2009) Emmanuel Martin et al.   PLOS BIOLOGY

Alveolar Type II Epithelial Cells Present Antigen to CD4+T Cells and Induce Foxp3+Regulatory T Cells

(2008) Marcus Gereke et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

MR1 uses an endocytic pathway to activate mucosal-associated invariant T cells

(2008) Shouxiong Huang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-21 and TGF-β are required for differentiation of human TH17 cells

(2008) Li Yang et al.   NATURE