Human ABCB1 with an ABCB11-like degenerate nucleotide binding site maintains transport activity by avoiding nucleotide occlusion

Conversion of chemical to mechanical energy by the nucleotide binding domains of ABCB1

(2020) Dániel Szöllősi et al.   Scientific Reports

Structural insight into substrate and inhibitor discrimination by human P-glycoprotein

(2019) Amer Alam et al.   SCIENCE

Comparison of mechanistic transport cycle models of ABC exporters

(2018) Dániel Szöllősi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Dissecting the Forces that Dominate Dimerization of the Nucleotide Binding Domains of ABCB1

(2018) Dániel Szöllősi et al.   BIOPHYSICAL JOURNAL

Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1

(2018) Amer Alam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation

(2018) Youngjin Kim et al.   SCIENCE

Molecular Mechanism of ATP Hydrolysis in an ABC Transporter

(2018) Marten Prieß et al.   ACS Central Science

Substrate-induced conformational changes in the nucleotide-binding domains of lipid bilayer–associated P-glycoprotein during ATP hydrolysis

(2017) Maria E. Zoghbi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Mechanism of Taurocholate Transport by the Bile Salt Export Pump, an ABC Transporter Associated with Intrahepatic Cholestasis

(2017) Muhammad Imran Sohail et al.   MOLECULAR PHARMACOLOGY

Energy transduction and alternating access of the mammalian ABC transporter P-glycoprotein

(2017) Brandy Verhalen et al.   NATURE

Interactions of retinoids with the ABC transporters P-glycoprotein and Breast Cancer Resistance Protein

(2017) Szabolcs Tarapcsák et al.   Scientific Reports

Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity

(2016) Lothar Esser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Corrigendum: g_membed: Efficient insertion of a membrane protein into an equilibrated lipid bilayer with minimal perturbation

(2016) Maarten G. Wolf et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

ATP Hydrolysis Mechanism in a Maltose Transporter Explored by QM/MM Metadynamics Simulation

(2016) Wei-Lin Hsu et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Crystal structure of the human sterol transporter ABCG5/ABCG8

(2016) Jyh-Yeuan Lee et al.   NATURE

A single active catalytic site is sufficient to promote transport in P-glycoprotein

(2016) Orsolya Bársony et al.   Scientific Reports

2′[18F]-fluoroethylrhodamine B is a promising radiotracer to measure P-glycoprotein function

(2015) György Trencsényi et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Reference sequence (RefSeq) database at NCBI: current status, taxonomic expansion, and functional annotation

(2015) Nuala A. O'Leary et al.   NUCLEIC ACIDS RESEARCH

18FDG a PET tumor diagnostic tracer is not a substrate of the ABC transporter P-glycoprotein

(2014) Zoárd T. Krasznai et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

The Q loops of the human multidrug resistance transporter ABCB1 are necessary to couple drug binding to the ATP catalytic cycle

(2014) Joseph K. Zolnerciks et al.   FASEB JOURNAL

The central cavity of ABCB1 undergoes alternating access during ATP hydrolysis

(2014) Jessica H. van Wonderen et al.   FEBS Journal

Structural basis for allosteric cross-talk between the asymmetric nucleotide binding sites of a heterodimeric ABC exporter

(2014) M. Hohl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanistic determinants of the directionality and energetics of active export by a heterodimeric ABC transporter

(2014) Nina Grossmann et al.   Nature Communications

The Deviant ATP-binding Site of the Multidrug Efflux Pump Pdr5 Plays an Active Role in the Transport Cycle

(2013) Christopher Furman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human P-glycoprotein Contains a Greasy Ball-and-Socket Joint at the Second Transmission Interface

(2013) Tip W. Loo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

On the Origin of Large Flexibility of P-glycoprotein in the Inward-facing State

(2013) Po-Chao Wen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states

(2013) C. A. Shintre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Correction: Reliable transgene-independent method for determining sleeping beauty transposon copy numbers

(2013) Orsolya Kolacsek et al.   Mobile DNA

Mechanism of the ABC transporter ATPase domains: catalytic models and the biochemical and biophysical record

(2012) Peter M. Jones et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans

(2012) Mi Sun Jin et al.   NATURE

Dynamic Ligand-induced Conformational Rearrangements in P-glycoprotein as Probed by Fluorescence Resonance Energy Transfer Spectroscopy

(2011) Brandy Verhalen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reliable transgene-independent method for determining Sleeping Beauty transposon copy numbers

(2011) Orsolya Kolacsek et al.   Mobile DNA

Characterization of an Asymmetric Occluded State of P-glycoprotein with Two Bound Nucleotides

(2010) Alena Siarheyeva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

g_membed: Efficient insertion of a membrane protein into an equilibrated lipid bilayer with minimal perturbation

(2010) Maarten G. Wolf et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Improved side-chain torsion potentials for the Amber ff99SB protein force field

(2010) Kresten Lindorff-Larsen et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Data-driven homology modelling of P-glycoprotein in the ATP-bound state indicates flexibility of the transmembrane domains

(2009) Thomas Stockner et al.   FEBS Journal

Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates

(2009) Lajos Mátés et al.   NATURE GENETICS

ABC transporters: the power to change

(2009) Douglas C. Rees et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular basis of multidrug transport by ABC transporters

(2008) Markus A. Seeger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS