Substrate-induced conformational changes in the nucleotide-binding domains of lipid bilayer–associated P-glycoprotein during ATP hydrolysis

Effects of a detergent micelle environment on P-glycoprotein (ABCB1)-ligand interactions

(2017) Suneet Shukla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Energy transduction and alternating access of the mammalian ABC transporter P-glycoprotein

(2017) Brandy Verhalen et al.   NATURE

P-glycoprotein ATPase activity requires lipids to activate a switch at the first transmission interface

(2016) Tip W. Loo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Lipid Bilayer Modulates the Structure and Function of an ATP-binding Cassette Exporter

(2016) Maria E. Zoghbi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanistic diversity in ATP-binding cassette (ABC) transporters

(2016) Kaspar P Locher   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanistic diversity in ATP-binding cassette (ABC) transporters

(2016) Kaspar P Locher   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Functional hemichannels formed by human connexin 26 expressed in bacteria

(2015) Mariana C. Fiori et al.   BIOSCIENCE REPORTS

Distinct Conformational Spectrum of Homologous Multidrug ABC Transporters

(2015) Arne Moeller et al.   STRUCTURE

Equilibrated Atomic Models of Outward-Facing P-glycoprotein and Effect of ATP Binding on Structural Dynamics

(2015) Lurong Pan et al.   Scientific Reports

Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein

(2015) Paul Szewczyk et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Directed evolution of P-glycoprotein cysteines reveals site-specific, non-conservative substitutions that preserve multidrug resistance

(2014) Douglas J. Swartz et al.   BIOSCIENCE REPORTS

The central cavity of ABCB1 undergoes alternating access during ATP hydrolysis

(2014) Jessica H. van Wonderen et al.   FEBS Journal

Identification of the Distance between the Homologous Halves of P-glycoprotein That Triggers the High/Low ATPase Activity Switch

(2014) Tip W. Loo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

3D Cryo-Electron Reconstruction of BmrA, a Bacterial Multidrug ABC Transporter in an Inward-Facing Conformation and in a Lipidic Environment

(2014) Pierre Frederic Fribourg et al.   JOURNAL OF MOLECULAR BIOLOGY

ATP binding to two sites is necessary for dimerization of nucleotide-binding domains of ABC proteins

(2013) Maria E. Zoghbi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Substrate Binding Stabilizes a Pre-translocation Intermediate in the ATP-binding Cassette Transport Protein MsbA

(2013) Rupak Doshi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hydrolysis at One of the Two Nucleotide-binding Sites Drives the Dissociation of ATP-binding Cassette Nucleotide-binding Domain Dimers

(2013) Maria E. Zoghbi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Association/Dissociation of the Nucleotide-binding Domains of the ATP-binding Cassette Protein MsbA Measured during Continuous Hydrolysis

(2013) Rebecca S. Cooper et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

On the Origin of Large Flexibility of P-glycoprotein in the Inward-facing State

(2013) Po-Chao Wen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Asymmetric Post-Hydrolysis State of the ABC Transporter ATPase Dimer

(2013) Anthony M. George et al.   PLoS One

Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain

(2013) A. B. Ward et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mass spectrometry reveals synergistic effects of nucleotides, lipids, and drugs binding to a multidrug resistance efflux pump

(2013) J. Marcoux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Refined structures of mouse P-glycoprotein

(2013) Jingzhi Li et al.   PROTEIN SCIENCE

Mechanism of the ABC transporter ATPase domains: catalytic models and the biochemical and biophysical record

(2012) Peter M. Jones et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Dissociation of ATP-binding Cassette Nucleotide-binding Domain Dimers into Monomers during the Hydrolysis Cycle

(2012) Maria E. Zoghbi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans

(2012) Mi Sun Jin et al.   NATURE

Molecular-Dynamics Simulations of the ATP/apo State of a Multidrug ATP-Binding Cassette Transporter Provide a Structural and Mechanistic Basis for the Asymmetric Occluded State

(2011) Peter M. Jones et al.   BIOPHYSICAL JOURNAL

Catalytic and transport cycles of ABC exporters

(2011) Marwan K. Al-Shawi   Essays in Biochemistry

The P-glycoprotein multidrug transporter

(2011) Frances J. Sharom   Essays in Biochemistry

Kinetics of the Association/Dissociation Cycle of an ATP-binding Cassette Nucleotide-binding Domain

(2011) Maria E. Zoghbi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

P-glycoprotein Retains Drug-stimulated ATPase Activity upon Covalent Linkage of the Two Nucleotide Binding Domains at Their C-terminal Ends

(2011) Brandy Verhalen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic Ligand-induced Conformational Rearrangements in P-glycoprotein as Probed by Fluorescence Resonance Energy Transfer Spectroscopy

(2011) Brandy Verhalen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heterologous Overexpression and Mutagenesis of the Human Bile Salt Export Pump (ABCB11) Using DREAM (Directed REcombination-Assisted Mutagenesis)

(2011) Jan Stindt et al.   PLoS One

A Gene Optimization Strategy that Enhances Production of Fully Functional P-Glycoprotein in Pichia pastoris

(2011) Jiangping Bai et al.   PLoS One

Human P-glycoprotein is active when the two halves are clamped together in the closed conformation

(2010) Tip W. Loo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

ABC Efflux Pump-Based Resistance to Chemotherapy Drugs

(2009) Paul D. W. Eckford et al.   CHEMICAL REVIEWS

Conformational Cycle of the ABC Transporter MsbA in Liposomes: Detailed Analysis Using Double Electron–Electron Resonance Spectroscopy

(2009) Ping Zou et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

(2009) S. G. Aller et al.   SCIENCE

ABC transporters: a riddle wrapped in a mystery inside an enigma

(2009) Peter M. Jones et al.   TRENDS IN BIOCHEMICAL SCIENCES

Spin-labeled lipid A

(2008) Lynn E. Bretscher et al.   ANALYTICAL BIOCHEMISTRY

Functional Characterization ofEscherichia coliMsbA

(2008) Paul D. W. Eckford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Opening of the ADP-bound active site in the ABC transporter ATPase dimer: Evidence for a constant contact, alternating sites model for the catalytic cycle

(2008) Peter M. Jones et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

ABC multidrug transporters: structure, function and role in chemoresistance

(2007) Frances J Sharom   PHARMACOGENOMICS