Article
Neurosciences
Yanxiao Li, Yee Ling Ng, Manish D. Paranjpe, Qi Ge, Fengyun Gu, Panlong Li, Shaozhen Yan, Jie Lu, Xiuying Wang, Yun Zhou
Summary: This study aimed to improve the statistical power in detecting changes in brain glucose metabolism, amyloid, and tau deposition in Alzheimer's disease studies by using a reference tissue-based quantification approach. The results showed that the tracer-specific reference tissue improved the detection of PET SUVR changes, which is beneficial for early diagnosis, disease progression monitoring, and therapeutic response in Alzheimer's disease.
HUMAN BRAIN MAPPING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Pascalle Mossel, Wejdan M. Arif, Giordana Salvi De Souza, Lara Garcia Varela, Chris W. J. van der Weijden, Hendrikus H. Boersma, Antoon T. M. Willemsen, Ronald Boellaard, Philip H. Elsinga, Ronald J. H. Borra, Rudi A. J. O. Dierckx, Adriaan A. Lammertsma, Anna L. Bartels, Gert Luurtsema
Summary: The aim of this study was to determine the best pharmacokinetic model to describe [F-18]MC225 kinetics in the human brain and assess test-retest variability. The reversible two tissue compartment model corrected for plasma metabolites with an estimated blood volume (VB) showed the highest AIC weight score. The preferred parameter to describe P-gp function in the human BBB using this model was [F-18]MC225 VT, which had an average test-retest variability of 28%.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Daniela-Elena Oprea-Lager, Eric Gontier, Lina Garcia-Canamaque, Mathieu Gauthe, Pierre Olivier, Mercedes Mitjavila, Pilar Tamayo, Philippe Robin, Ana Maria Garcia Vicente, Anne-Charlotte Bouyeure, Alban Bailliez, Antonio Rodriguez-Fernandez, Sinan Ben Mahmoud, Juan Antonio Vallejo-Casas, Philippe Maksud, Charles Merlin, Paul Blanc-Durand, Clement Drouet, Hubert Tissot, Irina Vierasu, Thierry Vander Borght, Evelyne Boos, Florence Chossat, Marina Hodolic, Caroline Rousseau
Summary: The purpose of this study was to compare the per-patient detection rates of [F-18]DCFPyL and [F-18]fluoromethylcholine PET/CT in patients with first prostate cancer biochemical recurrence. The results showed that [F-18]DCFPyL had a significantly higher detection rate compared to [F-18]fluoromethylcholine.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Keith L. Spinali, David J. Papke, Hina J. Shah
Summary: F-18-DCFPyl is used to detect recurrent or metastatic prostate cancer and can target nonprostatic disease entities that mimic prostate cancer. The interpreting physician needs to consider serum prostate-specific antigen levels and uptake distribution to avoid misdiagnosis of metastatic prostate cancer. We describe the association of F-18-DCFPyl uptake with a previously undescribed hepatic small vessel neoplasm.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Halil Komek, Canan Can, Ihsan Kaplan, Cihan Gundogan, Ferat Kepenek, Huseyin Karaoglan, Aykut Demirkiran, Senar Ebinc, Yunus Guzel, Ebubekir Gundes
Summary: [(68) Ga]Ga-DOTA-FAPI-04 PET/CT demonstrates higher sensitivity and specificity in the evaluation of primary lesions and metastases in patients with colorectal cancer.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Ya-Ting Huang, Tom Wei-Wu Chen, Li-Yu Chen, Ya-Yao Huang, Yen-Shen Lu
Summary: [F-18]fluoroestradiol (FES) can be used for noninvasive visualization and quantification of tumor estrogen receptor (ER) expression and activity. It has been FDA-approved as a diagnostic agent for detecting ER-positive lesions in patients with recurrent or metastatic breast cancer. PET imaging is also useful for detecting ER-positive lesions and malignancy in patients with uterine, ovarian, and other ER-positive solid tumors. This study reviews the use of FES PET imaging in patients with various types of cancer.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sang Woo Lee, Seong-Jang Kim
Summary: The systematic review and meta-analysis showed that F-18-FDG PET/CT has good diagnostic performance in detecting lymph node metastasis in penile cancer patients, with similar accuracy in detecting inguinal and pelvic lymph node metastasis.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Oncology
Lidija Antunovic, Alessia Artesani, Alessandro Vigano, Arturo Chiti, Armando Santoro, Martina Sollini, Silvia D. Morbelli, Rita De Sanctis
Summary: This study aimed to examine brain metabolic patterns on [F-18]Fluorodeoxyglucose ([F-18]FDG) positron emission tomography (PET) in breast cancer (BC), comparing patients with tension-type headache (TTH), migraine (MiG), and those without headache. The results showed that headache patients exhibited hypometabolism in specific brain regions before neoadjuvant chemotherapy (NAC) and headache patients with a good response to NAC showed hypermetabolic brain regions in the anterior medial frontal cortex.
Article
Nutrition & Dietetics
Thierry Galvez, Ikrame Berkane, Simon Thezenas, Marie-Claude Eberle, Nicolas Flori, Sophie Guillemard, Alina Diana Ilonca, Lore Santoro, Pierre-Olivier Kotzki, Pierre Senesse, Emmanuel Deshayes
Summary: F-18-FDG PET-CT is commonly used for the initial staging of various cancers. This study found a significant association between F-18-FDG uptake in the brain and initial weight loss in patients with esophageal cancer, providing new insights for the diagnosis and treatment of anorexia in cancer patients.
Article
Radiology, Nuclear Medicine & Medical Imaging
Joseph Therriault, Andrea L. Benedet, Tharick A. Pascoal, Melissa Savard, Nicholas J. Ashton, Mira Chamoun, Cecile Tissot, Firoza Lussier, Min Su Kang, Gleb Bezgin, Tina Wang, Jaime Fernandes-Arias, Gassan Massarweh, Paolo Vitali, Henrik Zetterberg, Kaj Blennow, Paramita Saha-Chaudhuri, Jean-Paul Soucy, Serge Gauthier, Pedro Rosa-Neto
Summary: This study assessed multiple methods for determining an optimal cutoff for F-18-AZD4694 PET positivity, with good convergence among different approaches. The findings suggest that a threshold of 1.55 SUVR may have reliable discriminative accuracy for amyloid-beta positivity on PET imaging.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Jin Qi, Elizabeth Kurian, Orhan K. oez
Summary: Hibernomas are rare benign tumors originating from fetal brown adipose tissue. They can occur in various parts of the body, with thigh, shoulder, back, and neck being the most common locations, and are rarely found in the abdominal cavity, retroperitoneum, breast, bones, scrotum, and perirectum. We present a case of a 58-year-old woman with a mediastinal mass, who was incidentally found to have an FDG-avid fat-containing lesion in the omentum abutting the stomach.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Oncology
Jian-Wei Yang, Ling-Ling Yuan, Yan Gao, Xu-Sheng Liu, Yu-Jiao Wang, Lu-Meng Zhou, Xue-Yan Kui, Xiao-Hui Li, Chang-Bin Ke, Zhi-Jun Pei
Summary: The study found a correlation between the expression levels of EIF2S2 gene and F-18-FDG PET/CT metabolic parameters in CRC patients, and a positive correlation between EIF2S2 and GLUT1 expression. Overexpression of EIF2S2 in CRC can promote glycolysis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sung Ryul Shim, Seong-Jang Kim
Summary: This study evaluated the diagnostic accuracies of F-18-FDG PET or PET/CT for Merkel cell carcinoma (MCC) through a systematic review and meta-analysis. The results showed that F-18-FDG PET/CT had excellent performance in diagnosing MCC and could be useful for exclusion and confirmation of the disease. Further large multicenter studies are needed to validate its diagnostic accuracy.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Luca Urso, Giovanni Christian Rocca, Francesca Borgia, Federica Lancia, Antonio Malorgio, Mauro Gagliano, Mauro Zanetto, Licia Uccelli, Corrado Cittanti, Carmelo Ippolito, Laura Evangelista, Mirco Bartolomei
Summary: By analyzing data from a multidisciplinary approach, [F-18]F-choline PET/CT plays an important role in the diagnosis and prognosis of PCa patients, helping to select initial treatment plans and being associated with longer biochemical recurrence-free survival.
Article
Radiology, Nuclear Medicine & Medical Imaging
Abarnaa Sivapathasundaram, Nicolas Golse, Alina Pascale, Emmanuel Durand, Mylene Sebagh, Florent L. Besson
Summary: Contrary to common belief, F-18-FDG/F-18-choline dual-tracer PET behavior is not a relevant surrogate of tumor differentiation in hepatocellular carcinoma (HCC). Future multitracer PET studies are necessary to improve our understanding of their biological significance in this field.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Jonathan Martinelli, Leonardo Maria Zapelli, Mariangela Boccalon, Adrienn Vagner, Gabor Nagy, Aniko Fekete, Dezso Szikra, Gyorgy Trencsenyi, Zsolt Baranyai, Lorenzo Tei
Summary: The introduction of a phenolate pendant arm in place of an acetate on AAZTA- and DATA-like ligands resulted in higher thermodynamic stability and kinetic inertness of Ga(III) complexes. The heptadentate AAZ3A-endoHB showed the highest logK(GaL) value of 27.35 and a remarkable resistance to hydroxide coordination, indicating improved kinetic inertness. The radiotracer synthesized using the bifunctional chelator AAZ3A-endoHB, labeled with Ga-68, showed stability in human serum and successfully targeted B16-F10 tumors in vivo for miniPET imaging.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Judit P. Szabo, Katalin Csige, Ibolya Kalman-Szabo, Viktoria Arato, Gabor Opposits, Istvan Joszai, Istvan Kertesz, Zita Kepes, Gabor Mehes, Ferenc Fenyvesi, Istvan Hajdu, Gyorgy Trencsenyi
Summary: This study evaluated the tumor-targeting potential of 68Ga-labelled cyclodextrin derivatives (CyDs). The results showed that both 68Ga-NODAGA-RAMEB and 68Ga-NODAGA-HP8CD can be used to identify different types of tumors, with the highest accumulation observed in PGE2 positive tumors.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Ibolya Kalman-Szabo, Szilvia Bunda, Norbert Lihi, Zsofia Szaniszlo, Dezso Szikra, Judit Szabo Peline, Aniko Fekete, Barbara Gyuricza, Daniel Szucs, Gabor Papp, Gyorgy Trencsenyi, Ferenc K. Kalman
Summary: Malignant melanoma is a significant public health issue with high metastatic potential, and the early detection using imaging techniques is crucial for long-term survival. The radio-labelled alpha-MSH analog NAPamide has been found to be a suitable diagnostic tool for melanoma detection. In this study, a new radiotracer, [61Cu]Cu-KFTGNAPamide, has been synthesized to take advantage of the positron emitter 61Cu and the melanoma specificity of NAPamide. The [61Cu]Cu-KFTG-NAPamide demonstrated excellent diagnostic features for B16-F10 melanoma tumors through PET imaging.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Oncology
Zita Kepes, Gyorgy Trencsenyi
Summary: Since metastases are responsible for the majority of cancer-related death, understanding the process of metastatisation is crucial for the development of new therapeutic and diagnostic approaches in cancer management. The subrenal capsule assay (SRCA)-induced tumor-bearing animal models provide a valuable tool for studying secondary tumor formation and evaluating the process of metastatisation.
Article
Pharmacology & Pharmacy
Zita Kepes, Viktoria Arato, Judit P. Szabo, Barbara Gyuricza, Daniel Szuecs, Istvan Hajdu, Aniko Fekete, Frank Bruchertseifer, Dezso Szikra, Gyoergy Trencsenyi
Summary: This study aimed to evaluate the in vivo tumor targeting capability of radiolabeled NGR-tripeptides (asparagine-glycine-arginine) that selectively target Aminopeptidase N (APN/CD13) on cancer cells. The study was conducted on CD13pos. HT1080 fibrosarcoma-bearing mice using [Bi-213]Bi-DOTAGA-cKNGRE. Positron emission tomography (PET) was performed for tumor verification and biodistribution studies were conducted post-injection. The results suggest that the therapeutic application of APN/CD13-affine [Bi-213]Bi-DOTAGA- cKNGRE shows promise in receptor-positive fibrosarcoma treatment.
Article
Medicine, General & Internal
Csaba Csikos, Adrienn Vagner, Gabor Nagy, Ibolya Kalman-Szabo, Judit P. Szabo, Minh Toan Ngo, Zoltan Szoboszlai, Dezso Szikra, Zoard Tibor Krasznai, Gyorgy Trencsenyi, Ildiko Garai
Summary: The aim of this study was to evaluate the biodistribution and tumor-targeting potential of Mn-52-labeled DOTAGA-bevacizumab. The VEGF-A targeting potential of the new immuno-PET ligand was assessed using the VEGF-A expressing KB-3-1 (human cervix carcinoma) tumor-bearing CB17 SCID mouse model and in vivo PET/MRI imaging. Due to the high and specific accumulation found in the subcutaneously located experimental cervix carcinoma tumors, [Mn-52]Mn-DOTAGA-bevacizumab is a promising PET probe for the detection of VEGF-A positive gynecological tumors, for patient selection, and monitoring the efficacy of therapies targeting angiogenesis.
Review
Biochemistry & Molecular Biology
Zita Kepes, Noemi Denes, Istvan Kertesz, Istvan Hajdu, Gyoergy Trencsenyi
Summary: As malignancies remain a major global health concern, early tumor identification is crucial. Targeting the COX-2/PGE2/EP axis could provide promising imaging probes for PGE2-positive tumors and anti-cancer drug design. Radiolabelled beta-cyclodextrins (CDs), such as RAMEB, have shown potential as vectors for molecular imaging of PGE2-related tumorigenesis. Preclinical studies using PET imaging with Ga-68 and Bi-205/206-labelled CD derivatives have evaluated their tumor-homing capability in PGE2-expressing tumors. This review highlights the importance of translating these findings into routine clinical usage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Zoltan M. Kohler, Gyorgy Trencsenyi, Laszlo Juhasz, Agnes Zvara, Judit P. Szabo, Laszlo Dux, Laszlo G. Puskas, Laszlo Rovo, Aniko Keller-Pinter
Summary: Skeletal muscle plays a crucial role in glucose metabolism. This study demonstrates that tilorone can improve glucose uptake and metabolism by enhancing BMP signaling and Akt2/AS160 signaling pathways in C2C12 myoblasts and differentiated myotubes. The in vivo experiments show that tilorone administration increases glucose uptake in skeletal muscle, liver, and adipose tissue of mice. These findings provide new insights for the treatment of type 2 diabetes.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Chemistry, Analytical
Ibolya Kalman-Szabo, Zita Kepes, Aniko Fekete, Adrienn Vagner, Gabor Nagy, Daniel Szucs, Barbara Gyuricza, Viktoria Arato, Jozsef Varga, Levente Karpati, Ildiko Garai, Istvan Mandity, Frank Bruchertseifer, Janos Elek, Dezs Szikra, Gyorgy Trencsenyi
Summary: The study investigated the biodistribution and tumor-targeting potential of newly synthesized Bi-213-conjugated MC1-R specific peptide-based radioligands. The results showed that these novel radiolabeled peptide probes displayed significant tumor affinity and could be promising molecular probes in melanoma imaging. The radiation absorbed dose assessment indicated the suitability of the NAPamide derivative for clinical use.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Review
Biotechnology & Applied Microbiology
Andras Polyak, Zita Kepes, Gyorgy Trencsenyi
Summary: Currently, there are limited efforts to trace, monitor, and visualize implantations, artificial organs, and bioengineered scaffolds for tissue engineering in vivo. Although X-Ray, CT, and MRI methods have been used for this purpose, the use of radiotracer-based nuclear imaging techniques is still challenging. PET and SPECT techniques offer specific, quantifiable, visual, and non-invasive feedback on implanted biomaterials, devices, or transplanted cells, making them promising tools for regenerative medicine and tissue engineering. These methods can improve research in biocompatibility, inertivity, immune-response evaluations, and have wide applications in various implant-related studies.
BIOENGINEERING-BASEL
(2023)
Review
Biochemistry & Molecular Biology
Gyorgy Trencsenyi, Kata Nora Enyedi, Gabor Mezo, Gabor Halmos, Zita Kepes
Summary: Angiogenesis plays a key role in tumor progression and metastasis. Targeting angiogenesis using specific vectors has gained attention from researchers. The high expression of angiogenesis-associated aminopeptidase N (APN/CD13) on the surface of activated endothelial cells and various tumor cells makes it a promising target for cancer imaging and therapy. Radiolabeled NGR peptides, which selectively bind to APN/CD13, have been investigated for non-invasive, real-time imaging of APN/CD13 overexpressing malignancies.Various radioisotopes, such as Ga-68, Cu-64, (99)mTc, Lu-177, Re-188, and Bi-213, have been used for labeling tumor vasculature homing NGR sequences in preclinical studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Gyoergy Trencsenyi, Gabor Halmos, Zita Kepes
Summary: Due to the increasing prevalence of malignant diseases and related metastases, there is a need for specific diagnostic vectors that can identify tumors in a timely and selective manner. Multi-target imaging using multivalent ligands has emerged as an effective way to increase the binding ability of peptide-based molecular vectors in cancer research. The colocalization of the asparagine-glycine-arginine (NGR) motif with angiogenesis-related Aminopeptidase N (APN/CD13) makes radiolabelled NGR-containing bispecific compounds valuable tools for molecular diagnostics of APN/CD13 overexpressing tumors. The establishment of vascular-homing heterobivalent probes not only expands the horizon of cancer diagnostics but also contributes to the goal of personalized tumor imaging.
Article
Chemistry, Medicinal
Daniel Szucs, Judit P. Szabo, Viktoria Arato, Barbara Gyuricza, Dezso Szikra, Imre Toth, Zita Kepes, Gyorgy Trencsenyi, Aniko Fekete
Summary: This study aimed to improve the pharmacokinetics of radiolabeled DOTA-NAPamide compounds. By incorporating 4-(p-iodo-phenyl)-butanoic acid, the radiopharmaceuticals exhibited prolonged circulation time in vivo, leading to enhanced tumor accumulation. However, caution should be exercised when using short-lived isotopes due to significant off-target radioactivity.
Review
Biochemistry & Molecular Biology
Gyorgy Trencsenyi, Zita Kepes
Summary: Angiogenesis-related cell-surface molecules play a key role in tumour formation, and radiolabelled imaging probes targeting these molecules are valuable in tumour identification. Scandium-44 has gained attention as a promising radiometal for PET imaging due to its ideal decay characteristics and suitable half-life. This review summarizes the preclinical achievements with Sc-44-labelled angiogenesis-specific molecular probes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Xuezhi Zhuo, Vito Fodera, Per Larsson, Zarah Schaal, Christel A. S. Bergstrom, Korbinian Lobmann, Aleksei Kabedev
Summary: Our previous work demonstrated that beta-lactoglobulin-stabilized amorphous solid dispersion (ASD) loaded with 70 % indomethacin remains stable for over 12 months. We further investigated the stabilization mechanisms by testing five other drug molecules and using experimental techniques and molecular dynamics simulations. The results showed that steric confinement, hydrogen bonding, and the glass transition temperature of the drug molecule play important roles in stabilizing ASDs with high drug loadings.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Sebastian Schmidt, Ulrike Holzgrabe
Summary: The binding of drugs to plasma proteins, such as human serum albumin (HSA), is crucial for determining pharmacokinetic parameters. This study investigated the enantioselective binding of S- and R-ketamine to HSA. It was found that ketamine has weak affinity to HSA, with no significant differences in binding behavior between the individual enantiomers and the racemate. The aromatic ring and N-methyl group were identified as the most strongly involved structural moieties in the binding of ketamine to HSA.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Yuchen Zhao, Han Wang, Lin Jin, Ziwei Zhang, Lianghu Liu, Mengqi Zhou, Xianzheng Zhang, Lingling Zhang
Summary: Interleukins (ILs) are important for communication between immune cells and non-immune cells, but dysregulation of ILs expression is a characteristic of autoinflammatory diseases. Drugs targeting ILs have significant clinical benefits, but may also cause adverse reactions. Fusion protein technology, with its ability to enhance therapeutic efficacy, has been explored for developing anti-inflammatory drugs. This review discusses the efficacy of fusion protein drugs developed with ILs or their receptors in treating autoinflammatory diseases, highlighting the potential of this technology in future anti-inflammatory drug development.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Serena Bertoni, Elena Simone, Stefano Sangiorgi, Beatrice Albertini, Nadia Passerini
Summary: This study investigated the correlation between the structure and release properties of solid lipid microparticles (MPs) with different liquid additives. The additives accelerated the conversion of the unstable alpha-form of tristearin to the stable beta-polymorph and caused structural modifications in the MPs. The presence of additives prolonged the drug release in water and resulted in higher release profiles in biorelevant media. The findings suggest that the release behavior can be influenced by the polymorphism and supramolecular-level structural modification of lipid formulations containing crystal modifiers.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Juulia Jarvinen, Ahmed B. Montaser, Santosh Kumar Adla, Jukka Leppanen, Marko Lehtonen, Kati-Sisko Vellonen, Tuomo Laitinen, Aaro Jalkanen, William F. Elmquist, Juri Timonen, Kristiina M. Huttunen, Jarkko Rautio
Summary: This study attempted to alter the brain distribution pattern of Palbociclib by creating and assessing two novel prodrugs. Although the prodrug design did not significantly improve Palbociclib brain delivery, the study provides valuable insights for future prodrug development and drug delivery strategies targeting specific transporters.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Review
Pharmacology & Pharmacy
Miao Wang, Xinyu Ma, Shiyu Zong, Yaqiong Su, Rui Su, Hong Zhang, Yang Liu, Chunliu Wang, Ye Li
Summary: This article discusses the potential and limitations of nasal administration in central nervous system drug delivery. Nasal gel viscosity can alleviate the impact of nasal mucociliary clearance on drug delivery, and materials such as gellan gum, chitosan, carbomer, cellulose, and poloxamer can be used to prepare nasal gels.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Bjarke Strom Larsen, Eric Kissi, Liebert Parreiras Nogueira, Natalja Genina, Ingunn Tho
Summary: This study investigates the influence of drug load and polymer molecular weight on the structure of 3D printed tablets. The results show that drug load and polymer molecular weight have a significant impact on the porosity and size of the tablets, while the effect of drug load on the total porosity of the tablets is minimal.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Zhentao Qiao, Fuhang Wang, Dongjian Han, Yuansong Zhuang, Qingjiao Jiang, Yi Zhang, Miaomiao Liu, Quanxu An, Zhiwei Wang, Deliang Shen
Summary: In this study, it was demonstrated that periadventitial delivery of rapamycin-fibrin glue (RPM-FG) can inhibit intimal hyperplasia (IH) in a rat carotid artery injury model without compromising re-endothelialization. This provides a promising direction for the future development of a safe, effective, and minimally invasive perivascular drug delivery method to treat vascular disease.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Neele Puhlmann, Rodrigo Vidaurre, Klaus Kuemmerer
Summary: Active pharmaceutical ingredients and their metabolites and transformation products are pollutants that can harm human and environmental health. Designing greener APIs is an effective strategy to address this issue. The drug discovery and development process can incorporate environmental parameters to achieve this design, and this process is highly flexible.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
