DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl 1H-NMR probe

Structure of the neurotensin receptor 1 in complex with β-arrestin 1

(2020) Weijiao Huang et al.   NATURE

Structure of the M2 muscarinic receptor–β-arrestin complex in a lipid nanodisc

(2020) Dean P. Staus et al.   NATURE

Designer membraneless organelles enable codon reassignment of selected mRNAs in eukaryotes

(2019) Christopher D. Reinkemeier et al.   SCIENCE

Trimethylsilyl reporter groups for NMR studies of conformational changes in G protein‐coupled receptors

(2019) Wanhui Hu et al.   FEBS LETTERS

Conformational Sensors and Domain Swapping Reveal Structural and Functional Differences between β-Arrestin Isoforms

(2019) Eshan Ghosh et al.   Cell Reports

Agonist-induced membrane nanodomain clustering drives GLP-1 receptor responses in pancreatic beta cells

(2019) Teresa Buenaventura et al.   PLOS BIOLOGY

A complex structure of arrestin-2 bound to a G protein-coupled receptor

(2019) Wanchao Yin et al.   CELL RESEARCH

Structure of an endosomal signaling GPCR–G protein–β-arrestin megacomplex

(2019) Anthony H. Nguyen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Molecular Basis of G Protein–Coupled Receptor Activation

(2018) William I. Weis et al.   Annual Review of Biochemistry

Catalytic activation of β-arrestin by GPCRs

(2018) Kelsie Eichel et al.   NATURE

Molecular mechanism of GPCR-mediated arrestin activation

(2018) Naomi R. Latorraca et al.   NATURE

Biased signalling: from simple switches to allosteric microprocessors

(2018) Jeffrey S. Smith et al.   NATURE REVIEWS DRUG DISCOVERY

Molecular mechanism of modulating arrestin conformation by GPCR phosphorylation

(2018) Andrija Sente et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanistic insights into allosteric regulation of the A2A adenosine G protein-coupled receptor by physiological cations

(2018) Libin Ye et al.   Nature Communications

Molecular mechanism of modulating arrestin conformation by GPCR phosphorylation

(2018) Andrija Sente et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the adenosine-bound human adenosine A1 receptor–Gi complex

(2018) Christopher J. Draper-Joyce et al.   NATURE

Structure of the µ-opioid receptor–Gi protein complex

(2018) Antoine Koehl et al.   NATURE

Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin

(2018) Fan Yang et al.   Nature Chemical Biology

Genetically encoded amino acids with tert-butyl and trimethylsilyl groups for site-selective studies of proteins by NMR spectroscopy

(2017) Choy Theng Loh et al.   JOURNAL OF BIOMOLECULAR NMR

Phosphorylation of G Protein-Coupled Receptors: From the Barcode Hypothesis to the Flute Model

(2017) Zhao Yang et al.   MOLECULAR PHARMACOLOGY

Application of Solution NMR to Structural Studies on α-Helical Integral Membrane Proteins

(2017) Dae-Won Sim et al.   MOLECULES

Expanding and reprogramming the genetic code

(2017) Jason W. Chin   NATURE

Phase-plate cryo-EM structure of a class B GPCR–G-protein complex

(2017) Yi-Lynn Liang et al.   NATURE

Single-molecule analysis of ligand efficacy in β2AR–G-protein activation

(2017) G. Glenn Gregorio et al.   NATURE

The Diverse Roles of Arrestin Scaffolds in G Protein–Coupled Receptor Signaling

(2017) Yuri K. Peterson et al.   PHARMACOLOGICAL REVIEWS

Distinct conformations of GPCR–β-arrestin complexes mediate desensitization, signaling, and endocytosis

(2017) Thomas J. Cahill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling

(2017) Chun-Hua Liu et al.   Nature Communications

Isotope-labeling strategies for solution NMR studies of macromolecular assemblies

(2016) Heyi Zhang et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Activation of the A2A adenosine G-protein-coupled receptor by conformational selection

(2016) Libin Ye et al.   NATURE

Nuclear magnetic resonance (NMR) applied to membrane–protein complexes

(2016) Mohammed Kaplan et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Functional competence of a partially engaged GPCR–β-arrestin complex

(2016) Punita Kumari et al.   Nature Communications

Structural Biology of the Major Facilitator Superfamily Transporters

(2015) Nieng Yan   Annual Review of Biophysics

Different downstream signalling of CCK1receptors regulates distinct functions of CCK in pancreatic beta cells

(2015) Shang-lei Ning et al.   BRITISH JOURNAL OF PHARMACOLOGY

Structural Insights into the Dynamic Process of β 2 -Adrenergic Receptor Signaling

(2015) Aashish Manglik et al.   CELL

Methyl-specific isotopic labeling: a molecular tool box for solution NMR studies of large proteins

(2015) Rime Kerfah et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

O-tert-Butyltyrosine, an NMR Tag for High-Molecular-Weight Systems and Measurements of Submicromolar Ligand Binding Affinities

(2015) Wan-Na Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser

(2015) Yanyong Kang et al.   NATURE

Structure of a PEGylated protein reveals a highly porous double-helical assembly

(2015) Giada Cattani et al.   Nature Chemistry

Phospho-selective mechanisms of arrestin conformations and functions revealed by unnatural amino acid incorporation and 19F-NMR

(2015) Fan Yang et al.   Nature Communications

A stress response pathway in mice upregulates somatostatin level and transcription in pancreatic delta cells through Gs and β-arrestin 1

(2014) Hong-Mei Wang et al.   DIABETOLOGIA

Visualization of arrestin recruitment by a G-protein-coupled receptor

(2014) Arun K. Shukla et al.   NATURE

Rhodanine hydrolysis leads to potent thioenolate mediated metallo-β-lactamase inhibition

(2014) Jürgen Brem et al.   Nature Chemistry

Crystal structure of a common GPCR-binding interface for G protein and arrestin

(2014) Michal Szczepek et al.   Nature Communications

How good are my data and what is the resolution?

(2013) Philip R. Evans et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A Genetically Encoded19F NMR Probe for Tyrosine Phosphorylation

(2013) Fahui Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fluorine-19 NMR of integral membrane proteins illustrated with studies of GPCRs

(2013) Tatiana Didenko et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide

(2013) Arun K. Shukla et al.   NATURE

Structural insights into biased G protein-coupled receptor signaling revealed by fluorescence spectroscopy

(2012) R. Rahmeh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biased Signaling Pathways in  2-Adrenergic Receptor Characterized by 19F-NMR

(2012) J. J. Liu et al.   SCIENCE

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A Biosynthetic Route to Photoclick Chemistry on Proteins

(2010) Jiangyun Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mutations of β-arrestin 2 that limit self-association also interfere with interactions with the β2-adrenoceptor and the ERK1/2 MAPKs: implications for β2-adrenoceptor signalling via the ERK1/2 MAPKs

(2008) Tian-Rui Xu et al.   BIOCHEMICAL JOURNAL