Agonist-induced membrane nanodomain clustering drives GLP-1 receptor responses in pancreatic beta cells

Mesoscale organization of domains in the plasma membrane – beyond the lipid raft

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Obesity and diabetes-Not only a simple link between two epidemics

(2018) Agata Chobot et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Exploring GPCR–Lipid Interactions by Molecular Dynamics Simulations: Excitements, Challenges, and the Way Forward

(2018) Durba Sengupta et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Biased signalling: from simple switches to allosteric microprocessors

(2018) Jeffrey S. Smith et al.   NATURE REVIEWS DRUG DISCOVERY

Control of insulin secretion by GLP-1

(2018) Ben Jones et al.   PEPTIDES

Studying GPCR Pharmacology in Membrane Microdomains: Fluorescence Correlation Spectroscopy Comes of Age

(2018) Stephen J. Briddon et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Single-Molecule Imaging of GPCR Interactions

(2018) Davide Calebiro et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Targeting GLP-1 receptor trafficking to improve agonist efficacy

(2018) Ben Jones et al.   Nature Communications

Glucagon-like peptide-1 receptor internalisation controls spatiotemporal signalling mediated by biased agonists

(2018) Madeleine M. Fletcher et al.   BIOCHEMICAL PHARMACOLOGY

Reprogramming G protein coupled receptor structure and function

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Structural insights into G-protein-coupled receptor allostery

(2018) David M. Thal et al.   NATURE

Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex

(2018) Yi-Lynn Liang et al.   NATURE

Single-molecule diffusion-based estimation of ligand effects on G protein–coupled receptors

(2018) Masataka Yanagawa et al.   Science Signaling

GLP-1 Receptor in Pancreatic α-Cells Regulates Glucagon Secretion in a Glucose-Dependent Bidirectional Manner

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Single-molecule imaging reveals receptor–G protein interactions at cell surface hot spots

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G Protein–Coupled Receptors Targeting Insulin Resistance, Obesity, and Type 2 Diabetes Mellitus

(2017) Darren M. Riddy et al.   PHARMACOLOGICAL REVIEWS

The Diverse Roles of Arrestin Scaffolds in G Protein–Coupled Receptor Signaling

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Membrane cholesterol access into a G-protein-coupled receptor

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Potent Prearranged Positive Allosteric Modulators of the Glucagon-like Peptide-1 Receptor

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Use of CRISPR/Cas9-engineered INS-1 pancreatic   cells to define the pharmacology of dual GIPR/GLP-1R agonists

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Cell membranes… and how long drugs may exert beneficial pharmacological activityin vivo

(2016) Georges Vauquelin   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Interaction of G protein coupled receptors and cholesterol

(2016) Gerald Gimpl   CHEMISTRY AND PHYSICS OF LIPIDS

Positive Allosteric Modulation of the Glucagon-like Peptide-1 Receptor by Diverse Electrophiles

(2016) Ana B. Bueno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Continuing Mystery of Lipid Rafts

(2016) Ilya Levental et al.   JOURNAL OF MOLECULAR BIOLOGY

Oligomerization of GPCRs involved in endocrine regulation

(2016) Gunnar Kleinau et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Fatty acylation of proteins: The long and the short of it

(2016) Marilyn D. Resh   PROGRESS IN LIPID RESEARCH

Mechanism of allosteric regulation of β2-adrenergic receptor by cholesterol

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Membrane-Mediated Oligomerization of G Protein Coupled Receptors and Its Implications for GPCR Function

(2016) Stefan Gahbauer et al.   Frontiers in Physiology

Lateral diffusion contributes to FRET from lanthanide-tagged membrane proteins

(2015) Tien-Hung Lan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nanodomains in biological membranes

(2015) Yuanqing Ma et al.   Essays in Biochemistry

Super-resolution optical microscopy of lipid plasma membrane dynamics

(2015) Christian Eggeling   Essays in Biochemistry

Minireview: Spatial Programming of G Protein-Coupled Receptor Activity: Decoding Signaling in Health and Disease

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A Broad G Protein-Coupled Receptor Internalization Assay that Combines SNAP-Tag Labeling, Diffusion-Enhanced Resonance Energy Transfer, and a Highly Emissive Terbium Cryptate

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Rafting through traffic: Membrane domains in cellular logistics

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Single Molecule Analysis of Functionally Asymmetric G Protein-coupled Receptor (GPCR) Oligomers Reveals Diverse Spatial and Structural Assemblies

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A potentiator of orthosteric ligand activity at GLP-1R acts via covalent modification

(2014) Whitney M Nolte et al.   Nature Chemical Biology

The GIP Receptor Displays Higher Basal Activity than the GLP-1 Receptor but Does Not Recruit GRK2 or Arrestin3 Effectively

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Influence of Lipid Composition on the Structural Stability of G-Protein Coupled Receptor

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The Identification of Novel Proteins That Interact With the GLP-1 Receptor and Restrain its Activity

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Time-resolved fluorescence ligand binding for G protein–coupled receptors

(2013) Alexander Emami-Nemini et al.   Nature Protocols

Signalling bias in new drug discovery: detection, quantification and therapeutic impact

(2013) Terry Kenakin et al.   NATURE REVIEWS DRUG DISCOVERY

Development of a cysteine-deprived and C-terminally truncated GLP-1 receptor

(2013) Christina Rye Underwood et al.   PEPTIDES

Anchored phosphatases modulate glucose homeostasis

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Palmitoylation of A-Kinase Anchoring Protein 79/150 Regulates Dendritic Endosomal Targeting and Synaptic Plasticity Mechanisms

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Regulation of GIP and GLP1 Receptor Cell Surface Expression by N-Glycosylation and Receptor Heteromerization

(2012) Gina M. Whitaker et al.   PLoS One

Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery

(2012) K. G. Harikumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-molecule analysis of fluorescently labeled G-protein-coupled receptors reveals complexes with distinct dynamics and organization

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Differential Regulation of Two Palmitoylation Sites in the Cytoplasmic Tail of the β1-Adrenergic Receptor

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A mTurquoise-Based cAMP Sensor for Both FLIM and Ratiometric Read-Out Has Improved Dynamic Range

(2011) Jeffrey B. Klarenbeek et al.   PLoS One

The Role of Palmitoylation in Signalling, Cellular Trafficking and Plasma Membrane Localization of Protease-Activated Receptor-2

(2011) Mark N. Adams et al.   PLoS One

Regulation of human EGF receptor by lipids

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Architecture and dynamics of an A-kinase anchoring protein 79 (AKAP79) signaling complex

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Understanding protein palmitoylation: Biological significance and enzymology

(2011) XiaoMu Guan et al.   Science China-Chemistry

Membrane Organization and Lipid Rafts

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Role of N-linked glycosylation in biosynthesis, trafficking, and function of the human glucagon-like peptide 1 receptor

(2010) Quan Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Long-lasting target binding and rebinding as mechanisms to prolong in vivo drug action

(2010) Georges Vauquelin et al.   BRITISH JOURNAL OF PHARMACOLOGY

Site-specific analysis of proteinS-acylation by resin-assisted capture

(2010) Michael T. Forrester et al.   JOURNAL OF LIPID RESEARCH

Switchable Nile Red-Based Probe for Cholesterol and Lipid Order at the Outer Leaflet of Biomembranes

(2010) Oleksandr A. Kucherak et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Visualization of PKA activity in plasma membrane microdomains

(2010) Charlene Depry et al.   Molecular BioSystems

Palmitoylation regulates raft affinity for the majority of integral raft proteins

(2010) I. Levental et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of the signal peptide in the synthesis and processing of the glucagon-like peptide-1 receptor

(2009) Y Huang et al.   BRITISH JOURNAL OF PHARMACOLOGY

G-protein-coupled receptors, cholesterol and palmitoylation: facts about fats

(2009) Bice Chini et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Proteome Scale Characterization of HumanS-Acylated Proteins in Lipid Raft-enriched and Non-raft Membranes

(2009) Wei Yang et al.   MOLECULAR & CELLULAR PROTEOMICS

Pathways and mechanisms of endocytic recycling

(2009) Barth D. Grant et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Clathrin-independent endocytosis: from nonexisting to an extreme degree of complexity

(2008) Kirsten Sandvig et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Robust single-particle tracking in live-cell time-lapse sequences

(2008) Khuloud Jaqaman et al.   NATURE METHODS

Cell-surface protein-protein interaction analysis with time-resolved FRET and snap-tag technologies: application to GPCR oligomerization

(2008) Damien Maurel et al.   NATURE METHODS