Functional competence of a partially engaged GPCR–β-arrestin complex

GPCR Signaling: β-arrestins Kiss and Remember

(2016) Ravi Ranjan et al.   CURRENT BIOLOGY

The conformational signature of β-arrestin2 predicts its trafficking and signalling functions

(2016) Mi-Hye Lee et al.   NATURE

β-Arrestin biosensors reveal a rapid, receptor-dependent activation/deactivation cycle

(2016) Susanne Nuber et al.   NATURE

β-Arrestin drives MAP kinase signalling from clathrin-coated structures after GPCR dissociation

(2016) K. Eichel et al.   NATURE CELL BIOLOGY

Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser

(2015) Yanyong Kang et al.   NATURE

Methodological advances: the unsung heroes of the GPCR structural revolution

(2015) Eshan Ghosh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Emerging Functional Divergence of β-Arrestin Isoforms in GPCR Function

(2015) Ashish Srivastava et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Phospho-selective mechanisms of arrestin conformations and functions revealed by unnatural amino acid incorporation and 19F-NMR

(2015) Fan Yang et al.   Nature Communications

Rhodopsin TM6 Can Interact with Two Separate and Distinct Sites on Arrestin: Evidence for Structural Plasticity and Multiple Docking Modes in Arrestin–Rhodopsin Binding

(2014) Abhinav Sinha et al.   BIOCHEMISTRY

Molecular mechanism of phosphorylation-dependent arrestin activation

(2014) Martin K Ostermaier et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Visualization of arrestin recruitment by a G-protein-coupled receptor

(2014) Arun K. Shukla et al.   NATURE

Emerging structural insights into biased GPCR signaling

(2014) Arun K. Shukla et al.   TRENDS IN BIOCHEMICAL SCIENCES

What is biased efficacy? Defining the relationship between intrinsic efficacy and free energy coupling

(2014) H. Ongun Onaran et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Crystal structure of a common GPCR-binding interface for G protein and arrestin

(2014) Michal Szczepek et al.   Nature Communications

Crystal structure of pre-activated arrestin p44

(2013) Yong Ju Kim et al.   NATURE

Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide

(2013) Arun K. Shukla et al.   NATURE

Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody

(2013) Aaron M. Ring et al.   NATURE

Signalling bias in new drug discovery: detection, quantification and therapeutic impact

(2013) Terry Kenakin et al.   NATURE REVIEWS DRUG DISCOVERY

Ubiquitin-dependent regulation of G protein-coupled receptor trafficking and signaling

(2012) Adriano Marchese et al.   CELLULAR SIGNALLING

Generating conformation-specific synthetic antibodies to trap proteins in selected functional states

(2012) Marcin Paduch et al.   METHODS

Conformation of receptor-bound visual arrestin

(2012) M. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biased Signaling Pathways in  2-Adrenergic Receptor Characterized by 19F-NMR

(2012) J. J. Liu et al.   SCIENCE

Distinct loops in arrestin differentially regulate ligand binding within the GPCR opsin

(2012) Martha E. Sommer et al.   Nature Communications

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Multiple ligand-specific conformations of the β2-adrenergic receptor

(2011) Alem W Kahsai et al.   Nature Chemical Biology

The Effect of Arrestin Conformation on the Recruitment of c-Raf1, MEK1, and ERK1/2 Activation

(2011) Sergio Coffa et al.   PLoS One

Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling

(2011) Arun K. Shukla et al.   TRENDS IN BIOCHEMICAL SCIENCES

β-arrestin-mediated receptor trafficking and signal transduction

(2011) Sudha K. Shenoy et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Arresting a Transient Receptor Potential (TRP) Channel

(2010) Arun K. Shukla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Teaching old receptors new tricks: biasing seven-transmembrane receptors

(2010) Sudarshan Rajagopal et al.   NATURE REVIEWS DRUG DISCOVERY

Global phosphorylation analysis of  -arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR)

(2010) K. Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic potential of β-arrestin- and G protein-biased agonists

(2010) Erin J. Whalen et al.   TRENDS IN MOLECULAR MEDICINE

Helix Formation in Arrestin Accompanies Recognition of Photoactivated Rhodopsin

(2009) Sophie E. Feuerstein et al.   BIOCHEMISTRY

Crystal structure of opsin in its G-protein-interacting conformation

(2008) Patrick Scheerer et al.   NATURE

Distinct conformational changes in  -arrestin report biased agonism at seven-transmembrane receptors

(2008) A. K. Shukla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complementary roles of the DRY motif and C-terminus tail of GPCRS for G protein coupling and β-arrestin interaction

(2007) Kyeong-Man Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS