Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling

GPCRs of adrenal chromaffin cells & catecholamines: The plot thickens

(2016) Anastasios Lymperopoulos et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

β-Arrestin drives MAP kinase signalling from clathrin-coated structures after GPCR dissociation

(2016) K. Eichel et al.   NATURE CELL BIOLOGY

Critical roles of Gi/oproteins and phospholipase C-δ1 in the activation of receptor-operated TRPC4 channels

(2016) Dhananjay P. Thakur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Monitoring G protein-coupled receptor and β-arrestin trafficking in live cells using enhanced bystander BRET

(2016) Yoon Namkung et al.   Nature Communications

Different downstream signalling of CCK1receptors regulates distinct functions of CCK in pancreatic beta cells

(2015) Shang-lei Ning et al.   BRITISH JOURNAL OF PHARMACOLOGY

Dopamine Controls Systemic Inflammation through Inhibition of NLRP3 Inflammasome

(2015) Yiqing Yan et al.   CELL

GPCR signaling and cardiac function

(2015) Leany A. Capote et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Universal allosteric mechanism for Gα activation by GPCRs

(2015) Tilman Flock et al.   NATURE

G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons

(2015) Masoud Ghamari-Langroudi et al.   NATURE

Structural insights into µ-opioid receptor activation

(2015) Weijiao Huang et al.   NATURE

Emerging Functional Divergence of β-Arrestin Isoforms in GPCR Function

(2015) Ashish Srivastava et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Phospho-selective mechanisms of arrestin conformations and functions revealed by unnatural amino acid incorporation and 19F-NMR

(2015) Fan Yang et al.   Nature Communications

Discovery of a Class of Endogenous Mammalian Lipids with Anti-Diabetic and Anti-inflammatory Effects

(2014) Mark M. Yore et al.   CELL

The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes

(2014) Hong-Mei Wang et al.   CELL RESEARCH

A stress response pathway in mice upregulates somatostatin level and transcription in pancreatic delta cells through Gs and β-arrestin 1

(2014) Hong-Mei Wang et al.   DIABETOLOGIA

Calcium influx activates adenylyl cyclase 8 for sustained insulin secretion in rat pancreatic beta cells

(2014) Haiqiang Dou et al.   DIABETOLOGIA

Constitutive GαiCoupling Activity of Very Large G Protein-coupled Receptor 1 (VLGR1) and Its Regulation by PDZD7 Protein

(2014) Qiao-Xia Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Divergent Transducer-specific Molecular Efficacies Generate Biased Agonism at a G Protein-coupled Receptor (GPCR)

(2014) Ryan T. Strachan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activating hotspot L205R mutation in PRKACA and adrenal Cushing's syndrome

(2014) Y. Cao et al.   SCIENCE

Biased ligands at G-protein-coupled receptors: promise and progress

(2014) Jonathan D. Violin et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Negative Impact of β-Arrestin-1 on Post-Myocardial Infarction Heart Failure via Cardiac and Adrenal-Dependent Neurohormonal Mechanisms

(2013) Ashley Bathgate-Siryk et al.   HYPERTENSION

βArrestins in Cardiac G Protein-Coupled Receptor Signaling and Function: Partners in Crime or “Good Cop, Bad Cop”?

(2013) Anastasios Lymperopoulos et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

First Clinical Experience with TRV027: Pharmacokinetics and Pharmacodynamics in Healthy Volunteers

(2013) David G. Soergel et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide

(2013) Arun K. Shukla et al.   NATURE

Receptor signals come in waves

(2013) Martin J. Lohse et al.   NATURE

Conformational biosensors reveal GPCR signalling from endosomes

(2013) Roshanak Irannejad et al.   NATURE

TREK-1 and Best1 Channels Mediate Fast and Slow Glutamate Release in Astrocytes upon GPCR Activation

(2012) Dong Ho Woo et al.   CELL

Thiopental-induced insulin secretion via activation of IP3-sensitive calcium stores in rat pancreatic β-cells

(2011) Hai-Qiang Dou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Adrenal Beta-Arrestin 1 Inhibition In Vivo Attenuates Post-Myocardial Infarction Progression to Heart Failure and Adverse Remodeling Via Reduction of Circulating Aldosterone Levels

(2011) Anastasios Lymperopoulos et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Melanopsin signalling in mammalian iris and retina

(2011) T. Xue et al.   NATURE

A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1

(2011) Makoto R. Hara et al.   NATURE

Alpha cells secrete acetylcholine as a non-neuronal paracrine signal priming beta cell function in humans

(2011) Rayner Rodriguez-Diaz et al.   NATURE MEDICINE

β-Arrestin: A signaling molecule and potential therapeutic target for heart failure

(2010) Nabila Noor et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

An adrenal  -arrestin 1-mediated signaling pathway underlies angiotensin II-induced aldosterone production in vitro and in vivo

(2009) A. Lymperopoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

On the origins of arrestin and rhodopsin

(2008) Carlos E Alvarez   BMC EVOLUTIONARY BIOLOGY

TRPC3 Channels Are Required for Synaptic Transmission and Motor Coordination

(2008) Jana Hartmann et al.   NEURON

Heterotrimeric G protein activation by G-protein-coupled receptors

(2007) William M. Oldham et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY